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The map label for this gene is cobW [H]

Identifier: 154247215

GI number: 154247215

Start: 3649553

End: 3650587

Strand: Reverse

Name: cobW [H]

Synonym: Xaut_3287

Alternate gene names: 154247215

Gene position: 3650587-3649553 (Counterclockwise)

Preceding gene: 154247216

Following gene: 154247214

Centisome position: 68.76

GC content: 69.86

Gene sequence:

>1035_bases
ATGACTTCGCTCGCCCGCGTGCCCTGCACCATCGTCACCGGCTTCCTCGGCGCGGGGAAGACCACGCTCATTCGCCACGT
GCTGGAGAATGCCGGCGGCAAGCGCCTCGCGGTGATCGTCAACGAGTTCGGCGACGTGGGCATCGACGGCGAGATCCTGA
AGGGCTGCGGCATCGAGAGCTGCTCCGAGGACACCATCGTGGAGCTGGCCAACGGCTGCCTGTGCTGCACGGTTGCCGAC
GATTTCGTGCCGGCATTGGACCAGATCCTGTCGCGCACCCCGCGCGTGGACCACATCCTCATCGAGACTTCCGGCCTCGC
TCTGCCCAAGCCTTTGGTGCAGGCGTTCCAGTGGCCTGCCATCAAGAGCCGGGTGACGGTGGACGGCGTGGTGGCGGTGG
TGGACGGCCCGGCCCTGGCCGAAGGGCGGGTGGCGCCGGACCTCTCGGCGCTGGCCGCCCAGCGCGCGGAAGACTCAAGC
CTCGACCATGACGACCCGGTGGAAGAGGTGTTCGAGGACCAGATCGCCTGCGCCGACCTCGTCATCCTCTCCAAGAGCGA
CCTGCTCGACGACGCCGGCTTCGCCATCGCCGAACGGGTAGTGGCGCAGAGCCTGCCCCGCGCGGTGAAGCTGGTGCGCG
CCACCGCCGGCAAGGTGGATATCGCCGTGTTGCTGGGCCTCGGCATCGGCGTGGAAGACGAGATCGACGCCCGCCGCACC
CATCACGACGACGAGGAAGACCACGACCACGACGAGTTCGAGAGCATCGTGCTCCCGCTCCCTGAAATCGCCGATCCCGT
CGCCCTCGCGGAGCGCGTGGTCGCGGCCGCCGGGACGCCGGACGTGCTGCGGGTGAAGGGCTTCGCGGCGGTGGCCGGCA
AGCCCATGCGGCTGCTGGTGCAGGGCGTTGGCCCACGCGTGTCGCACCATTTCGACCGGCCGTGGGGCGCAGCCGAGGAG
CGGCGCGGCGCACTGGTGGTCATCGGCCTCAAGGGCTTCGACCGCGCGGCGGTGGAGCGGGCCATCCTCGGCTGA

Upstream 100 bases:

>100_bases
CCTCGAGCGACGGTCTCATGCCCTGGCGCGGACGGCCCGACAGCCTCAAGCGCGGCATGGTCGCCCGCATCCCGCCTTTG
TCCCTTCCCAAGGAGCCTTG

Downstream 100 bases:

>100_bases
GGCGAACCGGACCCCATGCACATCCTCGCCACCACATCGACGACGCTGGAGGATCTGGCCGAGCCGGTCGATCTCGCCCA
GCCGCCCGGCGACATGGTGG

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTSLARVPCTIVTGFLGAGKTTLIRHVLENAGGKRLAVIVNEFGDVGIDGEILKGCGIESCSEDTIVELANGCLCCTVAD
DFVPALDQILSRTPRVDHILIETSGLALPKPLVQAFQWPAIKSRVTVDGVVAVVDGPALAEGRVAPDLSALAAQRAEDSS
LDHDDPVEEVFEDQIACADLVILSKSDLLDDAGFAIAERVVAQSLPRAVKLVRATAGKVDIAVLLGLGIGVEDEIDARRT
HHDDEEDHDHDEFESIVLPLPEIADPVALAERVVAAAGTPDVLRVKGFAAVAGKPMRLLVQGVGPRVSHHFDRPWGAAEE
RRGALVVIGLKGFDRAAVERAILG

Sequences:

>Translated_344_residues
MTSLARVPCTIVTGFLGAGKTTLIRHVLENAGGKRLAVIVNEFGDVGIDGEILKGCGIESCSEDTIVELANGCLCCTVAD
DFVPALDQILSRTPRVDHILIETSGLALPKPLVQAFQWPAIKSRVTVDGVVAVVDGPALAEGRVAPDLSALAAQRAEDSS
LDHDDPVEEVFEDQIACADLVILSKSDLLDDAGFAIAERVVAQSLPRAVKLVRATAGKVDIAVLLGLGIGVEDEIDARRT
HHDDEEDHDHDEFESIVLPLPEIADPVALAERVVAAAGTPDVLRVKGFAAVAGKPMRLLVQGVGPRVSHHFDRPWGAAEE
RRGALVVIGLKGFDRAAVERAILG
>Mature_343_residues
TSLARVPCTIVTGFLGAGKTTLIRHVLENAGGKRLAVIVNEFGDVGIDGEILKGCGIESCSEDTIVELANGCLCCTVADD
FVPALDQILSRTPRVDHILIETSGLALPKPLVQAFQWPAIKSRVTVDGVVAVVDGPALAEGRVAPDLSALAAQRAEDSSL
DHDDPVEEVFEDQIACADLVILSKSDLLDDAGFAIAERVVAQSLPRAVKLVRATAGKVDIAVLLGLGIGVEDEIDARRTH
HDDEEDHDHDEFESIVLPLPEIADPVALAERVVAAAGTPDVLRVKGFAAVAGKPMRLLVQGVGPRVSHHFDRPWGAAEER
RGALVVIGLKGFDRAAVERAILG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=347, Percent_Identity=28.2420749279539, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI126722884, Length=361, Percent_Identity=27.1468144044321, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI148727351, Length=360, Percent_Identity=26.9444444444444, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI146231952, Length=360, Percent_Identity=26.9444444444444, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223941779, Length=343, Percent_Identity=28.2798833819242, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI119120938, Length=134, Percent_Identity=39.5522388059701, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI223941776, Length=335, Percent_Identity=26.865671641791, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082430, Length=339, Percent_Identity=30.9734513274336, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788499, Length=212, Percent_Identity=30.188679245283, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=329, Percent_Identity=28.2674772036474, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36371; Mature: 36240

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLARVPCTIVTGFLGAGKTTLIRHVLENAGGKRLAVIVNEFGDVGIDGEILKGCGIES
CCCCHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCCC
CSEDTIVELANGCLCCTVADDFVPALDQILSRTPRVDHILIETSGLALPKPLVQAFQWPA
CCCHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCH
IKSRVTVDGVVAVVDGPALAEGRVAPDLSALAAQRAEDSSLDHDDPVEEVFEDQIACADL
HHCCEEECEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHE
VILSKSDLLDDAGFAIAERVVAQSLPRAVKLVRATAGKVDIAVLLGLGIGVEDEIDARRT
EEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHEECCCCCCCCCHHHHHC
HHDDEEDHDHDEFESIVLPLPEIADPVALAERVVAAAGTPDVLRVKGFAAVAGKPMRLLV
CCCCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHCCCCHHHHH
QGVGPRVSHHFDRPWGAAEERRGALVVIGLKGFDRAAVERAILG
HCCCCHHHHCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TSLARVPCTIVTGFLGAGKTTLIRHVLENAGGKRLAVIVNEFGDVGIDGEILKGCGIES
CCCHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCCC
CSEDTIVELANGCLCCTVADDFVPALDQILSRTPRVDHILIETSGLALPKPLVQAFQWPA
CCCHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCH
IKSRVTVDGVVAVVDGPALAEGRVAPDLSALAAQRAEDSSLDHDDPVEEVFEDQIACADL
HHCCEEECEEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHE
VILSKSDLLDDAGFAIAERVVAQSLPRAVKLVRATAGKVDIAVLLGLGIGVEDEIDARRT
EEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHEECCCCCCCCCHHHHHC
HHDDEEDHDHDEFESIVLPLPEIADPVALAERVVAAAGTPDVLRVKGFAAVAGKPMRLLV
CCCCCCCCCHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHCCCCHHHHH
QGVGPRVSHHFDRPWGAAEERRGALVVIGLKGFDRAAVERAILG
HCCCCHHHHCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]