Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 154245953

GI number: 154245953

Start: 2267184

End: 2268167

Strand: Reverse

Name: adhA [H]

Synonym: Xaut_2010

Alternate gene names: 154245953

Gene position: 2268167-2267184 (Counterclockwise)

Preceding gene: 154245954

Following gene: 154245945

Centisome position: 42.72

GC content: 72.36

Gene sequence:

>984_bases
ATGCTCGCCATGGTCCTGAAGCGCAGCGGCGACAGGTTGGTCGCGCAGGAGCGGCCCGACCCGGTCGCGGGACCGGGCGA
GGTGTTGATCGCGGTCACCGCCTGCGGCGTCTGCCGCACCGACCTCCATGTGGTGGACGGGGAACTGCCCCAGACCGTGC
GTCCCATCGTGCCCGGCCATGAGATCGTCGGGCGGGTGGCGATGCTGGGTGCCGGCGTGTCCCACCTCAGGCTCGGAGAG
CGGGTGGGCGTGGGCTGGCTCGGCCACGCCTGCGGCACCTGCCCCTATTGCGCCGCGCAGGAGGAAAACCTCTGCGACAC
TCCCGCCTTCACCGGCTGCACGCGGGACGGCGGCTTCGCCACTCACACGGTGGCGGATGCCAGCTTCGTCTATCCCCTCG
GCGAAGCGGGCGACGACACCGCGCTGGCGCCGCTGCTCTGCGCCGGCCTCATCGGCTGGCGCACCCTGAAGATGGCGGGG
GAAGGCCGGCGCGTCGGCGTCTACGGCTTCGGCGCGGCGGCTCACATCATCGCCCAGGTGGCCCGCTTCCAGGGCAGGGA
GATCTATGCCTTCACCCGGCCTGGGGATGAGGCGGCGCAGGACTTCGCCCGCTCCCTCGGCGCCGTCTATGCCGGCCCCT
CCGACGCCCCCGCCCCCGAGCCGCTGGACGCCGCCCTCATCTTCGCTCCGGCGGGGGAATTGGTGCCGCAGGCCCTGCGC
GCCGTGCGCAAGGGCGGACGCGTGGTGTGCGGCGGCATCCATATGAGCGACATCCCCTCCTTCCCCTATCGCTGGCTGTG
GGAGGAGCGGAAGATCCTGTCGGTGGCGAACCTGACCCGGGCGGATGCCCACGAGTTCCTGGCGCTGGCCCCCAAGGCCG
GCGTCACCACCCATGTGACGCCCTATCCCCTGGCGCAGGCCAACGAAGCGCTGGACGACCTGCGCCACGGCCGCCTGAAG
GGCGCGGCCGTGCTGGTGCCGTGA

Upstream 100 bases:

>100_bases
TCGACCGATGCCGAGCGAGTTACGCTCAAACGCCGCGCGGGCTTGACCGATGGCGGGTGAGCTTCTCTCACCCGCCATCG
GTCAATTCTCGGAGGTCCGC

Downstream 100 bases:

>100_bases
CCCCGAGGCCGGAACGTCCTCAACGCTGCATCACATAGGTGCCCGGCGCCGGCCCGAGCGCCGGATAGCCGGGGCCGCCG
ATCTTCGGCAGGCCCACCGG

Product: alcohol dehydrogenase zinc-binding type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MLAMVLKRSGDRLVAQERPDPVAGPGEVLIAVTACGVCRTDLHVVDGELPQTVRPIVPGHEIVGRVAMLGAGVSHLRLGE
RVGVGWLGHACGTCPYCAAQEENLCDTPAFTGCTRDGGFATHTVADASFVYPLGEAGDDTALAPLLCAGLIGWRTLKMAG
EGRRVGVYGFGAAAHIIAQVARFQGREIYAFTRPGDEAAQDFARSLGAVYAGPSDAPAPEPLDAALIFAPAGELVPQALR
AVRKGGRVVCGGIHMSDIPSFPYRWLWEERKILSVANLTRADAHEFLALAPKAGVTTHVTPYPLAQANEALDDLRHGRLK
GAAVLVP

Sequences:

>Translated_327_residues
MLAMVLKRSGDRLVAQERPDPVAGPGEVLIAVTACGVCRTDLHVVDGELPQTVRPIVPGHEIVGRVAMLGAGVSHLRLGE
RVGVGWLGHACGTCPYCAAQEENLCDTPAFTGCTRDGGFATHTVADASFVYPLGEAGDDTALAPLLCAGLIGWRTLKMAG
EGRRVGVYGFGAAAHIIAQVARFQGREIYAFTRPGDEAAQDFARSLGAVYAGPSDAPAPEPLDAALIFAPAGELVPQALR
AVRKGGRVVCGGIHMSDIPSFPYRWLWEERKILSVANLTRADAHEFLALAPKAGVTTHVTPYPLAQANEALDDLRHGRLK
GAAVLVP
>Mature_327_residues
MLAMVLKRSGDRLVAQERPDPVAGPGEVLIAVTACGVCRTDLHVVDGELPQTVRPIVPGHEIVGRVAMLGAGVSHLRLGE
RVGVGWLGHACGTCPYCAAQEENLCDTPAFTGCTRDGGFATHTVADASFVYPLGEAGDDTALAPLLCAGLIGWRTLKMAG
EGRRVGVYGFGAAAHIIAQVARFQGREIYAFTRPGDEAAQDFARSLGAVYAGPSDAPAPEPLDAALIFAPAGELVPQALR
AVRKGGRVVCGGIHMSDIPSFPYRWLWEERKILSVANLTRADAHEFLALAPKAGVTTHVTPYPLAQANEALDDLRHGRLK
GAAVLVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081918, Length=319, Percent_Identity=29.7805642633229, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082401, Length=335, Percent_Identity=27.1641791044776, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786518, Length=196, Percent_Identity=38.7755102040816, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787863, Length=184, Percent_Identity=32.0652173913043, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI226510992, Length=131, Percent_Identity=31.2977099236641, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790045, Length=272, Percent_Identity=27.2058823529412, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786825, Length=90, Percent_Identity=34.4444444444444, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=269, Percent_Identity=27.8810408921933, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=329, Percent_Identity=24.3161094224924, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=156, Percent_Identity=30.7692307692308, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=340, Percent_Identity=27.0588235294118, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=26.4880952380952, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=208, Percent_Identity=32.2115384615385, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=159, Percent_Identity=33.9622641509434, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319949, Length=201, Percent_Identity=33.8308457711443, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323980, Length=177, Percent_Identity=33.8983050847458, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34408; Mature: 34408

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAMVLKRSGDRLVAQERPDPVAGPGEVLIAVTACGVCRTDLHVVDGELPQTVRPIVPGH
CEEEEEECCCCEEEECCCCCCCCCCCCEEEEEECCCHHHCCCEEECCCCCCHHCCCCCCH
EIVGRVAMLGAGVSHLRLGERVGVGWLGHACGTCPYCAAQEENLCDTPAFTGCTRDGGFA
HHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
THTVADASFVYPLGEAGDDTALAPLLCAGLIGWRTLKMAGEGRRVGVYGFGAAAHIIAQV
EEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCHHHHHHHHH
ARFQGREIYAFTRPGDEAAQDFARSLGAVYAGPSDAPAPEPLDAALIFAPAGELVPQALR
HHHCCCEEEEEECCCHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEECCCHHHHHHHHH
AVRKGGRVVCGGIHMSDIPSFPYRWLWEERKILSVANLTRADAHEFLALAPKAGVTTHVT
HHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEECCC
PYPLAQANEALDDLRHGRLKGAAVLVP
CCCCHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MLAMVLKRSGDRLVAQERPDPVAGPGEVLIAVTACGVCRTDLHVVDGELPQTVRPIVPGH
CEEEEEECCCCEEEECCCCCCCCCCCCEEEEEECCCHHHCCCEEECCCCCCHHCCCCCCH
EIVGRVAMLGAGVSHLRLGERVGVGWLGHACGTCPYCAAQEENLCDTPAFTGCTRDGGFA
HHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
THTVADASFVYPLGEAGDDTALAPLLCAGLIGWRTLKMAGEGRRVGVYGFGAAAHIIAQV
EEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCHHHHHHHHH
ARFQGREIYAFTRPGDEAAQDFARSLGAVYAGPSDAPAPEPLDAALIFAPAGELVPQALR
HHHCCCEEEEEECCCHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEECCCHHHHHHHHH
AVRKGGRVVCGGIHMSDIPSFPYRWLWEERKILSVANLTRADAHEFLALAPKAGVTTHVT
HHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEECCC
PYPLAQANEALDDLRHGRLKGAAVLVP
CCCCHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]