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The map label for this gene is pbpC [H]

Identifier: 154247188

GI number: 154247188

Start: 3621250

End: 3623340

Strand: Direct

Name: pbpC [H]

Synonym: Xaut_3260

Alternate gene names: 154247188

Gene position: 3621250-3623340 (Clockwise)

Preceding gene: 154247187

Following gene: 154247189

Centisome position: 68.21

GC content: 74.18

Gene sequence:

>2091_bases
ATGAGCGCGATCCAGCCATCCGGGTCATCGCCCGCCGCCCCCGCCCGCCGCCGGCTGCTGCGGGTGGCGGGGGGCCTCGT
GCTAGGGGCCGGGCTGCTGGCCGGCGGGGCTTGGGCGGGGCTCCATCATCTGCGCGCCAACGCGCCGCCGGCGCCGCAGG
TGAAGGTGTCCGCCGAGGTGGTGGACCGCGAGGGCCGCCTGCTGCGGCCATTCGCGCTGCCCGATGGCCGCTGGCGGCTC
GCCGCCACGGCGGAGGACGTGGACCCGCGCCTCATCACCATGATCCTGGCCTATGAGGATCGCCGGTTCCAGCAACACGG
CGGCGTCGATGCGCTGGCGCTGCTGCGGGCAGCCGGGCAGGCGGCGGGATCGCGGCGCGTGGTCTCGGGCGGCTCGACGC
TGACCATGCAGGTGGCGCGGCTGACCCTGCCACCGCGTCCGCGCACCCTTGCCGCCAAGCTCGCCCAGATGCGCCGGGCG
CTGGAGCTGGAGGCCCATCTCTCCAAGCCCGAAATCCTCGGGCTCTACCTGACGCTCGCGCCCTATGGCGGCAACATCGA
GGGGGTGCGGGCGGCGGCGCTGACCTATTTCGGCAAGGAGCCGCGCCGGCTCACCCTCGGCGAGGCGGCCTTGCTGGTGG
CCCTGCCGCAGGCGCCGGAAACCCGCCGGCCGGATCGATTCCCGGCCCGGGCGCGGGCCGCGCGCGACCGGGTGCTGGAC
CGGCTCCTGTCCCAGGGCCTGCTTGTCGCCGACGAGGTGCGCGTGGCCAAGGCCGAGCCGGTGCCTACGGCGCGGCGCTC
CTTGCCGCAGCTCGCGCCCCACCTCGCCGAGCAGATGGTGGCGGAGCGGCCGGATCTCTCCCGCCACCTCTCGACCCTCG
ACGCTCCGCTGCAGGAGAAGCTGGAAGAGCTGGTTCGCGAGCGCACGCGGGCGCTGGGCCGCGGGCTCTCCTCCGCCGTG
GTGGTGATGGACAATGACAGTGCCGAGGTGCGGGCCTATGTGGCCTCGGCGGATTTCCTCGACAAGGAGCGGGCCGGCGC
GGTGGACCTCGCCCGCGCGGTGCGCTCGCCGGGCTCGACGCTGAAGCCCTTCATCTATGCCCTCGCCTTCGAGGACGGCA
TCGCCCATCCCGAGACGCTGATCGAGGACCGGCCCGCCCGCTTCGGCGGCTGGCGGCCGGAAAATTTCGACCGCAGCTTC
CAGGGCACCCTCTCCGTGCGCAAGGCGCTGCAACTGTCTTTGAACGTGCCCGCGGTGCGATTGCTGGATGCGGTGGGGCC
GCAGCGCCTCGCCACCCGCCTGCAGCAGGCCGGGGCGCGGCTGGAACTGCCGCCGGGCGCAGCACCGGCCTTGCCCATGG
GGCTCGGCGGCGTGGGTATCCGCCTCGTGGACCTCACGATGCTCTATGGCGCGCTGGCGCGGGGCGGCGAGGCGCATCCG
CTGGTGTTCCGCCGCGAGGGCGGCGCGGTGTCGGCGCCACGCCGGTCGCGGCTCGTGGATCAGGTGGCGGCCTGGTATGT
GGGCCAGTGCCTTCTGGGCACGCCGGCGCCGGAGAATGCGCTGGGTGGACGCATCGCCTTCAAGACCGGCACCTCCTACG
GCTATCGCGACAGCTGGGCCATGGGCTTCGACGGGCGGCGCACCGTGGGCGTCTGGGTGGGCCGGCCGGACGGACAGGCG
GTCCCCGACCTCACCGGCCGCGCGGCGGCCGCGCCGCTGCTGTTCGATGCCTTCGCCCGCATCGTCCGCACCCCGGCGGG
GCTCGGCCCGGCGCCGCGCGGGGCGGTGATGGCGGCGAATGCTCGCCTTCCCGTGCCGCAGCGCCATTTCGGCCGCACCC
GGCAGGAGCAGCCCTTGCAGGTGGTCTATCCGCCGGACGGCGCACGGGTGTCCGGCGCCGAGGCGGAGACGCTTGCGCTC
AAGGTGGATGGCGGCACCTTCCCGCTTACCCTGCTGATGGATGGCCGCCCGGTGGCCCAGGTGGAGGACCGGCGCACCCT
GTTCTGGACCCCGCAGGGGCGGGGCTTTGCCCGCCTCACCGTGATCGATGCGGTCGGGCTTTCCGACAGCGTGACGGTGC
GGGTCGAGTAG

Upstream 100 bases:

>100_bases
CCGGGCGCTATGCCCATCCCCCCGCCATGGTGGAGGACATGTACCGCCCCGACCGCTTCGCCCGCACCGCCGCCGGCACG
CTGGAGGTGGCGCCCGCCCG

Downstream 100 bases:

>100_bases
GGTCCACCACCCCAAAAAGAAAGTCCCGCACCACCTTGCGGTGGGCGGGACAGGCACTGGGAGGAAACGCGGAAGATGTC
ACGCTCCGGGGATGCGTCCC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 696; Mature: 695

Protein sequence:

>696_residues
MSAIQPSGSSPAAPARRRLLRVAGGLVLGAGLLAGGAWAGLHHLRANAPPAPQVKVSAEVVDREGRLLRPFALPDGRWRL
AATAEDVDPRLITMILAYEDRRFQQHGGVDALALLRAAGQAAGSRRVVSGGSTLTMQVARLTLPPRPRTLAAKLAQMRRA
LELEAHLSKPEILGLYLTLAPYGGNIEGVRAAALTYFGKEPRRLTLGEAALLVALPQAPETRRPDRFPARARAARDRVLD
RLLSQGLLVADEVRVAKAEPVPTARRSLPQLAPHLAEQMVAERPDLSRHLSTLDAPLQEKLEELVRERTRALGRGLSSAV
VVMDNDSAEVRAYVASADFLDKERAGAVDLARAVRSPGSTLKPFIYALAFEDGIAHPETLIEDRPARFGGWRPENFDRSF
QGTLSVRKALQLSLNVPAVRLLDAVGPQRLATRLQQAGARLELPPGAAPALPMGLGGVGIRLVDLTMLYGALARGGEAHP
LVFRREGGAVSAPRRSRLVDQVAAWYVGQCLLGTPAPENALGGRIAFKTGTSYGYRDSWAMGFDGRRTVGVWVGRPDGQA
VPDLTGRAAAAPLLFDAFARIVRTPAGLGPAPRGAVMAANARLPVPQRHFGRTRQEQPLQVVYPPDGARVSGAEAETLAL
KVDGGTFPLTLLMDGRPVAQVEDRRTLFWTPQGRGFARLTVIDAVGLSDSVTVRVE

Sequences:

>Translated_696_residues
MSAIQPSGSSPAAPARRRLLRVAGGLVLGAGLLAGGAWAGLHHLRANAPPAPQVKVSAEVVDREGRLLRPFALPDGRWRL
AATAEDVDPRLITMILAYEDRRFQQHGGVDALALLRAAGQAAGSRRVVSGGSTLTMQVARLTLPPRPRTLAAKLAQMRRA
LELEAHLSKPEILGLYLTLAPYGGNIEGVRAAALTYFGKEPRRLTLGEAALLVALPQAPETRRPDRFPARARAARDRVLD
RLLSQGLLVADEVRVAKAEPVPTARRSLPQLAPHLAEQMVAERPDLSRHLSTLDAPLQEKLEELVRERTRALGRGLSSAV
VVMDNDSAEVRAYVASADFLDKERAGAVDLARAVRSPGSTLKPFIYALAFEDGIAHPETLIEDRPARFGGWRPENFDRSF
QGTLSVRKALQLSLNVPAVRLLDAVGPQRLATRLQQAGARLELPPGAAPALPMGLGGVGIRLVDLTMLYGALARGGEAHP
LVFRREGGAVSAPRRSRLVDQVAAWYVGQCLLGTPAPENALGGRIAFKTGTSYGYRDSWAMGFDGRRTVGVWVGRPDGQA
VPDLTGRAAAAPLLFDAFARIVRTPAGLGPAPRGAVMAANARLPVPQRHFGRTRQEQPLQVVYPPDGARVSGAEAETLAL
KVDGGTFPLTLLMDGRPVAQVEDRRTLFWTPQGRGFARLTVIDAVGLSDSVTVRVE
>Mature_695_residues
SAIQPSGSSPAAPARRRLLRVAGGLVLGAGLLAGGAWAGLHHLRANAPPAPQVKVSAEVVDREGRLLRPFALPDGRWRLA
ATAEDVDPRLITMILAYEDRRFQQHGGVDALALLRAAGQAAGSRRVVSGGSTLTMQVARLTLPPRPRTLAAKLAQMRRAL
ELEAHLSKPEILGLYLTLAPYGGNIEGVRAAALTYFGKEPRRLTLGEAALLVALPQAPETRRPDRFPARARAARDRVLDR
LLSQGLLVADEVRVAKAEPVPTARRSLPQLAPHLAEQMVAERPDLSRHLSTLDAPLQEKLEELVRERTRALGRGLSSAVV
VMDNDSAEVRAYVASADFLDKERAGAVDLARAVRSPGSTLKPFIYALAFEDGIAHPETLIEDRPARFGGWRPENFDRSFQ
GTLSVRKALQLSLNVPAVRLLDAVGPQRLATRLQQAGARLELPPGAAPALPMGLGGVGIRLVDLTMLYGALARGGEAHPL
VFRREGGAVSAPRRSRLVDQVAAWYVGQCLLGTPAPENALGGRIAFKTGTSYGYRDSWAMGFDGRRTVGVWVGRPDGQAV
PDLTGRAAAAPLLFDAFARIVRTPAGLGPAPRGAVMAANARLPVPQRHFGRTRQEQPLQVVYPPDGARVSGAEAETLALK
VDGGTFPLTLLMDGRPVAQVEDRRTLFWTPQGRGFARLTVIDAVGLSDSVTVRVE

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=548, Percent_Identity=44.8905109489051, Blast_Score=433, Evalue=1e-122,
Organism=Escherichia coli, GI1786343, Length=572, Percent_Identity=30.0699300699301, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI87082258, Length=303, Percent_Identity=31.023102310231, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789601, Length=137, Percent_Identity=31.3868613138686, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 74615; Mature: 74484

Theoretical pI: Translated: 11.21; Mature: 11.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIQPSGSSPAAPARRRLLRVAGGLVLGAGLLAGGAWAGLHHLRANAPPAPQVKVSAEV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEHHH
VDREGRLLRPFALPDGRWRLAATAEDVDPRLITMILAYEDRRFQQHGGVDALALLRAAGQ
HCCCCCEEEEEECCCCCEEEEECCCCCCCHHEEEEEHHHHHHHHHHCCHHHHHHHHHHHH
AAGSRRVVSGGSTLTMQVARLTLPPRPRTLAAKLAQMRRALELEAHLSKPEILGLYLTLA
CCCCCEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
PYGGNIEGVRAAALTYFGKEPRRLTLGEAALLVALPQAPETRRPDRFPARARAARDRVLD
CCCCCCCHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
RLLSQGLLVADEVRVAKAEPVPTARRSLPQLAPHLAEQMVAERPDLSRHLSTLDAPLQEK
HHHHCCCEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHH
LEELVRERTRALGRGLSSAVVVMDNDSAEVRAYVASADFLDKERAGAVDLARAVRSPGST
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEHHHHHHHHHCCHHHHHHHHHCCCCC
LKPFIYALAFEDGIAHPETLIEDRPARFGGWRPENFDRSFQGTLSVRKALQLSLNVPAVR
HHHHHEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
LLDAVGPQRLATRLQQAGARLELPPGAAPALPMGLGGVGIRLVDLTMLYGALARGGEAHP
HHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
LVFRREGGAVSAPRRSRLVDQVAAWYVGQCLLGTPAPENALGGRIAFKTGTSYGYRDSWA
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCEE
MGFDGRRTVGVWVGRPDGQAVPDLTGRAAAAPLLFDAFARIVRTPAGLGPAPRGAVMAAN
ECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
ARLPVPQRHFGRTRQEQPLQVVYPPDGARVSGAEAETLALKVDGGTFPLTLLMDGRPVAQ
CCCCCCHHHHCCCCCCCCCEEEECCCCCEECCCCCEEEEEEECCCCEEEEEEECCCCCCE
VEDRRTLFWTPQGRGFARLTVIDAVGLSDSVTVRVE
ECCCEEEEECCCCCCEEEEEEEEEECCCCCEEEEEC
>Mature Secondary Structure 
SAIQPSGSSPAAPARRRLLRVAGGLVLGAGLLAGGAWAGLHHLRANAPPAPQVKVSAEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEHHH
VDREGRLLRPFALPDGRWRLAATAEDVDPRLITMILAYEDRRFQQHGGVDALALLRAAGQ
HCCCCCEEEEEECCCCCEEEEECCCCCCCHHEEEEEHHHHHHHHHHCCHHHHHHHHHHHH
AAGSRRVVSGGSTLTMQVARLTLPPRPRTLAAKLAQMRRALELEAHLSKPEILGLYLTLA
CCCCCEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
PYGGNIEGVRAAALTYFGKEPRRLTLGEAALLVALPQAPETRRPDRFPARARAARDRVLD
CCCCCCCHHHHHHHHHHCCCCCEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHH
RLLSQGLLVADEVRVAKAEPVPTARRSLPQLAPHLAEQMVAERPDLSRHLSTLDAPLQEK
HHHHCCCEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHH
LEELVRERTRALGRGLSSAVVVMDNDSAEVRAYVASADFLDKERAGAVDLARAVRSPGST
HHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEHHHHHHHHHCCHHHHHHHHHCCCCC
LKPFIYALAFEDGIAHPETLIEDRPARFGGWRPENFDRSFQGTLSVRKALQLSLNVPAVR
HHHHHEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHH
LLDAVGPQRLATRLQQAGARLELPPGAAPALPMGLGGVGIRLVDLTMLYGALARGGEAHP
HHHHCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
LVFRREGGAVSAPRRSRLVDQVAAWYVGQCLLGTPAPENALGGRIAFKTGTSYGYRDSWA
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCEE
MGFDGRRTVGVWVGRPDGQAVPDLTGRAAAAPLLFDAFARIVRTPAGLGPAPRGAVMAAN
ECCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
ARLPVPQRHFGRTRQEQPLQVVYPPDGARVSGAEAETLALKVDGGTFPLTLLMDGRPVAQ
CCCCCCHHHHCCCCCCCCCEEEECCCCCEECCCCCEEEEEEECCCCEEEEEEECCCCCCE
VEDRRTLFWTPQGRGFARLTVIDAVGLSDSVTVRVE
ECCCEEEEECCCCCCEEEEEEEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]