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The map label for this gene is prs [H]

Identifier: 154246494

GI number: 154246494

Start: 2846954

End: 2847907

Strand: Direct

Name: prs [H]

Synonym: Xaut_2553

Alternate gene names: 154246494

Gene position: 2846954-2847907 (Clockwise)

Preceding gene: 154246493

Following gene: 154246495

Centisome position: 53.63

GC content: 66.35

Gene sequence:

>954_bases
ATGTCAGCGGAGAACGGTCCCATGAAGCTCGTCGCGGGCAACTCAAACCGCGCGCTCGCTGAAGCCATCGCCGCTTATCT
CGCCACCCCGCTGACCAAGGCGGTGGTGCGACGCTTCGCGGACATGGAAATCTTCGTCGAGATCCAGGAAAACGTGCGCG
GGCAGGATGTGTTCGTGGTGCAGTCCACGGCCTTTCCGGCGAACGACCGCCTGATGGAGCTGCTCATCATCATCGATGCG
CTGCGGCGGGCCTCGTCCAAGCGCATCACGGCGGTGCTGCCCTATTTCGGCTACGCCCGGCAGGACCGCAAGCCCGGCCC
GCGCACGCCGATCTCCGCCAAGCTGGTGGCCAACCTCATCACCCATGCCGGCGCCGACCGGGTGATGACGCTGGACCTGC
ATGCAGGCCAGATCCAGGGCTTCTTCGACATCCCCACCGACAATCTCTATTCGGCCCCGGTGATGGTGCGCGACATCAAG
GAGCGGTTCGACCTCTCCAACGTCATGGTGGTTTCGCCGGACGTGGGCGGCGTGGTCCGCGCCCGGGCGCTGGCCAAGCG
CATCGACGCCCAGCTCGCCATCGTCGACAAGCGCCGCGAGCGCCCCGGCGAGAGCGAGGTGATGAACGTCATCGGCAATG
TGGAAGGCCGCTCCTGCATCCTGGTGGACGACATCGTCGATTCGGGTGGCACGCTGGTGAACGCGGCCGAGGCTCTGCTG
GCCCGCGGCGCAAAGGAAGTGCACGCCTACATCACCCATGGCGTGCTGTCGGGCGGGGCAGTGGCGCGCATCACCGCGTC
CAAGCTCAAGGAACTGGTGATCACCGATTCGATCCAGCCCACCGAGGCGGTGCGGGTGGCCCGCAACATCCGCGTGCTCT
CCATCGCCACCCTCATCGGCGAGGCCATCGCCCGCACGGCCCACGAAGAATCGGTCTCCAGCCTGTTCGACTGA

Upstream 100 bases:

>100_bases
TCGCCGATGCCTTGGGGCCTTTACAAGATTGTGACGGCCCGCCTATCAGAACGCCTCAAGCTTTCGATCAGCTCCCGGCC
GGACCGGGGCGGAGCGACCC

Downstream 100 bases:

>100_bases
GGCGTGTTGCTGCGGTGGATGGGGCGGAATGTTGCGCGAAAGGGTTGCGGTCCCTTAAATGAAGCCCGACCAATCGGCGG
GGCGGGGGCTCCAGTGCTCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSAENGPMKLVAGNSNRALAEAIAAYLATPLTKAVVRRFADMEIFVEIQENVRGQDVFVVQSTAFPANDRLMELLIIIDA
LRRASSKRITAVLPYFGYARQDRKPGPRTPISAKLVANLITHAGADRVMTLDLHAGQIQGFFDIPTDNLYSAPVMVRDIK
ERFDLSNVMVVSPDVGGVVRARALAKRIDAQLAIVDKRRERPGESEVMNVIGNVEGRSCILVDDIVDSGGTLVNAAEALL
ARGAKEVHAYITHGVLSGGAVARITASKLKELVITDSIQPTEAVRVARNIRVLSIATLIGEAIARTAHEESVSSLFD

Sequences:

>Translated_317_residues
MSAENGPMKLVAGNSNRALAEAIAAYLATPLTKAVVRRFADMEIFVEIQENVRGQDVFVVQSTAFPANDRLMELLIIIDA
LRRASSKRITAVLPYFGYARQDRKPGPRTPISAKLVANLITHAGADRVMTLDLHAGQIQGFFDIPTDNLYSAPVMVRDIK
ERFDLSNVMVVSPDVGGVVRARALAKRIDAQLAIVDKRRERPGESEVMNVIGNVEGRSCILVDDIVDSGGTLVNAAEALL
ARGAKEVHAYITHGVLSGGAVARITASKLKELVITDSIQPTEAVRVARNIRVLSIATLIGEAIARTAHEESVSSLFD
>Mature_316_residues
SAENGPMKLVAGNSNRALAEAIAAYLATPLTKAVVRRFADMEIFVEIQENVRGQDVFVVQSTAFPANDRLMELLIIIDAL
RRASSKRITAVLPYFGYARQDRKPGPRTPISAKLVANLITHAGADRVMTLDLHAGQIQGFFDIPTDNLYSAPVMVRDIKE
RFDLSNVMVVSPDVGGVVRARALAKRIDAQLAIVDKRRERPGESEVMNVIGNVEGRSCILVDDIVDSGGTLVNAAEALLA
RGAKEVHAYITHGVLSGGAVARITASKLKELVITDSIQPTEAVRVARNIRVLSIATLIGEAIARTAHEESVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=45.7792207792208, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=45.8064516129032, Blast_Score=290, Evalue=8e-79,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=45.4838709677419, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=45.3376205787781, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI4506133, Length=352, Percent_Identity=34.6590909090909, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI194018537, Length=351, Percent_Identity=33.9031339031339, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI310128524, Length=141, Percent_Identity=34.0425531914894, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310115209, Length=141, Percent_Identity=34.0425531914894, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310118259, Length=141, Percent_Identity=34.0425531914894, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI310119946, Length=141, Percent_Identity=34.0425531914894, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=52.8846153846154, Blast_Score=338, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=45.8064516129032, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=45.8064516129032, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=45.7792207792208, Blast_Score=286, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=45.8064516129032, Blast_Score=286, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=34.7181008902077, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=45.016077170418, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=45.8064516129032, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=45.8333333333333, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=39.7959183673469, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=46.5116279069767, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=45.1612903225806, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=42.042042042042, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=30.9659090909091, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=30.9659090909091, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=30.9659090909091, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=30.9659090909091, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651462, Length=371, Percent_Identity=30.7277628032345, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24651464, Length=371, Percent_Identity=30.7277628032345, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45552010, Length=371, Percent_Identity=30.7277628032345, Blast_Score=168, Evalue=5e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34247; Mature: 34116

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAENGPMKLVAGNSNRALAEAIAAYLATPLTKAVVRRFADMEIFVEIQENVRGQDVFVV
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHCCCCCEEEEE
QSTAFPANDRLMELLIIIDALRRASSKRITAVLPYFGYARQDRKPGPRTPISAKLVANLI
EECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHH
THAGADRVMTLDLHAGQIQGFFDIPTDNLYSAPVMVRDIKERFDLSNVMVVSPDVGGVVR
HHCCCCCEEEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHH
ARALAKRIDAQLAIVDKRRERPGESEVMNVIGNVEGRSCILVDDIVDSGGTLVNAAEALL
HHHHHHHHHHHHEEEEHHHCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCHHHHHHHHH
ARGAKEVHAYITHGVLSGGAVARITASKLKELVITDSIQPTEAVRVARNIRVLSIATLIG
HCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
EAIARTAHEESVSSLFD
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAENGPMKLVAGNSNRALAEAIAAYLATPLTKAVVRRFADMEIFVEIQENVRGQDVFVV
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEHHCCCCCEEEEE
QSTAFPANDRLMELLIIIDALRRASSKRITAVLPYFGYARQDRKPGPRTPISAKLVANLI
EECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHH
THAGADRVMTLDLHAGQIQGFFDIPTDNLYSAPVMVRDIKERFDLSNVMVVSPDVGGVVR
HHCCCCCEEEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHH
ARALAKRIDAQLAIVDKRRERPGESEVMNVIGNVEGRSCILVDDIVDSGGTLVNAAEALL
HHHHHHHHHHHHEEEEHHHCCCCHHHHHHHHHCCCCCEEEEEEHHHCCCCCHHHHHHHHH
ARGAKEVHAYITHGVLSGGAVARITASKLKELVITDSIQPTEAVRVARNIRVLSIATLIG
HCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
EAIARTAHEESVSSLFD
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]