Click here to switch to the map view.

The map label for this gene is rnr [H]

Identifier: 154247787

GI number: 154247787

Start: 4279815

End: 4282145

Strand: Reverse

Name: rnr [H]

Synonym: Xaut_3864

Alternate gene names: 154247787

Gene position: 4282145-4279815 (Counterclockwise)

Preceding gene: 154247788

Following gene: 154247786

Centisome position: 80.66

GC content: 69.63

Gene sequence:

>2331_bases
ATGCCCACGAAAGAGCAGGTGCTGGCCTTCATCGCCACCCAGAGCGGCGAAGTGGGCAAGCGCGAGATCGCCCGCGCCTT
CGGCCTCAACGCGGCGCAGAAGATCGAGCTGAAGAGCCTGCTGCGCGACCTCGCCGACACCGGAACGGTGGAGCGCAGCC
GCCGCCGGCTGCACGTGCCCGGCGCCCTGCCCGGCGTGGTGCTGGCCGACATCGTCTCCCGCGATGGCGACGGCGAGCTG
ATCGCCGTGCCGGTGGAGTGGGATACCGAGACCCAGGGCGACGCGCCGCCCATCCTTGTCCAGGTGCCGCGCCGCGCCGT
GGGCCCCGCCCCCGGCCTGGCCGACCGGGTGCTGCTGCGCATCGTGGAAGGCTCCATCGAGCATGGCGTTGCCCATGTGG
GCCGCGTCATCAAGGTGCTGGAGAAGGCGCGCAGGCAGACCATCGGCATCTTCCGTGCCGCCCCCGGCGGGGAAGGCGGC
GGGCGCATCATCCCCATCGACAAGAAGCAGCTCGGCCGCGAGCTTCAGGTGCCCCCAGGCGCCGAGCACGAGGCCAGGGA
TGGCGACCTCGTCACCGTCGAATTGATGCGCCAGCGGGTGTTCGGCCTGCCCACCGCGCGGGTGAAGGAAAAGCTGGGTT
CGCTGAGCTCCGAGAAGGCGGTGAGCCTGATCGCGCTGCACGCCCACGCCATCCCCCACGTCTTCCCCGAGGCGGTGCTG
AAGGAGGCCGAGGCGGCAAAACCCGTCACCCCGCGCGGCCGCGAGGACTGGCGCGATGTGCCCCTCGTCACCATCGACCC
ACCCGACGCCAAGGACCATGACGATGCCGTCCACGCCGTGGCCGACGACGATCCGGCCAACGACGGCGGCTTCATCGTCA
CGGTCGCTATCGCCGATGTGTCGGCCTATGTGCGTCCCGGCTCGCCGCTGGACCGCGAGGCGCTGATCCGCGGCAATTCG
GTGTATTTCCCGGACCGCGTGGTGCCCATGCTGCCGGAGCGCATCTCCAACGACCTGTGCTCGCTGCGCCCGAAGGAGGA
CCGCCCGGCGCTGGCGGTGCGCATGATCATCGGCGCGGACGGCAGGAAGCGCCACCACACCTTCCACCGCATCCTCATGC
GCTCGGCGGGCAAGCTCGCCTATGCCCAGGCCCAGAACGCCATCGAGGGCCGCACCGACGACACCACCGACCCGCTGCTC
AACGGCGTGCTGAAGCCGCTCTACGCCGCCTATGACTGCGTGAAGAAAGCCCGCGACGCCCGCCAGCCCCTCGACCTCGA
CCTGCCCGAGCGCAAGATCGTGCTGAAGGAAGACGGCACCGTGGACCGCGTGGTGGTGCCGGAGCGGCTCGACGCCCACC
GGCTCATCGAGGAGTTCATGATCCTCGCCAATGTGGCCGCCGCCGAGACGCTGGAGGAGAAGAAGACCCCCCTCATCTAC
CGCGTCCATGACGGCCCCTCGCTGGAGAAGCTCTCCAACCTGCGGGAATTCCTGAAGACCCTGGACATCGCCCTGGCCAA
GATCGACCAGGTGCGGCCCTCCCACTTCAACCGCATCCTGGCGCAGGTGAAGGACACCGACGCGGCGCCGTTGGTCAACC
AGGTGATCCTGCGCAGCCAGAGCCAGGCGGAATATGCCTCGGAGAATTACGGGCATTTCGGCCTGAACCTGCGCCGCTAC
GCCCATTTCACCTCGCCGATCCGCCGCTATGCGGATCTGGTGGTGCATCGCGGCCTGGTGCGGGCCATGGATTTCGGCTC
CGACGGCCTGCCTCCCGACGCGACCACCGCGACGCTGGGCGAAGTGGCAGCCGCCATCTCCGTCACCGAGCGCCGCGCCA
TGGCGGCCGAACGGGAGACCGTGGACCGGCTCATCGCCCATCATCTGGCCGACCAGATCGGCGCCACCTTCAACGCCCGC
ATCACCGGGGCCACCAAGGCGGGACTCTTCGTCGCGCTCGACATTACCGGGGCAGATGGCTTCATTCCGGCCTCAACGCT
GGGGCAGGATTATTATCGCTACGACGAAACCCGGCAGGCCCTGGTGGGCGAGCGGAGCGGCGAAATGCACCGCATCGGCG
ACCGGGTGGAGGTCAAGCTGGTGGAGGCGGCGCCGGTGGCCGGCGCCCTGCGGTTTGAGCTTCTGACGGAAGGCTCCTAT
GTAAAGGGGCCGCGCGGGCGTCCCGGCCCGCTCCGGCGGGGCGGTGCCAAGGGTGGCGCGCCAAAGGGCGGCTTTCCGAA
AGGCGGCGCCCGGCAGGGTCCGGCCGGACGGCATGCCGGCAGCGGTCATCCGGGCAAAGGCCCGCAGGGAAAGGGACGGT
CGCGCCCGTAA

Upstream 100 bases:

>100_bases
CAAGGCGCGCCCGGGTAAATCCCGCGCCTCGCGCAAGCAGGCGGCCGCCGAACATGCGCGGGTGGAGGCCCTGGTTGTCG
CCCGCCACGCCACCGGCGAA

Downstream 100 bases:

>100_bases
ATCGCGACCTGATGGGGGTCTGAAGGGGGTTCGACGGTGGACACGCCTGCGACCATGACGGTAACGACAACCCTCGCCGG
CTCCGAGCCGGGGGAGGCGC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 776; Mature: 775

Protein sequence:

>776_residues
MPTKEQVLAFIATQSGEVGKREIARAFGLNAAQKIELKSLLRDLADTGTVERSRRRLHVPGALPGVVLADIVSRDGDGEL
IAVPVEWDTETQGDAPPILVQVPRRAVGPAPGLADRVLLRIVEGSIEHGVAHVGRVIKVLEKARRQTIGIFRAAPGGEGG
GRIIPIDKKQLGRELQVPPGAEHEARDGDLVTVELMRQRVFGLPTARVKEKLGSLSSEKAVSLIALHAHAIPHVFPEAVL
KEAEAAKPVTPRGREDWRDVPLVTIDPPDAKDHDDAVHAVADDDPANDGGFIVTVAIADVSAYVRPGSPLDREALIRGNS
VYFPDRVVPMLPERISNDLCSLRPKEDRPALAVRMIIGADGRKRHHTFHRILMRSAGKLAYAQAQNAIEGRTDDTTDPLL
NGVLKPLYAAYDCVKKARDARQPLDLDLPERKIVLKEDGTVDRVVVPERLDAHRLIEEFMILANVAAAETLEEKKTPLIY
RVHDGPSLEKLSNLREFLKTLDIALAKIDQVRPSHFNRILAQVKDTDAAPLVNQVILRSQSQAEYASENYGHFGLNLRRY
AHFTSPIRRYADLVVHRGLVRAMDFGSDGLPPDATTATLGEVAAAISVTERRAMAAERETVDRLIAHHLADQIGATFNAR
ITGATKAGLFVALDITGADGFIPASTLGQDYYRYDETRQALVGERSGEMHRIGDRVEVKLVEAAPVAGALRFELLTEGSY
VKGPRGRPGPLRRGGAKGGAPKGGFPKGGARQGPAGRHAGSGHPGKGPQGKGRSRP

Sequences:

>Translated_776_residues
MPTKEQVLAFIATQSGEVGKREIARAFGLNAAQKIELKSLLRDLADTGTVERSRRRLHVPGALPGVVLADIVSRDGDGEL
IAVPVEWDTETQGDAPPILVQVPRRAVGPAPGLADRVLLRIVEGSIEHGVAHVGRVIKVLEKARRQTIGIFRAAPGGEGG
GRIIPIDKKQLGRELQVPPGAEHEARDGDLVTVELMRQRVFGLPTARVKEKLGSLSSEKAVSLIALHAHAIPHVFPEAVL
KEAEAAKPVTPRGREDWRDVPLVTIDPPDAKDHDDAVHAVADDDPANDGGFIVTVAIADVSAYVRPGSPLDREALIRGNS
VYFPDRVVPMLPERISNDLCSLRPKEDRPALAVRMIIGADGRKRHHTFHRILMRSAGKLAYAQAQNAIEGRTDDTTDPLL
NGVLKPLYAAYDCVKKARDARQPLDLDLPERKIVLKEDGTVDRVVVPERLDAHRLIEEFMILANVAAAETLEEKKTPLIY
RVHDGPSLEKLSNLREFLKTLDIALAKIDQVRPSHFNRILAQVKDTDAAPLVNQVILRSQSQAEYASENYGHFGLNLRRY
AHFTSPIRRYADLVVHRGLVRAMDFGSDGLPPDATTATLGEVAAAISVTERRAMAAERETVDRLIAHHLADQIGATFNAR
ITGATKAGLFVALDITGADGFIPASTLGQDYYRYDETRQALVGERSGEMHRIGDRVEVKLVEAAPVAGALRFELLTEGSY
VKGPRGRPGPLRRGGAKGGAPKGGFPKGGARQGPAGRHAGSGHPGKGPQGKGRSRP
>Mature_775_residues
PTKEQVLAFIATQSGEVGKREIARAFGLNAAQKIELKSLLRDLADTGTVERSRRRLHVPGALPGVVLADIVSRDGDGELI
AVPVEWDTETQGDAPPILVQVPRRAVGPAPGLADRVLLRIVEGSIEHGVAHVGRVIKVLEKARRQTIGIFRAAPGGEGGG
RIIPIDKKQLGRELQVPPGAEHEARDGDLVTVELMRQRVFGLPTARVKEKLGSLSSEKAVSLIALHAHAIPHVFPEAVLK
EAEAAKPVTPRGREDWRDVPLVTIDPPDAKDHDDAVHAVADDDPANDGGFIVTVAIADVSAYVRPGSPLDREALIRGNSV
YFPDRVVPMLPERISNDLCSLRPKEDRPALAVRMIIGADGRKRHHTFHRILMRSAGKLAYAQAQNAIEGRTDDTTDPLLN
GVLKPLYAAYDCVKKARDARQPLDLDLPERKIVLKEDGTVDRVVVPERLDAHRLIEEFMILANVAAAETLEEKKTPLIYR
VHDGPSLEKLSNLREFLKTLDIALAKIDQVRPSHFNRILAQVKDTDAAPLVNQVILRSQSQAEYASENYGHFGLNLRRYA
HFTSPIRRYADLVVHRGLVRAMDFGSDGLPPDATTATLGEVAAAISVTERRAMAAERETVDRLIAHHLADQIGATFNARI
TGATKAGLFVALDITGADGFIPASTLGQDYYRYDETRQALVGERSGEMHRIGDRVEVKLVEAAPVAGALRFELLTEGSYV
KGPRGRPGPLRRGGAKGGAPKGGFPKGGARQGPAGRHAGSGHPGKGPQGKGRSRP

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=442, Percent_Identity=29.8642533936652, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI190014623, Length=442, Percent_Identity=29.8642533936652, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI134288890, Length=359, Percent_Identity=32.5905292479109, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI219521928, Length=500, Percent_Identity=28.2, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI19115966, Length=499, Percent_Identity=28.2565130260521, Blast_Score=140, Evalue=6e-33,
Organism=Escherichia coli, GI87082383, Length=730, Percent_Identity=35.2054794520548, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1787542, Length=500, Percent_Identity=32.6, Blast_Score=183, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=487, Percent_Identity=30.1848049281314, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17553506, Length=356, Percent_Identity=31.4606741573034, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324552, Length=504, Percent_Identity=29.3650793650794, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320499, Length=384, Percent_Identity=22.3958333333333, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24649634, Length=604, Percent_Identity=27.317880794702, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24654592, Length=372, Percent_Identity=28.7634408602151, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922976, Length=372, Percent_Identity=28.7634408602151, Blast_Score=125, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654597, Length=372, Percent_Identity=28.7634408602151, Blast_Score=125, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 84090; Mature: 83959

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKEQVLAFIATQSGEVGKREIARAFGLNAAQKIELKSLLRDLADTGTVERSRRRLHVP
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHCCCEEECC
GALPGVVLADIVSRDGDGELIAVPVEWDTETQGDAPPILVQVPRRAVGPAPGLADRVLLR
CCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHCCCCCCHHHHHHHH
IVEGSIEHGVAHVGRVIKVLEKARRQTIGIFRAAPGGEGGGRIIPIDKKQLGRELQVPPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEEEEECHHHHCCCCCCCCC
AEHEARDGDLVTVELMRQRVFGLPTARVKEKLGSLSSEKAVSLIALHAHAIPHVFPEAVL
CCCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KEAEAAKPVTPRGREDWRDVPLVTIDPPDAKDHDDAVHAVADDDPANDGGFIVTVAIADV
HHHHHCCCCCCCCCCHHCCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECH
SAYVRPGSPLDREALIRGNSVYFPDRVVPMLPERISNDLCSLRPKEDRPALAVRMIIGAD
HHHCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
GRKRHHTFHRILMRSAGKLAYAQAQNAIEGRTDDTTDPLLNGVLKPLYAAYDCVKKARDA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQPLDLDLPERKIVLKEDGTVDRVVVPERLDAHRLIEEFMILANVAAAETLEEKKTPLIY
CCCCCCCCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
RVHDGPSLEKLSNLREFLKTLDIALAKIDQVRPSHFNRILAQVKDTDAAPLVNQVILRSQ
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SQAEYASENYGHFGLNLRRYAHFTSPIRRYADLVVHRGLVRAMDFGSDGLPPDATTATLG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
EVAAAISVTERRAMAAERETVDRLIAHHLADQIGATFNARITGATKAGLFVALDITGADG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCC
FIPASTLGQDYYRYDETRQALVGERSGEMHRIGDRVEVKLVEAAPVAGALRFELLTEGSY
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCHHHEEEEEECCCC
VKGPRGRPGPLRRGGAKGGAPKGGFPKGGARQGPAGRHAGSGHPGKGPQGKGRSRP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTKEQVLAFIATQSGEVGKREIARAFGLNAAQKIELKSLLRDLADTGTVERSRRRLHVP
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHCCCEEECC
GALPGVVLADIVSRDGDGELIAVPVEWDTETQGDAPPILVQVPRRAVGPAPGLADRVLLR
CCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHCCCCCCHHHHHHHH
IVEGSIEHGVAHVGRVIKVLEKARRQTIGIFRAAPGGEGGGRIIPIDKKQLGRELQVPPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEEEEECHHHHCCCCCCCCC
AEHEARDGDLVTVELMRQRVFGLPTARVKEKLGSLSSEKAVSLIALHAHAIPHVFPEAVL
CCCCCCCCCEEEHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KEAEAAKPVTPRGREDWRDVPLVTIDPPDAKDHDDAVHAVADDDPANDGGFIVTVAIADV
HHHHHCCCCCCCCCCHHCCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCEEEEEEEECH
SAYVRPGSPLDREALIRGNSVYFPDRVVPMLPERISNDLCSLRPKEDRPALAVRMIIGAD
HHHCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
GRKRHHTFHRILMRSAGKLAYAQAQNAIEGRTDDTTDPLLNGVLKPLYAAYDCVKKARDA
CCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RQPLDLDLPERKIVLKEDGTVDRVVVPERLDAHRLIEEFMILANVAAAETLEEKKTPLIY
CCCCCCCCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
RVHDGPSLEKLSNLREFLKTLDIALAKIDQVRPSHFNRILAQVKDTDAAPLVNQVILRSQ
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
SQAEYASENYGHFGLNLRRYAHFTSPIRRYADLVVHRGLVRAMDFGSDGLPPDATTATLG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
EVAAAISVTERRAMAAERETVDRLIAHHLADQIGATFNARITGATKAGLFVALDITGADG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCC
FIPASTLGQDYYRYDETRQALVGERSGEMHRIGDRVEVKLVEAAPVAGALRFELLTEGSY
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEEEECCCCCHHHEEEEEECCCC
VKGPRGRPGPLRRGGAKGGAPKGGFPKGGARQGPAGRHAGSGHPGKGPQGKGRSRP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]