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The map label for this gene is purC1 [H]

Identifier: 154248014

GI number: 154248014

Start: 4531513

End: 4532307

Strand: Reverse

Name: purC1 [H]

Synonym: Xaut_4093

Alternate gene names: 154248014

Gene position: 4532307-4531513 (Counterclockwise)

Preceding gene: 154248016

Following gene: 154248013

Centisome position: 85.37

GC content: 60.25

Gene sequence:

>795_bases
ATGGATTTCCTCAATCAGCGGTATATTCCCATGAGCCGCCGCCGCCGAATCTACGAAGGCAAGGCGAAAGTCCTCTATGA
AGGACCCGAGCCCGGCACACTCATCCAGCACTTCAAAGACGATGCCACCGCCTTCAATGCGAAGAAGCACGATGTCATCG
ACGGCAAAGGTGTGCTGAACAACCGGATCTCCGAGTACATCTTCTCGCGGCTGAACGACATCGGCGTGCCGACTCACTTC
ATCCGCCGGCTGAACATGCGCGAGCAGCTCATCCGCGAAGTGGAGATCATTCCGCTCGAGATCGTGGTGCGCAACGTCGC
CGCCGGCTCCATCTCGACCCGTCTCGGGATCGAGGAAGGCACGCCGCTGCCGCGCTCCATCATCGAGTTCTATTACAAGA
ACGACGCGCTCAACGACCCGATGGTGTCGGAAGAGCACATCACCGCCTTCGGCTGGGCCACCACCCAGGAAATCGACGAC
ATCATCGCGCTCGCGATCCGCGTCAACGACTTCCTGTCGGGCCTCTTCCTCGGCGCCGGCATCCGTCTTGTGGATTTCAA
GATGGAATGCGGTCGCCTGTGGGAAAACGACATGATGCGGATCGTCGTGGCCGACGAGATCAGCCCCGATTCGTGCCGGC
TGTGGGATATCAAGTCCAACGACAAGATGGACAAGGACCGCTTCCGCCGCGACATGGGCGGCCTCGTCGAGGCCTACAGC
GAAGTGGCGCGCCGTCTCGGAATCCTCATGGAGAATGATCCGACCCAGGGCAAGGGCCCGGTTCTGGTCAAGTGA

Upstream 100 bases:

>100_bases
CGCCTGATCGGCTAGTGTCCGAACGGGCTTGGTGTGAACTGGCAACATTCACCCCCGGTCCCGCCGAGGAGCGTCACCAG
AACGGAGCCTTGGCAAACCC

Downstream 100 bases:

>100_bases
GCCAGGTGAAGTGAGGCGTTGAGCCTTGCTACCGAAAAATGCTAGGCGGGGGCCGGATAGGCCCCCGTTTGCATTACAGC
ACGGCCCCGCCGCCCTGCGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase A [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDFLNQRYIPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLNNRISEYIFSRLNDIGVPTHF
IRRLNMREQLIREVEIIPLEIVVRNVAAGSISTRLGIEEGTPLPRSIIEFYYKNDALNDPMVSEEHITAFGWATTQEIDD
IIALAIRVNDFLSGLFLGAGIRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKMDKDRFRRDMGGLVEAYS
EVARRLGILMENDPTQGKGPVLVK

Sequences:

>Translated_264_residues
MDFLNQRYIPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLNNRISEYIFSRLNDIGVPTHF
IRRLNMREQLIREVEIIPLEIVVRNVAAGSISTRLGIEEGTPLPRSIIEFYYKNDALNDPMVSEEHITAFGWATTQEIDD
IIALAIRVNDFLSGLFLGAGIRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKMDKDRFRRDMGGLVEAYS
EVARRLGILMENDPTQGKGPVLVK
>Mature_264_residues
MDFLNQRYIPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLNNRISEYIFSRLNDIGVPTHF
IRRLNMREQLIREVEIIPLEIVVRNVAAGSISTRLGIEEGTPLPRSIIEFYYKNDALNDPMVSEEHITAFGWATTQEIDD
IIALAIRVNDFLSGLFLGAGIRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKMDKDRFRRDMGGLVEAYS
EVARRLGILMENDPTQGKGPVLVK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=255, Percent_Identity=30.9803921568627, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI5453539, Length=255, Percent_Identity=30.9803921568627, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI119220559, Length=262, Percent_Identity=29.7709923664122, Blast_Score=100, Evalue=9e-22,
Organism=Escherichia coli, GI1788820, Length=241, Percent_Identity=42.7385892116183, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=31.3304721030043, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=29.957805907173, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 30233; Mature: 30233

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLNQRYIPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLN
CCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
NRISEYIFSRLNDIGVPTHFIRRLNMREQLIREVEIIPLEIVVRNVAAGSISTRLGIEEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
TPLPRSIIEFYYKNDALNDPMVSEEHITAFGWATTQEIDDIIALAIRVNDFLSGLFLGAG
CCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKMDKDRFRRDMGGLVEAYS
CEEEEEEHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EVARRLGILMENDPTQGKGPVLVK
HHHHHHCCEECCCCCCCCCCEEEC
>Mature Secondary Structure
MDFLNQRYIPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLN
CCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
NRISEYIFSRLNDIGVPTHFIRRLNMREQLIREVEIIPLEIVVRNVAAGSISTRLGIEEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
TPLPRSIIEFYYKNDALNDPMVSEEHITAFGWATTQEIDDIIALAIRVNDFLSGLFLGAG
CCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKMDKDRFRRDMGGLVEAYS
CEEEEEEHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EVARRLGILMENDPTQGKGPVLVK
HHHHHHCCEECCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]