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The map label for this gene is catR [H]

Identifier: 154248279

GI number: 154248279

Start: 4832700

End: 4833611

Strand: Direct

Name: catR [H]

Synonym: Xaut_4359

Alternate gene names: 154248279

Gene position: 4832700-4833611 (Clockwise)

Preceding gene: 154248274

Following gene: 154248281

Centisome position: 91.03

GC content: 67.65

Gene sequence:

>912_bases
ATGGAACTGCGCCACCTCAGGTATTTCACAACCGTGGCCCGCGAGCGCAGCTTCACCCGCGCGGCGGAGAAGCTCCACAT
CGCCCAATCCCCCCTGAGCAGGCAGATGCGCGAGCTAGAGGAGGATCTGGGCGTCACCCTGTTCGAGCGGCCGAGCCGCC
CGGTGCGCCTCACCGCGGCCGGGCGCTTCTTCAACGAACATGCGTTGCAGATCCTCCAGCGGGCGGAGGAGCTGCGCATC
ACCACACGGCGCTTCGGCGAGGCCGGGCGACGGCAGTTCCTGATCGGGTTCGTCGGCTCGGTGCTCTATGGCGGGCTGCC
GGACGTGGTCCGGGGCTTTCGCGCCTGCTATGCCGGGCTTGAGGTGGCGCTCATCGAGATGAGCACCGTGGAGCAGATCG
CCGCCCTGAAAGAGGGGCGCATCGACGTGGGCTTCGGGCGCATCCGCTTCGACGATCCCGCCATCAGGCGCGAGGTGATC
GCCGAAGAGCCCCTGCTGGTGGCCCTGCCGCCGGACCACCGGCTGCTCGCCGCAGACGGTGTGTCATTTCAGGACATCGC
CGGGGAGCCGCTGGTGCTCTACCCCAAGTCGCCACGGCCGAGCTATGCCGATCAGGTGCTGTCCTTCTTCGGCGACCGGG
GTTGCACGCCCGTCATCGCGCAGGAGGTGCGCGAGCTGCAGACCGCGCTGGGCCTGGTGGCGGCGGGCATTGGCATCACT
TTGGTGCCGGACTCAGTGCGGCACCTGCATCGCGACGATGTCACCTATCGCCCGCTGCTGGAGGCGGGGATCACGTCCCC
GCTCATCATGAGCTGCCGGGCCAGCGATTCCTCGGCCGAGATCGGGCAGATCTTCGACCTCATCCGCAACATCTACCAGC
TCAAACAGGAGCTTGGCCGAACGCCGGCATGA

Upstream 100 bases:

>100_bases
ATCCGTGGAGTGTCCTTATGTTCGGCATAAGGAAAATCACGCCGACGGGGCGCGCGTCAAAGACAGTCTCGGTCGGTTTG
CATACCTAATAGGTCTGGAT

Downstream 100 bases:

>100_bases
GAACACCGGGATGAGAACGTCTCCATAAGGCGGAGCGGGGAAGCCCCCTGCGCCGCCATTGTGACGATGGGTCTTCAGCG
CGCCTTGGTGCTGCGGCCGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: CatBC operon transcriptional activator [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MELRHLRYFTTVARERSFTRAAEKLHIAQSPLSRQMRELEEDLGVTLFERPSRPVRLTAAGRFFNEHALQILQRAEELRI
TTRRFGEAGRRQFLIGFVGSVLYGGLPDVVRGFRACYAGLEVALIEMSTVEQIAALKEGRIDVGFGRIRFDDPAIRREVI
AEEPLLVALPPDHRLLAADGVSFQDIAGEPLVLYPKSPRPSYADQVLSFFGDRGCTPVIAQEVRELQTALGLVAAGIGIT
LVPDSVRHLHRDDVTYRPLLEAGITSPLIMSCRASDSSAEIGQIFDLIRNIYQLKQELGRTPA

Sequences:

>Translated_303_residues
MELRHLRYFTTVARERSFTRAAEKLHIAQSPLSRQMRELEEDLGVTLFERPSRPVRLTAAGRFFNEHALQILQRAEELRI
TTRRFGEAGRRQFLIGFVGSVLYGGLPDVVRGFRACYAGLEVALIEMSTVEQIAALKEGRIDVGFGRIRFDDPAIRREVI
AEEPLLVALPPDHRLLAADGVSFQDIAGEPLVLYPKSPRPSYADQVLSFFGDRGCTPVIAQEVRELQTALGLVAAGIGIT
LVPDSVRHLHRDDVTYRPLLEAGITSPLIMSCRASDSSAEIGQIFDLIRNIYQLKQELGRTPA
>Mature_303_residues
MELRHLRYFTTVARERSFTRAAEKLHIAQSPLSRQMRELEEDLGVTLFERPSRPVRLTAAGRFFNEHALQILQRAEELRI
TTRRFGEAGRRQFLIGFVGSVLYGGLPDVVRGFRACYAGLEVALIEMSTVEQIAALKEGRIDVGFGRIRFDDPAIRREVI
AEEPLLVALPPDHRLLAADGVSFQDIAGEPLVLYPKSPRPSYADQVLSFFGDRGCTPVIAQEVRELQTALGLVAAGIGIT
LVPDSVRHLHRDDVTYRPLLEAGITSPLIMSCRASDSSAEIGQIFDLIRNIYQLKQELGRTPA

Specific function: Positive regulator of the catBC operon that degrades catechol to acetyl-CoA. CatR binds in trans to the catR-catBC promoter-control region in the presence or absence of inducer but only activates the catBC operon in the presence of the inducer, cis-cis-mu

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=273, Percent_Identity=36.6300366300366, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1788887, Length=276, Percent_Identity=35.5072463768116, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI2367136, Length=266, Percent_Identity=36.0902255639098, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790399, Length=263, Percent_Identity=31.1787072243346, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI145693105, Length=244, Percent_Identity=28.2786885245902, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI157672245, Length=247, Percent_Identity=28.7449392712551, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87081904, Length=220, Percent_Identity=29.5454545454545, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788748, Length=245, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787806, Length=247, Percent_Identity=27.9352226720648, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790208, Length=248, Percent_Identity=28.2258064516129, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787601, Length=253, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=286, Percent_Identity=24.4755244755245, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=26.8292682926829, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788296, Length=257, Percent_Identity=26.4591439688716, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788481, Length=196, Percent_Identity=28.0612244897959, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787530, Length=207, Percent_Identity=24.6376811594203, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790783, Length=146, Percent_Identity=27.3972602739726, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789173, Length=170, Percent_Identity=30, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787949, Length=144, Percent_Identity=29.8611111111111, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33819; Mature: 33819

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFTTVARERSFTRAAEKLHIAQSPLSRQMRELEEDLGVTLFERPSRPVRLTAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEECCCCCCEEEEEH
GRFFNEHALQILQRAEELRITTRRFGEAGRRQFLIGFVGSVLYGGLPDVVRGFRACYAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
EVALIEMSTVEQIAALKEGRIDVGFGRIRFDDPAIRREVIAEEPLLVALPPDHRLLAADG
HHEEHHHHHHHHHHHHHCCCEEECCCEEEECCHHHHHHHHHCCCEEEEECCCCCEEEECC
VSFQDIAGEPLVLYPKSPRPSYADQVLSFFGDRGCTPVIAQEVRELQTALGLVAAGIGIT
CCHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
LVPDSVRHLHRDDVTYRPLLEAGITSPLIMSCRASDSSAEIGQIFDLIRNIYQLKQELGR
ECCHHHHHHHHCCCCHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
TPA
CCC
>Mature Secondary Structure
MELRHLRYFTTVARERSFTRAAEKLHIAQSPLSRQMRELEEDLGVTLFERPSRPVRLTAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCEEECCCCCCEEEEEH
GRFFNEHALQILQRAEELRITTRRFGEAGRRQFLIGFVGSVLYGGLPDVVRGFRACYAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
EVALIEMSTVEQIAALKEGRIDVGFGRIRFDDPAIRREVIAEEPLLVALPPDHRLLAADG
HHEEHHHHHHHHHHHHHCCCEEECCCEEEECCHHHHHHHHHCCCEEEEECCCCCEEEECC
VSFQDIAGEPLVLYPKSPRPSYADQVLSFFGDRGCTPVIAQEVRELQTALGLVAAGIGIT
CCHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
LVPDSVRHLHRDDVTYRPLLEAGITSPLIMSCRASDSSAEIGQIFDLIRNIYQLKQELGR
ECCHHHHHHHHCCCCHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
TPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1688844 [H]