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The map label for this gene is guaB [H]

Identifier: 154247052

GI number: 154247052

Start: 3463617

End: 3465149

Strand: Direct

Name: guaB [H]

Synonym: Xaut_3123

Alternate gene names: 154247052

Gene position: 3463617-3465149 (Clockwise)

Preceding gene: 154247051

Following gene: 154247061

Centisome position: 65.24

GC content: 68.43

Gene sequence:

>1533_bases
ATGACCACCCCGATTTCGAACGTCCCCCCGTCTGCGGCCATCTCCAGCGGCCGCGCGCCGTTCCGCGAGGCGCTGACGTT
CGACGACGTGCTGCTGACCCCGGGCGCCTCCGAGGTGATGCCGGGGCAGGTGGATGTCGCCACCCAGCTCACCAAGACCA
TCAGCCTCAACCTGCCCATCATCTCTGCCGCCATGGATACGGTGACCGAATCGCGCCTCGCCATCGCCATGGCGCAGGCC
GGCGGCATCGGCGTCATCCACCGCAACCTCACGCCCGAGCTTCAGGCCGAGCATGTGCGGCAGGTGAAGAAGTACGAATC
GGGCATGGTGGTGAACCCGGTCACCATCCATCCCGACGAGACACTCGCCCACGCCCTCACCCTCATGAAGCGCTACGGCA
TCTCCGGCATTCCGGTGGTGGAGCGCGGCGTGGGTGCCATCGCCGGTCGGCTGGTCGGCATCCTCACCAATCGCGACGTG
CGCTTCGCCCACAATCCCGAGCAGCGCGTGGCCGAGCTGATGACCAAGGACCGGCTCATCACCGTGCGCGAGGGCCAGGT
GAACCAGGAGGAGGCCAAGAGCCTCCTGCACCAGTACCGCATCGAGAAGCTGCTGGTGGTGGACAATGACGAGCGCTGCG
TCGGCCTCATCACCGTCAAGGACATCGAGAAGGCGGTGGCCTATCCCCACGCCGCCAAGGACGAGCAGGGCCGCCTGCGG
GTCGCTGCCGCGACGACCGTCGGTCCCGACGGCTTCGAGCGCACCGAGCGCCTGATCGATGCCGGCGTCGACCTCGTGGT
GGTGGATACCGCCCACGGCCATTCCCGCAAGGTGCTGGACCAAGTGGAGCGCATCAAGAAGCTCTCCAACCGCACCCAGA
TCCTCGCCGGCAACATCGCCACCGCCGAGGGGGCCCGCGCGCTCATCGATGCCGGGGCGGACGCGGTGAAGGTGGGTATC
GGCCCCGGCTCCATCTGCACCACCCGCATCGTGGCGGGCGTTGGCGTGCCCCAGCTCACCGCGGTGATGGATGCGGTGGA
AGCCGCCCACGCCACCGGCACCCCGGTGATCGCCGACGGCGGCATCAAGTATTCCGGCGACCTCGCCAAGGCGCTGGCGG
CCGGTGCCTCCGCCGCCATGGTAGGCTCGTTGCTCGCCGGCACCGACGAAAGCCCCGGCGAGGTGTTCCTCTATCAGGGC
CGCTCCTACAAGTCGTATCGCGGCATGGGCTCGGTGGGCGCCATGGCCCGCGGCTCGGCCGACCGCTACTTCCAGGCGGA
AGTGCGCGACACGCTCAAGCTGGTGCCGGAAGGCATCGAGGGCCAGGTGGCCTACAAGGGTCCGGTGGGGGCGGTGCTCC
ACCAGCTTGCCGGCGGCTTGCGGGCAGCCATGGGCTATGTGGGCGGCAGCACGCTGAAGGAATTCCGCGAGAAGGCCCAG
TTCGTGCGCATCTCTTCCGCCGGCCTGCGCGAGAGCCATGTGCATGACGTGACCATCACCCGCGAGAGCCCGAACTATCC
CACCAGCGTGTGA

Upstream 100 bases:

>100_bases
GGTATCGGCCACTGCCAACTCGTAGCGGGGTGTTTGACAGCAACCCGTTCCGGCCCCGATCCAGCGGCCCGGCTTCCCGC
GCCGCCTTAAGGAGTTGGCC

Downstream 100 bases:

>100_bases
CAGCTATGGGTGATGAGCTTGGCCCATCACCCATCGGTACAGGCCCGCGCGGCGCTTGAGCGCGACCTCCTTGGCGTCGG
TCAAAGACCGGCACCGCTCG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTTPISNVPPSAAISSGRAPFREALTFDDVLLTPGASEVMPGQVDVATQLTKTISLNLPIISAAMDTVTESRLAIAMAQA
GGIGVIHRNLTPELQAEHVRQVKKYESGMVVNPVTIHPDETLAHALTLMKRYGISGIPVVERGVGAIAGRLVGILTNRDV
RFAHNPEQRVAELMTKDRLITVREGQVNQEEAKSLLHQYRIEKLLVVDNDERCVGLITVKDIEKAVAYPHAAKDEQGRLR
VAAATTVGPDGFERTERLIDAGVDLVVVDTAHGHSRKVLDQVERIKKLSNRTQILAGNIATAEGARALIDAGADAVKVGI
GPGSICTTRIVAGVGVPQLTAVMDAVEAAHATGTPVIADGGIKYSGDLAKALAAGASAAMVGSLLAGTDESPGEVFLYQG
RSYKSYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVAYKGPVGAVLHQLAGGLRAAMGYVGGSTLKEFREKAQ
FVRISSAGLRESHVHDVTITRESPNYPTSV

Sequences:

>Translated_510_residues
MTTPISNVPPSAAISSGRAPFREALTFDDVLLTPGASEVMPGQVDVATQLTKTISLNLPIISAAMDTVTESRLAIAMAQA
GGIGVIHRNLTPELQAEHVRQVKKYESGMVVNPVTIHPDETLAHALTLMKRYGISGIPVVERGVGAIAGRLVGILTNRDV
RFAHNPEQRVAELMTKDRLITVREGQVNQEEAKSLLHQYRIEKLLVVDNDERCVGLITVKDIEKAVAYPHAAKDEQGRLR
VAAATTVGPDGFERTERLIDAGVDLVVVDTAHGHSRKVLDQVERIKKLSNRTQILAGNIATAEGARALIDAGADAVKVGI
GPGSICTTRIVAGVGVPQLTAVMDAVEAAHATGTPVIADGGIKYSGDLAKALAAGASAAMVGSLLAGTDESPGEVFLYQG
RSYKSYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVAYKGPVGAVLHQLAGGLRAAMGYVGGSTLKEFREKAQ
FVRISSAGLRESHVHDVTITRESPNYPTSV
>Mature_509_residues
TTPISNVPPSAAISSGRAPFREALTFDDVLLTPGASEVMPGQVDVATQLTKTISLNLPIISAAMDTVTESRLAIAMAQAG
GIGVIHRNLTPELQAEHVRQVKKYESGMVVNPVTIHPDETLAHALTLMKRYGISGIPVVERGVGAIAGRLVGILTNRDVR
FAHNPEQRVAELMTKDRLITVREGQVNQEEAKSLLHQYRIEKLLVVDNDERCVGLITVKDIEKAVAYPHAAKDEQGRLRV
AAATTVGPDGFERTERLIDAGVDLVVVDTAHGHSRKVLDQVERIKKLSNRTQILAGNIATAEGARALIDAGADAVKVGIG
PGSICTTRIVAGVGVPQLTAVMDAVEAAHATGTPVIADGGIKYSGDLAKALAAGASAAMVGSLLAGTDESPGEVFLYQGR
SYKSYRGMGSVGAMARGSADRYFQAEVRDTLKLVPEGIEGQVAYKGPVGAVLHQLAGGLRAAMGYVGGSTLKEFREKAQF
VRISSAGLRESHVHDVTITRESPNYPTSV

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=40.2892561983471, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI217035146, Length=458, Percent_Identity=40.6113537117904, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI156616279, Length=458, Percent_Identity=40.6113537117904, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI34328930, Length=458, Percent_Identity=40.6113537117904, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI34328928, Length=458, Percent_Identity=40.6113537117904, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=40.7079646017699, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035148, Length=458, Percent_Identity=39.7379912663755, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI217035150, Length=458, Percent_Identity=37.117903930131, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=39.6761133603239, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=39.6761133603239, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=39.6761133603239, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=39.6761133603239, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=37.9032258064516, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=60.6995884773662, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786293, Length=237, Percent_Identity=40.084388185654, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994385, Length=505, Percent_Identity=35.4455445544554, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=431, Percent_Identity=36.8909512761021, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=244, Percent_Identity=38.5245901639344, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=490, Percent_Identity=38.7755102040816, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=490, Percent_Identity=40.2040816326531, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6322012, Length=493, Percent_Identity=38.3367139959432, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=38.953488372093, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=120, Percent_Identity=40.8333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=39.6694214876033, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=39.6694214876033, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=40.0452488687783, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 53948; Mature: 53817

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPISNVPPSAAISSGRAPFREALTFDDVLLTPGASEVMPGQVDVATQLTKTISLNLPI
CCCCCCCCCCCHHHCCCCCCHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHEEECCCH
ISAAMDTVTESRLAIAMAQAGGIGVIHRNLTPELQAEHVRQVKKYESGMVVNPVTIHPDE
HHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCCH
TLAHALTLMKRYGISGIPVVERGVGAIAGRLVGILTNRDVRFAHNPEQRVAELMTKDRLI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCEEECCCHHHHHHHHHHCCCEE
TVREGQVNQEEAKSLLHQYRIEKLLVVDNDERCVGLITVKDIEKAVAYPHAAKDEQGRLR
EEECCCCCHHHHHHHHHHHHHCEEEEEECCCCEEEEEEHHHHHHHHCCCCCCCCCCCCEE
VAAATTVGPDGFERTERLIDAGVDLVVVDTAHGHSRKVLDQVERIKKLSNRTQILAGNIA
EEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCC
TAEGARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAVMDAVEAAHATGTPVIADG
CCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECC
GIKYSGDLAKALAAGASAAMVGSLLAGTDESPGEVFLYQGRSYKSYRGMGSVGAMARGSA
CEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCC
DRYFQAEVRDTLKLVPEGIEGQVAYKGPVGAVLHQLAGGLRAAMGYVGGSTLKEFREKAQ
CHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FVRISSAGLRESHVHDVTITRESPNYPTSV
EEEECCCCCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TTPISNVPPSAAISSGRAPFREALTFDDVLLTPGASEVMPGQVDVATQLTKTISLNLPI
CCCCCCCCCCHHHCCCCCCHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHEEECCCH
ISAAMDTVTESRLAIAMAQAGGIGVIHRNLTPELQAEHVRQVKKYESGMVVNPVTIHPDE
HHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEECCEEECCCH
TLAHALTLMKRYGISGIPVVERGVGAIAGRLVGILTNRDVRFAHNPEQRVAELMTKDRLI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCEEECCCHHHHHHHHHHCCCEE
TVREGQVNQEEAKSLLHQYRIEKLLVVDNDERCVGLITVKDIEKAVAYPHAAKDEQGRLR
EEECCCCCHHHHHHHHHHHHHCEEEEEECCCCEEEEEEHHHHHHHHCCCCCCCCCCCCEE
VAAATTVGPDGFERTERLIDAGVDLVVVDTAHGHSRKVLDQVERIKKLSNRTQILAGNIA
EEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCC
TAEGARALIDAGADAVKVGIGPGSICTTRIVAGVGVPQLTAVMDAVEAAHATGTPVIADG
CCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECC
GIKYSGDLAKALAAGASAAMVGSLLAGTDESPGEVFLYQGRSYKSYRGMGSVGAMARGSA
CEEECCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCC
DRYFQAEVRDTLKLVPEGIEGQVAYKGPVGAVLHQLAGGLRAAMGYVGGSTLKEFREKAQ
CHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FVRISSAGLRESHVHDVTITRESPNYPTSV
EEEECCCCCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA