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The map label for this gene is ldc [H]

Identifier: 154246672

GI number: 154246672

Start: 3027036

End: 3028334

Strand: Direct

Name: ldc [H]

Synonym: Xaut_2733

Alternate gene names: 154246672

Gene position: 3027036-3028334 (Clockwise)

Preceding gene: 154246667

Following gene: 154246673

Centisome position: 57.02

GC content: 70.28

Gene sequence:

>1299_bases
ATGTCGCAGTCCCGCTTCGCCAGCGCGCCTCCACCCGCAGTTACCGCCGCCGTTGCGACGCCCCGCTTCGCCTCCGGCCG
GGAGGCGGCGCTGCAACTGCGGCCGGACCAGCCGGTCTATTGCTTCCGCCCCCACGTGCTGGCCGCCGATGCCAGGGCCT
TCGTCGAGGCCTTTCCCGGTAAGACCGCCTATGCGGTGAAGACCAATGGCGAGCCCATGGTGCTGGACGTGCTGGCCAAG
GCCGGCATTTCCGCCTTCGACGTAGCCAGCCCCGCCGAGTTCGCTGCCGCCCGCGCCGCAGCTCCGGGGGCGGAGCTGCT
CTACATGCATCCGGTGAAGGCCCAGTCCGACATCCGCCTCGCCCTGGAGCACTACCGCATCCGCTCGACCGCCCTCGACC
ATGAGGACGAGGTGGCCAAGATCGTGCGCATCGTGCGCGCGCTGGATCTGGACCCGGAAGACCTCACCTTGTTCGTGCGC
ATCGCCTCCAAGGGGGACGCGGCCTACGAGCTGTCCAAGAAATTCGGCGCGGCGCCCGGCCATGCGGCGGAACTGCTCCA
GCGCATCCACGGCATCGGCATCAAGTGCGGCCTGTGCTTCCACGTGGGTAGCCAGGTGGAGGACCCGGACACCTATGCCC
GGGCGGTGGCGGTGGCGGCGGAGGTGCGGGCGGCGGCGGGGGTGCCCATCGTCGCCCTCGACGTGGGCGGCGGCTTTCCC
GCCACCTATGCCCGGAACCCGCGTCGCCCGGTGCCGCCCATGCCGCCGCTGGACGAGATCATCTCCGGCCTCATGGGCGC
GGTGGAGCGCAACGGCTTTGCCGGCACCCCGCTGGTAGCCGAGCCGGGGCGGGTGATCGTGGCGCGCGCCTTCTCGGTGA
TCGTGCGTGTGCTGCTGAAGAAGGGGCAGCGGCTCTATATCAATGATGGGATCTGGTCCTCCCTGTCGGATTCGTGGACC
GGCAAGATCCTCCTGCCGGTGCGCCATATCCCGGACCCCGCCCGCCGCCGCCGGCCGGGGAGGGGGGCGTCGGGTAGCGG
GCGGATCGAGCCGTTCCGCATCTATGGCGCCACCTGCGACAGCGTGGACGTGCTCTCGCGCCCCTTCTTCCTGCCCGAGA
GCGTGGACACCGGCGACTGGATCGAGATCGGCCACATCGGGGCCTATTCCCTCTCCCTGCGCACCCGCTTCAATGGGTTT
TATCCCGATACCTTCGTGGAGGTGGAGACCCCCTTCGAGGCGGGCGACGCGCCGGAGGGCTTCGCCGAGCCCGAGCGGCG
CGGCGGCGTGGAGGCTTAA

Upstream 100 bases:

>100_bases
AGGCCGATGGCAGAACGCGGCGGTCCGGTCGTGCTCTCGCCGGAAAAGCGCGGCATGCTTGATCCCCGACTCACCATCCG
TCGGCCGACCGGGAGGGTTC

Downstream 100 bases:

>100_bases
ATCCGAACTTGAACTCGCCGATGTCGGCGAACCTCTCGAACCCGAAACGGTGATCGAGCACACGCCCGTTTGAATTGCCC
CATCGGGGCGACGCCGCGAT

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSQSRFASAPPPAVTAAVATPRFASGREAALQLRPDQPVYCFRPHVLAADARAFVEAFPGKTAYAVKTNGEPMVLDVLAK
AGISAFDVASPAEFAAARAAAPGAELLYMHPVKAQSDIRLALEHYRIRSTALDHEDEVAKIVRIVRALDLDPEDLTLFVR
IASKGDAAYELSKKFGAAPGHAAELLQRIHGIGIKCGLCFHVGSQVEDPDTYARAVAVAAEVRAAAGVPIVALDVGGGFP
ATYARNPRRPVPPMPPLDEIISGLMGAVERNGFAGTPLVAEPGRVIVARAFSVIVRVLLKKGQRLYINDGIWSSLSDSWT
GKILLPVRHIPDPARRRRPGRGASGSGRIEPFRIYGATCDSVDVLSRPFFLPESVDTGDWIEIGHIGAYSLSLRTRFNGF
YPDTFVEVETPFEAGDAPEGFAEPERRGGVEA

Sequences:

>Translated_432_residues
MSQSRFASAPPPAVTAAVATPRFASGREAALQLRPDQPVYCFRPHVLAADARAFVEAFPGKTAYAVKTNGEPMVLDVLAK
AGISAFDVASPAEFAAARAAAPGAELLYMHPVKAQSDIRLALEHYRIRSTALDHEDEVAKIVRIVRALDLDPEDLTLFVR
IASKGDAAYELSKKFGAAPGHAAELLQRIHGIGIKCGLCFHVGSQVEDPDTYARAVAVAAEVRAAAGVPIVALDVGGGFP
ATYARNPRRPVPPMPPLDEIISGLMGAVERNGFAGTPLVAEPGRVIVARAFSVIVRVLLKKGQRLYINDGIWSSLSDSWT
GKILLPVRHIPDPARRRRPGRGASGSGRIEPFRIYGATCDSVDVLSRPFFLPESVDTGDWIEIGHIGAYSLSLRTRFNGF
YPDTFVEVETPFEAGDAPEGFAEPERRGGVEA
>Mature_431_residues
SQSRFASAPPPAVTAAVATPRFASGREAALQLRPDQPVYCFRPHVLAADARAFVEAFPGKTAYAVKTNGEPMVLDVLAKA
GISAFDVASPAEFAAARAAAPGAELLYMHPVKAQSDIRLALEHYRIRSTALDHEDEVAKIVRIVRALDLDPEDLTLFVRI
ASKGDAAYELSKKFGAAPGHAAELLQRIHGIGIKCGLCFHVGSQVEDPDTYARAVAVAAEVRAAAGVPIVALDVGGGFPA
TYARNPRRPVPPMPPLDEIISGLMGAVERNGFAGTPLVAEPGRVIVARAFSVIVRVLLKKGQRLYINDGIWSSLSDSWTG
KILLPVRHIPDPARRRRPGRGASGSGRIEPFRIYGATCDSVDVLSRPFFLPESVDTGDWIEIGHIGAYSLSLRTRFNGFY
PDTFVEVETPFEAGDAPEGFAEPERRGGVEA

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=29.7872340425532, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI16506287, Length=363, Percent_Identity=26.4462809917355, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI22538418, Length=365, Percent_Identity=25.4794520547945, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI21361583, Length=365, Percent_Identity=25.4794520547945, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=30.1369863013699, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322664, Length=369, Percent_Identity=29.2682926829268, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24586472, Length=358, Percent_Identity=27.9329608938547, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24586474, Length=355, Percent_Identity=27.6056338028169, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 46323; Mature: 46192

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSRFASAPPPAVTAAVATPRFASGREAALQLRPDQPVYCFRPHVLAADARAFVEAFPG
CCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEECCCEEHHHHHHHHHHCCC
KTAYAVKTNGEPMVLDVLAKAGISAFDVASPAEFAAARAAAPGAELLYMHPVKAQSDIRL
CEEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHH
ALEHYRIRSTALDHEDEVAKIVRIVRALDLDPEDLTLFVRIASKGDAAYELSKKFGAAPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCC
HAAELLQRIHGIGIKCGLCFHVGSQVEDPDTYARAVAVAAEVRAAAGVPIVALDVGGGFP
HHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
ATYARNPRRPVPPMPPLDEIISGLMGAVERNGFAGTPLVAEPGRVIVARAFSVIVRVLLK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
KGQRLYINDGIWSSLSDSWTGKILLPVRHIPDPARRRRPGRGASGSGRIEPFRIYGATCD
CCCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCC
SVDVLSRPFFLPESVDTGDWIEIGHIGAYSLSLRTRFNGFYPDTFVEVETPFEAGDAPEG
CHHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
FAEPERRGGVEA
CCCHHHCCCCCC
>Mature Secondary Structure 
SQSRFASAPPPAVTAAVATPRFASGREAALQLRPDQPVYCFRPHVLAADARAFVEAFPG
CCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCEEEECCCEEHHHHHHHHHHCCC
KTAYAVKTNGEPMVLDVLAKAGISAFDVASPAEFAAARAAAPGAELLYMHPVKAQSDIRL
CEEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHH
ALEHYRIRSTALDHEDEVAKIVRIVRALDLDPEDLTLFVRIASKGDAAYELSKKFGAAPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCC
HAAELLQRIHGIGIKCGLCFHVGSQVEDPDTYARAVAVAAEVRAAAGVPIVALDVGGGFP
HHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
ATYARNPRRPVPPMPPLDEIISGLMGAVERNGFAGTPLVAEPGRVIVARAFSVIVRVLLK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
KGQRLYINDGIWSSLSDSWTGKILLPVRHIPDPARRRRPGRGASGSGRIEPFRIYGATCD
CCCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCEEEEECCCCC
SVDVLSRPFFLPESVDTGDWIEIGHIGAYSLSLRTRFNGFYPDTFVEVETPFEAGDAPEG
CHHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCC
FAEPERRGGVEA
CCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]