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The map label for this gene is lspL [H]

Identifier: 154247496

GI number: 154247496

Start: 3991165

End: 3992169

Strand: Reverse

Name: lspL [H]

Synonym: Xaut_3569

Alternate gene names: 154247496

Gene position: 3992169-3991165 (Counterclockwise)

Preceding gene: 154247499

Following gene: 154247495

Centisome position: 75.2

GC content: 61.39

Gene sequence:

>1005_bases
ATGCGGTATCTTATTACTGGCACTGCAGGCTTCATCGGATTTCACTTGGCGAAGCGGCTGCTCGACGAGGGCCATTTTGT
CGTCGGTTACGATGGCATGACCAAGTATTACGACGTTGCATTGAAAGAAAAGCGGCACGCCATACTCGCCCGCTCCAACG
GCTTCAAGGCGGTGATTGCGGCGCTTGAGGACAAGGATGCGCTGGAGAAGGCGGCCGAGCTTGCCGAGCCGGACGTGATC
GTGCATCTCGCGGCCCAGGCCGGGGTCCGCTACAGCCTGGAGAATCCCCGCTCCTATATCGATTCCAACCTGGTGGGATC
GTTCAACGTCATCGATCTGGCGTCGCGCTTCAAGCCCAAGCACCTGCTGCTCGCATCTACCTCGTCCGTCTACGGCTCGA
ACGAAAAGGTCCCGTTCGCCGAGAGCGACAAGGCCGACGAGCCGATGACCATCTATGCGGCCACCAAGAAATCCATGGAG
GTGATGGCGCACAGCTATTCCCACCTCCACAAGATCCCCACCACGGCTTTCCGCTTCTTCACGGTCTACGGGCCGTGGGG
CCGGCCGGACATGGCGCTGTTCAAGTTCGTGGACGCGATCCGCAACGACCGGCCCATCGAAATCTACGGCGAAGGCAAGA
TGAGCCGGGATTTCACCTATATCGACGACCTCATTGAAGGCATCGTGCGGCTGATCGGCGTCCCGCCGGACGAAGCCAAC
CGGGTCACCGCCGAAGGCGTCATCGATACGCTGTCGCACCACGCGCCCTTCCGCATCGTCAATATCGGCGGCGGCCAGCC
GGTGGCGCTGATGCGCTTTGTCGAGACCATCGAGGAGAGCATGGGCAAGCCGGCAGTGCGCAAGATGCTGCCCATGCAGC
AGGGCGACGTGCCGCGCACATTCGCCGCCCCCGACTTGCTGGTGGCCCTGACGGGCTTCAAGCCGCAGATTGAAATCGAG
GTGGGCGTGCGCCGGTTCGCGGAGTGGTACCAGGAACATTATTGA

Upstream 100 bases:

>100_bases
TCCGTGGTAGACATGGCTGTGTGCAGTGCGGTAAGCGTGAAGCCGAGGCGGGCCATCGGGGGCTGAATGAAGCCAATCCG
CCCCGCATTGAGGGAATCGG

Downstream 100 bases:

>100_bases
TCCCGGAGCGCTCCCGTATTTGCCAGAGACGGCCCTACCGCCGCCTCCGCCGCGCCAACGCCGGCCTCTGGTTGCCTTGC
TGTGCCCATCCCCCGACCGG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: UDP-glucuronic acid epimerase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRYLITGTAGFIGFHLAKRLLDEGHFVVGYDGMTKYYDVALKEKRHAILARSNGFKAVIAALEDKDALEKAAELAEPDVI
VHLAAQAGVRYSLENPRSYIDSNLVGSFNVIDLASRFKPKHLLLASTSSVYGSNEKVPFAESDKADEPMTIYAATKKSME
VMAHSYSHLHKIPTTAFRFFTVYGPWGRPDMALFKFVDAIRNDRPIEIYGEGKMSRDFTYIDDLIEGIVRLIGVPPDEAN
RVTAEGVIDTLSHHAPFRIVNIGGGQPVALMRFVETIEESMGKPAVRKMLPMQQGDVPRTFAAPDLLVALTGFKPQIEIE
VGVRRFAEWYQEHY

Sequences:

>Translated_334_residues
MRYLITGTAGFIGFHLAKRLLDEGHFVVGYDGMTKYYDVALKEKRHAILARSNGFKAVIAALEDKDALEKAAELAEPDVI
VHLAAQAGVRYSLENPRSYIDSNLVGSFNVIDLASRFKPKHLLLASTSSVYGSNEKVPFAESDKADEPMTIYAATKKSME
VMAHSYSHLHKIPTTAFRFFTVYGPWGRPDMALFKFVDAIRNDRPIEIYGEGKMSRDFTYIDDLIEGIVRLIGVPPDEAN
RVTAEGVIDTLSHHAPFRIVNIGGGQPVALMRFVETIEESMGKPAVRKMLPMQQGDVPRTFAAPDLLVALTGFKPQIEIE
VGVRRFAEWYQEHY
>Mature_334_residues
MRYLITGTAGFIGFHLAKRLLDEGHFVVGYDGMTKYYDVALKEKRHAILARSNGFKAVIAALEDKDALEKAAELAEPDVI
VHLAAQAGVRYSLENPRSYIDSNLVGSFNVIDLASRFKPKHLLLASTSSVYGSNEKVPFAESDKADEPMTIYAATKKSME
VMAHSYSHLHKIPTTAFRFFTVYGPWGRPDMALFKFVDAIRNDRPIEIYGEGKMSRDFTYIDDLIEGIVRLIGVPPDEAN
RVTAEGVIDTLSHHAPFRIVNIGGGQPVALMRFVETIEESMGKPAVRKMLPMQQGDVPRTFAAPDLLVALTGFKPQIEIE
VGVRRFAEWYQEHY

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=342, Percent_Identity=22.5146198830409, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI42516563, Length=342, Percent_Identity=26.6081871345029, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI56237023, Length=356, Percent_Identity=22.1910112359551, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI56118217, Length=356, Percent_Identity=22.1910112359551, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI189083684, Length=356, Percent_Identity=22.1910112359551, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788353, Length=361, Percent_Identity=24.6537396121884, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994969, Length=362, Percent_Identity=25.6906077348066, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786974, Length=326, Percent_Identity=23.3128834355828, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539532, Length=241, Percent_Identity=33.195020746888, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982038, Length=360, Percent_Identity=26.6666666666667, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=358, Percent_Identity=26.536312849162, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17568069, Length=235, Percent_Identity=29.7872340425532, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319493, Length=358, Percent_Identity=24.3016759776536, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356223, Length=341, Percent_Identity=29.0322580645161, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19923002, Length=353, Percent_Identity=21.5297450424929, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.12 [H]

Molecular weight: Translated: 37328; Mature: 37328

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLITGTAGFIGFHLAKRLLDEGHFVVGYDGMTKYYDVALKEKRHAILARSNGFKAVIA
CEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEEEEECCCCEEEHH
ALEDKDALEKAAELAEPDVIVHLAAQAGVRYSLENPRSYIDSNLVGSFNVIDLASRFKPK
HHCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCHHHHCCCCCCCCHHHHHHHHCCCC
HLLLASTSSVYGSNEKVPFAESDKADEPMTIYAATKKSMEVMAHSYSHLHKIPTTAFRFF
EEEEEECCHHCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHEEEE
TVYGPWGRPDMALFKFVDAIRNDRPIEIYGEGKMSRDFTYIDDLIEGIVRLIGVPPDEAN
EEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
RVTAEGVIDTLSHHAPFRIVNIGGGQPVALMRFVETIEESMGKPAVRKMLPMQQGDVPRT
CEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCC
FAAPDLLVALTGFKPQIEIEVGVRRFAEWYQEHY
CCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYLITGTAGFIGFHLAKRLLDEGHFVVGYDGMTKYYDVALKEKRHAILARSNGFKAVIA
CEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEEEEECCCCEEEHH
ALEDKDALEKAAELAEPDVIVHLAAQAGVRYSLENPRSYIDSNLVGSFNVIDLASRFKPK
HHCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCHHHHCCCCCCCCHHHHHHHHCCCC
HLLLASTSSVYGSNEKVPFAESDKADEPMTIYAATKKSMEVMAHSYSHLHKIPTTAFRFF
EEEEEECCHHCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHEEEE
TVYGPWGRPDMALFKFVDAIRNDRPIEIYGEGKMSRDFTYIDDLIEGIVRLIGVPPDEAN
EEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
RVTAEGVIDTLSHHAPFRIVNIGGGQPVALMRFVETIEESMGKPAVRKMLPMQQGDVPRT
CEEHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCC
FAAPDLLVALTGFKPQIEIEVGVRRFAEWYQEHY
CCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]