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The map label for this gene is cvrA [H]

Identifier: 154248479

GI number: 154248479

Start: 5039336

End: 5041114

Strand: Reverse

Name: cvrA [H]

Synonym: Xaut_4559

Alternate gene names: 154248479

Gene position: 5041114-5039336 (Counterclockwise)

Preceding gene: 154248481

Following gene: 154248478

Centisome position: 94.96

GC content: 69.08

Gene sequence:

>1779_bases
ATGAGTTCGGTTTTCGTTTCCAATCTTGTTCTTCTTGTGGTTGCCGCCCTGGTGGTGGTCGGCACCCTGTCGAGCCTGCT
TGCGGCGCGGTTCGGTGCGCCCATCCTTCTGGTGTTCCTCGTCGTCGGCGTCGCGGCGGGGGAGGGCGGCCCCGGCGGCA
TCCATTTCAACGATTATTGGGCCACCTACATGGTGGGCTCGGCGGCGCTGGCGGTGATCCTGTTCGACGGCGGGCTGCGC
ATGCGCCTCGCCAGCATGCGCGGCGCCATCATTCCCGCCATCGGCCTGTCCACCGTCGGTGTGGTGATGACGGCGGCGCT
GGTGGCGCTGGTGGCGGGGCCTCTGCTTGGCCTCGACCCGCTGGAGAGCCTCCTGGTGGGCGCCATCGTCGCCTCCACCG
ATGCGGCGGCGGTGCTGTTCCTGGTGCGGGCGCAGGGCCTTCATCTCGGCCGGCGGGTGGGCTCGGTGATCGAGATCGAA
TCCGCCACCAACGACCCGGCGGCGGTGTTCCTCACCGTGCTGCTGGTGGAACTGCTCACCACCGACACCGGCAATCCCGG
CCTGGCCATGGTGTTCGGCGTGCTGCGCGAGATGGCGTTGGGCGCGGCGATGGGGGTGGCCGGCGGCTATGCCATCGTGG
CCCTGCTGAACCGGGTGGACCTGCCCGGCGGCCTGCATCCGGTGATGGTGATGGGCATTGCGGTGCTGCTGTTCGCGGTC
ACCTCGCTGCTGCACGGCTCGGGCTTCCTGGCGGTCTATCTCGCCGGCCTGGTGCTGGGGAACCGGCCGGTGCGGGCCAT
CGCCTCCATCACCTCGTTCCTCGATACCGTGACCTGGCTGTGCCAGATCGTCATGTTCGTGATGCTGGGCCTGCTGGTCT
CGCCCGAGAAGATCCTGCTCTATGCGCTGCCGGCGCTGGGGGTCGCCGCCTTCCTCATCCTGGTGGGGCGGCCGGCGGCG
GTGTTCCTGTGCCTTGCGCCGTTCCGCTTCTCGCTGAAGGAGAAGCTGTTCATCTCCTGGGCGGGCTTGCGCGGGGCGGT
GTCCATCTTCCTTGCCACCATCCCCATGCTGGCGCATTTGCCGCAGGCCGAGGTCTATTTCAACGTGGCCTTCGCCGTGG
TGCTGGTCTCGCTCATCCTTCACGGCTGGACCATGGCGGCGGTGGCGCGGCGGCTCGACGTGACCTTGTCCGATCCCGCC
CCCGGCATCCGCCGCTTCGAGATCGACCTGCCGGGACAGACCGACATGGAGCTGGTCGCCTATCCGGTGGTGGCCGGCAC
GCCCGCCATCGGGCAGGCCGCGCTGCCCACCTGGGCGCGACTGATGATGGTGGTGCGCGCCGGCCAGACCCTGACACCGG
AGGCCGCCGGTCACCTCAAGGTCGGCGACTACGGCTATGTGCTGGCGCCGCCCAAGCGGGTGCACCAGCTCGACCGCCTG
TTCCGTCCGCAGGAAGCGACGCCCATGGACGATGGCGCCGCCTTTCCCTTCGTGGGCGAGGTGCGGCTCGGCGACCTCAT
GAGCTTCTACGGCCTCACGGTGCCCGACTCGGAGCTTGGCCTCACCATCGCCGAGGCTTTCGCCGACCGCTCGGATGATC
ATCCCGCGCGCGGCATGCGCATCAAGTACGGCAATGCGGTGATCGAGGTGCGCGAGGTGGTGGACGGCCGCGTCACCTGG
GCCGTGCTGCGGCTGGAGGCGGGCCGGCTCAAGCGTTCCATCGCGAAGGTGCGGCGACTGTTCGGCCTCCAGCCCGAGGG
GGAGGACGACGAGGCGTGA

Upstream 100 bases:

>100_bases
TGACCTCGCGACCGCGACGATCAGAAGCTTACGCCTTCGGCTTCACAGACGCTACTGTTGCGTCTCAATCGCGAAGGGCG
GGCGGGTGGCCCGGCATGTG

Downstream 100 bases:

>100_bases
GACGCCGTCATGTTTGCGCCGCGAGGACGGTTCAAAACCCGCCGCGAGATCCATCGAGGAGGCGGGGATGAGGCTGTTCA
TGCGCCGGCGCGGGGAGGCG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MSSVFVSNLVLLVVAALVVVGTLSSLLAARFGAPILLVFLVVGVAAGEGGPGGIHFNDYWATYMVGSAALAVILFDGGLR
MRLASMRGAIIPAIGLSTVGVVMTAALVALVAGPLLGLDPLESLLVGAIVASTDAAAVLFLVRAQGLHLGRRVGSVIEIE
SATNDPAAVFLTVLLVELLTTDTGNPGLAMVFGVLREMALGAAMGVAGGYAIVALLNRVDLPGGLHPVMVMGIAVLLFAV
TSLLHGSGFLAVYLAGLVLGNRPVRAIASITSFLDTVTWLCQIVMFVMLGLLVSPEKILLYALPALGVAAFLILVGRPAA
VFLCLAPFRFSLKEKLFISWAGLRGAVSIFLATIPMLAHLPQAEVYFNVAFAVVLVSLILHGWTMAAVARRLDVTLSDPA
PGIRRFEIDLPGQTDMELVAYPVVAGTPAIGQAALPTWARLMMVVRAGQTLTPEAAGHLKVGDYGYVLAPPKRVHQLDRL
FRPQEATPMDDGAAFPFVGEVRLGDLMSFYGLTVPDSELGLTIAEAFADRSDDHPARGMRIKYGNAVIEVREVVDGRVTW
AVLRLEAGRLKRSIAKVRRLFGLQPEGEDDEA

Sequences:

>Translated_592_residues
MSSVFVSNLVLLVVAALVVVGTLSSLLAARFGAPILLVFLVVGVAAGEGGPGGIHFNDYWATYMVGSAALAVILFDGGLR
MRLASMRGAIIPAIGLSTVGVVMTAALVALVAGPLLGLDPLESLLVGAIVASTDAAAVLFLVRAQGLHLGRRVGSVIEIE
SATNDPAAVFLTVLLVELLTTDTGNPGLAMVFGVLREMALGAAMGVAGGYAIVALLNRVDLPGGLHPVMVMGIAVLLFAV
TSLLHGSGFLAVYLAGLVLGNRPVRAIASITSFLDTVTWLCQIVMFVMLGLLVSPEKILLYALPALGVAAFLILVGRPAA
VFLCLAPFRFSLKEKLFISWAGLRGAVSIFLATIPMLAHLPQAEVYFNVAFAVVLVSLILHGWTMAAVARRLDVTLSDPA
PGIRRFEIDLPGQTDMELVAYPVVAGTPAIGQAALPTWARLMMVVRAGQTLTPEAAGHLKVGDYGYVLAPPKRVHQLDRL
FRPQEATPMDDGAAFPFVGEVRLGDLMSFYGLTVPDSELGLTIAEAFADRSDDHPARGMRIKYGNAVIEVREVVDGRVTW
AVLRLEAGRLKRSIAKVRRLFGLQPEGEDDEA
>Mature_591_residues
SSVFVSNLVLLVVAALVVVGTLSSLLAARFGAPILLVFLVVGVAAGEGGPGGIHFNDYWATYMVGSAALAVILFDGGLRM
RLASMRGAIIPAIGLSTVGVVMTAALVALVAGPLLGLDPLESLLVGAIVASTDAAAVLFLVRAQGLHLGRRVGSVIEIES
ATNDPAAVFLTVLLVELLTTDTGNPGLAMVFGVLREMALGAAMGVAGGYAIVALLNRVDLPGGLHPVMVMGIAVLLFAVT
SLLHGSGFLAVYLAGLVLGNRPVRAIASITSFLDTVTWLCQIVMFVMLGLLVSPEKILLYALPALGVAAFLILVGRPAAV
FLCLAPFRFSLKEKLFISWAGLRGAVSIFLATIPMLAHLPQAEVYFNVAFAVVLVSLILHGWTMAAVARRLDVTLSDPAP
GIRRFEIDLPGQTDMELVAYPVVAGTPAIGQAALPTWARLMMVVRAGQTLTPEAAGHLKVGDYGYVLAPPKRVHQLDRLF
RPQEATPMDDGAAFPFVGEVRLGDLMSFYGLTVPDSELGLTIAEAFADRSDDHPARGMRIKYGNAVIEVREVVDGRVTWA
VLRLEAGRLKRSIAKVRRLFGLQPEGEDDEA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=538, Percent_Identity=39.2193308550186, Blast_Score=333, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 62406; Mature: 62275

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVFVSNLVLLVVAALVVVGTLSSLLAARFGAPILLVFLVVGVAAGEGGPGGIHFNDYW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ATYMVGSAALAVILFDGGLRMRLASMRGAIIPAIGLSTVGVVMTAALVALVAGPLLGLDP
HHHHHHHHHEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LESLLVGAIVASTDAAAVLFLVRAQGLHLGRRVGSVIEIESATNDPAAVFLTVLLVELLT
HHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHH
TDTGNPGLAMVFGVLREMALGAAMGVAGGYAIVALLNRVDLPGGLHPVMVMGIAVLLFAV
CCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TSLLHGSGFLAVYLAGLVLGNRPVRAIASITSFLDTVTWLCQIVMFVMLGLLVSPEKILL
HHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
YALPALGVAAFLILVGRPAAVFLCLAPFRFSLKEKLFISWAGLRGAVSIFLATIPMLAHL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHC
PQAEVYFNVAFAVVLVSLILHGWTMAAVARRLDVTLSDPAPGIRRFEIDLPGQTDMELVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEEEECCCCCCCHHEE
YPVVAGTPAIGQAALPTWARLMMVVRAGQTLTPEAAGHLKVGDYGYVLAPPKRVHQLDRL
EEHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEECCHHHHHHHHHH
FRPQEATPMDDGAAFPFVGEVRLGDLMSFYGLTVPDSELGLTIAEAFADRSDDHPARGMR
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEE
IKYGNAVIEVREVVDGRVTWAVLRLEAGRLKRSIAKVRRLFGLQPEGEDDEA
EEECCHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SSVFVSNLVLLVVAALVVVGTLSSLLAARFGAPILLVFLVVGVAAGEGGPGGIHFNDYW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
ATYMVGSAALAVILFDGGLRMRLASMRGAIIPAIGLSTVGVVMTAALVALVAGPLLGLDP
HHHHHHHHHEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LESLLVGAIVASTDAAAVLFLVRAQGLHLGRRVGSVIEIESATNDPAAVFLTVLLVELLT
HHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHH
TDTGNPGLAMVFGVLREMALGAAMGVAGGYAIVALLNRVDLPGGLHPVMVMGIAVLLFAV
CCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TSLLHGSGFLAVYLAGLVLGNRPVRAIASITSFLDTVTWLCQIVMFVMLGLLVSPEKILL
HHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
YALPALGVAAFLILVGRPAAVFLCLAPFRFSLKEKLFISWAGLRGAVSIFLATIPMLAHL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHC
PQAEVYFNVAFAVVLVSLILHGWTMAAVARRLDVTLSDPAPGIRRFEIDLPGQTDMELVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEEEECCCCCCCHHEE
YPVVAGTPAIGQAALPTWARLMMVVRAGQTLTPEAAGHLKVGDYGYVLAPPKRVHQLDRL
EEHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEECCHHHHHHHHHH
FRPQEATPMDDGAAFPFVGEVRLGDLMSFYGLTVPDSELGLTIAEAFADRSDDHPARGMR
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEE
IKYGNAVIEVREVVDGRVTWAVLRLEAGRLKRSIAKVRRLFGLQPEGEDDEA
EEECCHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA