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The map label for this gene is msrA2 [H]

Identifier: 154246899

GI number: 154246899

Start: 3289928

End: 3290440

Strand: Direct

Name: msrA2 [H]

Synonym: Xaut_2967

Alternate gene names: 154246899

Gene position: 3289928-3290440 (Clockwise)

Preceding gene: 154246898

Following gene: 154246900

Centisome position: 61.97

GC content: 60.23

Gene sequence:

>513_bases
ATGACGACTGAACGCGCTGTTCTCGCCGGCGGCTGCTTCTGGGGCATGCAGGATCTTATCCGCAAGCTGCCCGGTGTAAT
CTCCACCCGTGTCGGTTACACGGGCGGCGATGTGCCGAATGCGACATATCGCAATCACGGCACTCATGCCGAGGCGATCG
AGATCACCTTCGATCCCTCTCAGACCACCTATCGCCGATTGCTTGAGTTCTTCTTCCAGATCCACGACCCGACGACGCTC
AACCGTCAGGGGAACGACCGAGGCGCGAGCTACCGTTCCGCGATCTATTTTACCAACGACCAGCAGAAGGCCGTTGCGCT
CGATACGATTGCAGATGTTGAAGCGTCGGGCCTATGGCCAGGCAAGGTCGTCACCGAGGTCGAGCCAGTCGGTGATTTCT
GGGAGGCAGAGCCCGAGCATCAGGATTATCTCGAGCGAATTCCCCACGGGTACACCTGCCACTTTGCACGTCCGGACTGG
GTGTTGCCGCGCAGGGCCGGTGCTGCCGCTTAG

Upstream 100 bases:

>100_bases
TGCGTTACTGTATCAATTCGGCTTCGCTGCGCTTCGTACCCCGCGGCGAGATGGAGAGCCAAGGTTACGGTGAATATCTC
AACCAGGTGGAGGATATCTG

Downstream 100 bases:

>100_bases
CAAACCTGCGGCTCGTGGTTTAACGCCGCGAGCCGACATCGGAGGGCTTCATGGAAACGGGAATTGTGGGTCTGCCTGCC
CCTCCGCTGGAGAATATCCG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTTERAVLAGGCFWGMQDLIRKLPGVISTRVGYTGGDVPNATYRNHGTHAEAIEITFDPSQTTYRRLLEFFFQIHDPTTL
NRQGNDRGASYRSAIYFTNDQQKAVALDTIADVEASGLWPGKVVTEVEPVGDFWEAEPEHQDYLERIPHGYTCHFARPDW
VLPRRAGAAA

Sequences:

>Translated_170_residues
MTTERAVLAGGCFWGMQDLIRKLPGVISTRVGYTGGDVPNATYRNHGTHAEAIEITFDPSQTTYRRLLEFFFQIHDPTTL
NRQGNDRGASYRSAIYFTNDQQKAVALDTIADVEASGLWPGKVVTEVEPVGDFWEAEPEHQDYLERIPHGYTCHFARPDW
VLPRRAGAAA
>Mature_169_residues
TTERAVLAGGCFWGMQDLIRKLPGVISTRVGYTGGDVPNATYRNHGTHAEAIEITFDPSQTTYRRLLEFFFQIHDPTTLN
RQGNDRGASYRSAIYFTNDQQKAVALDTIADVEASGLWPGKVVTEVEPVGDFWEAEPEHQDYLERIPHGYTCHFARPDWV
LPRRAGAAA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=38.7096774193548, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=38.7096774193548, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI208609993, Length=105, Percent_Identity=38.0952380952381, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=44.078947368421, Blast_Score=123, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=140, Percent_Identity=42.1428571428571, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=36.5269461077844, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24664627, Length=146, Percent_Identity=34.2465753424658, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=35.2941176470588, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=148, Percent_Identity=33.1081081081081, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19057; Mature: 18926

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTERAVLAGGCFWGMQDLIRKLPGVISTRVGYTGGDVPNATYRNHGTHAEAIEITFDPS
CCCCCEEEECHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
QTTYRRLLEFFFQIHDPTTLNRQGNDRGASYRSAIYFTNDQQKAVALDTIADVEASGLWP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEHHHHHCCCCCCCCC
GKVVTEVEPVGDFWEAEPEHQDYLERIPHGYTCHFARPDWVLPRRAGAAA
CCEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTERAVLAGGCFWGMQDLIRKLPGVISTRVGYTGGDVPNATYRNHGTHAEAIEITFDPS
CCCCEEEECHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
QTTYRRLLEFFFQIHDPTTLNRQGNDRGASYRSAIYFTNDQQKAVALDTIADVEASGLWP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEHHHHHCCCCCCCCC
GKVVTEVEPVGDFWEAEPEHQDYLERIPHGYTCHFARPDWVLPRRAGAAA
CCEEEECCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]