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The map label for this gene is cusB [H]

Identifier: 154247896

GI number: 154247896

Start: 4399163

End: 4400584

Strand: Reverse

Name: cusB [H]

Synonym: Xaut_3973

Alternate gene names: 154247896

Gene position: 4400584-4399163 (Counterclockwise)

Preceding gene: 154247897

Following gene: 154247895

Centisome position: 82.89

GC content: 67.16

Gene sequence:

>1422_bases
GTGAAACGGATCGGCCTTGTGGGCCTCGCTCTCGCCGCCATTCTGGCGGCGGGGATCGGAGGCTATTGGGCGGGCGTCCG
GGATTTCCCAGTAGCCGGCCTGCGCGAATGGTTCGGTGTCGAGGCGACCCTTGCGGCGGCTGAGCCGGTCGGGACGGGAG
CGGTGATCTATTATCAGGATCCCGACGGCAAGCCGGTCTATTCGGCAACGCCGCGCCGGACCAGGGATGGCCGGGCTTTC
CGCACCGTTCGCGCCAGCGAGGATGTGAGCTTCGAAGGCAGGCCGCCGGCGACAGTTGAGGCGGCTGGGCAGGCCGGCCC
GCGGCGCATCCTCTACTACCGCAACCCGATGGGTCTGCCGGACACCTCGCCGATGCCGAAGAAGGACTCGATGGGGATGG
ACTACATCCCCGTCCATGAGGGCGAGGACGACAACGGCTCGGTCGTGAAGGTCTCGCTTGGCAAGCTGCAGCGGACCGGT
GTGCGATCCGAGTTGGCCGCGCGGCGTGTCGTCGGCAGGCTGGTGCGGGTGCCGGGAACCGTCCAGCTCGACGAGCGGCG
CATCTCCGTGGTCGCCACCCGGAGCGACGCCTTCATCAACGAGGTGGCGAACGTCACCACGGGCGACCGGGTGACGAAGG
GCCAGATGCTGCTCCGGCTTTATGCGCCGGATATCGCCACCGCCGGCGCCCAGCTCCTAACCGATCTCAAAAGCGGCGGC
CGCGATAGTGCTCTCGGAGGCGCCCGCCAGCGCCTAGAGAATCTCGGCCTGCCGCCTGAAGCGATCGCCGAGATCGAGCG
CACGCGCAAGGTGCCGCTGTCGATGACGTGGCGTGCGCCGCGCGATGGCGTCGTACTCGAACGCAATGTCGTCGACGGCA
TGAAGGCAGCACCGGGCGATGTGCTGTTCCGCCTCGCCGACATTTCGACCATCTGGGTACTGGCGGATGTGCCGGAGTTC
GATCTTGGGGCCGTCCGGCTCGGCGCGCCGGTGACGATCCGGGCTCGAAGCCTGCCGGGACGCACCTTCGAAGGACGTGT
GTCGCTGATCTATCCGCAGGTCGGTGAAGCAACGCGGGCCACGCGAGTGCGGATCGAGATCGCCAATCCCGGCGGTGTTC
TGCTTCCCAATATGTATGCCGAAGTGGAGATCGGCACAGGCGATGCCGCGCCGGTGGTTGCTGTCCCCGATAGCGCGGTG
ATCGACACCGGCACGCGGCAGGTCGTGATCATTGATCGTGGAGAGGGCCGGTTCGAACCGCGCGAGGTAAAGATCGGCCT
GCGCGGCGAAGGCTTCACCGAGATCCGCGAGGGCATCGCGGAAGGCGACCGTGTCGTTGTCGCGGCGAACTTCCTGATCG
ACGCCGAGAGCAATCTGAAGGCGGCGCTGCGTGGCCTGACACCTGCGGAGGCACAGCCATGA

Upstream 100 bases:

>100_bases
CCAACTTGATGATGGCCGGCGGCTGGCGGCTTTCGCTCGGCGCCAAGATCCAGGGTGAGACCGGCACGCTCGAGAACAAG
CTGGTCCTGAAGGCCGTACC

Downstream 100 bases:

>100_bases
TCGCCCACCTCATCGGCTGGTCCGCCCGCAACCTCGTGCTGGTCTTCATTGGCACAGTGTTCGCCGTCGCTGCCGGGCTC
TATGCGCTGAAAACGCTGCC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKRIGLVGLALAAILAAGIGGYWAGVRDFPVAGLREWFGVEATLAAAEPVGTGAVIYYQDPDGKPVYSATPRRTRDGRAF
RTVRASEDVSFEGRPPATVEAAGQAGPRRILYYRNPMGLPDTSPMPKKDSMGMDYIPVHEGEDDNGSVVKVSLGKLQRTG
VRSELAARRVVGRLVRVPGTVQLDERRISVVATRSDAFINEVANVTTGDRVTKGQMLLRLYAPDIATAGAQLLTDLKSGG
RDSALGGARQRLENLGLPPEAIAEIERTRKVPLSMTWRAPRDGVVLERNVVDGMKAAPGDVLFRLADISTIWVLADVPEF
DLGAVRLGAPVTIRARSLPGRTFEGRVSLIYPQVGEATRATRVRIEIANPGGVLLPNMYAEVEIGTGDAAPVVAVPDSAV
IDTGTRQVVIIDRGEGRFEPREVKIGLRGEGFTEIREGIAEGDRVVVAANFLIDAESNLKAALRGLTPAEAQP

Sequences:

>Translated_473_residues
MKRIGLVGLALAAILAAGIGGYWAGVRDFPVAGLREWFGVEATLAAAEPVGTGAVIYYQDPDGKPVYSATPRRTRDGRAF
RTVRASEDVSFEGRPPATVEAAGQAGPRRILYYRNPMGLPDTSPMPKKDSMGMDYIPVHEGEDDNGSVVKVSLGKLQRTG
VRSELAARRVVGRLVRVPGTVQLDERRISVVATRSDAFINEVANVTTGDRVTKGQMLLRLYAPDIATAGAQLLTDLKSGG
RDSALGGARQRLENLGLPPEAIAEIERTRKVPLSMTWRAPRDGVVLERNVVDGMKAAPGDVLFRLADISTIWVLADVPEF
DLGAVRLGAPVTIRARSLPGRTFEGRVSLIYPQVGEATRATRVRIEIANPGGVLLPNMYAEVEIGTGDAAPVVAVPDSAV
IDTGTRQVVIIDRGEGRFEPREVKIGLRGEGFTEIREGIAEGDRVVVAANFLIDAESNLKAALRGLTPAEAQP
>Mature_473_residues
MKRIGLVGLALAAILAAGIGGYWAGVRDFPVAGLREWFGVEATLAAAEPVGTGAVIYYQDPDGKPVYSATPRRTRDGRAF
RTVRASEDVSFEGRPPATVEAAGQAGPRRILYYRNPMGLPDTSPMPKKDSMGMDYIPVHEGEDDNGSVVKVSLGKLQRTG
VRSELAARRVVGRLVRVPGTVQLDERRISVVATRSDAFINEVANVTTGDRVTKGQMLLRLYAPDIATAGAQLLTDLKSGG
RDSALGGARQRLENLGLPPEAIAEIERTRKVPLSMTWRAPRDGVVLERNVVDGMKAAPGDVLFRLADISTIWVLADVPEF
DLGAVRLGAPVTIRARSLPGRTFEGRVSLIYPQVGEATRATRVRIEIANPGGVLLPNMYAEVEIGTGDAAPVVAVPDSAV
IDTGTRQVVIIDRGEGRFEPREVKIGLRGEGFTEIREGIAEGDRVVVAANFLIDAESNLKAALRGLTPAEAQP

Specific function: Part of a cation efflux system that mediates resistance to copper and silver [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786787, Length=374, Percent_Identity=31.5508021390374, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87081796, Length=167, Percent_Identity=31.1377245508982, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 50625; Mature: 50625

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIGLVGLALAAILAAGIGGYWAGVRDFPVAGLREWFGVEATLAAAEPVGTGAVIYYQD
CCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCEEEEEECCCCCCCEEEEEEC
PDGKPVYSATPRRTRDGRAFRTVRASEDVSFEGRPPATVEAAGQAGPRRILYYRNPMGLP
CCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCC
DTSPMPKKDSMGMDYIPVHEGEDDNGSVVKVSLGKLQRTGVRSELAARRVVGRLVRVPGT
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHCCCCC
VQLDERRISVVATRSDAFINEVANVTTGDRVTKGQMLLRLYAPDIATAGAQLLTDLKSGG
EEECCCEEEEEEECCHHHHHHHHCCCCCCCEECCEEEEEEECCCHHHHHHHHHHHHHCCC
RDSALGGARQRLENLGLPPEAIAEIERTRKVPLSMTWRAPRDGVVLERNVVDGMKAAPGD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCHHCCCCCCCHH
VLFRLADISTIWVLADVPEFDLGAVRLGAPVTIRARSLPGRTFEGRVSLIYPQVGEATRA
HEEEEECCEEEEEEECCCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCCE
TRVRIEIANPGGVLLPNMYAEVEIGTGDAAPVVAVPDSAVIDTGTRQVVIIDRGEGRFEP
EEEEEEEECCCCEECCCCEEEEEECCCCCCCEEECCCCCEEECCCCEEEEEECCCCCCCC
REVKIGLRGEGFTEIREGIAEGDRVVVAANFLIDAESNLKAALRGLTPAEAQP
EEEEEEECCCCHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKRIGLVGLALAAILAAGIGGYWAGVRDFPVAGLREWFGVEATLAAAEPVGTGAVIYYQD
CCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHCCEEEEEECCCCCCCEEEEEEC
PDGKPVYSATPRRTRDGRAFRTVRASEDVSFEGRPPATVEAAGQAGPRRILYYRNPMGLP
CCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCCCC
DTSPMPKKDSMGMDYIPVHEGEDDNGSVVKVSLGKLQRTGVRSELAARRVVGRLVRVPGT
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHCCCCC
VQLDERRISVVATRSDAFINEVANVTTGDRVTKGQMLLRLYAPDIATAGAQLLTDLKSGG
EEECCCEEEEEEECCHHHHHHHHCCCCCCCEECCEEEEEEECCCHHHHHHHHHHHHHCCC
RDSALGGARQRLENLGLPPEAIAEIERTRKVPLSMTWRAPRDGVVLERNVVDGMKAAPGD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCHHCCCCCCCHH
VLFRLADISTIWVLADVPEFDLGAVRLGAPVTIRARSLPGRTFEGRVSLIYPQVGEATRA
HEEEEECCEEEEEEECCCCCCCCEEEECCCEEEEEECCCCCCCCCEEEEEECCCCCCCCE
TRVRIEIANPGGVLLPNMYAEVEIGTGDAAPVVAVPDSAVIDTGTRQVVIIDRGEGRFEP
EEEEEEEECCCCEECCCCEEEEEECCCCCCCEEECCCCCEEECCCCEEEEEECCCCCCCC
REVKIGLRGEGFTEIREGIAEGDRVVVAANFLIDAESNLKAALRGLTPAEAQP
EEEEEEECCCCHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]