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The map label for this gene is rfbD [C]

Identifier: 154247473

GI number: 154247473

Start: 3957932

End: 3958831

Strand: Reverse

Name: rfbD [C]

Synonym: Xaut_3546

Alternate gene names: 154247473

Gene position: 3958831-3957932 (Counterclockwise)

Preceding gene: 154247474

Following gene: 154247472

Centisome position: 74.57

GC content: 71.67

Gene sequence:

>900_bases
GTGACCCGCATCCTCCTGTTTGGCGCCGGCGGCCAGCTCGGGCGCGAGGTAACGGCGCTCGCCGCCGAGCGCGGCCTTGA
TACGGTCGGGCTTGGCCACGACGCTTTGGACATCGCTGATCCGGTGGCGGTGGCCCGGGCGATCGAGGCGGCGCGGCCCG
ATGCGCTGATCAACGCCGCTGCCTATACCGCCGTGGACAAGGCCGAGACCGAACAGAAAATGGCGGCGCGCATCAATGCC
TTCGCCCCCGGCCTGATCGCCGAGCGCTGCGCCCGCTACCGCACCCCCCTCATCCATGTCTCCACCGACTATGTGTTCGA
CGGCACCAAGGCCGGCGCCTATGTGGAGGCGGACCCCATCGCCCCGCTGGGCGTCTACGGCCGCACCAAGGCCGCCGGCG
AGGCAGCGGTGCGCGCGGCCAGCGAGCGGCACGTCATCGTGCGCACCTCGTGGGTCTACGGCGCCCACGGCAACAACTTC
CTGAAGACCATGCTGCGGCTCGCCGCTGAGCGGGACCTGCTGAAGGTGGTGAGCGACCAGCGCGGCTGCCCCACCGCGAC
GCGCGACCTCGCCGAGGCGGTGCTGGCGGCAGCACAAGCCGCTGCACGAGGCGACGCCCGCTGGGGCACCTACCATTTCG
CCGGAACCGGCGCGACCACCTGGCACGGCTTCGCCAGCGCCATCGTGGCGGCAGCGGCCGTGCACACCGGCAAGACGCCG
GAAGTCGCACCCATCACCACCGCCGAGTATCCCACGCCGGCGCAGCGGCCGAAGAACTCCGAACTGGCCAGCGACCTGTT
CGAGCGCACCTTCGGCGTCCGGGCCGCGCCGTGGGAACAGCGCGTGGGCGAGGTCGTGGACGCGCTGCTGGCGCACCAAG
CCCCCGTGGAAGCAACCTGA

Upstream 100 bases:

>100_bases
CCCTCGACAACCGCGCAGGGTGGGTGCCCTGGCGCCAGCGCGACCAGGGCCAGCGCCTTGGGCTCGAAAATCCGGCCTCA
TCCAAGCTGGGGGTTGTATC

Downstream 100 bases:

>100_bases
AGCGGCGCCTCCCCTGCGGGGGCACCACGCTCCGGAACCCGGATCGGGGCCGCCACGGAGGACATGCCGTCGCACTTTTG
AAGCCTGGCCACATCCTGTA

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTRILLFGAGGQLGREVTALAAERGLDTVGLGHDALDIADPVAVARAIEAARPDALINAAAYTAVDKAETEQKMAARINA
FAPGLIAERCARYRTPLIHVSTDYVFDGTKAGAYVEADPIAPLGVYGRTKAAGEAAVRAASERHVIVRTSWVYGAHGNNF
LKTMLRLAAERDLLKVVSDQRGCPTATRDLAEAVLAAAQAAARGDARWGTYHFAGTGATTWHGFASAIVAAAAVHTGKTP
EVAPITTAEYPTPAQRPKNSELASDLFERTFGVRAAPWEQRVGEVVDALLAHQAPVEAT

Sequences:

>Translated_299_residues
MTRILLFGAGGQLGREVTALAAERGLDTVGLGHDALDIADPVAVARAIEAARPDALINAAAYTAVDKAETEQKMAARINA
FAPGLIAERCARYRTPLIHVSTDYVFDGTKAGAYVEADPIAPLGVYGRTKAAGEAAVRAASERHVIVRTSWVYGAHGNNF
LKTMLRLAAERDLLKVVSDQRGCPTATRDLAEAVLAAAQAAARGDARWGTYHFAGTGATTWHGFASAIVAAAAVHTGKTP
EVAPITTAEYPTPAQRPKNSELASDLFERTFGVRAAPWEQRVGEVVDALLAHQAPVEAT
>Mature_298_residues
TRILLFGAGGQLGREVTALAAERGLDTVGLGHDALDIADPVAVARAIEAARPDALINAAAYTAVDKAETEQKMAARINAF
APGLIAERCARYRTPLIHVSTDYVFDGTKAGAYVEADPIAPLGVYGRTKAAGEAAVRAASERHVIVRTSWVYGAHGNNFL
KTMLRLAAERDLLKVVSDQRGCPTATRDLAEAVLAAAQAAARGDARWGTYHFAGTGATTWHGFASAIVAAAAVHTGKTPE
VAPITTAEYPTPAQRPKNSELASDLFERTFGVRAAPWEQRVGEVVDALLAHQAPVEAT

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=282, Percent_Identity=29.0780141843972, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI11034825, Length=282, Percent_Identity=29.0780141843972, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1788352, Length=299, Percent_Identity=40.4682274247492, Blast_Score=202, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31506; Mature: 31375

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRILLFGAGGQLGREVTALAAERGLDTVGLGHDALDIADPVAVARAIEAARPDALINAA
CCEEEEECCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
AYTAVDKAETEQKMAARINAFAPGLIAERCARYRTPLIHVSTDYVFDGTKAGAYVEADPI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCEEECCCCCCCEEECCCC
APLGVYGRTKAAGEAAVRAASERHVIVRTSWVYGAHGNNFLKTMLRLAAERDLLKVVSDQ
CCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
RGCPTATRDLAEAVLAAAQAAARGDARWGTYHFAGTGATTWHGFASAIVAAAAVHTGKTP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
EVAPITTAEYPTPAQRPKNSELASDLFERTFGVRAAPWEQRVGEVVDALLAHQAPVEAT
CCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TRILLFGAGGQLGREVTALAAERGLDTVGLGHDALDIADPVAVARAIEAARPDALINAA
CEEEEECCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
AYTAVDKAETEQKMAARINAFAPGLIAERCARYRTPLIHVSTDYVFDGTKAGAYVEADPI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCEEECCCCCCCEEECCCC
APLGVYGRTKAAGEAAVRAASERHVIVRTSWVYGAHGNNFLKTMLRLAAERDLLKVVSDQ
CCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
RGCPTATRDLAEAVLAAAQAAARGDARWGTYHFAGTGATTWHGFASAIVAAAAVHTGKTP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
EVAPITTAEYPTPAQRPKNSELASDLFERTFGVRAAPWEQRVGEVVDALLAHQAPVEAT
CCCCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]