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The map label for this gene is fhuB [H]

Identifier: 154246722

GI number: 154246722

Start: 3081764

End: 3083737

Strand: Direct

Name: fhuB [H]

Synonym: Xaut_2783

Alternate gene names: 154246722

Gene position: 3081764-3083737 (Clockwise)

Preceding gene: 154246721

Following gene: 154246723

Centisome position: 58.05

GC content: 72.8

Gene sequence:

>1974_bases
ATGCCCGTGGCTGAACGTTCCGTCCGCCTGTTCCGTCCCGCCGTGCTGGTGCTGGCGGTGTTCGCCGCAGCGCTGAGCGC
GGAGAGCCTTTATGCCCGCATCGGCACCGGCTCGCTGGTGCAGGCGCTGGTCCGCCCTGGCCCCATGGGTGAGGTGGTGG
TGCATTTCAGCTGGCTGCCGCGCCTGCTGGTGTCGTGGCTGTGCGGGGCGGCGCTTGGTCTTTCGGGCGTGCTGATGCAG
CAGGTGCTGCGCAATCCGCTGGCCTCGCCCACCACGCTGGGCGTGTCCGCCGGCGCCCACCTTGCCCTCGTGGTGGCGAC
CCTGGCGGTGCCGGGCCTTGCCGGCTTCGGGCGCGAGGCGGTGGCGCTGGCGGGCAGCGGTGTTGCCGCCGTGCTGGTGT
TCTCGCTGGCTTGGAACAAGGGGCTGGCGCCGCTCGCGGTGGTGCTGGCGGGCATGGTGGTGAGCCTCTATTTCGGCGCC
CTCGGCGCCACTCTGGTGCTGTTCAACCAGAATTATCTCGCCGGCCTGTTCATCTGGGGCGCGGGCTCCCTCGCCCAGCA
GGATTGGGATGTGGTGGTGCATCTGGCGCCGCTGGTGGCGGCTTCGGGCCTCGGCGCGGCGCTGATGGTGCGCCCGCTGG
CGCTGCTCGATCTCGATGAAGAGGGCGCGCGCAGCCTCGGCGTGCCGCTGGTGGGGCTGCGCCTCGCGGCGCTGGCGCTG
GCGGTGGTGCTGGCGGCGGCGGTGGTGAGCGCGGTGGGCGTGGTGGGCTTCATCGGCCTCGCCGCGCCGGCGCTGGCGAC
GCTTGCCGGCGCGCGCACTTTCGCCGCCCGGCTGGTGTGGGGACCACTCATCGGCGCGGTGCTGCTGTGGCTCACCGATC
AACTGGTGCAATTGCTGGCCGGGCTCTATGGCGATCTGGTGCCCACCGGCGCGCTCACCGCTCTGTTCGGCACGCCTCTG
CTGCTGTGGCTGCTGCCCCGGCTTCAACGTGATGTCCGTCCGCCGCGCATGGTCGCCCCGGTACTGGAGCCGCGTTTGGA
GAGGCCGGGGCTGGCGCTGGGCCAGGTGGCCGTCGTGCTCTGCGTGCTGCTGTTGCCGGCGCTGCTGCTGTCCCACCTTG
CGGGCGGCTGGAGCCTCGATCTGTCCGGCGATTTCCTGGACTGGCGCTGGCCACGGGTGGCGGCGGCGCTGGCCGCCGGC
GGCCTCCTCGCCATGGCGGGAACCGTGACCCAGCGCGTCACCGGCAATCCCATGGCGAGCCCGGAAGTTCTGGGCCTCAC
CTCGGGCGCGGCTTTGGCCCTCATCGTGGTGGTGATGGCGCTGCCCGGCGCCGACCGCGCCACCGAGATCGCGGCCGGCG
CGGCCGGCGCGGCGCTCACCACCTTCGGCCTGCTGGCGCTGACCCGCCGCGCCGCGTTCGCGCCGGACAGCATATTGCTC
GCCGGCATCGCGCTGGGGGCCCTGTTCGACGCTTTGGTGGTGGCAGTGACGGCCTCCGGCGATCCGCGCGCCATGACGCT
TCTGGCGTGGCTCGCCGGGTCCACCGCGCGCGTTGGGGGAGCCGAAGCGGTCACCGGCCTCGTCGCCCTCGCGGTGCTGG
GGGCGGCGGCAGTGCCGTTCAGCCGCTGGCTCGATCTGTTGCCGCTGGGCACGGTGACCGCCGGCGCCGTGGGGGTGGAC
GTGAAGCTCGCCCGCCTGCTGCTGCTGCTGCTCACGGCGGTGATGACCGCCACCGCCACGCTGATCGTGGGGCCGCTGAC
CTTCGTGGGCCTGCTGGCGCCGCACCTCGCGCGTCTCGCGGGGTTTTCGCGCGCGCTGCCGCATCTGATCGCGGCGGCCT
TCATCGGCGCCCTGGTGATGGTGGGAGCCGATGTTCTGGGGCGCACGCTGATCTATCCCCGGCAGATCCCCACCGGCCTT
CTCGCCACGCTCATCGGCGCGCCCTATCTGCTGTGGCGGATCCGGCGGCTGTGA

Upstream 100 bases:

>100_bases
ACCGTGTGGTCGTTCGGCGGCCTCGTCTCCGCCATGCGCTTTGCCCGCGTGCTGGCCGACCATGCCGCCGCGTCCGCCGT
CTCCGGCGCGAGGAGGGGGG

Downstream 100 bases:

>100_bases
GGGACATCCCATGATCCCCGTCCTCGCCCCCATCTTCCACGGTCCGCTGGAGCCCTATGCGGACACGCTGGTGCTGCCCG
GCGACAAGCCCGGCGCCTTT

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MPVAERSVRLFRPAVLVLAVFAAALSAESLYARIGTGSLVQALVRPGPMGEVVVHFSWLPRLLVSWLCGAALGLSGVLMQ
QVLRNPLASPTTLGVSAGAHLALVVATLAVPGLAGFGREAVALAGSGVAAVLVFSLAWNKGLAPLAVVLAGMVVSLYFGA
LGATLVLFNQNYLAGLFIWGAGSLAQQDWDVVVHLAPLVAASGLGAALMVRPLALLDLDEEGARSLGVPLVGLRLAALAL
AVVLAAAVVSAVGVVGFIGLAAPALATLAGARTFAARLVWGPLIGAVLLWLTDQLVQLLAGLYGDLVPTGALTALFGTPL
LLWLLPRLQRDVRPPRMVAPVLEPRLERPGLALGQVAVVLCVLLLPALLLSHLAGGWSLDLSGDFLDWRWPRVAAALAAG
GLLAMAGTVTQRVTGNPMASPEVLGLTSGAALALIVVVMALPGADRATEIAAGAAGAALTTFGLLALTRRAAFAPDSILL
AGIALGALFDALVVAVTASGDPRAMTLLAWLAGSTARVGGAEAVTGLVALAVLGAAAVPFSRWLDLLPLGTVTAGAVGVD
VKLARLLLLLLTAVMTATATLIVGPLTFVGLLAPHLARLAGFSRALPHLIAAAFIGALVMVGADVLGRTLIYPRQIPTGL
LATLIGAPYLLWRIRRL

Sequences:

>Translated_657_residues
MPVAERSVRLFRPAVLVLAVFAAALSAESLYARIGTGSLVQALVRPGPMGEVVVHFSWLPRLLVSWLCGAALGLSGVLMQ
QVLRNPLASPTTLGVSAGAHLALVVATLAVPGLAGFGREAVALAGSGVAAVLVFSLAWNKGLAPLAVVLAGMVVSLYFGA
LGATLVLFNQNYLAGLFIWGAGSLAQQDWDVVVHLAPLVAASGLGAALMVRPLALLDLDEEGARSLGVPLVGLRLAALAL
AVVLAAAVVSAVGVVGFIGLAAPALATLAGARTFAARLVWGPLIGAVLLWLTDQLVQLLAGLYGDLVPTGALTALFGTPL
LLWLLPRLQRDVRPPRMVAPVLEPRLERPGLALGQVAVVLCVLLLPALLLSHLAGGWSLDLSGDFLDWRWPRVAAALAAG
GLLAMAGTVTQRVTGNPMASPEVLGLTSGAALALIVVVMALPGADRATEIAAGAAGAALTTFGLLALTRRAAFAPDSILL
AGIALGALFDALVVAVTASGDPRAMTLLAWLAGSTARVGGAEAVTGLVALAVLGAAAVPFSRWLDLLPLGTVTAGAVGVD
VKLARLLLLLLTAVMTATATLIVGPLTFVGLLAPHLARLAGFSRALPHLIAAAFIGALVMVGADVLGRTLIYPRQIPTGL
LATLIGAPYLLWRIRRL
>Mature_656_residues
PVAERSVRLFRPAVLVLAVFAAALSAESLYARIGTGSLVQALVRPGPMGEVVVHFSWLPRLLVSWLCGAALGLSGVLMQQ
VLRNPLASPTTLGVSAGAHLALVVATLAVPGLAGFGREAVALAGSGVAAVLVFSLAWNKGLAPLAVVLAGMVVSLYFGAL
GATLVLFNQNYLAGLFIWGAGSLAQQDWDVVVHLAPLVAASGLGAALMVRPLALLDLDEEGARSLGVPLVGLRLAALALA
VVLAAAVVSAVGVVGFIGLAAPALATLAGARTFAARLVWGPLIGAVLLWLTDQLVQLLAGLYGDLVPTGALTALFGTPLL
LWLLPRLQRDVRPPRMVAPVLEPRLERPGLALGQVAVVLCVLLLPALLLSHLAGGWSLDLSGDFLDWRWPRVAAALAAGG
LLAMAGTVTQRVTGNPMASPEVLGLTSGAALALIVVVMALPGADRATEIAAGAAGAALTTFGLLALTRRAAFAPDSILLA
GIALGALFDALVVAVTASGDPRAMTLLAWLAGSTARVGGAEAVTGLVALAVLGAAAVPFSRWLDLLPLGTVTAGAVGVDV
KLARLLLLLLTAVMTATATLIVGPLTFVGLLAPHLARLAGFSRALPHLIAAAFIGALVMVGADVLGRTLIYPRQIPTGLL
ATLIGAPYLLWRIRRL

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=611, Percent_Identity=46.3175122749591, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1790741, Length=280, Percent_Identity=36.0714285714286, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=32.8519855595668, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786805, Length=277, Percent_Identity=36.4620938628159, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1786804, Length=240, Percent_Identity=35, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788004, Length=276, Percent_Identity=31.5217391304348, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 66849; Mature: 66718

Theoretical pI: Translated: 10.87; Mature: 10.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAERSVRLFRPAVLVLAVFAAALSAESLYARIGTGSLVQALVRPGPMGEVVVHFSWLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHH
RLLVSWLCGAALGLSGVLMQQVLRNPLASPTTLGVSAGAHLALVVATLAVPGLAGFGREA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCHH
VALAGSGVAAVLVFSLAWNKGLAPLAVVLAGMVVSLYFGALGATLVLFNQNYLAGLFIWG
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEEC
AGSLAQQDWDVVVHLAPLVAASGLGAALMVRPLALLDLDEEGARSLGVPLVGLRLAALAL
CCHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHH
AVVLAAAVVSAVGVVGFIGLAAPALATLAGARTFAARLVWGPLIGAVLLWLTDQLVQLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLYGDLVPTGALTALFGTPLLLWLLPRLQRDVRPPRMVAPVLEPRLERPGLALGQVAVVL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
CVLLLPALLLSHLAGGWSLDLSGDFLDWRWPRVAAALAAGGLLAMAGTVTQRVTGNPMAS
HHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCC
PEVLGLTSGAALALIVVVMALPGADRATEIAAGAAGAALTTFGLLALTRRAAFAPDSILL
CCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
AGIALGALFDALVVAVTASGDPRAMTLLAWLAGSTARVGGAEAVTGLVALAVLGAAAVPF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCH
SRWLDLLPLGTVTAGAVGVDVKLARLLLLLLTAVMTATATLIVGPLTFVGLLAPHLARLA
HHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFSRALPHLIAAAFIGALVMVGADVLGRTLIYPRQIPTGLLATLIGAPYLLWRIRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure 
PVAERSVRLFRPAVLVLAVFAAALSAESLYARIGTGSLVQALVRPGPMGEVVVHFSWLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHH
RLLVSWLCGAALGLSGVLMQQVLRNPLASPTTLGVSAGAHLALVVATLAVPGLAGFGREA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCHH
VALAGSGVAAVLVFSLAWNKGLAPLAVVLAGMVVSLYFGALGATLVLFNQNYLAGLFIWG
HHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEEC
AGSLAQQDWDVVVHLAPLVAASGLGAALMVRPLALLDLDEEGARSLGVPLVGLRLAALAL
CCHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHH
AVVLAAAVVSAVGVVGFIGLAAPALATLAGARTFAARLVWGPLIGAVLLWLTDQLVQLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLYGDLVPTGALTALFGTPLLLWLLPRLQRDVRPPRMVAPVLEPRLERPGLALGQVAVVL
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
CVLLLPALLLSHLAGGWSLDLSGDFLDWRWPRVAAALAAGGLLAMAGTVTQRVTGNPMAS
HHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCC
PEVLGLTSGAALALIVVVMALPGADRATEIAAGAAGAALTTFGLLALTRRAAFAPDSILL
CCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
AGIALGALFDALVVAVTASGDPRAMTLLAWLAGSTARVGGAEAVTGLVALAVLGAAAVPF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCH
SRWLDLLPLGTVTAGAVGVDVKLARLLLLLLTAVMTATATLIVGPLTFVGLLAPHLARLA
HHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFSRALPHLIAAAFIGALVMVGADVLGRTLIYPRQIPTGLLATLIGAPYLLWRIRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]