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The map label for this gene is acdA [H]

Identifier: 154248192

GI number: 154248192

Start: 4738915

End: 4740087

Strand: Direct

Name: acdA [H]

Synonym: Xaut_4272

Alternate gene names: 154248192

Gene position: 4738915-4740087 (Clockwise)

Preceding gene: 154248191

Following gene: 154248193

Centisome position: 89.26

GC content: 65.73

Gene sequence:

>1173_bases
ATGCTGCCGAACAGCCAAGCCGGCTTCGATTTCGACCTCGGCGAGACCGCCGACATGCTGCGCGACACCGTGCGTTCGTT
CTCGGACGCCGAGATCGCCCCGCGCGCCGCCGAGATCGACAGGACCAACCAGTTTCCCCGCGACCTGTGGCCCAAGCTCG
GCGCGCTGGGCCTGCTCGGCGTCACGGCGGAGGAGGAATATGGCGGATCGGGCCTTGGCTATCTCGAGCACGTCATCGCC
ATGGAAGAGATTTCCCGCGCCTCGGCCTCGGTGGGCCTGTCCTATGGCGCGCACTCCAATTTGTGCATCAACCAGATCAG
CCGCAACGGCACCGCCGAGCAGAAGGCGAAGTACCTGCCCAAGCTGATTTCCGGCGAGCATGTGGGTGCGCTCGCCATGT
CGGAGCCGGGGGCGGGGTCGGACGTGGTCTCCATGCGCACTCGCGCCGACAAGAAGGGCGACCGCTACATCCTCAACGGC
TCCAAGATGTGGATCACCAACGGCCCCATCGCCGAGACTCTGGTGGTTTATGCCAAGACCGATCCGGCCGCCGGCCCCAA
GGGCATGACCGCCTTCCTGGTGGAGAGGGACTTTCCCGGCTTCTCCACCGCCCAGAAGCTCGACAAGCTGGGCATGCGCG
GCTCCGACACCGGCGAACTGGTGTTTCAGGATTGCGAGGTGCCCGAGGAGAACGTGCTCGGTGCCGTGGGCCGGGGCGTC
AACGTGCTCATGAGCGGGCTCGATTATGAGCGCGCGGTGCTGGCGGGCGGCCCCACGGGCATCATGCAGGCGTGCATGGA
TATCGTCCTGCCCTATGTCCACGAGCGCAAGCAGTTCGGCCAGCCCATCGGCACGTTCCAGCTGATGCAGGGCAAGATCG
CCGACATGTATGTGACCATGAATGCCACCAAGGCTTACGTCTATGCTGTGGCCAAGGCCTGCGACCGTGGCGCCACCACC
CGCGAGGACGCAGCGGGCGCCATCCTCTATGCGGCGGAAAAGGCCACGTGGATGGCGCTGGAAGCCATCCAGACCCTGGG
CGGCAACGGCTATATCAACGACTATCCCACGGGCCGCCTGCTGCGCGACGCCAAGCTCTACGAGATCGGCGCCGGCACCA
GCGAGATCCGCCGCATGCTCATCGGCCGCCAGCTGTTCGACAAGACGGCCTGA

Upstream 100 bases:

>100_bases
CCATTGAATAAACGGACAACCGTTTTATTCTAGCGCCGCTTCCCCGCTGGCGCCTGCGCCCGGTGCAATAAGATCCGGGG
AGCGTGGGAGGGACAACAAG

Downstream 100 bases:

>100_bases
GCGGGCGCCGCGCCCGCATGGTGGCAAGGTCGGAACCCGGATCACGCCGGGTTCCGTTCGCGCAAGCGCGGACGCCGACT
TCGGCCGCACCCGATGCCCC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MLPNSQAGFDFDLGETADMLRDTVRSFSDAEIAPRAAEIDRTNQFPRDLWPKLGALGLLGVTAEEEYGGSGLGYLEHVIA
MEEISRASASVGLSYGAHSNLCINQISRNGTAEQKAKYLPKLISGEHVGALAMSEPGAGSDVVSMRTRADKKGDRYILNG
SKMWITNGPIAETLVVYAKTDPAAGPKGMTAFLVERDFPGFSTAQKLDKLGMRGSDTGELVFQDCEVPEENVLGAVGRGV
NVLMSGLDYERAVLAGGPTGIMQACMDIVLPYVHERKQFGQPIGTFQLMQGKIADMYVTMNATKAYVYAVAKACDRGATT
REDAAGAILYAAEKATWMALEAIQTLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRQLFDKTA

Sequences:

>Translated_390_residues
MLPNSQAGFDFDLGETADMLRDTVRSFSDAEIAPRAAEIDRTNQFPRDLWPKLGALGLLGVTAEEEYGGSGLGYLEHVIA
MEEISRASASVGLSYGAHSNLCINQISRNGTAEQKAKYLPKLISGEHVGALAMSEPGAGSDVVSMRTRADKKGDRYILNG
SKMWITNGPIAETLVVYAKTDPAAGPKGMTAFLVERDFPGFSTAQKLDKLGMRGSDTGELVFQDCEVPEENVLGAVGRGV
NVLMSGLDYERAVLAGGPTGIMQACMDIVLPYVHERKQFGQPIGTFQLMQGKIADMYVTMNATKAYVYAVAKACDRGATT
REDAAGAILYAAEKATWMALEAIQTLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRQLFDKTA
>Mature_390_residues
MLPNSQAGFDFDLGETADMLRDTVRSFSDAEIAPRAAEIDRTNQFPRDLWPKLGALGLLGVTAEEEYGGSGLGYLEHVIA
MEEISRASASVGLSYGAHSNLCINQISRNGTAEQKAKYLPKLISGEHVGALAMSEPGAGSDVVSMRTRADKKGDRYILNG
SKMWITNGPIAETLVVYAKTDPAAGPKGMTAFLVERDFPGFSTAQKLDKLGMRGSDTGELVFQDCEVPEENVLGAVGRGV
NVLMSGLDYERAVLAGGPTGIMQACMDIVLPYVHERKQFGQPIGTFQLMQGKIADMYVTMNATKAYVYAVAKACDRGATT
REDAAGAILYAAEKATWMALEAIQTLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRQLFDKTA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=66.1333333333333, Blast_Score=517, Evalue=1e-147,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=68.4365781710914, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=41.3333333333333, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=37.6021798365123, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI187960098, Length=384, Percent_Identity=37.7604166666667, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI4557231, Length=384, Percent_Identity=37.7604166666667, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI21361497, Length=371, Percent_Identity=39.622641509434, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=33.9572192513369, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI76496475, Length=343, Percent_Identity=37.9008746355685, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI4557235, Length=343, Percent_Identity=37.9008746355685, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI7656849, Length=380, Percent_Identity=33.1578947368421, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4503943, Length=370, Percent_Identity=31.3513513513514, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=31.9672131147541, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI38505218, Length=375, Percent_Identity=22.1333333333333, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=29.7368421052632, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=30.7894736842105, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI87082384, Length=258, Percent_Identity=29.8449612403101, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87081702, Length=292, Percent_Identity=25.3424657534247, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=64.7214854111406, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=38.3202099737533, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=37.6623376623377, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17570075, Length=386, Percent_Identity=36.7875647668394, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=35.5795148247978, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=35.3099730458221, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71990804, Length=296, Percent_Identity=38.8513513513513, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=369, Percent_Identity=33.0623306233062, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=34.7578347578348, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=36.4963503649635, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=30.6666666666667, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=38.5281385281385, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=35.4385964912281, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.5177111716621, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=31.1827956989247, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.5439330543933, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI86563381, Length=268, Percent_Identity=27.9850746268657, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=268, Percent_Identity=27.9850746268657, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=64.6437994722955, Blast_Score=496, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=41.005291005291, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=41.4634146341463, Blast_Score=288, Evalue=5e-78,
Organism=Drosophila melanogaster, GI24660351, Length=386, Percent_Identity=38.0829015544041, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=35.5795148247978, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI281363737, Length=368, Percent_Identity=36.9565217391304, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=30.9711286089239, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI221473076, Length=327, Percent_Identity=24.4648318042813, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550141, Length=327, Percent_Identity=24.4648318042813, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41978; Mature: 41978

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPNSQAGFDFDLGETADMLRDTVRSFSDAEIAPRAAEIDRTNQFPRDLWPKLGALGLLG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCHHEEE
VTAEEEYGGSGLGYLEHVIAMEEISRASASVGLSYGAHSNLCINQISRNGTAEQKAKYLP
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
KLISGEHVGALAMSEPGAGSDVVSMRTRADKKGDRYILNGSKMWITNGPIAETLVVYAKT
HHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCEEEEEEEC
DPAAGPKGMTAFLVERDFPGFSTAQKLDKLGMRGSDTGELVFQDCEVPEENVLGAVGRGV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCH
NVLMSGLDYERAVLAGGPTGIMQACMDIVLPYVHERKQFGQPIGTFQLMQGKIADMYVTM
HHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEEEE
NATKAYVYAVAKACDRGATTREDAAGAILYAAEKATWMALEAIQTLGGNGYINDYPTGRL
CCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCH
LRDAKLYEIGAGTSEIRRMLIGRQLFDKTA
HHCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPNSQAGFDFDLGETADMLRDTVRSFSDAEIAPRAAEIDRTNQFPRDLWPKLGALGLLG
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCHHEEE
VTAEEEYGGSGLGYLEHVIAMEEISRASASVGLSYGAHSNLCINQISRNGTAEQKAKYLP
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
KLISGEHVGALAMSEPGAGSDVVSMRTRADKKGDRYILNGSKMWITNGPIAETLVVYAKT
HHHCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCEEEEEEEC
DPAAGPKGMTAFLVERDFPGFSTAQKLDKLGMRGSDTGELVFQDCEVPEENVLGAVGRGV
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHCCCH
NVLMSGLDYERAVLAGGPTGIMQACMDIVLPYVHERKQFGQPIGTFQLMQGKIADMYVTM
HHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEEEE
NATKAYVYAVAKACDRGATTREDAAGAILYAAEKATWMALEAIQTLGGNGYINDYPTGRL
CCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCH
LRDAKLYEIGAGTSEIRRMLIGRQLFDKTA
HHCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]