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The map label for this gene is thiE [H]

Identifier: 154247007

GI number: 154247007

Start: 3417830

End: 3418456

Strand: Direct

Name: thiE [H]

Synonym: Xaut_3078

Alternate gene names: 154247007

Gene position: 3417830-3418456 (Clockwise)

Preceding gene: 154247006

Following gene: 154247008

Centisome position: 64.38

GC content: 73.84

Gene sequence:

>627_bases
ATGTCTTCCCCTTTGCCGCCGCCCGGCGCCCGACTCATGCTCGTCTTCACCCTCACGCCCGAGCTGCGGCCGGACGCGGC
GGCTGCGGCCGTGCGCGCCGGTGACGTGGCGGCCGTGGTGCTGCGCGTGCCCAAAGACGGCGCGCCCGATATCCGCCACC
TGCGCGCCGTGGCCGAGGCGCTCCAGAAGCACGATGCAGCGGTGCTGGTGGAGGGGCCGGACACTCTCGTCACCGCCGCC
GGCCTCGATGGGGTCCATGTGAGCGATCTGCGCGGCCTTCAGGCCGCGCTGCGCGAGCTGAAGCCGCAGGCCATCGTGGG
GGCGGGCGGCCTCGCCAGCCGCCACGACGCCATGGAGGCCGGGGAAAGCGGGGCGGACTATGTCTTCTTCGGCGCGCTGG
AGCCCCGGCCGGGGGACGCTCCTGAGATTCTTGATCTCGTGGCCTGGTGGGCCGAGCTGTTCGAGGTGCCCTGCGTGGGT
CTTGCCGCCTCCCTCGACGAGGCCGAGGCTCTGGCCCAGGCCGGCGCCGATTTCGTCGCGCTGGCCGAGGCGCTGGTGGC
GGACGGCGGCGCGGCGACGGTGACGGCGGCCATGGACCGCCTTTCGCGCGTGGACGCCCAGCCATGA

Upstream 100 bases:

>100_bases
GGTAGAGCAGATACCAGTCAGATTGCGCCGCAGCCTGATCGGCCCGAGCTCCTGCGGGCCGTGCCCCCAATTTGCCGATT
TCTTGGCCGACCGATCATCC

Downstream 100 bases:

>100_bases
GCATGGGTCAGGTCCGGCGCGTTTCGACGGCGTCTGCGCGGGGAATGGCGCGCGTCTGCGCCCTGAACCTCGCGCTGGTC
CTTGCGCTGGTGGGCGCGCC

Product: thiamine monophosphate synthase

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSSPLPPPGARLMLVFTLTPELRPDAAAAAVRAGDVAAVVLRVPKDGAPDIRHLRAVAEALQKHDAAVLVEGPDTLVTAA
GLDGVHVSDLRGLQAALRELKPQAIVGAGGLASRHDAMEAGESGADYVFFGALEPRPGDAPEILDLVAWWAELFEVPCVG
LAASLDEAEALAQAGADFVALAEALVADGGAATVTAAMDRLSRVDAQP

Sequences:

>Translated_208_residues
MSSPLPPPGARLMLVFTLTPELRPDAAAAAVRAGDVAAVVLRVPKDGAPDIRHLRAVAEALQKHDAAVLVEGPDTLVTAA
GLDGVHVSDLRGLQAALRELKPQAIVGAGGLASRHDAMEAGESGADYVFFGALEPRPGDAPEILDLVAWWAELFEVPCVG
LAASLDEAEALAQAGADFVALAEALVADGGAATVTAAMDRLSRVDAQP
>Mature_207_residues
SSPLPPPGARLMLVFTLTPELRPDAAAAAVRAGDVAAVVLRVPKDGAPDIRHLRAVAEALQKHDAAVLVEGPDTLVTAAG
LDGVHVSDLRGLQAALRELKPQAIVGAGGLASRHDAMEAGESGADYVFFGALEPRPGDAPEILDLVAWWAELFEVPCVGL
AASLDEAEALAQAGADFVALAEALVADGGAATVTAAMDRLSRVDAQP

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 21262; Mature: 21131

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPLPPPGARLMLVFTLTPELRPDAAAAAVRAGDVAAVVLRVPKDGAPDIRHLRAVAEA
CCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
LQKHDAAVLVEGPDTLVTAAGLDGVHVSDLRGLQAALRELKPQAIVGAGGLASRHDAMEA
HHHCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHC
GESGADYVFFGALEPRPGDAPEILDLVAWWAELFEVPCVGLAASLDEAEALAQAGADFVA
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHH
LAEALVADGGAATVTAAMDRLSRVDAQP
HHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSPLPPPGARLMLVFTLTPELRPDAAAAAVRAGDVAAVVLRVPKDGAPDIRHLRAVAEA
CCCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHH
LQKHDAAVLVEGPDTLVTAAGLDGVHVSDLRGLQAALRELKPQAIVGAGGLASRHDAMEA
HHHCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHC
GESGADYVFFGALEPRPGDAPEILDLVAWWAELFEVPCVGLAASLDEAEALAQAGADFVA
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHH
LAEALVADGGAATVTAAMDRLSRVDAQP
HHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA