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The map label for this gene is gor [H]

Identifier: 154247152

GI number: 154247152

Start: 3571932

End: 3573299

Strand: Direct

Name: gor [H]

Synonym: Xaut_3224

Alternate gene names: 154247152

Gene position: 3571932-3573299 (Clockwise)

Preceding gene: 154247150

Following gene: 154247155

Centisome position: 67.28

GC content: 68.49

Gene sequence:

>1368_bases
ATGTCACGGCGAGAAGTCGACCTGTTTGTCATCGGCGCGGGCTCGGGCGGGGTGCGCGCGGCGCGCATCGCGGCCCAGCA
CGGCGCCCGGGTGATGATGGCGGAGGAATACCGCGTCGGCGGCACCTGTGTCATCCGTGGCTGCGTGCCCAAGAAGCTGT
TCGTTTATGCCGGCCGTTTCGCCCACGATATCGAGGATATGGCTGGCTTCGGCTGGCGGGTGACCGAGCCGGAGTTCGAC
TGGCTGACCCTCGTCGCCAACAAGGACAAGGAGATCGCCCGCCTCGAGGCCATCTACCGCCGCAATGCGGAGAATGCCGG
GGTGGAGGTGGTGGCCTCCCGCGCCGTGGTGGTGGGCCCCAACTCGGTCCGTCTCCTCGCCACCGGGGAGGAGATCGGGG
CCCGCTACATCCTTCTCGCCACCGGCGCCCGGCCGGCGCTGGGCCCGGCCATTCCGGGCTGTGAGCTCGCCATCACCTCC
AACGAGGCGTTCAACCTCACCCATTTCCCCAACCGCATCCTGGTGCAGGGCGCCGGCTATATCGCGGTGGAATTCGCCGG
CCTGTTCCGCGCGCTGGGGGCCGATGTCACCCTGGTCTATCGCGCCGACAAGGTGCTGCGCGGCTTCGACGGGGAGATCC
GCGACCATCTGGAAGCCGAGATGACCCGCGCCGGCATCCACCTCAAGCCGGGACGAACCCTGACCTCCATCGAGGTGATC
AACGGCGGCAAGCGGGTCACCCTGTCGGATGGCTCGGTGGTCGAGGTGGACGACGTGATGCTCGCCCTCGGCCGCATTCC
CAACACGGCCCATCTGGGCCTCGACACGGTCGGGGTGAAGCTCGACGAAGTGGGCGCCGTGGTGGTGGATGAGACGGGCG
CGACCAACGTGCCGTCCATCTATGCGGTGGGCGACGTGACCAACCGCATCAACCTGACCCCGGTCGCCATCCGCGAGGGC
CATGCCTTCGCCGACACGGTGTTCGGCAACAAGCCCTGGACCGTGGACCACTCCCTGGTGGCCACCGCGGTCTTCTCCGA
GCCGGAGATCGGCACCGTGGGCCTCTCGGAAGAGGCGGCTCGCGCCCTCGGCCGGCCCATCGACATCTACAGCACCTCGT
TCCGCCCGCTGAAGGCGACGCTCTCGGGCCGCGAGACCCGCACCTTCATGAAGCTGGTGGTGGACAAGGAGAGCGACGTG
GTGCTCGGCTGCCACATCATGGGCGATGCGGCGTCCGAGATGATCCAGCTCGCCGGCGTGGCGCTGGGGCTGAAGGCGAA
GAAGGCGGATTTCGACCGCACCGTCGCCGTGCACCCCACCTCCGCCGAGGAACTGGTGACCCTGCGCACGCCCACGCGCA
GCGTCTGA

Upstream 100 bases:

>100_bases
TGGGCCCCGGCGCATGGGGCACGACCGTGGCTTTCCCTTGACGGATGGGAGCGCCGGCCGTTTTGTGGCGGCCGTTGCGC
GGCGCGAAGGACGGTTTGGA

Downstream 100 bases:

>100_bases
CCGGGGGGCGGGGTGTCGCCACCGTTCCGATCCCCTTGGGACCGGAACGGATGTGGTGCGGCGCGCTCAGAGCCGGTTGA
AATTCACGCCAATTGGCGCT

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSRREVDLFVIGAGSGGVRAARIAAQHGARVMMAEEYRVGGTCVIRGCVPKKLFVYAGRFAHDIEDMAGFGWRVTEPEFD
WLTLVANKDKEIARLEAIYRRNAENAGVEVVASRAVVVGPNSVRLLATGEEIGARYILLATGARPALGPAIPGCELAITS
NEAFNLTHFPNRILVQGAGYIAVEFAGLFRALGADVTLVYRADKVLRGFDGEIRDHLEAEMTRAGIHLKPGRTLTSIEVI
NGGKRVTLSDGSVVEVDDVMLALGRIPNTAHLGLDTVGVKLDEVGAVVVDETGATNVPSIYAVGDVTNRINLTPVAIREG
HAFADTVFGNKPWTVDHSLVATAVFSEPEIGTVGLSEEAARALGRPIDIYSTSFRPLKATLSGRETRTFMKLVVDKESDV
VLGCHIMGDAASEMIQLAGVALGLKAKKADFDRTVAVHPTSAEELVTLRTPTRSV

Sequences:

>Translated_455_residues
MSRREVDLFVIGAGSGGVRAARIAAQHGARVMMAEEYRVGGTCVIRGCVPKKLFVYAGRFAHDIEDMAGFGWRVTEPEFD
WLTLVANKDKEIARLEAIYRRNAENAGVEVVASRAVVVGPNSVRLLATGEEIGARYILLATGARPALGPAIPGCELAITS
NEAFNLTHFPNRILVQGAGYIAVEFAGLFRALGADVTLVYRADKVLRGFDGEIRDHLEAEMTRAGIHLKPGRTLTSIEVI
NGGKRVTLSDGSVVEVDDVMLALGRIPNTAHLGLDTVGVKLDEVGAVVVDETGATNVPSIYAVGDVTNRINLTPVAIREG
HAFADTVFGNKPWTVDHSLVATAVFSEPEIGTVGLSEEAARALGRPIDIYSTSFRPLKATLSGRETRTFMKLVVDKESDV
VLGCHIMGDAASEMIQLAGVALGLKAKKADFDRTVAVHPTSAEELVTLRTPTRSV
>Mature_454_residues
SRREVDLFVIGAGSGGVRAARIAAQHGARVMMAEEYRVGGTCVIRGCVPKKLFVYAGRFAHDIEDMAGFGWRVTEPEFDW
LTLVANKDKEIARLEAIYRRNAENAGVEVVASRAVVVGPNSVRLLATGEEIGARYILLATGARPALGPAIPGCELAITSN
EAFNLTHFPNRILVQGAGYIAVEFAGLFRALGADVTLVYRADKVLRGFDGEIRDHLEAEMTRAGIHLKPGRTLTSIEVIN
GGKRVTLSDGSVVEVDDVMLALGRIPNTAHLGLDTVGVKLDEVGAVVVDETGATNVPSIYAVGDVTNRINLTPVAIREGH
AFADTVFGNKPWTVDHSLVATAVFSEPEIGTVGLSEEAARALGRPIDIYSTSFRPLKATLSGRETRTFMKLVVDKESDVV
LGCHIMGDAASEMIQLAGVALGLKAKKADFDRTVAVHPTSAEELVTLRTPTRSV

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=40.3470715835141, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=34.341252699784, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI33519430, Length=461, Percent_Identity=34.056399132321, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI33519428, Length=461, Percent_Identity=34.056399132321, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI33519426, Length=461, Percent_Identity=34.056399132321, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI148277065, Length=461, Percent_Identity=34.056399132321, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI148277071, Length=461, Percent_Identity=34.056399132321, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI291045266, Length=463, Percent_Identity=32.829373650108, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=30.5494505494506, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=29.8056155507559, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=38.6574074074074, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=29.3859649122807, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082354, Length=452, Percent_Identity=27.212389380531, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87081717, Length=447, Percent_Identity=27.0693512304251, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789065, Length=208, Percent_Identity=31.25, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983419, Length=452, Percent_Identity=39.3805309734513, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983429, Length=452, Percent_Identity=39.3805309734513, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=32.9853862212944, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=34.6555323590814, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=32.0960698689956, Blast_Score=187, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=36.5591397849462, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=27.5268817204301, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=26.6949152542373, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737741, Length=480, Percent_Identity=34.1666666666667, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24640549, Length=475, Percent_Identity=34.1052631578947, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24640553, Length=475, Percent_Identity=34.1052631578947, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24640551, Length=475, Percent_Identity=34.1052631578947, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=29.5896328293737, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48666; Mature: 48535

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRREVDLFVIGAGSGGVRAARIAAQHGARVMMAEEYRVGGTCVIRGCVPKKLFVYAGRF
CCCCEEEEEEEECCCCCCCCEEHHHHCCCEEEEEECEECCCEEEEECCCCCEEEEECCHH
AHDIEDMAGFGWRVTEPEFDWLTLVANKDKEIARLEAIYRRNAENAGVEVVASRAVVVGP
HHHHHHHCCCCEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCEEEECC
NSVRLLATGEEIGARYILLATGARPALGPAIPGCELAITSNEAFNLTHFPNRILVQGAGY
CCEEEEEECHHHCCEEEEEECCCCCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCCE
IAVEFAGLFRALGADVTLVYRADKVLRGFDGEIRDHLEAEMTRAGIHLKPGRTLTSIEVI
EEEEHHHHHHHHCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHCCEEECCCCEEEEEEEE
NGGKRVTLSDGSVVEVDDVMLALGRIPNTAHLGLDTVGVKLDEVGAVVVDETGATNVPSI
CCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCCEEECEEEHHCCEEEEECCCCCCCCEE
YAVGDVTNRINLTPVAIREGHAFADTVFGNKPWTVDHSLVATAVFSEPEIGTVGLSEEAA
EEECCCCCEEECEEEEEECCCEEEHHHCCCCCCEECCHHEEEEEECCCCCCEECCCHHHH
RALGRPIDIYSTSFRPLKATLSGRETRTFMKLVVDKESDVVLGCHIMGDAASEMIQLAGV
HHHCCCEEEEECCCCEEEEECCCCHHHEEEEEEECCCCCEEEEEEEECHHHHHHHHHHHH
ALGLKAKKADFDRTVAVHPTSAEELVTLRTPTRSV
HCCCEECCCCCCCEEEECCCCHHHEEEEECCCCCC
>Mature Secondary Structure 
SRREVDLFVIGAGSGGVRAARIAAQHGARVMMAEEYRVGGTCVIRGCVPKKLFVYAGRF
CCCEEEEEEEECCCCCCCCEEHHHHCCCEEEEEECEECCCEEEEECCCCCEEEEECCHH
AHDIEDMAGFGWRVTEPEFDWLTLVANKDKEIARLEAIYRRNAENAGVEVVASRAVVVGP
HHHHHHHCCCCEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCEEEECC
NSVRLLATGEEIGARYILLATGARPALGPAIPGCELAITSNEAFNLTHFPNRILVQGAGY
CCEEEEEECHHHCCEEEEEECCCCCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCCE
IAVEFAGLFRALGADVTLVYRADKVLRGFDGEIRDHLEAEMTRAGIHLKPGRTLTSIEVI
EEEEHHHHHHHHCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHCCEEECCCCEEEEEEEE
NGGKRVTLSDGSVVEVDDVMLALGRIPNTAHLGLDTVGVKLDEVGAVVVDETGATNVPSI
CCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCCEEECEEEHHCCEEEEECCCCCCCCEE
YAVGDVTNRINLTPVAIREGHAFADTVFGNKPWTVDHSLVATAVFSEPEIGTVGLSEEAA
EEECCCCCEEECEEEEEECCCEEEHHHCCCCCCEECCHHEEEEEECCCCCCEECCCHHHH
RALGRPIDIYSTSFRPLKATLSGRETRTFMKLVVDKESDVVLGCHIMGDAASEMIQLAGV
HHHCCCEEEEECCCCEEEEECCCCHHHEEEEEEECCCCCEEEEEEEECHHHHHHHHHHHH
ALGLKAKKADFDRTVAVHPTSAEELVTLRTPTRSV
HCCCEECCCCCCCEEEECCCCHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]