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The map label for this gene is lon [H]

Identifier: 154247520

GI number: 154247520

Start: 4018008

End: 4020425

Strand: Direct

Name: lon [H]

Synonym: Xaut_3593

Alternate gene names: 154247520

Gene position: 4018008-4020425 (Clockwise)

Preceding gene: 154247519

Following gene: 154247521

Centisome position: 75.68

GC content: 65.3

Gene sequence:

>2418_bases
ATGACGAGCCAGAAGCCGCGCCCGCCGCTCGTTGCCGGGGTGTCCCAGACCTACCCGGTCCTGCCTCTTCGGGACATCGT
GGTTTTTCCACATATGATTGTTCCCCTCTTCGTGGGGCGCGAGAAGTCCATCCGCGCCCTCGAAGAGGTCATGCGCGGCG
ATACCTACATCCTCCTCGCCACCCAGGAGAACGCCTCGGACGACGATCCCGCCGCCGAAGCCATCTTCTCCGTGGGCACG
CTCGCGACCGTCCTGCAGCTGCTGAAGCTGCCCGACGGCACCGTGAAGGTGTTGGTGGAGGGCGTTAGCCGCGCCCAGGT
GACCCGCTACACCGAGCGTACCGATCTCTATGAAGCCGAGGCCATCACCCTCGACGACGAGAGCGGCGACCAGGTGGAGG
CCGAGGCGCTTGCGCGCTCGGTGGTCACCGAGTTCGAGAATTATGTGAAGCTCAACAAGAAGGTGTCGCCGGAGGTGGTG
GGCGTCGTCAGCCAGATCGACGACCACTCCAAGCTCGCCGACACCGTCGCCTCGCACCTCGCCGTGAAGATCCCGGAGAA
GCAAGGCGTCCTGGAGATGCTCAAGGTCGCCGACCGCCTGGAGAAGGTGCTCGGCCTGATGGAGAGCGAGATCTCCGTCC
TGCAGGTGGAAAAGCGCATCCGCACCCGCGTCAAGCGGCAGATGGAGAAGACCCAGCGCGAGTACTACCTCAACGAGCAG
ATGAAGGCGATCCAGAAGGAGCTTGGCGACGAGGACGGCAAGGACGACCTGCAGGAGCTGGAAGACCGCATCAAGCGCAC
CAAGCTCACCAAGGAAGCCCGCGAAAAGGCCACCCACGAGCTGAAGAAGCTGCGTCAGATGTCGCCCATGTCGGCGGAAG
CCACCGTGGTGCGCAATTACCTGGACTGGCTGCTGTCGATCCCGTGGGGCGTGAAGAGCAAGGTCAAGAAGGACCTGCCC
TTCGCCCAGCAGATCCTCGACAGCGACCACTACGGCCTCGACAAGGTCAAGGAGCGCATCGTCGAGTATCTCGCCGTGCA
GAGCCGCGCCAACAAGCTCACCGGGCCCATCCTGTGCCTCGTCGGCCCCCCCGGCGTGGGCAAAACCTCGCTCGGCAAGT
CCATCGCCAAGGCGACGGGCCGTGAGTTCGTGCGCGTCGCCCTGGGCGGCGTGCGGGACGAGGCGGAGATCCGCGGTCAC
CGGCGGACCTACATCGGGTCCATGCCGGGCAAGATTATCCAGTCCATGCGCAAGGCCAAGAAGTCGAACCCGCTCTTCCT
GCTGGATGAGATCGACAAGATGGGCGCCGATTTCCGCGGCGATCCGTCCTCGGCCCTGCTCGAGGTGCTGGATCCGGAGC
AGAACCACACCTTCGCCGACCACTATCTGGAGGTGGACTACGACCTTTCGAACGTCATGTTCGTGACCACGGCGAACACG
CTGAACATCCCGCCGGCCCTTCTGGACCGCATGGAGGTGATCCGCATCGCCGGCTACACCGAGGACGAGAAGGTGGAGAT
CGCGCGCAAGCACCTTCTGCCCAACTCGCTTGGCAAGCATGGCCTGACGCCGAAGGAGTTCACCATCGACGACGGTGCGC
TGCTCCAGCTGGTCCGCCGCTACACGCGGGAAGCCGGTGTGCGCAACCTCGAGCGCGAGATCTCCACGCTGGCCCGCAAG
GCGGTGAAGGAGCTGGTGCTGTCGAAGAAGAAGTCGGTGAAGGTGACCGCCAAGAACCTCGAGGATTTCCTCGGCGTGCC
GCGCTACCGGTACGGCGAGGTGGAGACCGAGGACCAGGTGGGTGTCGTCACCGGCCTCGCCTGGACCGAGGTGGGCGGCG
AGTTGCTGACCATCGAAGGCCTCATGATGCCCGGCAAGGGCAAGATGACGGTCACCGGCAACCTGCGCGACGTGATGAAG
GAATCGATCTCGGCTGCGGCGTCCTACGTGCGCTCGCGGGCGGTTGATTTCGGCATCGAGCCGCCATTGTTCGAGCGGCG
CGACATTCACGTCCATGTGCCGGAAGGCGCCACTCCGAAGGACGGCCCGTCCGCCGGTGTCGCCATGGCCACGGCCATCG
TCTCGGTGATGACCGGCATTGCGGTGCGCCGCGATGTGGCCATGACGGGTGAGATCACCCTGCGGGGCCGGGTGCTGCCC
ATCGGCGGCCTCAAGGAGAAGCTCCTTGCGGCCCTGCGCGGTGGCATCAAGAAGGTGCTGATCCCCGAGGAGAACGCCAA
GGACCTGGCGGACATCCCGGCCAACGTGAAGAACGCGCTGGAGATCGTTCCGGTCTCCCGCATGGACGAGGTGCTCGCCA
ATGCGCTCGTTCGCCCGCCGGTTCCGATCACCTGGGAAGAGCGCCCGGTGAACGCCCCGGTGCCGGGCGAGGAGACCCCC
GGCGTGGTCGCCCACTGA

Upstream 100 bases:

>100_bases
TCAGCATTGAAATTCCACGCCCGTCTCCGGCCGCGTGCACGCGCGGCAACGCTCAGTTGTGCGTTTTTCCAGCGCGTGTA
CTTCTTGAAAGGATTGCGTC

Downstream 100 bases:

>100_bases
CGAAAGATCTGGCCGGATTGCCCGCAAACCGGCCAGATTGAAGCGTTTTCCAGCGAAAAGAGAGGGCGTGTTGCCGCTTC
CCCCCATCAAGCCGGGGGAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MTSQKPRPPLVAGVSQTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMRGDTYILLATQENASDDDPAAEAIFSVGT
LATVLQLLKLPDGTVKVLVEGVSRAQVTRYTERTDLYEAEAITLDDESGDQVEAEALARSVVTEFENYVKLNKKVSPEVV
GVVSQIDDHSKLADTVASHLAVKIPEKQGVLEMLKVADRLEKVLGLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
MKAIQKELGDEDGKDDLQELEDRIKRTKLTKEAREKATHELKKLRQMSPMSAEATVVRNYLDWLLSIPWGVKSKVKKDLP
FAQQILDSDHYGLDKVKERIVEYLAVQSRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRVALGGVRDEAEIRGH
RRTYIGSMPGKIIQSMRKAKKSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFADHYLEVDYDLSNVMFVTTANT
LNIPPALLDRMEVIRIAGYTEDEKVEIARKHLLPNSLGKHGLTPKEFTIDDGALLQLVRRYTREAGVRNLEREISTLARK
AVKELVLSKKKSVKVTAKNLEDFLGVPRYRYGEVETEDQVGVVTGLAWTEVGGELLTIEGLMMPGKGKMTVTGNLRDVMK
ESISAAASYVRSRAVDFGIEPPLFERRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIAVRRDVAMTGEITLRGRVLP
IGGLKEKLLAALRGGIKKVLIPEENAKDLADIPANVKNALEIVPVSRMDEVLANALVRPPVPITWEERPVNAPVPGEETP
GVVAH

Sequences:

>Translated_805_residues
MTSQKPRPPLVAGVSQTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMRGDTYILLATQENASDDDPAAEAIFSVGT
LATVLQLLKLPDGTVKVLVEGVSRAQVTRYTERTDLYEAEAITLDDESGDQVEAEALARSVVTEFENYVKLNKKVSPEVV
GVVSQIDDHSKLADTVASHLAVKIPEKQGVLEMLKVADRLEKVLGLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
MKAIQKELGDEDGKDDLQELEDRIKRTKLTKEAREKATHELKKLRQMSPMSAEATVVRNYLDWLLSIPWGVKSKVKKDLP
FAQQILDSDHYGLDKVKERIVEYLAVQSRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRVALGGVRDEAEIRGH
RRTYIGSMPGKIIQSMRKAKKSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFADHYLEVDYDLSNVMFVTTANT
LNIPPALLDRMEVIRIAGYTEDEKVEIARKHLLPNSLGKHGLTPKEFTIDDGALLQLVRRYTREAGVRNLEREISTLARK
AVKELVLSKKKSVKVTAKNLEDFLGVPRYRYGEVETEDQVGVVTGLAWTEVGGELLTIEGLMMPGKGKMTVTGNLRDVMK
ESISAAASYVRSRAVDFGIEPPLFERRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIAVRRDVAMTGEITLRGRVLP
IGGLKEKLLAALRGGIKKVLIPEENAKDLADIPANVKNALEIVPVSRMDEVLANALVRPPVPITWEERPVNAPVPGEETP
GVVAH
>Mature_804_residues
TSQKPRPPLVAGVSQTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMRGDTYILLATQENASDDDPAAEAIFSVGTL
ATVLQLLKLPDGTVKVLVEGVSRAQVTRYTERTDLYEAEAITLDDESGDQVEAEALARSVVTEFENYVKLNKKVSPEVVG
VVSQIDDHSKLADTVASHLAVKIPEKQGVLEMLKVADRLEKVLGLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQM
KAIQKELGDEDGKDDLQELEDRIKRTKLTKEAREKATHELKKLRQMSPMSAEATVVRNYLDWLLSIPWGVKSKVKKDLPF
AQQILDSDHYGLDKVKERIVEYLAVQSRANKLTGPILCLVGPPGVGKTSLGKSIAKATGREFVRVALGGVRDEAEIRGHR
RTYIGSMPGKIIQSMRKAKKSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFADHYLEVDYDLSNVMFVTTANTL
NIPPALLDRMEVIRIAGYTEDEKVEIARKHLLPNSLGKHGLTPKEFTIDDGALLQLVRRYTREAGVRNLEREISTLARKA
VKELVLSKKKSVKVTAKNLEDFLGVPRYRYGEVETEDQVGVVTGLAWTEVGGELLTIEGLMMPGKGKMTVTGNLRDVMKE
SISAAASYVRSRAVDFGIEPPLFERRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIAVRRDVAMTGEITLRGRVLPI
GGLKEKLLAALRGGIKKVLIPEENAKDLADIPANVKNALEIVPVSRMDEVLANALVRPPVPITWEERPVNAPVPGEETPG
VVAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=774, Percent_Identity=39.1472868217054, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=832, Percent_Identity=37.6201923076923, Blast_Score=526, Evalue=1e-149,
Organism=Escherichia coli, GI1786643, Length=764, Percent_Identity=64.5287958115183, Blast_Score=1001, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=40.606936416185, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=785, Percent_Identity=32.8662420382166, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=737, Percent_Identity=39.6200814111262, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=650, Percent_Identity=43.3846153846154, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=650, Percent_Identity=43.3846153846154, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89001; Mature: 88870

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQKPRPPLVAGVSQTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMRGDTYILLA
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEE
TQENASDDDPAAEAIFSVGTLATVLQLLKLPDGTVKVLVEGVSRAQVTRYTERTDLYEAE
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEECC
AITLDDESGDQVEAEALARSVVTEFENYVKLNKKVSPEVVGVVSQIDDHSKLADTVASHL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
AVKIPEKQGVLEMLKVADRLEKVLGLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDEDGKDDLQELEDRIKRTKLTKEAREKATHELKKLRQMSPMSAEATVVRNY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LDWLLSIPWGVKSKVKKDLPFAQQILDSDHYGLDKVKERIVEYLAVQSRANKLTGPILCL
HHHHHHCCCCHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VGPPGVGKTSLGKSIAKATGREFVRVALGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHH
KSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFADHYLEVDYDLSNVMFVTTANT
CCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHEEEEEECCCCEEEEEECCC
LNIPPALLDRMEVIRIAGYTEDEKVEIARKHLLPNSLGKHGLTPKEFTIDDGALLQLVRR
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHH
YTREAGVRNLEREISTLARKAVKELVLSKKKSVKVTAKNLEDFLGVPRYRYGEVETEDQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCC
GVVTGLAWTEVGGELLTIEGLMMPGKGKMTVTGNLRDVMKESISAAASYVRSRAVDFGIE
HHHCCCHHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
PPLFERRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIAVRRDVAMTGEITLRGRVLP
CCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEECEEEEEEEEEE
IGGLKEKLLAALRGGIKKVLIPEENAKDLADIPANVKNALEIVPVSRMDEVLANALVRPP
CCCHHHHHHHHHHCCCEEEECCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
VPITWEERPVNAPVPGEETPGVVAH
CCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSQKPRPPLVAGVSQTYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMRGDTYILLA
CCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEE
TQENASDDDPAAEAIFSVGTLATVLQLLKLPDGTVKVLVEGVSRAQVTRYTERTDLYEAE
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEECC
AITLDDESGDQVEAEALARSVVTEFENYVKLNKKVSPEVVGVVSQIDDHSKLADTVASHL
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHH
AVKIPEKQGVLEMLKVADRLEKVLGLMESEISVLQVEKRIRTRVKRQMEKTQREYYLNEQ
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAIQKELGDEDGKDDLQELEDRIKRTKLTKEAREKATHELKKLRQMSPMSAEATVVRNY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LDWLLSIPWGVKSKVKKDLPFAQQILDSDHYGLDKVKERIVEYLAVQSRANKLTGPILCL
HHHHHHCCCCHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VGPPGVGKTSLGKSIAKATGREFVRVALGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHH
KSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNHTFADHYLEVDYDLSNVMFVTTANT
CCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHEEEEEECCCCEEEEEECCC
LNIPPALLDRMEVIRIAGYTEDEKVEIARKHLLPNSLGKHGLTPKEFTIDDGALLQLVRR
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHH
YTREAGVRNLEREISTLARKAVKELVLSKKKSVKVTAKNLEDFLGVPRYRYGEVETEDQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCC
GVVTGLAWTEVGGELLTIEGLMMPGKGKMTVTGNLRDVMKESISAAASYVRSRAVDFGIE
HHHCCCHHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCC
PPLFERRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIAVRRDVAMTGEITLRGRVLP
CCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEECEEEEEEEEEE
IGGLKEKLLAALRGGIKKVLIPEENAKDLADIPANVKNALEIVPVSRMDEVLANALVRPP
CCCHHHHHHHHHHCCCEEEECCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
VPITWEERPVNAPVPGEETPGVVAH
CCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA