Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 154246761

GI number: 154246761

Start: 3143317

End: 3144396

Strand: Direct

Name: serA [H]

Synonym: Xaut_2822

Alternate gene names: 154246761

Gene position: 3143317-3144396 (Clockwise)

Preceding gene: 154246760

Following gene: 154246764

Centisome position: 59.21

GC content: 71.02

Gene sequence:

>1080_bases
ATGTGTGGGTTGATCTTAGCGGGGTTGATCTTGGCGGCGCGGAAGGAGAGGAGAGGGGGCCCTCCGCCTGAAAGGTCCGC
TCCGTTGCCAGCTTCCCGCCCCAAGATTCTGATCACCACCCGCCTGTTCGACGATGCCGCCACCCGCTTCCTGGAGGCCC
AGGGCTTCGAGGTGGTGCCCTCCGGCCTGCCCGGCGACGCGCTTGATTCCAACATTCCGGACGCCGATCTCAACGCCCTG
CTGGAGGGTGCGGCCGGCTGGATCGTCGGCCAGCGGGCGGTGACCCGGGACGTGCTGGCCGCCCACCCGCAGCTGAAGGT
GATCGCCCGGCGGGGTGTCGGCTATGACCGGGTGGACGTGGATGCGGCGCGAGATCTCGGCCGGGTGGTGACCATCGCTG
CCGGGGCCAACGATCCGGCGGTGGCGGACCACACCATCGCCCTCATGCTCGCGGTGCTGCGCCGCCTGAAGGCAAGCCAG
GCCGCCATCGCGCGGGGCGACTGGCGGGTGCTGGTCGGCGCCGACCTCACCGGCAAGACGGTGGGCCTCATCGGCTTCGG
CCGCATCGGCCGGCAGGTGGCGCGCCGCCTGTCGGGCTTCGATGTGACCGTGCTGGTCACCTCGCGCACGCCGGATCCCG
AGGCGGCGGGCGTCACCTTCGTGGCGCTGGACGAACTGATCGCGCGCAGCGACGTGGTGAGCCTGCACGCCCCGCTGGTT
CCGGAGACTCGCCACGTCATCAATGCGGCGACGCTGAAGGCCATGAAGCGTAGCGCGGTGGTGGTGAATACCTCGCGCGG
CGGCCTCATCGACGACGCGACTCTTCTTGCCGCGCTGGAGGCCGGCGAGATCGCGGGCGCCGGCCTCGACGTGTTCGAGG
CGGAGGCGGATGAAGCCCTGCACCCCCTCGCAGAGGCCCTGGCCGCGCGAGAGAACGTGGTGGCCACTGCCCATGCGGCT
GGATCGAGCGAGGAGGCGCTGGCCCGCGGCAACCTCATTTCCGCGCAATGCGTGGCGGCGGCGCTTGCCGGTGCGCCTTT
CCCGCCCGGCTGCCTGATCGCCGACGGGCGCGTGAAGTAG

Upstream 100 bases:

>100_bases
GAAGGTTGCCTGAATAAAGCCCGCCGGGCCGGCGGGCTTCGGGGGCGAACCGGTTTCGCCCCCATCCCTTCAAGGCGGTG
CCGATGGTGCCGCCTTTTGC

Downstream 100 bases:

>100_bases
TTCGTTTACCCTATTGAAAACAAAACGATCCTCCCCGCTCAGGCGTCTGCGCCCGAGCAGGGAGGGTCCTGGAGCCGGAG
GCTGGGACGAGCTTGAGTCT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MCGLILAGLILAARKERRGGPPPERSAPLPASRPKILITTRLFDDAATRFLEAQGFEVVPSGLPGDALDSNIPDADLNAL
LEGAAGWIVGQRAVTRDVLAAHPQLKVIARRGVGYDRVDVDAARDLGRVVTIAAGANDPAVADHTIALMLAVLRRLKASQ
AAIARGDWRVLVGADLTGKTVGLIGFGRIGRQVARRLSGFDVTVLVTSRTPDPEAAGVTFVALDELIARSDVVSLHAPLV
PETRHVINAATLKAMKRSAVVVNTSRGGLIDDATLLAALEAGEIAGAGLDVFEAEADEALHPLAEALAARENVVATAHAA
GSSEEALARGNLISAQCVAAALAGAPFPPGCLIADGRVK

Sequences:

>Translated_359_residues
MCGLILAGLILAARKERRGGPPPERSAPLPASRPKILITTRLFDDAATRFLEAQGFEVVPSGLPGDALDSNIPDADLNAL
LEGAAGWIVGQRAVTRDVLAAHPQLKVIARRGVGYDRVDVDAARDLGRVVTIAAGANDPAVADHTIALMLAVLRRLKASQ
AAIARGDWRVLVGADLTGKTVGLIGFGRIGRQVARRLSGFDVTVLVTSRTPDPEAAGVTFVALDELIARSDVVSLHAPLV
PETRHVINAATLKAMKRSAVVVNTSRGGLIDDATLLAALEAGEIAGAGLDVFEAEADEALHPLAEALAARENVVATAHAA
GSSEEALARGNLISAQCVAAALAGAPFPPGCLIADGRVK
>Mature_359_residues
MCGLILAGLILAARKERRGGPPPERSAPLPASRPKILITTRLFDDAATRFLEAQGFEVVPSGLPGDALDSNIPDADLNAL
LEGAAGWIVGQRAVTRDVLAAHPQLKVIARRGVGYDRVDVDAARDLGRVVTIAAGANDPAVADHTIALMLAVLRRLKASQ
AAIARGDWRVLVGADLTGKTVGLIGFGRIGRQVARRLSGFDVTVLVTSRTPDPEAAGVTFVALDELIARSDVVSLHAPLV
PETRHVINAATLKAMKRSAVVVNTSRGGLIDDATLLAALEAGEIAGAGLDVFEAEADEALHPLAEALAARENVVATAHAA
GSSEEALARGNLISAQCVAAALAGAPFPPGCLIADGRVK

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=311, Percent_Identity=34.0836012861736, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI6912396, Length=291, Percent_Identity=33.6769759450172, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=38.4920634920635, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580578, Length=251, Percent_Identity=38.2470119521912, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI4557499, Length=251, Percent_Identity=38.2470119521912, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=36.2549800796813, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=36.2549800796813, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=35.5212355212355, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=32.5, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789279, Length=266, Percent_Identity=32.7067669172932, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1788660, Length=242, Percent_Identity=26.8595041322314, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081824, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=313, Percent_Identity=30.0319488817891, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=282, Percent_Identity=32.2695035460993, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=30.9815950920245, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324055, Length=229, Percent_Identity=33.6244541484716, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=323, Percent_Identity=29.4117647058824, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=309, Percent_Identity=27.5080906148867, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=175, Percent_Identity=27.4285714285714, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=28.9940828402367, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921140, Length=309, Percent_Identity=32.0388349514563, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28571528, Length=261, Percent_Identity=37.1647509578544, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=35.9848484848485, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=35.9848484848485, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585514, Length=264, Percent_Identity=35.9848484848485, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574282, Length=264, Percent_Identity=35.9848484848485, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552429, Length=264, Percent_Identity=35.9848484848485, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646446, Length=246, Percent_Identity=36.9918699186992, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646448, Length=246, Percent_Identity=36.9918699186992, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646452, Length=246, Percent_Identity=36.9918699186992, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646450, Length=246, Percent_Identity=36.9918699186992, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI62472511, Length=246, Percent_Identity=36.9918699186992, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=32.4626865671642, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24585516, Length=256, Percent_Identity=31.25, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37081; Mature: 37081

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGLILAGLILAARKERRGGPPPERSAPLPASRPKILITTRLFDDAATRFLEAQGFEVVP
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEECC
SGLPGDALDSNIPDADLNALLEGAAGWIVGQRAVTRDVLAAHPQLKVIARRGVGYDRVDV
CCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHCCCCCCCCCH
DAARDLGRVVTIAAGANDPAVADHTIALMLAVLRRLKASQAAIARGDWRVLVGADLTGKT
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCE
VGLIGFGRIGRQVARRLSGFDVTVLVTSRTPDPEAAGVTFVALDELIARSDVVSLHAPLV
EEEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHEECCCCC
PETRHVINAATLKAMKRSAVVVNTSRGGLIDDATLLAALEAGEIAGAGLDVFEAEADEAL
CCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHH
HPLAEALAARENVVATAHAAGSSEEALARGNLISAQCVAAALAGAPFPPGCLIADGRVK
HHHHHHHHHHHCEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCC
>Mature Secondary Structure
MCGLILAGLILAARKERRGGPPPERSAPLPASRPKILITTRLFDDAATRFLEAQGFEVVP
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEECC
SGLPGDALDSNIPDADLNALLEGAAGWIVGQRAVTRDVLAAHPQLKVIARRGVGYDRVDV
CCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEHHHCCCCCCCCCH
DAARDLGRVVTIAAGANDPAVADHTIALMLAVLRRLKASQAAIARGDWRVLVGADLTGKT
HHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCE
VGLIGFGRIGRQVARRLSGFDVTVLVTSRTPDPEAAGVTFVALDELIARSDVVSLHAPLV
EEEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHEECCCCC
PETRHVINAATLKAMKRSAVVVNTSRGGLIDDATLLAALEAGEIAGAGLDVFEAEADEAL
CCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCHHHHH
HPLAEALAARENVVATAHAAGSSEEALARGNLISAQCVAAALAGAPFPPGCLIADGRVK
HHHHHHHHHHHCEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]