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The map label for this gene is cycA [C]

Identifier: 154247953

GI number: 154247953

Start: 4459837

End: 4461339

Strand: Reverse

Name: cycA [C]

Synonym: Xaut_4032

Alternate gene names: 154247953

Gene position: 4461339-4459837 (Counterclockwise)

Preceding gene: 154247954

Following gene: 154247951

Centisome position: 84.03

GC content: 66.2

Gene sequence:

>1503_bases
ATGGCAGATGGCAGCAAGGCCGGCGTGACGTACACCACGGTGGACGTCGCCTATTTCGAGCAGCGGGCGCTGAAACGGCA
TGCACGGGTCTGGTCGCTTTGGGCGCTGGGCGTCGGAGCGGTGATCTCGGGCCATTTCTCGGGCTGGAACCTGGGCATCG
CCTCGGGCGGCTGGGGTGGCATGTTCATCGCCGCCGTCATCATCGCCATCATGTATCTGGGGCTCACCTTCTCCATCGCC
GAGATGTCGCCGGCCCTGCCCCATACGGGCGCCGCCTATTCCTTCGCCCGCACCACCATGGGGCCATGGGGCGGCTTCAT
CACCGGCCTGTGCGAGAATGTGGAATACGTGATCACACCGGCAGTGGTGGTGTCCTTCATCGGCTCCTACATGGGCTCCA
TCTTCGGTACGCCTCCGGCGTTCCAGCCGGTCTACTGGATCTTCGGCTACATCCTGTTCGTGGGGCTCAACATCGCCGGC
GTGGAACTCTCGTTCCGGGTGACGCTGGTGGTTACGCTGGCGGCACTCGCCTGCCTCGTTGCCTTCTGGGTGAGCGCCCT
GCCGGTGGCGAACTTCTCGCGATGGGCCCTCAACATCGGCGTCGGGCCGGACGGGACGGCGGTGGAGTTGCCCAACGGCG
GCGGCCCGTTCCTGCCCTTCGGCCTTTCGGGGGCGCTTGCCGCCCTGCCCTTCGCCGTCTGGCTGTTCCTCGCCATCGAG
CAATTGCCCCTGGCGGCCGAGGAATCGGTGGACCCGAAGACCGACATGCCCAAGGGCATCATGGCAGGCATGGCGACCCT
CATCGTCTCCGCCTTCATGATCCTGTGGCTCAACTCATCCGTGGCGAACGGCGCGTTCGGCCTGTCCACCTCGCTGGAGC
CCCTGCTGGACGGCTTCAAGGCCATCTACGGCGACGGGCTCGCCCGTCTGCTCGCCTTCGTGGCGGTGATCGGGCTGATC
GCCTCGTTCCACACCATCATCTATGCCCAGGGCCGGCAGATCTATTCGCTCTCCCGCGCCGGCTATTTCCCGCGCGGCCT
TTCCGTGACCCACGGCGGGCGCAAGACGCCTCACGTGGCCATGATCGCCGGCGCCATCGTCGGCCTGGTGATCATGCTCG
GCATCTGGTTCGCGCTGGGGGCGGAGGCGGGCGCGGCGGCCATCGGTGGCACGCTGCTCAACATGGCGGTGTTCGGCGCC
ATGCTGTCCTACGTGATGCAGGCCCTGTCGTTCATCCTGATGCGCAGGAACATGCCGCACATCGAGCGGCCCTATAAAAG
CCCGTTCGGAGTCCCCGGGGCGGTGCTGACAATCGTCATCGCCCTCGTCACCATCTACTTCCAGCTGTCGGACCCCATCT
ATCGCAACGGGGTGCTCGGCGTGGCCCTGTGGTTCGCCGCGGGCCTCGCCTATTTCGCCGCCATCGGCCGCCACAAGCTG
GTGCTGTCGCCGGAGGAGGAATTCGCCATGTCCGGGGGCAAGGCGGAGTACAAGTCCTACTGA

Upstream 100 bases:

>100_bases
GCATTACGCTGCGGAAATTGCCAGACTGGCAACAAAGTTGCCTGTGCGTAAGCTTGGGCGCGGAGTGGCTCCGGCGCCCG
TTCACGGAGGGCTGGGTCTC

Downstream 100 bases:

>100_bases
ATGGATGGCGGCCCGTCTTGCTGGCGGGCCGCCGTTCGCATCACACCTGCTCGGACGACACCACGCGGAAGGTGTGCATC
TCGTCGTCTTCGCGAACCGA

Product: amino acid permease-associated protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MADGSKAGVTYTTVDVAYFEQRALKRHARVWSLWALGVGAVISGHFSGWNLGIASGGWGGMFIAAVIIAIMYLGLTFSIA
EMSPALPHTGAAYSFARTTMGPWGGFITGLCENVEYVITPAVVVSFIGSYMGSIFGTPPAFQPVYWIFGYILFVGLNIAG
VELSFRVTLVVTLAALACLVAFWVSALPVANFSRWALNIGVGPDGTAVELPNGGGPFLPFGLSGALAALPFAVWLFLAIE
QLPLAAEESVDPKTDMPKGIMAGMATLIVSAFMILWLNSSVANGAFGLSTSLEPLLDGFKAIYGDGLARLLAFVAVIGLI
ASFHTIIYAQGRQIYSLSRAGYFPRGLSVTHGGRKTPHVAMIAGAIVGLVIMLGIWFALGAEAGAAAIGGTLLNMAVFGA
MLSYVMQALSFILMRRNMPHIERPYKSPFGVPGAVLTIVIALVTIYFQLSDPIYRNGVLGVALWFAAGLAYFAAIGRHKL
VLSPEEEFAMSGGKAEYKSY

Sequences:

>Translated_500_residues
MADGSKAGVTYTTVDVAYFEQRALKRHARVWSLWALGVGAVISGHFSGWNLGIASGGWGGMFIAAVIIAIMYLGLTFSIA
EMSPALPHTGAAYSFARTTMGPWGGFITGLCENVEYVITPAVVVSFIGSYMGSIFGTPPAFQPVYWIFGYILFVGLNIAG
VELSFRVTLVVTLAALACLVAFWVSALPVANFSRWALNIGVGPDGTAVELPNGGGPFLPFGLSGALAALPFAVWLFLAIE
QLPLAAEESVDPKTDMPKGIMAGMATLIVSAFMILWLNSSVANGAFGLSTSLEPLLDGFKAIYGDGLARLLAFVAVIGLI
ASFHTIIYAQGRQIYSLSRAGYFPRGLSVTHGGRKTPHVAMIAGAIVGLVIMLGIWFALGAEAGAAAIGGTLLNMAVFGA
MLSYVMQALSFILMRRNMPHIERPYKSPFGVPGAVLTIVIALVTIYFQLSDPIYRNGVLGVALWFAAGLAYFAAIGRHKL
VLSPEEEFAMSGGKAEYKSY
>Mature_499_residues
ADGSKAGVTYTTVDVAYFEQRALKRHARVWSLWALGVGAVISGHFSGWNLGIASGGWGGMFIAAVIIAIMYLGLTFSIAE
MSPALPHTGAAYSFARTTMGPWGGFITGLCENVEYVITPAVVVSFIGSYMGSIFGTPPAFQPVYWIFGYILFVGLNIAGV
ELSFRVTLVVTLAALACLVAFWVSALPVANFSRWALNIGVGPDGTAVELPNGGGPFLPFGLSGALAALPFAVWLFLAIEQ
LPLAAEESVDPKTDMPKGIMAGMATLIVSAFMILWLNSSVANGAFGLSTSLEPLLDGFKAIYGDGLARLLAFVAVIGLIA
SFHTIIYAQGRQIYSLSRAGYFPRGLSVTHGGRKTPHVAMIAGAIVGLVIMLGIWFALGAEAGAAAIGGTLLNMAVFGAM
LSYVMQALSFILMRRNMPHIERPYKSPFGVPGAVLTIVIALVTIYFQLSDPIYRNGVLGVALWFAAGLAYFAAIGRHKLV
LSPEEEFAMSGGKAEYKSY

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790653, Length=473, Percent_Identity=24.3128964059197, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786789, Length=434, Percent_Identity=23.2718894009217, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786602, Length=372, Percent_Identity=23.1182795698925, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221512776, Length=432, Percent_Identity=24.537037037037, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666159, Length=432, Percent_Identity=24.537037037037, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668806, Length=453, Percent_Identity=22.7373068432671, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356285, Length=453, Percent_Identity=22.7373068432671, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668802, Length=453, Percent_Identity=22.7373068432671, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52917; Mature: 52786

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGSKAGVTYTTVDVAYFEQRALKRHARVWSLWALGVGAVISGHFSGWNLGIASGGWGG
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHH
MFIAAVIIAIMYLGLTFSIAEMSPALPHTGAAYSFARTTMGPWGGFITGLCENVEYVITP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
AVVVSFIGSYMGSIFGTPPAFQPVYWIFGYILFVGLNIAGVELSFRVTLVVTLAALACLV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHH
AFWVSALPVANFSRWALNIGVGPDGTAVELPNGGGPFLPFGLSGALAALPFAVWLFLAIE
HHHHHHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QLPLAAEESVDPKTDMPKGIMAGMATLIVSAFMILWLNSSVANGAFGLSTSLEPLLDGFK
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
AIYGDGLARLLAFVAVIGLIASFHTIIYAQGRQIYSLSRAGYFPRGLSVTHGGRKTPHVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCCCHHH
MIAGAIVGLVIMLGIWFALGAEAGAAAIGGTLLNMAVFGAMLSYVMQALSFILMRRNMPH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IERPYKSPFGVPGAVLTIVIALVTIYFQLSDPIYRNGVLGVALWFAAGLAYFAAIGRHKL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCEE
VLSPEEEFAMSGGKAEYKSY
EECCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ADGSKAGVTYTTVDVAYFEQRALKRHARVWSLWALGVGAVISGHFSGWNLGIASGGWGG
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHH
MFIAAVIIAIMYLGLTFSIAEMSPALPHTGAAYSFARTTMGPWGGFITGLCENVEYVITP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
AVVVSFIGSYMGSIFGTPPAFQPVYWIFGYILFVGLNIAGVELSFRVTLVVTLAALACLV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHH
AFWVSALPVANFSRWALNIGVGPDGTAVELPNGGGPFLPFGLSGALAALPFAVWLFLAIE
HHHHHHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QLPLAAEESVDPKTDMPKGIMAGMATLIVSAFMILWLNSSVANGAFGLSTSLEPLLDGFK
HCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
AIYGDGLARLLAFVAVIGLIASFHTIIYAQGRQIYSLSRAGYFPRGLSVTHGGRKTPHVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHCCCCCCCCCCCCCCCCCCHHH
MIAGAIVGLVIMLGIWFALGAEAGAAAIGGTLLNMAVFGAMLSYVMQALSFILMRRNMPH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IERPYKSPFGVPGAVLTIVIALVTIYFQLSDPIYRNGVLGVALWFAAGLAYFAAIGRHKL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCEE
VLSPEEEFAMSGGKAEYKSY
EECCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]