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The map label for this gene is serS

Identifier: 154248324

GI number: 154248324

Start: 4884516

End: 4885922

Strand: Reverse

Name: serS

Synonym: Xaut_4404

Alternate gene names: 154248324

Gene position: 4885922-4884516 (Counterclockwise)

Preceding gene: 154248325

Following gene: 154248323

Centisome position: 92.03

GC content: 63.61

Gene sequence:

>1407_bases
ATGCACGATATCAAATGGATCCGGGACGAGCCGGTAGGGCTCATCACCGCGCTGGTGCGGCGCGGCGGCGGGTCCGATGA
GGCGAAGTCGGCGGCCGAAAAGCTGGTCGCGTATCTGATCGGCCTTGATGAACAACGGCGCAGGACGCTGACTGACCTCG
AAGGCAAGCTGGCCCGTCGTAACGCGGCCTCGAAGGAGATTGGCCAGGCGAAAGCCCAGAAGGATGAGGAGCGGGCGTCG
CGCCTGATGGCTGAGGTCGCGAATTTGAAGGCTGATATTCCAACGCTTGAAGCGCTGGCGAAGGACTGGGAAAAATCTCT
CGATAACGCTCTCGCCGCCATCCCCAACGCCCCGCTCGCCGAGGTGCCGCCGGGCGCCGACGAGCACGACAATGTGGAGA
AGAGCCGCTTCGGCGTGGCGCGCTCCTACGCCTTCACCCCGAAGCAGCATTTCGAGGTGGGTGAAGCTCTCGGCCAGATG
GATTTCGAGACCGCCGCCAAGCTCTCCGGCGCCCGCTTCGTGGTGAACAAGGGGCCCCTGGCCCGGCTGGAGCGCGCGTT
GGGGCAGTTCTTCTTGGACGTGCACACCGGCGAGCATGGCTACATGGAAGTGAACCCGCCATTGCTGGTGCGGGATGATG
CGATGTTTGGGACCGCGCAACTGCCAAAGTTCCGGGAGGATCAGTTCTTTGTAAATACAGTTGATGGGATTGAGGCTATA
TCGGCAGAGACTAAAGGGTTTGAGACGTTTTCAGACGAGTTCAAGTCGAAATTGACTGAGGCGATGTCGTATCAGGGGCG
CTGGCTCATCCCCACCGCCGAAGTCCCCCTCACCAACCTTGTCCGCGAGTCCATCCTCTCCGAGGAAGAACTGCCCCTGC
GCCTCACCGCCTGCACGCCCTGCTTCCGGGCCGAGGCGGGTGCGGCGGGGCGCGATACGCGGGGCATGATCCGCCAGCAC
CAGTTCACCAAGGTGGAACTGGTCTCCATCACCACGCCGGAGAAGTCGGCCGAGGAGCACGAGCGCATGCTCGCCTGCGC
CGAAGCGGTGCTGAAGAAGCTCGACCTGCATTATCGCGTGGTCACGCTCTGCACTGGTGACATGGGCTTCGCCTCGCAGA
AGACCTACGACATCGAGGTGTGGCTGCCGGGGCAGGGGGCGTTCCGCGAAATCTCCTCCTGCTCGGTGTGCGGCGATTTC
CAGGCCCGGCGCATGAATGCCCGCTACCGCCCCGCCGAGGGGAAAGGCCCGCGCTTCGTCCATACGCTGAACGGCTCGGG
CGTGGCGGTGGGCCGCGCGCTGGTGGCGGTGCTGGAAACCTACCAGCAGGAGAACGGTGCCGTCACAGTGCCGGATGCAC
TCCTGCCCTATATGGGCGGGCTGAAGACCATCGAGAAGCTGAAGTAG

Upstream 100 bases:

>100_bases
CTGTCAATCTGGTGCAATCGGCCGGACGTGGATGCCCGGCACAAGGCCGGGCATGACGGTGGTGCGGGGGGCCGGCGCTG
TCCCCATGCGGAGCCTTGCC

Downstream 100 bases:

>100_bases
AGGCGGCCCTCGCTTGAGGACGCCCGCGACACCAAAGTCGTCCCCCGGCTCGACCGGGGGGCTAACCCCTCCGCGACACA
AGTGACAGACGCCGAAGAGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MHDIKWIRDEPVGLITALVRRGGGSDEAKSAAEKLVAYLIGLDEQRRRTLTDLEGKLARRNAASKEIGQAKAQKDEERAS
RLMAEVANLKADIPTLEALAKDWEKSLDNALAAIPNAPLAEVPPGADEHDNVEKSRFGVARSYAFTPKQHFEVGEALGQM
DFETAAKLSGARFVVNKGPLARLERALGQFFLDVHTGEHGYMEVNPPLLVRDDAMFGTAQLPKFREDQFFVNTVDGIEAI
SAETKGFETFSDEFKSKLTEAMSYQGRWLIPTAEVPLTNLVRESILSEEELPLRLTACTPCFRAEAGAAGRDTRGMIRQH
QFTKVELVSITTPEKSAEEHERMLACAEAVLKKLDLHYRVVTLCTGDMGFASQKTYDIEVWLPGQGAFREISSCSVCGDF
QARRMNARYRPAEGKGPRFVHTLNGSGVAVGRALVAVLETYQQENGAVTVPDALLPYMGGLKTIEKLK

Sequences:

>Translated_468_residues
MHDIKWIRDEPVGLITALVRRGGGSDEAKSAAEKLVAYLIGLDEQRRRTLTDLEGKLARRNAASKEIGQAKAQKDEERAS
RLMAEVANLKADIPTLEALAKDWEKSLDNALAAIPNAPLAEVPPGADEHDNVEKSRFGVARSYAFTPKQHFEVGEALGQM
DFETAAKLSGARFVVNKGPLARLERALGQFFLDVHTGEHGYMEVNPPLLVRDDAMFGTAQLPKFREDQFFVNTVDGIEAI
SAETKGFETFSDEFKSKLTEAMSYQGRWLIPTAEVPLTNLVRESILSEEELPLRLTACTPCFRAEAGAAGRDTRGMIRQH
QFTKVELVSITTPEKSAEEHERMLACAEAVLKKLDLHYRVVTLCTGDMGFASQKTYDIEVWLPGQGAFREISSCSVCGDF
QARRMNARYRPAEGKGPRFVHTLNGSGVAVGRALVAVLETYQQENGAVTVPDALLPYMGGLKTIEKLK
>Mature_468_residues
MHDIKWIRDEPVGLITALVRRGGGSDEAKSAAEKLVAYLIGLDEQRRRTLTDLEGKLARRNAASKEIGQAKAQKDEERAS
RLMAEVANLKADIPTLEALAKDWEKSLDNALAAIPNAPLAEVPPGADEHDNVEKSRFGVARSYAFTPKQHFEVGEALGQM
DFETAAKLSGARFVVNKGPLARLERALGQFFLDVHTGEHGYMEVNPPLLVRDDAMFGTAQLPKFREDQFFVNTVDGIEAI
SAETKGFETFSDEFKSKLTEAMSYQGRWLIPTAEVPLTNLVRESILSEEELPLRLTACTPCFRAEAGAAGRDTRGMIRQH
QFTKVELVSITTPEKSAEEHERMLACAEAVLKKLDLHYRVVTLCTGDMGFASQKTYDIEVWLPGQGAFREISSCSVCGDF
QARRMNARYRPAEGKGPRFVHTLNGSGVAVGRALVAVLETYQQENGAVTVPDALLPYMGGLKTIEKLK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=386, Percent_Identity=34.7150259067358, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI8923421, Length=348, Percent_Identity=30.7471264367816, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI225579074, Length=348, Percent_Identity=30.7471264367816, Blast_Score=165, Evalue=8e-41,
Organism=Escherichia coli, GI1787120, Length=464, Percent_Identity=47.4137931034483, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17539260, Length=460, Percent_Identity=31.304347826087, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=184, Percent_Identity=34.2391304347826, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321799, Length=425, Percent_Identity=28.7058823529412, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6320226, Length=459, Percent_Identity=30.0653594771242, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24581334, Length=359, Percent_Identity=32.8690807799443, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17737985, Length=394, Percent_Identity=29.6954314720812, Blast_Score=153, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_XANP2 (A7INN1)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001419282.1
- ProteinModelPortal:   A7INN1
- SMR:   A7INN1
- STRING:   A7INN1
- GeneID:   5421255
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_4404
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   XAUT78245:XAUT_4404-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 51599; Mature: 51599

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 326-326 BINDING 426-426

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIKWIRDEPVGLITALVRRGGGSDEAKSAAEKLVAYLIGLDEQRRRTLTDLEGKLARR
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
NAASKEIGQAKAQKDEERASRLMAEVANLKADIPTLEALAKDWEKSLDNALAAIPNAPLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EVPPGADEHDNVEKSRFGVARSYAFTPKQHFEVGEALGQMDFETAAKLSGARFVVNKGPL
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCH
ARLERALGQFFLDVHTGEHGYMEVNPPLLVRDDAMFGTAQLPKFREDQFFVNTVDGIEAI
HHHHHHHHHHEEEEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCEEEECHHHHHHH
SAETKGFETFSDEFKSKLTEAMSYQGRWLIPTAEVPLTNLVRESILSEEELPLRLTACTP
HHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCC
CFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPEKSAEEHERMLACAEAVLKKLDLHYRV
HHHCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEE
VTLCTGDMGFASQKTYDIEVWLPGQGAFREISSCSVCGDFQARRMNARYRPAEGKGPRFV
EEEEECCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEE
HTLNGSGVAVGRALVAVLETYQQENGAVTVPDALLPYMGGLKTIEKLK
EEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MHDIKWIRDEPVGLITALVRRGGGSDEAKSAAEKLVAYLIGLDEQRRRTLTDLEGKLARR
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
NAASKEIGQAKAQKDEERASRLMAEVANLKADIPTLEALAKDWEKSLDNALAAIPNAPLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
EVPPGADEHDNVEKSRFGVARSYAFTPKQHFEVGEALGQMDFETAAKLSGARFVVNKGPL
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCH
ARLERALGQFFLDVHTGEHGYMEVNPPLLVRDDAMFGTAQLPKFREDQFFVNTVDGIEAI
HHHHHHHHHHEEEEECCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCEEEECHHHHHHH
SAETKGFETFSDEFKSKLTEAMSYQGRWLIPTAEVPLTNLVRESILSEEELPLRLTACTP
HHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCC
CFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPEKSAEEHERMLACAEAVLKKLDLHYRV
HHHCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEE
VTLCTGDMGFASQKTYDIEVWLPGQGAFREISSCSVCGDFQARRMNARYRPAEGKGPRFV
EEEEECCCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEE
HTLNGSGVAVGRALVAVLETYQQENGAVTVPDALLPYMGGLKTIEKLK
EEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA