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The map label for this gene is fadA [C]

Identifier: 154247992

GI number: 154247992

Start: 4504273

End: 4505460

Strand: Reverse

Name: fadA [C]

Synonym: Xaut_4071

Alternate gene names: 154247992

Gene position: 4505460-4504273 (Counterclockwise)

Preceding gene: 154247993

Following gene: 154247991

Centisome position: 84.87

GC content: 69.36

Gene sequence:

>1188_bases
ATGGCACAGGTGGTGGTGGGCGGGGTGGGCATGACCCGCTTCGTGAAACCGAGCGAAAGCCCGAGCTACGTGGCGCTGGC
GGGCGAGGCGGTGCGCAGCGCGCTGGCGGATGCCGGCATCGACTATGCCAAGGTCCAGCAGGCCTATGTGGGCTACGTCT
ATGGCGATTCCACCAGCGGCCAGAAGGCGCTCTACGGCGTGGGCCTCACCGGCATCCCGGTGGTGAACGTGAACAACAAT
TGCGCCACCGGCTCCACCGCCTTGTGGCTGGCCCGCAACGCGATCCTGTCGGGACAGGCCGAGTGCGTGCTGGCGCTCGG
CTTCGAGCAGATGCAGCCGGGCGCCCTGGTGGAGCATTGGAAGGACCGGCCGGGGCCGCTGGAAGACTTCATCAAGGTCA
CCACCGACGTGGCTTATGACGGCGACGTGCCCATGGCGCCGAAGATGTTCGGCGGCGCCGGCATCGCACACCAGAACAAG
TATGGCACCAGGGACACCACCTTCGCCGCCATCCGCGCCAAGGCTAGCCGCCATGCGGTCCACAATGCCCGCGCCATCTT
CCGCAAGGAGGTGAGCGTGGAGGAGGTGATGGCCTCGCCGCCGGTGACGCGCCTGCTCACCCGCCTGCAATGCTGCCCGC
CCACCTGCGGCGCGGCGGCCGCCATCCTGTGCACGCCGGAGTTCGCGCGGCGCCACGGCATCGACACCACCGTGACCATC
GCCGCCCAGGCCATGACCACGGACTTTCCCTCCAGCTTCGAGCCGGACCTGATGCGGGTGGTGGGCTACGACATGACCGC
CGCGGCGGCGGCCTCGGTGTGGGCGCAGGCAGGCCTCGGCCCCGACGAGGTGGACGTGGCCGAGCTGCACGACTGCTTCA
CCGCCAACGAGCTGATTACCTATGAGGGCCTCGGCTTCTGCCCGGAGGGCGGGGCGGAGAAGTTCATCCTCGACGGCGAC
AACACCTATGGCGGCAAGGTGGTCACCAATCCCTCGGGCGGGCTGCTCTCCAAGGGCCATCCGCTGGGCGCTACCGGCCT
TGCGCAATGCTTCGAGCTGACCGGCCAGCTGCGCGGCACCCTGGAGGCGCGGCAGGTGGAGGGGGCGCGGGTGGCGCTCC
AGCACAATCTCGGCCTCGGCGGCGCCTGCGTGGTCACCCTCTACACGGCGGACCGGGGCACACGATGA

Upstream 100 bases:

>100_bases
GTCCGACAAACCGATAAACTGATTAACGATGGGCACCCTCCGGCGCAGTCACCCTGCCGGTGCGCTCCACCATCGGCACA
ATCAAATTCAGGGGAAACGC

Downstream 100 bases:

>100_bases
TCGACCGCAGCTTCATCGGCCACGTATTCGATCCGTTCACGGTGGAGGTGGAGAAGGGGCGCATCCGCTTCTTCGCCCGC
ACCATCGGCGAGACCAATCC

Product: lipid-transfer protein

Products: CoA; oxoacyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAQVVVGGVGMTRFVKPSESPSYVALAGEAVRSALADAGIDYAKVQQAYVGYVYGDSTSGQKALYGVGLTGIPVVNVNNN
CATGSTALWLARNAILSGQAECVLALGFEQMQPGALVEHWKDRPGPLEDFIKVTTDVAYDGDVPMAPKMFGGAGIAHQNK
YGTRDTTFAAIRAKASRHAVHNARAIFRKEVSVEEVMASPPVTRLLTRLQCCPPTCGAAAAILCTPEFARRHGIDTTVTI
AAQAMTTDFPSSFEPDLMRVVGYDMTAAAAASVWAQAGLGPDEVDVAELHDCFTANELITYEGLGFCPEGGAEKFILDGD
NTYGGKVVTNPSGGLLSKGHPLGATGLAQCFELTGQLRGTLEARQVEGARVALQHNLGLGGACVVTLYTADRGTR

Sequences:

>Translated_395_residues
MAQVVVGGVGMTRFVKPSESPSYVALAGEAVRSALADAGIDYAKVQQAYVGYVYGDSTSGQKALYGVGLTGIPVVNVNNN
CATGSTALWLARNAILSGQAECVLALGFEQMQPGALVEHWKDRPGPLEDFIKVTTDVAYDGDVPMAPKMFGGAGIAHQNK
YGTRDTTFAAIRAKASRHAVHNARAIFRKEVSVEEVMASPPVTRLLTRLQCCPPTCGAAAAILCTPEFARRHGIDTTVTI
AAQAMTTDFPSSFEPDLMRVVGYDMTAAAAASVWAQAGLGPDEVDVAELHDCFTANELITYEGLGFCPEGGAEKFILDGD
NTYGGKVVTNPSGGLLSKGHPLGATGLAQCFELTGQLRGTLEARQVEGARVALQHNLGLGGACVVTLYTADRGTR
>Mature_394_residues
AQVVVGGVGMTRFVKPSESPSYVALAGEAVRSALADAGIDYAKVQQAYVGYVYGDSTSGQKALYGVGLTGIPVVNVNNNC
ATGSTALWLARNAILSGQAECVLALGFEQMQPGALVEHWKDRPGPLEDFIKVTTDVAYDGDVPMAPKMFGGAGIAHQNKY
GTRDTTFAAIRAKASRHAVHNARAIFRKEVSVEEVMASPPVTRLLTRLQCCPPTCGAAAAILCTPEFARRHGIDTTVTIA
AQAMTTDFPSSFEPDLMRVVGYDMTAAAAASVWAQAGLGPDEVDVAELHDCFTANELITYEGLGFCPEGGAEKFILDGDN
TYGGKVVTNPSGGLLSKGHPLGATGLAQCFELTGQLRGTLEARQVEGARVALQHNLGLGGACVVTLYTADRGTR

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=393, Percent_Identity=55.7251908396947, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI302344760, Length=393, Percent_Identity=52.1628498727735, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI302344767, Length=322, Percent_Identity=55.5900621118012, Blast_Score=344, Evalue=7e-95,
Organism=Homo sapiens, GI302344762, Length=392, Percent_Identity=48.469387755102, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI55956775, Length=354, Percent_Identity=45.1977401129944, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17537653, Length=394, Percent_Identity=44.9238578680203, Blast_Score=324, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24585051, Length=391, Percent_Identity=55.2429667519182, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI19921506, Length=391, Percent_Identity=54.7314578005115, Blast_Score=418, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16 [C]

Molecular weight: Translated: 41434; Mature: 41303

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVVVGGVGMTRFVKPSESPSYVALAGEAVRSALADAGIDYAKVQQAYVGYVYGDSTSG
CCEEEEECCCCEEEECCCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHEEEEECCCCCC
QKALYGVGLTGIPVVNVNNNCATGSTALWLARNAILSGQAECVLALGFEQMQPGALVEHW
CEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECHHHCCCCHHHHHH
KDRPGPLEDFIKVTTDVAYDGDVPMAPKMFGGAGIAHQNKYGTRDTTFAAIRAKASRHAV
CCCCCCHHHHHHHHHCEEECCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
HNARAIFRKEVSVEEVMASPPVTRLLTRLQCCPPTCGAAAAILCTPEFARRHGIDTTVTI
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHHCCCCCEEEE
AAQAMTTDFPSSFEPDLMRVVGYDMTAAAAASVWAQAGLGPDEVDVAELHDCFTANELIT
EEHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEE
YEGLGFCPEGGAEKFILDGDNTYGGKVVTNPSGGLLSKGHPLGATGLAQCFELTGQLRGT
ECCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
LEARQVEGARVALQHNLGLGGACVVTLYTADRGTR
HHHHHCCCEEEEEEECCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure 
AQVVVGGVGMTRFVKPSESPSYVALAGEAVRSALADAGIDYAKVQQAYVGYVYGDSTSG
CEEEEECCCCEEEECCCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHEEEEECCCCCC
QKALYGVGLTGIPVVNVNNNCATGSTALWLARNAILSGQAECVLALGFEQMQPGALVEHW
CEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECHHHCCCCHHHHHH
KDRPGPLEDFIKVTTDVAYDGDVPMAPKMFGGAGIAHQNKYGTRDTTFAAIRAKASRHAV
CCCCCCHHHHHHHHHCEEECCCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
HNARAIFRKEVSVEEVMASPPVTRLLTRLQCCPPTCGAAAAILCTPEFARRHGIDTTVTI
HHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHHCCCCCEEEE
AAQAMTTDFPSSFEPDLMRVVGYDMTAAAAASVWAQAGLGPDEVDVAELHDCFTANELIT
EEHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEE
YEGLGFCPEGGAEKFILDGDNTYGGKVVTNPSGGLLSKGHPLGATGLAQCFELTGQLRGT
ECCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
LEARQVEGARVALQHNLGLGGACVVTLYTADRGTR
HHHHHCCCEEEEEEECCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acyl-CoA; acetyl-CoA [C]

Specific reaction: Acyl-CoA + acetyl-CoA = CoA + oxoacyl-CoA [C]

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]