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The map label for this gene is ribBA [H]

Identifier: 154248057

GI number: 154248057

Start: 4577305

End: 4578618

Strand: Reverse

Name: ribBA [H]

Synonym: Xaut_4136

Alternate gene names: 154248057

Gene position: 4578618-4577305 (Counterclockwise)

Preceding gene: 154248058

Following gene: 154248056

Centisome position: 86.24

GC content: 67.96

Gene sequence:

>1314_bases
ATGAAGCTCGCGGAATGGCTTTCAGCGACCGGAACGAAGCGTAGCGCCTTTGCGAAGCAGGTGGGCATGTCGCCTGCCAG
CGTCACGGCCCTGTGCAACGACGACCGCGCCTGGATTTCCCGCGAGACCGCCGAGAAGATCGCGCAGGCCACGGGACACG
AGGTCACGCCGAACGATTTCCTCGGGCTTCCCGCGCCCAGTATCCGAGGTTTAGCCGTGACCGATAATACCCAGGCCCGC
GTCCAGTCCGCCATCGAAGCGTTCGCGCGGGGAGAGATCGTGGTCGTCACCGACGACGATGATCGCGAGAACGAAGGCGA
TCTCATCCTCGCCGCTTCCCTCGCCACGCCGGAGAAGATGGCTTTCGTCATCCGCAACACCTCCGGCATCGTCTGCACGC
CCCTGCCCCCGTCCGAGGCCAAGCGGCTGCGGCTCGATCCCATGGTGTCGAACAACGATGCGCCCATGGGCACCGCCTTC
ACCATCTCCATTGACGTGAAGCACGGCACTACGACCGGCATCTCGGCAGAAGAGCGCACCAACACCGTGCGGGCGCTGGC
CAATCCCAACATGGGCGCGGCCGATTTCGTGCGGCCGGGCCACGTGTTCCCGCTCATCGCCAAGGAAGGCGGCGTGCTCA
TGCGCTCGGGCCACACCGAGGCGGCCGTGGACCTGTGCCGGCTCGCGGGCGTGCCGCCGGTGGGCGTCATCGCCGAACTG
GTGAACGACGACGGCACCGTGCAGCGCGGCCCGCAGGTCACCGCCTTTTCCGAGAAGCACGGCCTCACCCGCATCTCGGT
GGCGGACCTCATCTCCTACCGGCAGGCCCGCGAGAAGCTGGTGACGCGTGCGGCGGAATTTCCCGTGCCCACCTGCGTCG
GCGAGCTGCAGGGCTTTTCCTATGTGACGCCGTTTGATCCGGTGAACCACCTGGCGCTGGTCAAGGGCCGCATCGGCGAC
GGCGAGAAGGTGCTGGTGCGCCTGCACCGCGCCGATCCCATCGCCGACGCCTTCGGCGGCGGCAAGACCATCCAGCGGGC
GCTGGAGCGCATCGAGGCGGAAGGCCGCGGCGTGCTGGTCTATCTGCGCGACGGCACCGCCGGCGTGCCCGCCGTCGCCA
TGGGCCATGGCGGGGAAAAGTCGTCCAGCGAGATCGAGCGTGACCGCCACTGGCGTGAGGTCGGCCTCGGCGCCCAGATC
CTGCGCGACCTCGGCATCGTCTCGATTCGCCTGCTGGCCTCCAAGTCCCGCACCTATGTGGGCCTCGCCGGCTTCGGCAT
CGAGATTGTGGACACCGAGCCCCTCGACGCCTGA

Upstream 100 bases:

>100_bases
CTGCCTCCCCGGCAGCCTTTTTGCCAACCGCAAAATTCAGCGAACGTGAATGCTGAAAATTTTTCATTGTCACTGAATTT
TCCCGCGTTATGCTGCCGGC

Downstream 100 bases:

>100_bases
GTGCATGCGCCAATTTTGTGCAGCGCAGGTGCCGCTAAGCTGTTGTGACAGAACAACGACAGTTTTGCCTTGCGGGTGGA
AGCGAGCAATCGCAACGCTT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKLAEWLSATGTKRSAFAKQVGMSPASVTALCNDDRAWISRETAEKIAQATGHEVTPNDFLGLPAPSIRGLAVTDNTQAR
VQSAIEAFARGEIVVVTDDDDRENEGDLILAASLATPEKMAFVIRNTSGIVCTPLPPSEAKRLRLDPMVSNNDAPMGTAF
TISIDVKHGTTTGISAEERTNTVRALANPNMGAADFVRPGHVFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
VNDDGTVQRGPQVTAFSEKHGLTRISVADLISYRQAREKLVTRAAEFPVPTCVGELQGFSYVTPFDPVNHLALVKGRIGD
GEKVLVRLHRADPIADAFGGGKTIQRALERIEAEGRGVLVYLRDGTAGVPAVAMGHGGEKSSSEIERDRHWREVGLGAQI
LRDLGIVSIRLLASKSRTYVGLAGFGIEIVDTEPLDA

Sequences:

>Translated_437_residues
MKLAEWLSATGTKRSAFAKQVGMSPASVTALCNDDRAWISRETAEKIAQATGHEVTPNDFLGLPAPSIRGLAVTDNTQAR
VQSAIEAFARGEIVVVTDDDDRENEGDLILAASLATPEKMAFVIRNTSGIVCTPLPPSEAKRLRLDPMVSNNDAPMGTAF
TISIDVKHGTTTGISAEERTNTVRALANPNMGAADFVRPGHVFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
VNDDGTVQRGPQVTAFSEKHGLTRISVADLISYRQAREKLVTRAAEFPVPTCVGELQGFSYVTPFDPVNHLALVKGRIGD
GEKVLVRLHRADPIADAFGGGKTIQRALERIEAEGRGVLVYLRDGTAGVPAVAMGHGGEKSSSEIERDRHWREVGLGAQI
LRDLGIVSIRLLASKSRTYVGLAGFGIEIVDTEPLDA
>Mature_437_residues
MKLAEWLSATGTKRSAFAKQVGMSPASVTALCNDDRAWISRETAEKIAQATGHEVTPNDFLGLPAPSIRGLAVTDNTQAR
VQSAIEAFARGEIVVVTDDDDRENEGDLILAASLATPEKMAFVIRNTSGIVCTPLPPSEAKRLRLDPMVSNNDAPMGTAF
TISIDVKHGTTTGISAEERTNTVRALANPNMGAADFVRPGHVFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
VNDDGTVQRGPQVTAFSEKHGLTRISVADLISYRQAREKLVTRAAEFPVPTCVGELQGFSYVTPFDPVNHLALVKGRIGD
GEKVLVRLHRADPIADAFGGGKTIQRALERIEAEGRGVLVYLRDGTAGVPAVAMGHGGEKSSSEIERDRHWREVGLGAQI
LRDLGIVSIRLLASKSRTYVGLAGFGIEIVDTEPLDA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=200, Percent_Identity=49.5, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=202, Percent_Identity=50, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46550; Mature: 46550

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAEWLSATGTKRSAFAKQVGMSPASVTALCNDDRAWISRETAEKIAQATGHEVTPNDF
CCHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
LGLPAPSIRGLAVTDNTQARVQSAIEAFARGEIVVVTDDDDRENEGDLILAASLATPEKM
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCE
AFVIRNTSGIVCTPLPPSEAKRLRLDPMVSNNDAPMGTAFTISIDVKHGTTTGISAEERT
EEEEECCCCEEEECCCCCHHHEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHH
NTVRALANPNMGAADFVRPGHVFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
CCEEEECCCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHH
VNDDGTVQRGPQVTAFSEKHGLTRISVADLISYRQAREKLVTRAAEFPVPTCVGELQGFS
HCCCCCCCCCCCEEEEHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCE
YVTPFDPVNHLALVKGRIGDGEKVLVRLHRADPIADAFGGGKTIQRALERIEAEGRGVLV
EECCCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHCCCCCEEEE
YLRDGTAGVPAVAMGHGGEKSSSEIERDRHWREVGLGAQILRDLGIVSIRLLASKSRTYV
EEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEEEEEECCCCCEE
GLAGFGIEIVDTEPLDA
EEEECCEEEECCCCCCC
>Mature Secondary Structure
MKLAEWLSATGTKRSAFAKQVGMSPASVTALCNDDRAWISRETAEKIAQATGHEVTPNDF
CCHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
LGLPAPSIRGLAVTDNTQARVQSAIEAFARGEIVVVTDDDDRENEGDLILAASLATPEKM
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCE
AFVIRNTSGIVCTPLPPSEAKRLRLDPMVSNNDAPMGTAFTISIDVKHGTTTGISAEERT
EEEEECCCCEEEECCCCCHHHEEEECCCCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHH
NTVRALANPNMGAADFVRPGHVFPLIAKEGGVLMRSGHTEAAVDLCRLAGVPPVGVIAEL
CCEEEECCCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHHHH
VNDDGTVQRGPQVTAFSEKHGLTRISVADLISYRQAREKLVTRAAEFPVPTCVGELQGFS
HCCCCCCCCCCCEEEEHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCE
YVTPFDPVNHLALVKGRIGDGEKVLVRLHRADPIADAFGGGKTIQRALERIEAEGRGVLV
EECCCCCCCCEEEEECCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHHCCCCCEEEE
YLRDGTAGVPAVAMGHGGEKSSSEIERDRHWREVGLGAQILRDLGIVSIRLLASKSRTYV
EEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEEEEEECCCCCEE
GLAGFGIEIVDTEPLDA
EEEECCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA