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The map label for this gene is penA [H]

Identifier: 154245794

GI number: 154245794

Start: 2082004

End: 2083848

Strand: Reverse

Name: penA [H]

Synonym: Xaut_1850

Alternate gene names: 154245794

Gene position: 2083848-2082004 (Counterclockwise)

Preceding gene: 154245795

Following gene: 154245793

Centisome position: 39.25

GC content: 67.37

Gene sequence:

>1845_bases
GTGCTGCTGGACACCGTCGGCCGCTATGCCGCCGCCGCCGGCCGCGCCGTGCTGCGCGCCCTGCGCCGCGCCGCCATCGC
CACCTGGAACGTCGCCTCGGCGCTCGCGGTGCGCCTCGGCCACCTCGCCTGGCGCGCCGGCCGGCATATGGTGCGCGGCT
TGTTCGGCCTCGACCGGGGCGATGCGGACACGGTGGCGCGCGGACGCATCAAGCTGATCATGTTCGCCTTCTGCGCGGTG
TTCATCGCCATCGCGACGCAGCTGTCGCACCTCGCCATCATCTCTGATCCCGGCGCCACCCGCGGCCGCAGCACGGACGC
GGTGAGCTCGGCGCGCCCGGATATCATCGATCGCAACGGCGACATCATTGCCATCGACGTGAAGTCGCCGTCCCTGTTCG
CCGAGCCGCGCCGCCTCATCGATCCCGACGAGGCGCTGGAAGGCCTGCTGAAGGTGCTGCCCGACCTCGACGTGGAGGAA
AGCCGCAAGCGGCTGAATTCCGGCAAGGGCTTCGCCTGGCTGAAGCGGGAGATCACCCCGGCGCAGATGCGCGCCATCCA
CCGCCTCGGCCTGCCCGGCATCGGCTTCCTGAAGGAAAACCGCCGCATCTATCCGGACGGGCCCATCCTGTCCCATGTCA
TGGGCGGCGTGAACGTGGACAACCAGGGCATCTCGGGCCTCGAAAAATACATCGACGGCCGGGGCCTCGCCGAGCTGCAC
CTCGCGGGCTTTGCCACCGACCTCCAGCAGGAGCCGGTGGAGCTGTCCATGGACATGCGGGTCCAGCACGCCGTGCGCGA
CGAGCTGATCCGGGCCAAGAACAAGTTCTCCGCCCTCCACGCCATGGCGGTGGTGACCGATGTCAACACCGGCGAGATCA
TCTCCATGGTGTCGCTGCCGGACTTCGACCCCAACGTGCCCGGCAACCCGAAGGACGACGCCTATCTCAACCGGCTCACC
ACCGGCGTGTTCGAGATGGGCTCCACCTTCAAGGCCCTGTCCTTCGCCATGGCGCTGGATTCCGGCAAGATCGGGCTGAA
CTCCTCGTTCGACGCCCGCGGCGCCATGCATTTCGGCCGCTTCAAGATCTCCGACTACCACGCCGAGAACCGGGTGCTGA
CGGTGCCGGAGATCTTCCTCGCGTCGTCCAACGTGGGCACGGCGAAGATGGTGCTCTCCCTCGGGGTCGAGGCCCACAAG
GCGTTCCTGAAGAAGATGGGCCAGCTCGACCGGCTGCGCACCGAGCTGCCGGAAAGCTCGGAACCCATCGTGCCCAAGCG
CTGGGGCGAACTGAACTCGGCCACCATCGCCTTCGGCCACGGCCTCTCTGTCGCCCCGCTGCAGGCGGTGATGGCGGTGA
ATTCCATGGTGAACGGCGGCTATCTCATCACCCCCACCTTCATCAAGCGCACCCCCGAGGAGGCGCAGAAGGTGGCAGTG
CGGGTGCTGAAGCCCGAGACCTCGGACAAGATGCGCTACATCATGCGCCTCAACGCCGAGAAGGGCACCGCCACCAAGGC
GGAGGTTCCCGGCTATCTGGTGGGCGGCAAGACCGGCACCGCCGAGAAGGTGGTGAACGGGCGCTATGCCAAGAACAAGC
TGCTCACCTCCTTCACCGCGATCTTCCCCATGGACAAGCCGCGCTACCTGGTCCTGGTGATGCTGGATGAGCCCAAGGCC
ACCTCGGAGACCTACGGCTTTGCCACCTCGGGCTGGAACGCGGCGCCCACCGCCGGCAAGATCGTGGAGCGCATCGCGCC
CCTGCTGAACATCGCGCCGCGGCAGAACCTGCCCAATGCGGAACAGCTGCTGCGCATGCCGCTCAAGGTCGCCGACCGTC
ACTGA

Upstream 100 bases:

>100_bases
GGTCGAGAAGACGCCCTTTTCCGCCCGCATCGCCCGTTTCGCCGCCGACACTGCGGCCGCCCTGGGTCCGGAGATCCAGA
AGGCCGACGCCGCCTGCGCG

Downstream 100 bases:

>100_bases
GAGCCCTCGCTCAAGCGCCGCGCGGGCTTGACCTTGGTCGGTGAGAAACGCGCCCCGGCTCTTGGAATCGTCCTTGGCCG
CACATTGATACCACCCGCGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MLLDTVGRYAAAAGRAVLRALRRAAIATWNVASALAVRLGHLAWRAGRHMVRGLFGLDRGDADTVARGRIKLIMFAFCAV
FIAIATQLSHLAIISDPGATRGRSTDAVSSARPDIIDRNGDIIAIDVKSPSLFAEPRRLIDPDEALEGLLKVLPDLDVEE
SRKRLNSGKGFAWLKREITPAQMRAIHRLGLPGIGFLKENRRIYPDGPILSHVMGGVNVDNQGISGLEKYIDGRGLAELH
LAGFATDLQQEPVELSMDMRVQHAVRDELIRAKNKFSALHAMAVVTDVNTGEIISMVSLPDFDPNVPGNPKDDAYLNRLT
TGVFEMGSTFKALSFAMALDSGKIGLNSSFDARGAMHFGRFKISDYHAENRVLTVPEIFLASSNVGTAKMVLSLGVEAHK
AFLKKMGQLDRLRTELPESSEPIVPKRWGELNSATIAFGHGLSVAPLQAVMAVNSMVNGGYLITPTFIKRTPEEAQKVAV
RVLKPETSDKMRYIMRLNAEKGTATKAEVPGYLVGGKTGTAEKVVNGRYAKNKLLTSFTAIFPMDKPRYLVLVMLDEPKA
TSETYGFATSGWNAAPTAGKIVERIAPLLNIAPRQNLPNAEQLLRMPLKVADRH

Sequences:

>Translated_614_residues
MLLDTVGRYAAAAGRAVLRALRRAAIATWNVASALAVRLGHLAWRAGRHMVRGLFGLDRGDADTVARGRIKLIMFAFCAV
FIAIATQLSHLAIISDPGATRGRSTDAVSSARPDIIDRNGDIIAIDVKSPSLFAEPRRLIDPDEALEGLLKVLPDLDVEE
SRKRLNSGKGFAWLKREITPAQMRAIHRLGLPGIGFLKENRRIYPDGPILSHVMGGVNVDNQGISGLEKYIDGRGLAELH
LAGFATDLQQEPVELSMDMRVQHAVRDELIRAKNKFSALHAMAVVTDVNTGEIISMVSLPDFDPNVPGNPKDDAYLNRLT
TGVFEMGSTFKALSFAMALDSGKIGLNSSFDARGAMHFGRFKISDYHAENRVLTVPEIFLASSNVGTAKMVLSLGVEAHK
AFLKKMGQLDRLRTELPESSEPIVPKRWGELNSATIAFGHGLSVAPLQAVMAVNSMVNGGYLITPTFIKRTPEEAQKVAV
RVLKPETSDKMRYIMRLNAEKGTATKAEVPGYLVGGKTGTAEKVVNGRYAKNKLLTSFTAIFPMDKPRYLVLVMLDEPKA
TSETYGFATSGWNAAPTAGKIVERIAPLLNIAPRQNLPNAEQLLRMPLKVADRH
>Mature_614_residues
MLLDTVGRYAAAAGRAVLRALRRAAIATWNVASALAVRLGHLAWRAGRHMVRGLFGLDRGDADTVARGRIKLIMFAFCAV
FIAIATQLSHLAIISDPGATRGRSTDAVSSARPDIIDRNGDIIAIDVKSPSLFAEPRRLIDPDEALEGLLKVLPDLDVEE
SRKRLNSGKGFAWLKREITPAQMRAIHRLGLPGIGFLKENRRIYPDGPILSHVMGGVNVDNQGISGLEKYIDGRGLAELH
LAGFATDLQQEPVELSMDMRVQHAVRDELIRAKNKFSALHAMAVVTDVNTGEIISMVSLPDFDPNVPGNPKDDAYLNRLT
TGVFEMGSTFKALSFAMALDSGKIGLNSSFDARGAMHFGRFKISDYHAENRVLTVPEIFLASSNVGTAKMVLSLGVEAHK
AFLKKMGQLDRLRTELPESSEPIVPKRWGELNSATIAFGHGLSVAPLQAVMAVNSMVNGGYLITPTFIKRTPEEAQKVAV
RVLKPETSDKMRYIMRLNAEKGTATKAEVPGYLVGGKTGTAEKVVNGRYAKNKLLTSFTAIFPMDKPRYLVLVMLDEPKA
TSETYGFATSGWNAAPTAGKIVERIAPLLNIAPRQNLPNAEQLLRMPLKVADRH

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=553, Percent_Identity=30.5605786618445, Blast_Score=188, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66913; Mature: 66913

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLDTVGRYAAAAGRAVLRALRRAAIATWNVASALAVRLGHLAWRAGRHMVRGLFGLDRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DADTVARGRIKLIMFAFCAVFIAIATQLSHLAIISDPGATRGRSTDAVSSARPDIIDRNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHCCCCCCCCCC
DIIAIDVKSPSLFAEPRRLIDPDEALEGLLKVLPDLDVEESRKRLNSGKGFAWLKREITP
CEEEEEECCCCHHHCCHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEHHHCCCH
AQMRAIHRLGLPGIGFLKENRRIYPDGPILSHVMGGVNVDNQGISGLEKYIDGRGLAELH
HHHHHHHHCCCCCCCEECCCCEECCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHH
LAGFATDLQQEPVELSMDMRVQHAVRDELIRAKNKFSALHAMAVVTDVNTGEIISMVSLP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECC
DFDPNVPGNPKDDAYLNRLTTGVFEMGSTFKALSFAMALDSGKIGLNSSFDARGAMHFGR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECE
FKISDYHAENRVLTVPEIFLASSNVGTAKMVLSLGVEAHKAFLKKMGQLDRLRTELPESS
EEEECCCCCCCEEECCHHEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCC
EPIVPKRWGELNSATIAFGHGLSVAPLQAVMAVNSMVNGGYLITPTFIKRTPEEAQKVAV
CCCCCHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEECHHHHCCHHHHHHHHH
RVLKPETSDKMRYIMRLNAEKGTATKAEVPGYLVGGKTGTAEKVVNGRYAKNKLLTSFTA
HHCCCCCHHHHEEHHEECCCCCCCCCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHH
IFPMDKPRYLVLVMLDEPKATSETYGFATSGWNAAPTAGKIVERIAPLLNIAPRQNLPNA
HCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCH
EQLLRMPLKVADRH
HHHHHCCHHHCCCC
>Mature Secondary Structure
MLLDTVGRYAAAAGRAVLRALRRAAIATWNVASALAVRLGHLAWRAGRHMVRGLFGLDRG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DADTVARGRIKLIMFAFCAVFIAIATQLSHLAIISDPGATRGRSTDAVSSARPDIIDRNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHCCCCCCCCCC
DIIAIDVKSPSLFAEPRRLIDPDEALEGLLKVLPDLDVEESRKRLNSGKGFAWLKREITP
CEEEEEECCCCHHHCCHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEHHHCCCH
AQMRAIHRLGLPGIGFLKENRRIYPDGPILSHVMGGVNVDNQGISGLEKYIDGRGLAELH
HHHHHHHHCCCCCCCEECCCCEECCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHH
LAGFATDLQQEPVELSMDMRVQHAVRDELIRAKNKFSALHAMAVVTDVNTGEIISMVSLP
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECC
DFDPNVPGNPKDDAYLNRLTTGVFEMGSTFKALSFAMALDSGKIGLNSSFDARGAMHFGR
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECE
FKISDYHAENRVLTVPEIFLASSNVGTAKMVLSLGVEAHKAFLKKMGQLDRLRTELPESS
EEEECCCCCCCEEECCHHEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCC
EPIVPKRWGELNSATIAFGHGLSVAPLQAVMAVNSMVNGGYLITPTFIKRTPEEAQKVAV
CCCCCHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEECHHHHCCHHHHHHHHH
RVLKPETSDKMRYIMRLNAEKGTATKAEVPGYLVGGKTGTAEKVVNGRYAKNKLLTSFTA
HHCCCCCHHHHEEHHEECCCCCCCCCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHHHHH
IFPMDKPRYLVLVMLDEPKATSETYGFATSGWNAAPTAGKIVERIAPLLNIAPRQNLPNA
HCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCH
EQLLRMPLKVADRH
HHHHHCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]