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The map label for this gene is argH

Identifier: 154245682

GI number: 154245682

Start: 1955242

End: 1956630

Strand: Direct

Name: argH

Synonym: Xaut_1738

Alternate gene names: 154245682

Gene position: 1955242-1956630 (Clockwise)

Preceding gene: 154245676

Following gene: 154245683

Centisome position: 36.83

GC content: 68.32

Gene sequence:

>1389_bases
ATGAGCAACAAGATGTGGGGCGGGCGCTTTACCTCCGCCCCCGACGCCATCATGGAGGAGATCAACGCCTCCATCGGCTT
CGACCAGCGTCTTTATGCGCAGGACATCGCCGGATCCAAGGCCCACGCAAAGATGCTCGCGGCCCAAGGCATCGTGGCGG
CGCAAGATGCCGACAGGATCGCGGAGGGTCTAGACACGATCCTGTCAGAGATCGAGGCCGGCAATTTCACCTTCAAGCGC
GAGCTCGAGGACATCCACATGAACGTGGAGAGCCGCCTCGCCGAGCTGATCGGAGCCTCCGCCGGCCGCCTCCACACCGC
CCGCTCGCGCAACGACCAGGTGGCCACCGACTTCCGCCTCTATGTGCGCGACACATTGGACGCCCTCGACGCCCAGCTCG
CCGACCTGCAGCGGGCTCTGGCCGAGAAGGCGCTGGCCCACGCCGCCACCGTCATGCCCGGCTTCACTCATTTGCAGACC
GCCCAGCCGGTGACCTTCGGCCACCACCTGATGGCCTATGTGGAGATGGTGGCGCGCGACCGCGGCCGCCTCGCCGATGC
GCGCAAGCGCCTGAACGAGTGCCCGCTGGGCTCGGCGGCGCTGGCCGGCACCTCCTTCCCCATCGACAGGGACGCGACCG
CGAAAGCGCTCGGCTTCGACCGGCCCACCGCCAATTCGCTGGACGCCGTCTCCGACCGCGACTTCGTCATGGAGACGCTT
TCAGCCGCCTCCATCTGCGCGGTGCATCTCTCGCGCTTCGCCGAGGAGGTGGTGATCTGGACCTCGCCGTCCTTCGCCCT
GGTGAAGCTCTCGGACAAGTTCACCACCGGCTCGTCCATCATGCCGCAGAAGCGCAACCCGGACGCGGCCGAGCTGGTGC
GGGCCAAGGCCGGGCGCATCATCGGCGCGCTCACCGGCATCCTGGTGGTGATGAAGGGCCTGCCGCTGGCCTATGCCAAG
GACATGCAGGAGGACAAGGAAGGCGCCTTCGACGCCTTCTCGGCTCTGTCCCTGGTGGTGGCGGCCTCGGCCGGCATGGT
GCGCGACATCGTCCCGGACGAGAAGCGCATGGAGAAGGCGGCGGGCCAGGGCTATTCCACCGCCACCGACCTTGCCGACT
GGCTGGTGCGCGCCCTCAACATCCCGTTCCGGGAGGCCCACCACATCACCGGGCGCATCGTCGGGCTCGCCTCCGACCGC
GGCATTGCGCTGCACAAGCTGTCCCTCGACGACATGCAGGGGGTGGATGCGCGGATCACCCAGGACGTGTTCTCGGTGCT
GTCCGTGGTGCGCTCCGTGCGCAGCCGGGTGAGCTATGGCGGCACCGCGCCGACCCGGGTGCGGACCCAGGCCAAGCGCT
GGCTCAAGAAGCTCGGGGTCCCGGCGTGA

Upstream 100 bases:

>100_bases
GCGCCGCCCCTTGGGAGGCGTCGTTGCCGGCCCGGTCGCCGTCTCGTCTGTTTCGGTCGCGCGGGGCTGGTCGGCTTCGG
TCATCACGAGGGGATCCGTC

Downstream 100 bases:

>100_bases
CGCACCCTGCTCCATCACCCATCTCGCAGCGCGGGAGGCGGGGGCTCGCCTTTGGCGCGGCGCGGGCTATAGTGGCGGCC
ACCTTTTCCGGAACGGCCCC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSNKMWGGRFTSAPDAIMEEINASIGFDQRLYAQDIAGSKAHAKMLAAQGIVAAQDADRIAEGLDTILSEIEAGNFTFKR
ELEDIHMNVESRLAELIGASAGRLHTARSRNDQVATDFRLYVRDTLDALDAQLADLQRALAEKALAHAATVMPGFTHLQT
AQPVTFGHHLMAYVEMVARDRGRLADARKRLNECPLGSAALAGTSFPIDRDATAKALGFDRPTANSLDAVSDRDFVMETL
SAASICAVHLSRFAEEVVIWTSPSFALVKLSDKFTTGSSIMPQKRNPDAAELVRAKAGRIIGALTGILVVMKGLPLAYAK
DMQEDKEGAFDAFSALSLVVAASAGMVRDIVPDEKRMEKAAGQGYSTATDLADWLVRALNIPFREAHHITGRIVGLASDR
GIALHKLSLDDMQGVDARITQDVFSVLSVVRSVRSRVSYGGTAPTRVRTQAKRWLKKLGVPA

Sequences:

>Translated_462_residues
MSNKMWGGRFTSAPDAIMEEINASIGFDQRLYAQDIAGSKAHAKMLAAQGIVAAQDADRIAEGLDTILSEIEAGNFTFKR
ELEDIHMNVESRLAELIGASAGRLHTARSRNDQVATDFRLYVRDTLDALDAQLADLQRALAEKALAHAATVMPGFTHLQT
AQPVTFGHHLMAYVEMVARDRGRLADARKRLNECPLGSAALAGTSFPIDRDATAKALGFDRPTANSLDAVSDRDFVMETL
SAASICAVHLSRFAEEVVIWTSPSFALVKLSDKFTTGSSIMPQKRNPDAAELVRAKAGRIIGALTGILVVMKGLPLAYAK
DMQEDKEGAFDAFSALSLVVAASAGMVRDIVPDEKRMEKAAGQGYSTATDLADWLVRALNIPFREAHHITGRIVGLASDR
GIALHKLSLDDMQGVDARITQDVFSVLSVVRSVRSRVSYGGTAPTRVRTQAKRWLKKLGVPA
>Mature_461_residues
SNKMWGGRFTSAPDAIMEEINASIGFDQRLYAQDIAGSKAHAKMLAAQGIVAAQDADRIAEGLDTILSEIEAGNFTFKRE
LEDIHMNVESRLAELIGASAGRLHTARSRNDQVATDFRLYVRDTLDALDAQLADLQRALAEKALAHAATVMPGFTHLQTA
QPVTFGHHLMAYVEMVARDRGRLADARKRLNECPLGSAALAGTSFPIDRDATAKALGFDRPTANSLDAVSDRDFVMETLS
AASICAVHLSRFAEEVVIWTSPSFALVKLSDKFTTGSSIMPQKRNPDAAELVRAKAGRIIGALTGILVVMKGLPLAYAKD
MQEDKEGAFDAFSALSLVVAASAGMVRDIVPDEKRMEKAAGQGYSTATDLADWLVRALNIPFREAHHITGRIVGLASDRG
IALHKLSLDDMQGVDARITQDVFSVLSVVRSVRSRVSYGGTAPTRVRTQAKRWLKKLGVPA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=455, Percent_Identity=43.7362637362637, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=455, Percent_Identity=43.7362637362637, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI68303547, Length=455, Percent_Identity=41.5384615384615, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI68303549, Length=455, Percent_Identity=41.3186813186813, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1790398, Length=444, Percent_Identity=48.8738738738739, Blast_Score=415, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=42.6991150442478, Blast_Score=373, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221473854, Length=454, Percent_Identity=40.7488986784141, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI78706858, Length=454, Percent_Identity=40.7488986784141, Blast_Score=345, Evalue=3e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_XANP2 (A7IG40)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001416640.1
- ProteinModelPortal:   A7IG40
- SMR:   A7IG40
- STRING:   A7IG40
- GeneID:   5423328
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_1738
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   CLSK2516665
- BioCyc:   XAUT78245:XAUT_1738-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 49958; Mature: 49826

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKMWGGRFTSAPDAIMEEINASIGFDQRLYAQDIAGSKAHAKMLAAQGIVAAQDADRI
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHH
AEGLDTILSEIEAGNFTFKRELEDIHMNVESRLAELIGASAGRLHTARSRNDQVATDFRL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHH
YVRDTLDALDAQLADLQRALAEKALAHAATVMPGFTHLQTAQPVTFGHHLMAYVEMVARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
RGRLADARKRLNECPLGSAALAGTSFPIDRDATAKALGFDRPTANSLDAVSDRDFVMETL
HCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHH
SAASICAVHLSRFAEEVVIWTSPSFALVKLSDKFTTGSSIMPQKRNPDAAELVRAKAGRI
HHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IGALTGILVVMKGLPLAYAKDMQEDKEGAFDAFSALSLVVAASAGMVRDIVPDEKRMEKA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHH
AGQGYSTATDLADWLVRALNIPFREAHHITGRIVGLASDRGIALHKLSLDDMQGVDARIT
HCCCCCHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCCEEEEEECCHHHCCCHHHHH
QDVFSVLSVVRSVRSRVSYGGTAPTRVRTQAKRWLKKLGVPA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNKMWGGRFTSAPDAIMEEINASIGFDQRLYAQDIAGSKAHAKMLAAQGIVAAQDADRI
CCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHH
AEGLDTILSEIEAGNFTFKRELEDIHMNVESRLAELIGASAGRLHTARSRNDQVATDFRL
HHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHH
YVRDTLDALDAQLADLQRALAEKALAHAATVMPGFTHLQTAQPVTFGHHLMAYVEMVARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
RGRLADARKRLNECPLGSAALAGTSFPIDRDATAKALGFDRPTANSLDAVSDRDFVMETL
HCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHH
SAASICAVHLSRFAEEVVIWTSPSFALVKLSDKFTTGSSIMPQKRNPDAAELVRAKAGRI
HHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IGALTGILVVMKGLPLAYAKDMQEDKEGAFDAFSALSLVVAASAGMVRDIVPDEKRMEKA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHH
AGQGYSTATDLADWLVRALNIPFREAHHITGRIVGLASDRGIALHKLSLDDMQGVDARIT
HCCCCCHHHHHHHHHHHHHCCCHHHHHHHCEEEEEEECCCCEEEEEECCHHHCCCHHHHH
QDVFSVLSVVRSVRSRVSYGGTAPTRVRTQAKRWLKKLGVPA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA