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The map label for this gene is accC [H]

Identifier: 154247430

GI number: 154247430

Start: 3898140

End: 3899498

Strand: Direct

Name: accC [H]

Synonym: Xaut_3502

Alternate gene names: 154247430

Gene position: 3898140-3899498 (Clockwise)

Preceding gene: 154247429

Following gene: 154247432

Centisome position: 73.43

GC content: 66.08

Gene sequence:

>1359_bases
ATGTTCAGAAAAATCCTCATCGCCAACCGCGGCGAGATCGCGCTGCGCATCCTGCGCGCCTGCAAGGAGCTGGGCATTGC
GACGGTCGCGGTCCACTCCACCGCCGATGCCGACGCCATGCATGTCCGCCTCGCCGACGAGAGCGTGTGCATCGGCCCGC
CGGCCGCCCGCGAGAGCTATCTCAACATCCCCTCTCTGCTCGCCGCCTGCGAGATCACGGGGGCGGATGCGGTGCATCCC
GGCTACGGCTTCCTGGCTGAGAATGCCCGGTTCGCTGAGATCCTGGCCGATCACAACATCCATTTCATCGGGCCCAAGGC
GGAGCACATCCGCATCATGGGCGACAAGATCGAGGCCAAGAAGACGGCCCAGTCCCTCGGCATTCCGGTGGTGCCGGGGT
CCGATGGCGGCATCCATTCCGATGACGAGGCCCATCGCGTCGCCGACGAGATCGGCTTCCCGGTGCTGGTGAAGGCGGCT
GCTGGCGGCGGCGGGCGCGGCATGAAGGTGGCGATGACCAAGGAGGACCTCTCCGAGGCCCTCTCCACCGCCCGCAACGA
GGCCAAGTCGGCCTTCGGCGACGACGCGGTCTATCTGGAAAAGTATCTCTCCACCCCGCGCCACATCGAGGTGCAGGTGC
TGGGCGACGGCAAGGGCCACGCCATTCATCTGGGCGAACGCGATTGCTCGCTGCAGCGCCGCCACCAGAAGGTGTGGGAA
GAGGCGCCGTCCCCGGTGATCACCCCTGAGCAGCGGGCGCGGATCGGCGAGACCTGTGCCAAGGCCATGCGCGACCTGGG
CTATCTCGGCGTGGGAACCATCGAGTTCCTGTATGAGAACGGGGAGTTCTATTTCATCGAGATGAACACCCGCATCCAGG
TGGAGCACCCGGTGACGGAGATGGTCACCGGCATCGACCTGATCAACGAGCAGATCCGGGTGGCCGCCGGCGAGCCCCTG
ACCCTCACCCAGAAGGACGTGGTGATCGAGGGCCATGCCATCGAGTGCCGGGTGAATGCGGAGCACCCCACTACTTTCCG
GCCCTCGCCGGGCAAGATCACCCACTATCACGTGCCCGGCGGCCTCGGCATCCGCGTGGATTCCAACGCCTATCAGGGCT
ACGTGATCCCCCCCACCTACGACAGCCTGGTGGGCAAGCTGATCGTGCACGGCAAGACGCGGGACGAATGCCTGCGCCGC
CTGCGCCGTGCGCTCGACGAGTTCGTGGTGGACGGCATCGACACCACGCTGCCGCTGTTCCGCACCCTCGTGCGCACCCG
CGACATCGCCGAGGGCAAGTACGACATCCACTGGCTGGAACACTTCCTCTCCGAGGGCGAGGGCAAAAAGGTCGGCTGA

Upstream 100 bases:

>100_bases
CGGGTTCCGGTTCGCATGACGAGAACGCGTTAACGCAGAAACTTGGAGCAGGGCCGCGATGCATCGAAGCGCGCACCTGC
TTTAGAGGCAGGCACCGCTG

Downstream 100 bases:

>100_bases
GGCCAACAGCAATAAGGCGCCCCAGGGCGCCTTATTTTTTGCGTCCCTCGCGCCGCGCGCGAGGCTGCGCCTCAGTCCCG
CGAGACGTGGTCGGGCTTGC

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFRKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPAARESYLNIPSLLAACEITGADAVHP
GYGFLAENARFAEILADHNIHFIGPKAEHIRIMGDKIEAKKTAQSLGIPVVPGSDGGIHSDDEAHRVADEIGFPVLVKAA
AGGGGRGMKVAMTKEDLSEALSTARNEAKSAFGDDAVYLEKYLSTPRHIEVQVLGDGKGHAIHLGERDCSLQRRHQKVWE
EAPSPVITPEQRARIGETCAKAMRDLGYLGVGTIEFLYENGEFYFIEMNTRIQVEHPVTEMVTGIDLINEQIRVAAGEPL
TLTQKDVVIEGHAIECRVNAEHPTTFRPSPGKITHYHVPGGLGIRVDSNAYQGYVIPPTYDSLVGKLIVHGKTRDECLRR
LRRALDEFVVDGIDTTLPLFRTLVRTRDIAEGKYDIHWLEHFLSEGEGKKVG

Sequences:

>Translated_452_residues
MFRKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPAARESYLNIPSLLAACEITGADAVHP
GYGFLAENARFAEILADHNIHFIGPKAEHIRIMGDKIEAKKTAQSLGIPVVPGSDGGIHSDDEAHRVADEIGFPVLVKAA
AGGGGRGMKVAMTKEDLSEALSTARNEAKSAFGDDAVYLEKYLSTPRHIEVQVLGDGKGHAIHLGERDCSLQRRHQKVWE
EAPSPVITPEQRARIGETCAKAMRDLGYLGVGTIEFLYENGEFYFIEMNTRIQVEHPVTEMVTGIDLINEQIRVAAGEPL
TLTQKDVVIEGHAIECRVNAEHPTTFRPSPGKITHYHVPGGLGIRVDSNAYQGYVIPPTYDSLVGKLIVHGKTRDECLRR
LRRALDEFVVDGIDTTLPLFRTLVRTRDIAEGKYDIHWLEHFLSEGEGKKVG
>Mature_452_residues
MFRKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPAARESYLNIPSLLAACEITGADAVHP
GYGFLAENARFAEILADHNIHFIGPKAEHIRIMGDKIEAKKTAQSLGIPVVPGSDGGIHSDDEAHRVADEIGFPVLVKAA
AGGGGRGMKVAMTKEDLSEALSTARNEAKSAFGDDAVYLEKYLSTPRHIEVQVLGDGKGHAIHLGERDCSLQRRHQKVWE
EAPSPVITPEQRARIGETCAKAMRDLGYLGVGTIEFLYENGEFYFIEMNTRIQVEHPVTEMVTGIDLINEQIRVAAGEPL
TLTQKDVVIEGHAIECRVNAEHPTTFRPSPGKITHYHVPGGLGIRVDSNAYQGYVIPPTYDSLVGKLIVHGKTRDECLRR
LRRALDEFVVDGIDTTLPLFRTLVRTRDIAEGKYDIHWLEHFLSEGEGKKVG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=47.6614699331849, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=449, Percent_Identity=47.6614699331849, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI65506442, Length=449, Percent_Identity=47.6614699331849, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI116805327, Length=423, Percent_Identity=44.9172576832151, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=46.2921348314607, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=46.2921348314607, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=46.2921348314607, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=29.3542074363992, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=29.3542074363992, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=29.3542074363992, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=29.3542074363992, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=29.3542074363992, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=29.6296296296296, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI18105007, Length=256, Percent_Identity=24.609375, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=60.3603603603604, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1786216, Length=185, Percent_Identity=26.4864864864865, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=449, Percent_Identity=45.8797327394209, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=434, Percent_Identity=44.2396313364055, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=41.9642857142857, Blast_Score=344, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=28.1746031746032, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=28.1746031746032, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=499, Percent_Identity=26.8537074148297, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=42.4107142857143, Blast_Score=357, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=42.9545454545455, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=43.4090909090909, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6323863, Length=479, Percent_Identity=32.3590814196242, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=30.1158301158301, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6322331, Length=262, Percent_Identity=24.4274809160305, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=46.9798657718121, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=46.9798657718121, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=46.9798657718121, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=46.9798657718121, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=46.9798657718121, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=46.9798657718121, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=46.9798657718121, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=46.9798657718121, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=46.9798657718121, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=46.9798657718121, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651757, Length=424, Percent_Identity=45.0471698113208, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=388, Percent_Identity=44.0721649484536, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=28.8801571709234, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=28.8801571709234, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=28.8801571709234, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=28.8801571709234, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49520; Mature: 49520

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPAARESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCHHHHHH
LNIPSLLAACEITGADAVHPGYGFLAENARFAEILADHNIHFIGPKAEHIRIMGDKIEAK
CCHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCEEEEECCHHHHH
KTAQSLGIPVVPGSDGGIHSDDEAHRVADEIGFPVLVKAAAGGGGRGMKVAMTKEDLSEA
HHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHH
LSTARNEAKSAFGDDAVYLEKYLSTPRHIEVQVLGDGKGHAIHLGERDCSLQRRHQKVWE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPSPVITPEQRARIGETCAKAMRDLGYLGVGTIEFLYENGEFYFIEMNTRIQVEHPVTE
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MVTGIDLINEQIRVAAGEPLTLTQKDVVIEGHAIECRVNAEHPTTFRPSPGKITHYHVPG
HHHHHHHHCCHHEEECCCCEEEECCCEEEECCEEEEEECCCCCCCCCCCCCCEEEEECCC
GLGIRVDSNAYQGYVIPPTYDSLVGKLIVHGKTRDECLRRLRRALDEFVVDGIDTTLPLF
CEEEEECCCCCCCEECCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
RTLVRTRDIAEGKYDIHWLEHFLSEGEGKKVG
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFRKILIANRGEIALRILRACKELGIATVAVHSTADADAMHVRLADESVCIGPPAARESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEECCCCEECCCCHHHHHH
LNIPSLLAACEITGADAVHPGYGFLAENARFAEILADHNIHFIGPKAEHIRIMGDKIEAK
CCHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCEEEEECCHHHHH
KTAQSLGIPVVPGSDGGIHSDDEAHRVADEIGFPVLVKAAAGGGGRGMKVAMTKEDLSEA
HHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHH
LSTARNEAKSAFGDDAVYLEKYLSTPRHIEVQVLGDGKGHAIHLGERDCSLQRRHQKVWE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPSPVITPEQRARIGETCAKAMRDLGYLGVGTIEFLYENGEFYFIEMNTRIQVEHPVTE
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
MVTGIDLINEQIRVAAGEPLTLTQKDVVIEGHAIECRVNAEHPTTFRPSPGKITHYHVPG
HHHHHHHHCCHHEEECCCCEEEECCCEEEECCEEEEEECCCCCCCCCCCCCCEEEEECCC
GLGIRVDSNAYQGYVIPPTYDSLVGKLIVHGKTRDECLRRLRRALDEFVVDGIDTTLPLF
CEEEEECCCCCCCEECCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
RTLVRTRDIAEGKYDIHWLEHFLSEGEGKKVG
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]