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The map label for this gene is bioF [C]

Identifier: 154247728

GI number: 154247728

Start: 4210289

End: 4211623

Strand: Reverse

Name: bioF [C]

Synonym: Xaut_3804

Alternate gene names: 154247728

Gene position: 4211623-4210289 (Counterclockwise)

Preceding gene: 154247729

Following gene: 154247724

Centisome position: 79.33

GC content: 70.56

Gene sequence:

>1335_bases
ATGAGCGGCGGCGGCCGCCTCTCGGACGACGAGTTCGAGCGGCTCATGGCCGAGATGAAGGCACCCACCCCTGCGGCCGC
GCCCAAAGCGCCCGAGCGGGCCGACCACAGGCCGCAGACGGCGTTCGAGACCCTGCCTCGCTTCACGGAACTGAGAACGC
AACGCGCCGCGGCGGAGCTGCTGGGGCTCGAAAGCCCCTATCACCGCGTTCACGAGATGCGCGCAGGTGCCGTGTCCAGG
ATCGACGGGCGCGAGGTGGTGAATTTCGCCTCCTACGACTATCTCGGCCTCAACGGCGACCCGCGCATCACCCGCGCCGT
TGCCGAGGCGGCGGCGCAGTGGGGCACCAGCGTGTCATCCAGCCGCCTGTCCGCCGGCGAGCGCCCGGCCCATGGCGCGT
TGGAGGCAGGGCTCGCCGCCATCTACGGAGCCGAGGCGGCCCTCGCCTTCGTGAGCGGCCATGCCACCGCGCTGGCGGTG
ATCCCCACCCTCATGGGGCCGAACGACCTCGTCGTCACCGACGCCCTCATGCACAATTGCGTGCTGCTCGGCGCCCAGTA
CAGCCCCGCCACCCGCCGCACCTTCCCCCACAATGACCTTGACGCCCTTGAGGCCATGCTGGCGCGCGACCGGGACCGCT
TCGGCCGCGTCCTGATCGTCAGTGAGGGCCTGTTCTCCATGGACGGCGACGGGCCGGACCTGAAGCGTCTCGTGGCGCTG
AAGGGGCGGTTTGGCTGCTGGCTCATGATCGACGACGCCCACGGCCTCGGCGTGCTGGGTGGCACGGGGCGGGGCATCGC
CGAGCATGCGGGCGTCGATCCGCGGGCCGTGGACATCTGGTTCGGCACGCTCTCCAAGACGCTGGTGAGCTGTGGGGGCT
ATATCGCGGGATCGACGGCCATCATCGACTATCTCAAGGCCTTTGCTCCGGGCATGGTCTACAGCGTCGGCATGCCGGTG
CCGGTGGCGGAGGCCGCCCGCGTCGCGCTGGAACTGATGATCGCCGAGCCCGAGCGGGTGAAGCGCTTGGCGGCCAATGG
CGCGCGCCTCCGGGCCCAGTTGGTGGCCGGTGGCTTCGATGTGGGGGCCGCCTGGGGCTTTGGCATCGTCCCGGTCATCG
TGGGCGAGACCATCAAGACCGTGCAGCTCGCCCAAAAGCTTCTGGAGCGCGGCATCAATGTCTTCCCGGTGCTGCCGCCG
GGGGTGCCGGACCGCTCGGCCCGCCTGCGCTTCTTCCTGTCGGCCGCCCATAGCGACGCCCATCTCGATCAGGCTCTGGA
GGCCCTCACGCAGGAGGCCGCCGCCCTCGGCCTGCCGCGTCCGCGATCCGGCTGA

Upstream 100 bases:

>100_bases
CGGCGATGCTGGAGCAGCACGGCGTCAGCCTCGCCCCGGAAGACGGCAGCGCCATCCTCAAGGCCATCGGTGCCCGGCGC
GGCGCAACCGGGCGATCAGC

Downstream 100 bases:

>100_bases
CGGCATCGAGCCACGCCTCGAAGGCGGGCTCCCAGTCGAGCATCCCGCGCTCGGCGGCGAGGGTCCCGCGGAGGCGGGCG
GCAAGCGCCTTGTCCTCGAC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSGGGRLSDDEFERLMAEMKAPTPAAAPKAPERADHRPQTAFETLPRFTELRTQRAAAELLGLESPYHRVHEMRAGAVSR
IDGREVVNFASYDYLGLNGDPRITRAVAEAAAQWGTSVSSSRLSAGERPAHGALEAGLAAIYGAEAALAFVSGHATALAV
IPTLMGPNDLVVTDALMHNCVLLGAQYSPATRRTFPHNDLDALEAMLARDRDRFGRVLIVSEGLFSMDGDGPDLKRLVAL
KGRFGCWLMIDDAHGLGVLGGTGRGIAEHAGVDPRAVDIWFGTLSKTLVSCGGYIAGSTAIIDYLKAFAPGMVYSVGMPV
PVAEAARVALELMIAEPERVKRLAANGARLRAQLVAGGFDVGAAWGFGIVPVIVGETIKTVQLAQKLLERGINVFPVLPP
GVPDRSARLRFFLSAAHSDAHLDQALEALTQEAAALGLPRPRSG

Sequences:

>Translated_444_residues
MSGGGRLSDDEFERLMAEMKAPTPAAAPKAPERADHRPQTAFETLPRFTELRTQRAAAELLGLESPYHRVHEMRAGAVSR
IDGREVVNFASYDYLGLNGDPRITRAVAEAAAQWGTSVSSSRLSAGERPAHGALEAGLAAIYGAEAALAFVSGHATALAV
IPTLMGPNDLVVTDALMHNCVLLGAQYSPATRRTFPHNDLDALEAMLARDRDRFGRVLIVSEGLFSMDGDGPDLKRLVAL
KGRFGCWLMIDDAHGLGVLGGTGRGIAEHAGVDPRAVDIWFGTLSKTLVSCGGYIAGSTAIIDYLKAFAPGMVYSVGMPV
PVAEAARVALELMIAEPERVKRLAANGARLRAQLVAGGFDVGAAWGFGIVPVIVGETIKTVQLAQKLLERGINVFPVLPP
GVPDRSARLRFFLSAAHSDAHLDQALEALTQEAAALGLPRPRSG
>Mature_443_residues
SGGGRLSDDEFERLMAEMKAPTPAAAPKAPERADHRPQTAFETLPRFTELRTQRAAAELLGLESPYHRVHEMRAGAVSRI
DGREVVNFASYDYLGLNGDPRITRAVAEAAAQWGTSVSSSRLSAGERPAHGALEAGLAAIYGAEAALAFVSGHATALAVI
PTLMGPNDLVVTDALMHNCVLLGAQYSPATRRTFPHNDLDALEAMLARDRDRFGRVLIVSEGLFSMDGDGPDLKRLVALK
GRFGCWLMIDDAHGLGVLGGTGRGIAEHAGVDPRAVDIWFGTLSKTLVSCGGYIAGSTAIIDYLKAFAPGMVYSVGMPVP
VAEAARVALELMIAEPERVKRLAANGARLRAQLVAGGFDVGAAWGFGIVPVIVGETIKTVQLAQKLLERGINVFPVLPPG
VPDRSARLRFFLSAAHSDAHLDQALEALTQEAAALGLPRPRSG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=374, Percent_Identity=35.5614973262032, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4758668, Length=375, Percent_Identity=35.2, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI7657118, Length=366, Percent_Identity=32.7868852459016, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=32.5648414985591, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI83977442, Length=364, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI83977440, Length=364, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI83977444, Length=364, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4502025, Length=372, Percent_Identity=28.7634408602151, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI40316939, Length=372, Percent_Identity=28.7634408602151, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=29.8387096774194, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=38, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=32.0610687022901, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=33.4246575342466, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=31.5217391304348, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=31.5217391304348, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71994529, Length=404, Percent_Identity=31.1881188118812, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71982617, Length=290, Percent_Identity=29.6551724137931, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982625, Length=290, Percent_Identity=29.6551724137931, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=32.3369565217391, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320438, Length=383, Percent_Identity=27.6762402088773, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=349, Percent_Identity=24.9283667621776, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136286, Length=373, Percent_Identity=32.7077747989276, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24662918, Length=358, Percent_Identity=30.1675977653631, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17137420, Length=311, Percent_Identity=29.5819935691318, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653280, Length=296, Percent_Identity=27.7027027027027, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653276, Length=296, Percent_Identity=27.7027027027027, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24653278, Length=296, Percent_Identity=27.7027027027027, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 47051; Mature: 46920

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGGRLSDDEFERLMAEMKAPTPAAAPKAPERADHRPQTAFETLPRFTELRTQRAAAEL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGLESPYHRVHEMRAGAVSRIDGREVVNFASYDYLGLNGDPRITRAVAEAAAQWGTSVSS
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCH
SRLSAGERPAHGALEAGLAAIYGAEAALAFVSGHATALAVIPTLMGPNDLVVTDALMHNC
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEHHHHHHHH
VLLGAQYSPATRRTFPHNDLDALEAMLARDRDRFGRVLIVSEGLFSMDGDGPDLKRLVAL
HEEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHCCEEEEECCCCCCCCCCHHHHHHHHH
KGRFGCWLMIDDAHGLGVLGGTGRGIAEHAGVDPRAVDIWFGTLSKTLVSCGGYIAGSTA
CCCCEEEEEEECCCCCEEECCCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHCCHHCCHHH
IIDYLKAFAPGMVYSVGMPVPVAEAARVALELMIAEPERVKRLAANGARLRAQLVAGGFD
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCC
VGAAWGFGIVPVIVGETIKTVQLAQKLLERGINVFPVLPPGVPDRSARLRFFLSAAHSDA
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCHH
HLDQALEALTQEAAALGLPRPRSG
HHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SGGGRLSDDEFERLMAEMKAPTPAAAPKAPERADHRPQTAFETLPRFTELRTQRAAAEL
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGLESPYHRVHEMRAGAVSRIDGREVVNFASYDYLGLNGDPRITRAVAEAAAQWGTSVSS
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCH
SRLSAGERPAHGALEAGLAAIYGAEAALAFVSGHATALAVIPTLMGPNDLVVTDALMHNC
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEHHHHHHHH
VLLGAQYSPATRRTFPHNDLDALEAMLARDRDRFGRVLIVSEGLFSMDGDGPDLKRLVAL
HEEECCCCCCCCCCCCCCCHHHHHHHHHHCHHHHCCEEEEECCCCCCCCCCHHHHHHHHH
KGRFGCWLMIDDAHGLGVLGGTGRGIAEHAGVDPRAVDIWFGTLSKTLVSCGGYIAGSTA
CCCCEEEEEEECCCCCEEECCCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHCCHHCCHHH
IIDYLKAFAPGMVYSVGMPVPVAEAARVALELMIAEPERVKRLAANGARLRAQLVAGGFD
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCC
VGAAWGFGIVPVIVGETIKTVQLAQKLLERGINVFPVLPPGVPDRSARLRFFLSAAHSDA
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCHH
HLDQALEALTQEAAALGLPRPRSG
HHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA