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The map label for this gene is dxr [H]

Identifier: 154248353

GI number: 154248353

Start: 4919373

End: 4920542

Strand: Reverse

Name: dxr [H]

Synonym: Xaut_4433

Alternate gene names: 154248353

Gene position: 4920542-4919373 (Counterclockwise)

Preceding gene: 154248354

Following gene: 154248352

Centisome position: 92.68

GC content: 70.34

Gene sequence:

>1170_bases
ATGAAGCGCCTTTCCATCCTCGGGGCCACCGGCTCCATCGGCCACAGCGTCCGGACCCTCCTGGCCGATGCGCCCGGCCT
CTATGAGGTGGAAGCGGTCGCCGGCGGACGGGATGTCGCGGCACTGGCCGAGACCGCCCGTGCGCTCAATGCGCGCTTTG
CCGCCATCGCCGATCCGGCGGCGGGCAGGGCGCTCGCCGAAGCGCTGGCCGGCTCCGGCATCGCCAGCGGCGCCGGTCCC
TCGGCCCTGATCGAGGCGGCCCAGCGCGAGGCGGACGTGGTGGTAAGCGCCATCGTCGGCGTGGCGGGCCTTGCGCCCAC
CGTGGCTGCCTTCGCGCCGGGCCGGCGCATCGCGCTGGCCAACAAGGAATGTCTGGTGGCCGCCGGTGCCTTCTTCATGG
CCGAGGCGGCGCGGCAGGGCACCGAGATCCTGCCCGTGGACAGCGAGCACAACGCCATCTTCCAGGCGCTGGAGGCCGGC
CCACGCAAGGCGGTGGAGAAGATCACGCTCACGGCCTCGGGCGGCCCGTTCCGGCTGAAAAGCCGGGAGGAGATCGCGCG
GGCACTGCCGAAGGATGCGCTCAAGCACCCCAACTGGTCGATGGGCGCCAAGATCACCATCGATTCGGCCACCCTCATGA
ACAAGGGCCTCGAACTGATCGAGGCGATGCACCTGTTCGCCCTGCCGCCCGAGCGCTTCGACGCGGTGGTGCATCCCGAG
TCGGTGGTCCACGGGCTGGTGTCGTTTGTCGATGGGTCCGTGACAGCCGGCCTCGCCATGCCCGACATGTGCGTGCCGAT
CGCCCATTGCCTGGCGTTTCCGGATCGAATCGTCACCTCCTGCCGCCGGCTGGACCTGGTGGCCCTGGGCCGCCTCAGCT
TCGAGGCGCCGGACGAGGCCCGCTTCCCGGCGCTGGCGCTCGCCCGCGCCGCCATGGCCGCCGACGGGATGGCCGCAACC
ATTCTGAACGCGGCCAACGAGGTGGCGGTCGCGGCGTATCTTGAGGGGCGGATCGGCTTTTACGGCATCACCGATACCGT
GGCCGCGACGCTGGACCGCATCAATGGCGGTCCTGCGCCCGCCAGCGTCGCCGATGCCATGGAGGCGGATGCACAGGCGC
GCCGTGCTGCTGCCGTGCTCTTGCCTAAGTTTTCCGCAAAGGCATCTTAG

Upstream 100 bases:

>100_bases
GACGGATTCGCTGCCGCATCCCTAGCCGCCGTGGTGGTGGCGCTCCTGCGCAGCGCGAGCGATCCGGCGGCGGGGCTGCT
CTTGTGGTAGGACGTGTTTC

Downstream 100 bases:

>100_bases
GATCAGTTTGCCGCCTCGGCGGACGGTAGGCTTTTATACCGTCCGTTTTGGCGGACGATGGTCTTGATGCCGGGCGGCCC
GGCAGCATCTGGCCGGCTCA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKRLSILGATGSIGHSVRTLLADAPGLYEVEAVAGGRDVAALAETARALNARFAAIADPAAGRALAEALAGSGIASGAGP
SALIEAAQREADVVVSAIVGVAGLAPTVAAFAPGRRIALANKECLVAAGAFFMAEAARQGTEILPVDSEHNAIFQALEAG
PRKAVEKITLTASGGPFRLKSREEIARALPKDALKHPNWSMGAKITIDSATLMNKGLELIEAMHLFALPPERFDAVVHPE
SVVHGLVSFVDGSVTAGLAMPDMCVPIAHCLAFPDRIVTSCRRLDLVALGRLSFEAPDEARFPALALARAAMAADGMAAT
ILNAANEVAVAAYLEGRIGFYGITDTVAATLDRINGGPAPASVADAMEADAQARRAAAVLLPKFSAKAS

Sequences:

>Translated_389_residues
MKRLSILGATGSIGHSVRTLLADAPGLYEVEAVAGGRDVAALAETARALNARFAAIADPAAGRALAEALAGSGIASGAGP
SALIEAAQREADVVVSAIVGVAGLAPTVAAFAPGRRIALANKECLVAAGAFFMAEAARQGTEILPVDSEHNAIFQALEAG
PRKAVEKITLTASGGPFRLKSREEIARALPKDALKHPNWSMGAKITIDSATLMNKGLELIEAMHLFALPPERFDAVVHPE
SVVHGLVSFVDGSVTAGLAMPDMCVPIAHCLAFPDRIVTSCRRLDLVALGRLSFEAPDEARFPALALARAAMAADGMAAT
ILNAANEVAVAAYLEGRIGFYGITDTVAATLDRINGGPAPASVADAMEADAQARRAAAVLLPKFSAKAS
>Mature_389_residues
MKRLSILGATGSIGHSVRTLLADAPGLYEVEAVAGGRDVAALAETARALNARFAAIADPAAGRALAEALAGSGIASGAGP
SALIEAAQREADVVVSAIVGVAGLAPTVAAFAPGRRIALANKECLVAAGAFFMAEAARQGTEILPVDSEHNAIFQALEAG
PRKAVEKITLTASGGPFRLKSREEIARALPKDALKHPNWSMGAKITIDSATLMNKGLELIEAMHLFALPPERFDAVVHPE
SVVHGLVSFVDGSVTAGLAMPDMCVPIAHCLAFPDRIVTSCRRLDLVALGRLSFEAPDEARFPALALARAAMAADGMAAT
ILNAANEVAVAAYLEGRIGFYGITDTVAATLDRINGGPAPASVADAMEADAQARRAAAVLLPKFSAKAS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=42.1994884910486, Blast_Score=276, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 39880; Mature: 39880

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSILGATGSIGHSVRTLLADAPGLYEVEAVAGGRDVAALAETARALNARFAAIADPA
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCH
AGRALAEALAGSGIASGAGPSALIEAAQREADVVVSAIVGVAGLAPTVAAFAPGRRIALA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
NKECLVAAGAFFMAEAARQGTEILPVDSEHNAIFQALEAGPRKAVEKITLTASGGPFRLK
CCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCHHHHHHEEEEEECCCCEEEC
SREEIARALPKDALKHPNWSMGAKITIDSATLMNKGLELIEAMHLFALPPERFDAVVHPE
CHHHHHHHCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHH
SVVHGLVSFVDGSVTAGLAMPDMCVPIAHCLAFPDRIVTSCRRLDLVALGRLSFEAPDEA
HHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCC
RFPALALARAAMAADGMAATILNAANEVAVAAYLEGRIGFYGITDTVAATLDRINGGPAP
CCHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHCCCCCCC
ASVADAMEADAQARRAAAVLLPKFSAKAS
HHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MKRLSILGATGSIGHSVRTLLADAPGLYEVEAVAGGRDVAALAETARALNARFAAIADPA
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCH
AGRALAEALAGSGIASGAGPSALIEAAQREADVVVSAIVGVAGLAPTVAAFAPGRRIALA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
NKECLVAAGAFFMAEAARQGTEILPVDSEHNAIFQALEAGPRKAVEKITLTASGGPFRLK
CCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHCCHHHHHHEEEEEECCCCEEEC
SREEIARALPKDALKHPNWSMGAKITIDSATLMNKGLELIEAMHLFALPPERFDAVVHPE
CHHHHHHHCCHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHH
SVVHGLVSFVDGSVTAGLAMPDMCVPIAHCLAFPDRIVTSCRRLDLVALGRLSFEAPDEA
HHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCC
RFPALALARAAMAADGMAATILNAANEVAVAAYLEGRIGFYGITDTVAATLDRINGGPAP
CCHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHCCCCCCC
ASVADAMEADAQARRAAAVLLPKFSAKAS
HHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA