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The map label for this gene is gcvT [H]

Identifier: 154247116

GI number: 154247116

Start: 3534582

End: 3535712

Strand: Direct

Name: gcvT [H]

Synonym: Xaut_3187

Alternate gene names: 154247116

Gene position: 3534582-3535712 (Clockwise)

Preceding gene: 154247107

Following gene: 154247118

Centisome position: 66.58

GC content: 67.73

Gene sequence:

>1131_bases
ATGACGAGCGCACCCATCTGGCGCCAATCGATCCTCAACGAGCGTCACCGGGAGCTGGGGTCGAAGCTCGAGGACTCGTG
GAACGACATGGCGATCCCGCAGCACTACGCCACCGATCCCTATGAGGAGACGGAGGCGGTGCGCACCCGCGCGGGGCTGT
TCGACGTGTCCGCCCTCAAGATCATCAACGTGGGCGGCAAGGACGCGCTGGCCTTCCTGAACCAACTGGTCACCGCCGAC
ATCACCAAGGTGCCGGCCGGCCGCTCCGCGATCGCCTCCATCGTGGGCGACGACGGCGGGCTGATCGATGACGTGCTGAT
CTATGTGGATGGTGACGGCGCGTTCCGCCTCTCCCACGGCGGCGGCGCGCTGGAAGACGCGCTGCCCCTCGTGGCCGAGG
GCTTCGACGTCACCTTCTCCCGCGACAACGACGTGCACATCCTGTCGCTGCAGGGCCCCAAGGCCCTCGACATCCTCGCC
CCCCACACCCCCATGGACCTGAAAGGCCTACCCTATTTCGGGCACGGCAGGACCACCCTGTTCGGCGTCCCGGTGTCGCT
GGCGCGCGGCGGCTATTCGGCCGAGCGGGGCTATGAGGTGTTCTGCGCCGCCAAGGACGCCGTCGCCCTGTGGGACAAGA
TCCTGGAGGCGGGCAAGCCGTTCGGCGCCATGCCGGTGTCGTGGGATTGCCTGGACATCGTGCGGGTGGAAGGCGCCTTG
CTGTTCTTCCCCTTCGACATGCCCCACAAGGACACCACCCCGTTCGAGGTGCTGATGGACTGGTCGGTGGACCTCTCCAA
GCCGGACTTCCGCGGCAAGGCGGCCCTCCTCGCCCGCAAGGGCACCGAGCGCACCCACCAGGCCGGGCTGGAAGTGCTCG
CCGCCAAGGCCATCACCCCCGGCGCGAAGATCTTCAAGGATGGGGAAGAGGTGGGCGTGGTGAATTCCACCACCTACAGC
CGACACCTCATGAAGTCGCTGGCCCTGGTCTCGCTGCGGCCGGACGTGACCGCCCTCGGTACCGGCGTGAGCGTGGTGGA
TGGCGAGGAGAGCTTCGAGGCCAATGTGGTCCGCACGCCCTTCTACGATCCCATGCGCCTGCGCACCCACCCGCTGGACG
AGCGGGCCTGA

Upstream 100 bases:

>100_bases
CGCACAGGATGCGCCCCGTCGCGGCGGGCGTGCGGCGCATCGCACCCCGTCGCCTTCCCATTCAATGCTGTCCGACAGCT
GAAAAGAGAGAGGGGACAGA

Downstream 100 bases:

>100_bases
ATCGAAAGGGGCCGGCAGAACCGGCCCCTTCCTTTCGCGTCTTCGGTTCAGAGCGGCTTGAGGCCGGCCTCGATGGCGGC
CCGCCGGCCTTCCAGGAATG

Product: glycine cleavage T protein (aminomethyl transferase)

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTSAPIWRQSILNERHRELGSKLEDSWNDMAIPQHYATDPYEETEAVRTRAGLFDVSALKIINVGGKDALAFLNQLVTAD
ITKVPAGRSAIASIVGDDGGLIDDVLIYVDGDGAFRLSHGGGALEDALPLVAEGFDVTFSRDNDVHILSLQGPKALDILA
PHTPMDLKGLPYFGHGRTTLFGVPVSLARGGYSAERGYEVFCAAKDAVALWDKILEAGKPFGAMPVSWDCLDIVRVEGAL
LFFPFDMPHKDTTPFEVLMDWSVDLSKPDFRGKAALLARKGTERTHQAGLEVLAAKAITPGAKIFKDGEEVGVVNSTTYS
RHLMKSLALVSLRPDVTALGTGVSVVDGEESFEANVVRTPFYDPMRLRTHPLDERA

Sequences:

>Translated_376_residues
MTSAPIWRQSILNERHRELGSKLEDSWNDMAIPQHYATDPYEETEAVRTRAGLFDVSALKIINVGGKDALAFLNQLVTAD
ITKVPAGRSAIASIVGDDGGLIDDVLIYVDGDGAFRLSHGGGALEDALPLVAEGFDVTFSRDNDVHILSLQGPKALDILA
PHTPMDLKGLPYFGHGRTTLFGVPVSLARGGYSAERGYEVFCAAKDAVALWDKILEAGKPFGAMPVSWDCLDIVRVEGAL
LFFPFDMPHKDTTPFEVLMDWSVDLSKPDFRGKAALLARKGTERTHQAGLEVLAAKAITPGAKIFKDGEEVGVVNSTTYS
RHLMKSLALVSLRPDVTALGTGVSVVDGEESFEANVVRTPFYDPMRLRTHPLDERA
>Mature_375_residues
TSAPIWRQSILNERHRELGSKLEDSWNDMAIPQHYATDPYEETEAVRTRAGLFDVSALKIINVGGKDALAFLNQLVTADI
TKVPAGRSAIASIVGDDGGLIDDVLIYVDGDGAFRLSHGGGALEDALPLVAEGFDVTFSRDNDVHILSLQGPKALDILAP
HTPMDLKGLPYFGHGRTTLFGVPVSLARGGYSAERGYEVFCAAKDAVALWDKILEAGKPFGAMPVSWDCLDIVRVEGALL
FFPFDMPHKDTTPFEVLMDWSVDLSKPDFRGKAALLARKGTERTHQAGLEVLAAKAITPGAKIFKDGEEVGVVNSTTYSR
HLMKSLALVSLRPDVTALGTGVSVVDGEESFEANVVRTPFYDPMRLRTHPLDERA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=339, Percent_Identity=27.1386430678466, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI44662838, Length=368, Percent_Identity=24.4565217391304, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI257796258, Length=336, Percent_Identity=24.702380952381, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI257796256, Length=308, Percent_Identity=25, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1789272, Length=343, Percent_Identity=27.9883381924198, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=26.5415549597855, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320222, Length=393, Percent_Identity=26.7175572519084, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=27.7777777777778, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20130091, Length=353, Percent_Identity=24.0793201133144, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40790; Mature: 40659

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAPIWRQSILNERHRELGSKLEDSWNDMAIPQHYATDPYEETEAVRTRAGLFDVSALK
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEE
IINVGGKDALAFLNQLVTADITKVPAGRSAIASIVGDDGGLIDDVLIYVDGDGAFRLSHG
EEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCEEEEECC
GGALEDALPLVAEGFDVTFSRDNDVHILSLQGPKALDILAPHTPMDLKGLPYFGHGRTTL
CCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCCEECCCCEEE
FGVPVSLARGGYSAERGYEVFCAAKDAVALWDKILEAGKPFGAMPVSWDCLDIVRVEGAL
EECCHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCEE
LFFPFDMPHKDTTPFEVLMDWSVDLSKPDFRGKAALLARKGTERTHQAGLEVLAAKAITP
EEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GAKIFKDGEEVGVVNSTTYSRHLMKSLALVSLRPDVTALGTGVSVVDGEESFEANVVRTP
CHHHHCCCCCEEEEECCHHHHHHHHHHHHHEECCCCHHHCCCEEEECCCCCCCCCEEECC
FYDPMRLRTHPLDERA
CCCCHHHCCCCCCCCC
>Mature Secondary Structure 
TSAPIWRQSILNERHRELGSKLEDSWNDMAIPQHYATDPYEETEAVRTRAGLFDVSALK
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEE
IINVGGKDALAFLNQLVTADITKVPAGRSAIASIVGDDGGLIDDVLIYVDGDGAFRLSHG
EEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCEEEEECC
GGALEDALPLVAEGFDVTFSRDNDVHILSLQGPKALDILAPHTPMDLKGLPYFGHGRTTL
CCCHHHHHHHHHCCCEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCCEECCCCEEE
FGVPVSLARGGYSAERGYEVFCAAKDAVALWDKILEAGKPFGAMPVSWDCLDIVRVEGAL
EECCHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCEE
LFFPFDMPHKDTTPFEVLMDWSVDLSKPDFRGKAALLARKGTERTHQAGLEVLAAKAITP
EEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GAKIFKDGEEVGVVNSTTYSRHLMKSLALVSLRPDVTALGTGVSVVDGEESFEANVVRTP
CHHHHCCCCCEEEEECCHHHHHHHHHHHHHEECCCCHHHCCCEEEECCCCCCCCCEEECC
FYDPMRLRTHPLDERA
CCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA