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The map label for this gene is pyrC [H]

Identifier: 154247841

GI number: 154247841

Start: 4336770

End: 4338086

Strand: Reverse

Name: pyrC [H]

Synonym: Xaut_3918

Alternate gene names: 154247841

Gene position: 4338086-4336770 (Counterclockwise)

Preceding gene: 154247842

Following gene: 154247840

Centisome position: 81.71

GC content: 70.99

Gene sequence:

>1317_bases
ATGCGTGACGGCCGCCTCATCCTCCGCGATCCCCACCCGCTCTTGCTCGCCAACGCGCGGGTCATCGATCCCTCCCGTGG
CTCGGATTTCCACGGCGATGTCTATCTCGCCGACGGCGTCATCAAGGATGCCGGCTTCGGCATCGCCGCCTCGGGTGTGC
CCGACGGCGCGGAAGTGGTGGACTGCAAGGGCGCCGTGGTCGCGCCCGGCCTCGTGGACATGTGCGCCTTCGTGGGCGAG
CCCGGCGCCGAGCATCGCGAGACGCTGGCCTCCGCCAGCCACGCGGCAGCGGCGGGCGGCGTCACCACCATCATCTGCCA
GCCCACCACCGACCCGGTGGTGGACGACCCGGCCATCGTGGACTTCATCCTGCGCCGGGCGCGGGATACGGCGGTGGTGC
GGGTTCACCCGATGGCGGCCATCACCAAGGGCCTGAAGGGCGAGGAGATGACCGAGATCGGCCTGCTCCAGGCCGCCGGC
GCCGTCGCCTTCACGGACGGCCACCGTTCCGTGGCGAGCGCCCAGGTGCTGCGCCGGACCCTGACCTACGCCCGCGACTT
CGACGCCCTCCTGGTGCACCACACCGAGGATGCGAGCATGTCGCAGGGGGCCATGAACGAGGGCGCCTTCGCCGCTCGCC
TCGGCCTCTCCGGCAATCCCAAGGCCGCCGAGACCATCGTGCTGGAGCGCGACGTACGGCTGGTCGCCGGCGCGCGCGGG
CGCTACCACGCGGCGGCGCTCACCTGCGCTGAATCCCTCGCCGTGCTGGAGCGCGCCAAGGAAGCCGGCCTGCCGGTGAC
GGCGTCCGCCACCATCAATCACCTGTCCTTCAACGAGCTGGATATCGGCGCCTACCGCACCTATTTCCGCCTCGCCCCGC
CGCTGCGCGCTGAGGAGGACCGTCAGGCGCTGATCCGCGCCATCGCCTCCGGCCTCATCGACGTGGTGGTCTCCGACCAT
CTGCCACAGGACGTGGAAGGCAAGCGCCTGCCCTTCTCGGAGGCGGAGCCCGGCGCCATCGGTCTCGAAACCCTGCTGTC
CGCCGCCCTGCGCCTGGTGCACTCGGACCAGGTGGACCTGGTGACCCTGCTGGCCGCCCTTTCCACCCGTCCGGCGGCGA
TCCTGGGCCTTGATGCCGGCACGCTGCGCCCCGGCGCGCCGGCGGACGTGACGGTGTTCGACCCCGGCATGCCCTATGTG
CTGGAACCGTCCATGCTCAAGTCACGCTGCCGCAACACCCCGTTCGACGAAGCCCGCCTCGACGGGCGCGTGCTGCGCAC
CATCGTTGCCGGGGCGACCGTGTACGAATACGTTTGA

Upstream 100 bases:

>100_bases
GCGGTGGCCGACGGGCCTCGCTCCCTCATCCGCGAACAGGTGGAGATGGGCGTCGCCGTGCGCATGGCCGTGCTCGACAC
CCTCGCCCGGAAGCTGCCCA

Downstream 100 bases:

>100_bases
TGGGCTCACGCAGCGTCGCCCACCCCGACTCGCGACGCTGCGTCGGCATCCTGTTTCGACGCGCCGTCGTCAGGCTTACC
GGTCTCCACTGCGCGCGAAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRDGRLILRDPHPLLLANARVIDPSRGSDFHGDVYLADGVIKDAGFGIAASGVPDGAEVVDCKGAVVAPGLVDMCAFVGE
PGAEHRETLASASHAAAAGGVTTIICQPTTDPVVDDPAIVDFILRRARDTAVVRVHPMAAITKGLKGEEMTEIGLLQAAG
AVAFTDGHRSVASAQVLRRTLTYARDFDALLVHHTEDASMSQGAMNEGAFAARLGLSGNPKAAETIVLERDVRLVAGARG
RYHAAALTCAESLAVLERAKEAGLPVTASATINHLSFNELDIGAYRTYFRLAPPLRAEEDRQALIRAIASGLIDVVVSDH
LPQDVEGKRLPFSEAEPGAIGLETLLSAALRLVHSDQVDLVTLLAALSTRPAAILGLDAGTLRPGAPADVTVFDPGMPYV
LEPSMLKSRCRNTPFDEARLDGRVLRTIVAGATVYEYV

Sequences:

>Translated_438_residues
MRDGRLILRDPHPLLLANARVIDPSRGSDFHGDVYLADGVIKDAGFGIAASGVPDGAEVVDCKGAVVAPGLVDMCAFVGE
PGAEHRETLASASHAAAAGGVTTIICQPTTDPVVDDPAIVDFILRRARDTAVVRVHPMAAITKGLKGEEMTEIGLLQAAG
AVAFTDGHRSVASAQVLRRTLTYARDFDALLVHHTEDASMSQGAMNEGAFAARLGLSGNPKAAETIVLERDVRLVAGARG
RYHAAALTCAESLAVLERAKEAGLPVTASATINHLSFNELDIGAYRTYFRLAPPLRAEEDRQALIRAIASGLIDVVVSDH
LPQDVEGKRLPFSEAEPGAIGLETLLSAALRLVHSDQVDLVTLLAALSTRPAAILGLDAGTLRPGAPADVTVFDPGMPYV
LEPSMLKSRCRNTPFDEARLDGRVLRTIVAGATVYEYV
>Mature_438_residues
MRDGRLILRDPHPLLLANARVIDPSRGSDFHGDVYLADGVIKDAGFGIAASGVPDGAEVVDCKGAVVAPGLVDMCAFVGE
PGAEHRETLASASHAAAAGGVTTIICQPTTDPVVDDPAIVDFILRRARDTAVVRVHPMAAITKGLKGEEMTEIGLLQAAG
AVAFTDGHRSVASAQVLRRTLTYARDFDALLVHHTEDASMSQGAMNEGAFAARLGLSGNPKAAETIVLERDVRLVAGARG
RYHAAALTCAESLAVLERAKEAGLPVTASATINHLSFNELDIGAYRTYFRLAPPLRAEEDRQALIRAIASGLIDVVVSDH
LPQDVEGKRLPFSEAEPGAIGLETLLSAALRLVHSDQVDLVTLLAALSTRPAAILGLDAGTLRPGAPADVTVFDPGMPYV
LEPSMLKSRCRNTPFDEARLDGRVLRTIVAGATVYEYV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=24.780701754386, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786722, Length=452, Percent_Identity=26.1061946902655, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87082175, Length=431, Percent_Identity=24.1299303944316, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322218, Length=391, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859883, Length=420, Percent_Identity=24.7619047619048, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46178; Mature: 46178

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDGRLILRDPHPLLLANARVIDPSRGSDFHGDVYLADGVIKDAGFGIAASGVPDGAEVV
CCCCCEEEECCCCEEEECCEEECCCCCCCCCCCEEEECCEEECCCCCEEECCCCCCCCEE
DCKGAVVAPGLVDMCAFVGEPGAEHRETLASASHAAAAGGVTTIICQPTTDPVVDDPAIV
ECCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
DFILRRARDTAVVRVHPMAAITKGLKGEEMTEIGLLQAAGAVAFTDGHRSVASAQVLRRT
HHHHHHCCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
LTYARDFDALLVHHTEDASMSQGAMNEGAFAARLGLSGNPKAAETIVLERDVRLVAGARG
HHHHHCCCEEEEEECCCCCHHCCCCCCCCEEEEECCCCCCCHHEEEEEECCCEEEECCCC
RYHAAALTCAESLAVLERAKEAGLPVTASATINHLSFNELDIGAYRTYFRLAPPLRAEED
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCCCCCCHHHHHHHEECCCCCCCHH
RQALIRAIASGLIDVVVSDHLPQDVEGKRLPFSEAEPGAIGLETLLSAALRLVHSDQVDL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHH
VTLLAALSTRPAAILGLDAGTLRPGAPADVTVFDPGMPYVLEPSMLKSRCRNTPFDEARL
HHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEECHHHHHHHHCCCCCHHHHH
DGRVLRTIVAGATVYEYV
HHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MRDGRLILRDPHPLLLANARVIDPSRGSDFHGDVYLADGVIKDAGFGIAASGVPDGAEVV
CCCCCEEEECCCCEEEECCEEECCCCCCCCCCCEEEECCEEECCCCCEEECCCCCCCCEE
DCKGAVVAPGLVDMCAFVGEPGAEHRETLASASHAAAAGGVTTIICQPTTDPVVDDPAIV
ECCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
DFILRRARDTAVVRVHPMAAITKGLKGEEMTEIGLLQAAGAVAFTDGHRSVASAQVLRRT
HHHHHHCCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
LTYARDFDALLVHHTEDASMSQGAMNEGAFAARLGLSGNPKAAETIVLERDVRLVAGARG
HHHHHCCCEEEEEECCCCCHHCCCCCCCCEEEEECCCCCCCHHEEEEEECCCEEEECCCC
RYHAAALTCAESLAVLERAKEAGLPVTASATINHLSFNELDIGAYRTYFRLAPPLRAEED
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEECCCCCCCCHHHHHHHEECCCCCCCHH
RQALIRAIASGLIDVVVSDHLPQDVEGKRLPFSEAEPGAIGLETLLSAALRLVHSDQVDL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHH
VTLLAALSTRPAAILGLDAGTLRPGAPADVTVFDPGMPYVLEPSMLKSRCRNTPFDEARL
HHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEECHHHHHHHHCCCCCHHHHH
DGRVLRTIVAGATVYEYV
HHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA