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The map label for this gene is aslA [H]

Identifier: 154247339

GI number: 154247339

Start: 3802405

End: 3803985

Strand: Reverse

Name: aslA [H]

Synonym: Xaut_3411

Alternate gene names: 154247339

Gene position: 3803985-3802405 (Counterclockwise)

Preceding gene: 154247340

Following gene: 154247327

Centisome position: 71.65

GC content: 62.43

Gene sequence:

>1581_bases
ATGTGTATCCGAGGATTACTGGGAGCATTCATGCTCACGGCGACCGCGACGTTGACAGCCGTCACGCCGGCAGCCGCACA
GCAGCAACCGACCTCCAAGCCCAACATTCTCGTCATCTTCGGTGACGATATCGGGCAAACCAATCTGTCGACCTACAGCT
TCGGCCTGATGGGCTATCGCACGCCGAACATCGACAGGATCGCCAACGAGGGCCTGAAGTTCACCGACTATTATGCCGAG
CAGAGCTGCACGGCGGGCCGCTCGACCTTCATCACCGGCCAGTCGACCCTGCGTACGGGCCTGTCAAAGGTGGGCCTGCC
CGGCGCCGATCTCGGCCTTCAGGCCAGCGACGTCACCATGGCCTCCGCGCTGAAGGACCTCGGCTACGCCACCGGCCAGT
TCGGCAAGAACCACCTCGGCGACCGCGACGAATTCCTGCCGACCGCGCACGGGTTCGACGAATTCATGGGCAACCTCTAC
CACCTCAATGCGGAGGAGGAGCCGGAGAATTTCAACTATCCGCAGGATCCCGCCTTCCGCAAGCAGTTCGGCCCGCGCGG
CGTCATCAAGAGCTCGGCCGACGGCAAGATCGAGGACACCGGCCCGCTGACGCGCAAGCGCATGGAGACGGTGGACGACG
AGACCTCCAAGGCCGCCATCGACTTCATCGACCGACAGGCGGCGGCCAAGAAGCCCTTCTTCGTGTGGATGAACACCACG
CGGATGCATTTCCGCACTCATGTCCGCGCTGAAAACCGCAGCAAGCCCGGTCTCACCGCGCTGACCGAATATGCCGACGG
CATGATCGAGACCGACAAGGTGATCGGCACGATCCTCGACAAGATCGACCAGCTCAAGCTGGCCGACAACACCATCGTCA
TCTACACCACCGACAACGGCCCCCACCAGAATTCCTGGCCGGATGCGGGCACCACGCCATTCCGCAGCGAGAAGAACACC
AATTGGGAAGGCGCATTCCGCGTTCCGGCCCTGATCCGCTGGCCGGGACATATCCAGCCGGGTTCGGTCGCGAACGGCAT
CTTCTCCGGCCTCGACTGGTTCCCCACCCTGCTCGCCGCGGCGGGAGACACGACCATCAAGGAACGTCTCCTCAAGGGCA
CGACCATTGCCGGCAAGCAGTACAAGAACCATCTCGACGGCTATAACCAGCTCGACTATCTCACCGGAAAGAGCGACAAG
AGCGCCCGCAAGGAGTTCATCTACTTCAACGACGACGGCCAGATCGTGGCCATGCGCTACGAGAACTGGAAGCTGGTCTT
CTCTGAACAGCGCGCGACAGGCACGCTGCGCGTCTGGGCGGAGCCGTTCACGCAGCTGCGTCTTCCCAAGATGTTCGACC
TGCGTTCCGATCCCTATGAGCGGGCCGACCTCACATCCAACACCTATTACGACTGGATGCTCGACCGCGCCTACCTGGTC
GTGCCGGCCCAAGCTGGGGTCGCGAAGTTCCTGGGCACCTTCAAGGAGTTTCCGCCAGCGCAGCGCCCGGCGAGCTTCTC
GATCGATCAGATCCAGAGCCAGCTCGAAGAGCAGTTCAAGAACGTAGCCGGGGGCCAGTAG

Upstream 100 bases:

>100_bases
GAGGCCGTTGCTTCCCCTTATCGACGGGAACAGCGCGCAGCATGTCATCGCGGCGTCTTCAGCGGTATCTATACGTCGCA
AGTTTTCATGGGAGGCGAGG

Downstream 100 bases:

>100_bases
GCGCCTGCCAAGGCGGTACGCCGATCGCGCCCCGGCACCTGTTGAGGTGCCGGGGCGTTTTCGTGTCGGCATCACCGATG
TATTGGGGCGGCGGGCAGCG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MCIRGLLGAFMLTATATLTAVTPAAAQQQPTSKPNILVIFGDDIGQTNLSTYSFGLMGYRTPNIDRIANEGLKFTDYYAE
QSCTAGRSTFITGQSTLRTGLSKVGLPGADLGLQASDVTMASALKDLGYATGQFGKNHLGDRDEFLPTAHGFDEFMGNLY
HLNAEEEPENFNYPQDPAFRKQFGPRGVIKSSADGKIEDTGPLTRKRMETVDDETSKAAIDFIDRQAAAKKPFFVWMNTT
RMHFRTHVRAENRSKPGLTALTEYADGMIETDKVIGTILDKIDQLKLADNTIVIYTTDNGPHQNSWPDAGTTPFRSEKNT
NWEGAFRVPALIRWPGHIQPGSVANGIFSGLDWFPTLLAAAGDTTIKERLLKGTTIAGKQYKNHLDGYNQLDYLTGKSDK
SARKEFIYFNDDGQIVAMRYENWKLVFSEQRATGTLRVWAEPFTQLRLPKMFDLRSDPYERADLTSNTYYDWMLDRAYLV
VPAQAGVAKFLGTFKEFPPAQRPASFSIDQIQSQLEEQFKNVAGGQ

Sequences:

>Translated_526_residues
MCIRGLLGAFMLTATATLTAVTPAAAQQQPTSKPNILVIFGDDIGQTNLSTYSFGLMGYRTPNIDRIANEGLKFTDYYAE
QSCTAGRSTFITGQSTLRTGLSKVGLPGADLGLQASDVTMASALKDLGYATGQFGKNHLGDRDEFLPTAHGFDEFMGNLY
HLNAEEEPENFNYPQDPAFRKQFGPRGVIKSSADGKIEDTGPLTRKRMETVDDETSKAAIDFIDRQAAAKKPFFVWMNTT
RMHFRTHVRAENRSKPGLTALTEYADGMIETDKVIGTILDKIDQLKLADNTIVIYTTDNGPHQNSWPDAGTTPFRSEKNT
NWEGAFRVPALIRWPGHIQPGSVANGIFSGLDWFPTLLAAAGDTTIKERLLKGTTIAGKQYKNHLDGYNQLDYLTGKSDK
SARKEFIYFNDDGQIVAMRYENWKLVFSEQRATGTLRVWAEPFTQLRLPKMFDLRSDPYERADLTSNTYYDWMLDRAYLV
VPAQAGVAKFLGTFKEFPPAQRPASFSIDQIQSQLEEQFKNVAGGQ
>Mature_526_residues
MCIRGLLGAFMLTATATLTAVTPAAAQQQPTSKPNILVIFGDDIGQTNLSTYSFGLMGYRTPNIDRIANEGLKFTDYYAE
QSCTAGRSTFITGQSTLRTGLSKVGLPGADLGLQASDVTMASALKDLGYATGQFGKNHLGDRDEFLPTAHGFDEFMGNLY
HLNAEEEPENFNYPQDPAFRKQFGPRGVIKSSADGKIEDTGPLTRKRMETVDDETSKAAIDFIDRQAAAKKPFFVWMNTT
RMHFRTHVRAENRSKPGLTALTEYADGMIETDKVIGTILDKIDQLKLADNTIVIYTTDNGPHQNSWPDAGTTPFRSEKNT
NWEGAFRVPALIRWPGHIQPGSVANGIFSGLDWFPTLLAAAGDTTIKERLLKGTTIAGKQYKNHLDGYNQLDYLTGKSDK
SARKEFIYFNDDGQIVAMRYENWKLVFSEQRATGTLRVWAEPFTQLRLPKMFDLRSDPYERADLTSNTYYDWMLDRAYLV
VPAQAGVAKFLGTFKEFPPAQRPASFSIDQIQSQLEEQFKNVAGGQ

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4503899, Length=481, Percent_Identity=31.1850311850312, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI146229331, Length=461, Percent_Identity=31.6702819956616, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI146229329, Length=461, Percent_Identity=31.6702819956616, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI6005990, Length=461, Percent_Identity=31.6702819956616, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI146229324, Length=461, Percent_Identity=31.6702819956616, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI45430057, Length=459, Percent_Identity=28.1045751633987, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI157266309, Length=546, Percent_Identity=27.2893772893773, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI109389362, Length=460, Percent_Identity=25.8695652173913, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI58743319, Length=444, Percent_Identity=28.3783783783784, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI38569405, Length=480, Percent_Identity=25, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI146229327, Length=388, Percent_Identity=29.8969072164948, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI59797060, Length=455, Percent_Identity=24.3956043956044, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI38569407, Length=368, Percent_Identity=26.3586956521739, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI53831991, Length=269, Percent_Identity=27.1375464684015, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI71852586, Length=149, Percent_Identity=36.9127516778523, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71852584, Length=149, Percent_Identity=36.241610738255, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI31742482, Length=165, Percent_Identity=33.9393939393939, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790233, Length=497, Percent_Identity=30.1810865191147, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081924, Length=409, Percent_Identity=23.4718826405868, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI115533416, Length=450, Percent_Identity=27.3333333333333, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI115533418, Length=418, Percent_Identity=26.7942583732057, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17559078, Length=148, Percent_Identity=36.4864864864865, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366397, Length=374, Percent_Identity=29.9465240641711, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI281366395, Length=374, Percent_Identity=29.9465240641711, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24666163, Length=374, Percent_Identity=29.9465240641711, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24666175, Length=413, Percent_Identity=26.1501210653753, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281363223, Length=469, Percent_Identity=25.1599147121535, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24666109, Length=426, Percent_Identity=26.2910798122066, Blast_Score=113, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 58548; Mature: 58548

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIRGLLGAFMLTATATLTAVTPAAAQQQPTSKPNILVIFGDDIGQTNLSTYSFGLMGYR
CCHHHHHHHHHHHHHHHHHEECCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECC
TPNIDRIANEGLKFTDYYAEQSCTAGRSTFITGQSTLRTGLSKVGLPGADLGLQASDVTM
CCCHHHHHHCCCEEHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHH
ASALKDLGYATGQFGKNHLGDRDEFLPTAHGFDEFMGNLYHLNAEEEPENFNYPQDPAFR
HHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCHHH
KQFGPRGVIKSSADGKIEDTGPLTRKRMETVDDETSKAAIDFIDRQAAAKKPFFVWMNTT
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECC
RMHFRTHVRAENRSKPGLTALTEYADGMIETDKVIGTILDKIDQLKLADNTIVIYTTDNG
EEEEHEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCEEEEEECCCC
PHQNSWPDAGTTPFRSEKNTNWEGAFRVPALIRWPGHIQPGSVANGIFSGLDWFPTLLAA
CCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
AGDTTIKERLLKGTTIAGKQYKNHLDGYNQLDYLTGKSDKSARKEFIYFNDDGQIVAMRY
CCCHHHHHHHHCCCCCCCHHHHHHCCCCCHHHEECCCCCCCCCCEEEEECCCCCEEEEEE
ENWKLVFSEQRATGTLRVWAEPFTQLRLPKMFDLRSDPYERADLTSNTYYDWMLDRAYLV
CCEEEEEECCCCCCEEEEECCCHHHCCCCHHHCCCCCCCHHHCCCCCCCHHHEECCEEEE
VPAQAGVAKFLGTFKEFPPAQRPASFSIDQIQSQLEEQFKNVAGGQ
EECHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCIRGLLGAFMLTATATLTAVTPAAAQQQPTSKPNILVIFGDDIGQTNLSTYSFGLMGYR
CCHHHHHHHHHHHHHHHHHEECCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECC
TPNIDRIANEGLKFTDYYAEQSCTAGRSTFITGQSTLRTGLSKVGLPGADLGLQASDVTM
CCCHHHHHHCCCEEHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCHHHHH
ASALKDLGYATGQFGKNHLGDRDEFLPTAHGFDEFMGNLYHLNAEEEPENFNYPQDPAFR
HHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCHHH
KQFGPRGVIKSSADGKIEDTGPLTRKRMETVDDETSKAAIDFIDRQAAAKKPFFVWMNTT
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECC
RMHFRTHVRAENRSKPGLTALTEYADGMIETDKVIGTILDKIDQLKLADNTIVIYTTDNG
EEEEHEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCEEEEEECCCC
PHQNSWPDAGTTPFRSEKNTNWEGAFRVPALIRWPGHIQPGSVANGIFSGLDWFPTLLAA
CCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
AGDTTIKERLLKGTTIAGKQYKNHLDGYNQLDYLTGKSDKSARKEFIYFNDDGQIVAMRY
CCCHHHHHHHHCCCCCCCHHHHHHCCCCCHHHEECCCCCCCCCCEEEEECCCCCEEEEEE
ENWKLVFSEQRATGTLRVWAEPFTQLRLPKMFDLRSDPYERADLTSNTYYDWMLDRAYLV
CCEEEEEECCCCCCEEEEECCCHHHCCCCHHHCCCCCCCHHHCCCCCCCHHHEECCEEEE
VPAQAGVAKFLGTFKEFPPAQRPASFSIDQIQSQLEEQFKNVAGGQ
EECHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]