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The map label for this gene is metC [H]

Identifier: 154248465

GI number: 154248465

Start: 5022415

End: 5023611

Strand: Reverse

Name: metC [H]

Synonym: Xaut_4545

Alternate gene names: 154248465

Gene position: 5023611-5022415 (Counterclockwise)

Preceding gene: 154248475

Following gene: 154248464

Centisome position: 94.63

GC content: 67.17

Gene sequence:

>1197_bases
ATGTCGCATGGGCACGATGATGGAACAGGCAGCGGCACCGGTCTGAGGCCTGCGACGAAAGTCGTACACTCCGGCCGTGA
TCCCAAGCGTTTCGACGGTTTCGTCAATACGCCGGTGGTGCGCGGATCGACCGTTCTTTCGGCAACCTATGACGATCTCA
TCCACCATCGCGGCCGCTACAGCTACGGCCGGCGGGGCAATCCCACCACCGAAGGCTTCGAGACGGCGCTGAGGGCTCTG
GAGGGCGGCGATGGAATCGCCCTCACCCCGTCCGGGCTTTCGGCCTGCTCCATCTCCCTGCTCTCCGTGCTCGATGCCGG
CGATCACCTGCTGATGGTGGACACCGCCTATCGTCCCACGCGCACCTTCTGCGACCAGGTGCTGAAGCGCCTCGGGGTGG
AGACCACCTATTATGATCCGCTGGTGGGCTCAGGCATCGCCGAGCTTATCCGCGACAACACCCGCGCCATCTTCCTCGAA
TCGCCGGGCTCGCAGAGCTTCGAGATGCAGGACGTGCCGGCCATCACGGCAGTGGCGCGGGCGCGGGGCATCACCACGCT
GATCGACAACACCTGGGCGACGCCGCTCTTCTTCAAGCCTCATGCCTTCGGGGTCGACATCTCGATCCAGGCCGGCACGA
AGTACATCGGCGGCCATGCGGACCTGAATCTCGGCACCATTTCCGCCGTGGGGCCGGCGTGGAAGAAGGTGATCGCCACC
CACGGCACCCTGGGCATCACCATCAGCCCGGATGACGCGGCGCTTGGCGCGCGCGGCCTGCGCACCCTTGCGGTGCGGCT
GGCGCACCACCAGCGCTCCGGGCTGGAGGTGGCGCAGTGGCTTCAGGATCGGCCGGAAGTGTCGCGAGTGCTGCATCCCG
CCCTGCCCACCGATCCCGGCCACGCCATCTGGAAGCGCGACTTCACCGGCGCTACCGGCCTGTTCAGCCTGATCCTGAAG
GAGGTGCCGGAGCGCGCCGTGGCGGCCTTCTTCGATGCCCTCGCCCTGTTCGGCATGGGCTATTCGTGGGGCGGCTACGA
GAGCCTCGCCATTCCGTTCGATTGCCGCGACTATCGCACGGCGACGGTCTGGGACGTGGAAGGCCCCGGCGTGCGCCTGC
ACATCGGGCTCGAGGACGTGGCCGACCTGAAGGCCGATCTGGACCAGGCCTTCGCCAGGATGCGGGCGGCGGCCTGA

Upstream 100 bases:

>100_bases
GGGCGACCCAAGACGTCTATCCCGCCCATCACAGCCCCTCGGCGCGGGCGGGTCAATAGTAGGGCCGTGCACCGGCCGAC
CATCGGCACAGGAGAATTGC

Downstream 100 bases:

>100_bases
CGCTGCCCGTACATCCACCAACAGGGACCGTTCTCCCGGTCGGATGGGGTGCCCCGCCCGACCGGAACGTGCATCAGCCA
TGATCGTGCGGCCGCGACCG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSHGHDDGTGSGTGLRPATKVVHSGRDPKRFDGFVNTPVVRGSTVLSATYDDLIHHRGRYSYGRRGNPTTEGFETALRAL
EGGDGIALTPSGLSACSISLLSVLDAGDHLLMVDTAYRPTRTFCDQVLKRLGVETTYYDPLVGSGIAELIRDNTRAIFLE
SPGSQSFEMQDVPAITAVARARGITTLIDNTWATPLFFKPHAFGVDISIQAGTKYIGGHADLNLGTISAVGPAWKKVIAT
HGTLGITISPDDAALGARGLRTLAVRLAHHQRSGLEVAQWLQDRPEVSRVLHPALPTDPGHAIWKRDFTGATGLFSLILK
EVPERAVAAFFDALALFGMGYSWGGYESLAIPFDCRDYRTATVWDVEGPGVRLHIGLEDVADLKADLDQAFARMRAAA

Sequences:

>Translated_398_residues
MSHGHDDGTGSGTGLRPATKVVHSGRDPKRFDGFVNTPVVRGSTVLSATYDDLIHHRGRYSYGRRGNPTTEGFETALRAL
EGGDGIALTPSGLSACSISLLSVLDAGDHLLMVDTAYRPTRTFCDQVLKRLGVETTYYDPLVGSGIAELIRDNTRAIFLE
SPGSQSFEMQDVPAITAVARARGITTLIDNTWATPLFFKPHAFGVDISIQAGTKYIGGHADLNLGTISAVGPAWKKVIAT
HGTLGITISPDDAALGARGLRTLAVRLAHHQRSGLEVAQWLQDRPEVSRVLHPALPTDPGHAIWKRDFTGATGLFSLILK
EVPERAVAAFFDALALFGMGYSWGGYESLAIPFDCRDYRTATVWDVEGPGVRLHIGLEDVADLKADLDQAFARMRAAA
>Mature_397_residues
SHGHDDGTGSGTGLRPATKVVHSGRDPKRFDGFVNTPVVRGSTVLSATYDDLIHHRGRYSYGRRGNPTTEGFETALRALE
GGDGIALTPSGLSACSISLLSVLDAGDHLLMVDTAYRPTRTFCDQVLKRLGVETTYYDPLVGSGIAELIRDNTRAIFLES
PGSQSFEMQDVPAITAVARARGITTLIDNTWATPLFFKPHAFGVDISIQAGTKYIGGHADLNLGTISAVGPAWKKVIATH
GTLGITISPDDAALGARGLRTLAVRLAHHQRSGLEVAQWLQDRPEVSRVLHPALPTDPGHAIWKRDFTGATGLFSLILKE
VPERAVAAFFDALALFGMGYSWGGYESLAIPFDCRDYRTATVWDVEGPGVRLHIGLEDVADLKADLDQAFARMRAAA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=335, Percent_Identity=32.5373134328358, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI299473759, Length=335, Percent_Identity=30.1492537313433, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI25453487, Length=334, Percent_Identity=30.8383233532934, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789383, Length=387, Percent_Identity=44.1860465116279, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1790375, Length=383, Percent_Identity=30.5483028720627, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=372, Percent_Identity=31.989247311828, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17560056, Length=338, Percent_Identity=33.1360946745562, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=339, Percent_Identity=31.858407079646, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321170, Length=328, Percent_Identity=46.3414634146341, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6319307, Length=396, Percent_Identity=30.5555555555556, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323333, Length=391, Percent_Identity=26.0869565217391, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=360, Percent_Identity=25.2777777777778, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321904, Length=383, Percent_Identity=24.0208877284595, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922554, Length=382, Percent_Identity=34.8167539267016, Blast_Score=208, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42803; Mature: 42672

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHGHDDGTGSGTGLRPATKVVHSGRDPKRFDGFVNTPVVRGSTVLSATYDDLIHHRGRY
CCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCCEECCCEEEHHHHHHHHHHCCCC
SYGRRGNPTTEGFETALRALEGGDGIALTPSGLSACSISLLSVLDAGDHLLMVDTAYRPT
CCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCH
RTFCDQVLKRLGVETTYYDPLVGSGIAELIRDNTRAIFLESPGSQSFEMQDVPAITAVAR
HHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
ARGITTLIDNTWATPLFFKPHAFGVDISIQAGTKYIGGHADLNLGTISAVGPAWKKVIAT
HCCCCEECCCCCCCCEEECCCEEEEEEEEECCCEEECCCCCCCCCEEHHCCHHHHHHHHC
HGTLGITISPDDAALGARGLRTLAVRLAHHQRSGLEVAQWLQDRPEVSRVLHPALPTDPG
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCCCCC
HAIWKRDFTGATGLFSLILKEVPERAVAAFFDALALFGMGYSWGGYESLAIPFDCRDYRT
CHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCE
ATVWDVEGPGVRLHIGLEDVADLKADLDQAFARMRAAA
EEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHGHDDGTGSGTGLRPATKVVHSGRDPKRFDGFVNTPVVRGSTVLSATYDDLIHHRGRY
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCCEECCCEEEHHHHHHHHHHCCCC
SYGRRGNPTTEGFETALRALEGGDGIALTPSGLSACSISLLSVLDAGDHLLMVDTAYRPT
CCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCH
RTFCDQVLKRLGVETTYYDPLVGSGIAELIRDNTRAIFLESPGSQSFEMQDVPAITAVAR
HHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
ARGITTLIDNTWATPLFFKPHAFGVDISIQAGTKYIGGHADLNLGTISAVGPAWKKVIAT
HCCCCEECCCCCCCCEEECCCEEEEEEEEECCCEEECCCCCCCCCEEHHCCHHHHHHHHC
HGTLGITISPDDAALGARGLRTLAVRLAHHQRSGLEVAQWLQDRPEVSRVLHPALPTDPG
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHCCCCCCCCC
HAIWKRDFTGATGLFSLILKEVPERAVAAFFDALALFGMGYSWGGYESLAIPFDCRDYRT
CHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCE
ATVWDVEGPGVRLHIGLEDVADLKADLDQAFARMRAAA
EEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]