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The map label for this gene is trxA [C]

Identifier: 154247229

GI number: 154247229

Start: 3671772

End: 3672092

Strand: Direct

Name: trxA [C]

Synonym: Xaut_3301

Alternate gene names: 154247229

Gene position: 3671772-3672092 (Clockwise)

Preceding gene: 154247228

Following gene: 154247234

Centisome position: 69.16

GC content: 61.99

Gene sequence:

>321_bases
ATGTCGGTCGAGAAGGTTTCGGATCAGAATTTTGAGCAGGACGTGCTTCAGTCCAGCGCGCCGGTCATCGTGGACTTCTG
GGCCGAGTGGTGCGGCCCCTGCCGCATGGTCGCCCCCATCCTCGAGGAAGTCTCTGGCGAGATGGGCGAGAAGATCCGTA
TCGTGAAGCTGAACGTGGACGAGAATCCTGCCACCGCTTCCAAGTACGGCATCATGTCCATCCCCACCCTGCTGCTGTTC
AAGGACGGCAAGATCGCCTCCCGCCAGGTCGGCGCCGCCCCCAAGGCGAAGCTGGTGCAGTGGATCAACGGCGCCATCTG
A

Upstream 100 bases:

>100_bases
TCACCTCGCCGTGACGGCGCCTTGACGAAGAGGGGAGGGGCTCCCTACGTTCGGTCCCAACATTCAGTGGTTCCCCCGGT
TCCCCCCTACGAGGTCTGCC

Downstream 100 bases:

>100_bases
GCCCGTAGGGTCGCTCTGAAAAAACAAGCCGCCGTTGCCTTGACGGGCAGCGGCGGCTTTGTCGTGTCTGGCTGTCGTGA
TGGGGTGTCGCGCTCAGAAC

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSVEKVSDQNFEQDVLQSSAPVIVDFWAEWCGPCRMVAPILEEVSGEMGEKIRIVKLNVDENPATASKYGIMSIPTLLLF
KDGKIASRQVGAAPKAKLVQWINGAI

Sequences:

>Translated_106_residues
MSVEKVSDQNFEQDVLQSSAPVIVDFWAEWCGPCRMVAPILEEVSGEMGEKIRIVKLNVDENPATASKYGIMSIPTLLLF
KDGKIASRQVGAAPKAKLVQWINGAI
>Mature_105_residues
SVEKVSDQNFEQDVLQSSAPVIVDFWAEWCGPCRMVAPILEEVSGEMGEKIRIVKLNVDENPATASKYGIMSIPTLLLFK
DGKIASRQVGAAPKAKLVQWINGAI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=31.9587628865979, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=51.5151515151515, Blast_Score=126, Evalue=3e-31,
Organism=Escherichia coli, GI1788936, Length=92, Percent_Identity=44.5652173913043, Blast_Score=100, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI212646193, Length=95, Percent_Identity=44.2105263157895, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=37.7777777777778, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=97, Percent_Identity=32.9896907216495, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=100, Percent_Identity=34, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=97, Percent_Identity=32.9896907216495, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=34.6153846153846, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=90, Percent_Identity=36.6666666666667, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=75, Percent_Identity=49.3333333333333, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321648, Length=75, Percent_Identity=45.3333333333333, Blast_Score=74, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=95, Percent_Identity=32.6315789473684, Blast_Score=72, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=37, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=35.1648351648352, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358065, Length=100, Percent_Identity=35, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664269, Length=89, Percent_Identity=31.4606741573034, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11605; Mature: 11473

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEKVSDQNFEQDVLQSSAPVIVDFWAEWCGPCRMVAPILEEVSGEMGEKIRIVKLNVD
CCCCCCCCCCHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECC
ENPATASKYGIMSIPTLLLFKDGKIASRQVGAAPKAKLVQWINGAI
CCCCCCCCCCHHCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SVEKVSDQNFEQDVLQSSAPVIVDFWAEWCGPCRMVAPILEEVSGEMGEKIRIVKLNVD
CCCCCCCCCHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECC
ENPATASKYGIMSIPTLLLFKDGKIASRQVGAAPKAKLVQWINGAI
CCCCCCCCCCHHCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]