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The map label for this gene is trpA

Identifier: 154245639

GI number: 154245639

Start: 1907274

End: 1908119

Strand: Direct

Name: trpA

Synonym: Xaut_1695

Alternate gene names: 154245639

Gene position: 1907274-1908119 (Clockwise)

Preceding gene: 154245638

Following gene: 154245640

Centisome position: 35.93

GC content: 70.57

Gene sequence:

>846_bases
TTGCATCCAGGCAGGCCCATGACCACGCGCATCTCCACCCGCTTCGCCGCGCTGAAAGAGGAAGGCCGCCCCGGCCTCGT
CACCTTCGTCACGGCGGGCGATCCGGACGGGGAGACCTCCCTCGCCATCCTCAAGGCGCTGCCCGGCGCCGGCGCGGACG
TGATCGAGCTGGGCATTCCCTTCACCGATCCCATGGCCGACGGCCCGGCCATCCAGGCGGCGGGCCTGCGCGCGCTCAAG
GGCGGCCAGACCCTGGCCAAGACCATCGAGATGGTCCGGGTCTTCCGCACCGAGGACACCACCACGCCGGTGGTGCTCAT
GGGCTATTTCAATCCCATCTACATCTATGGCGTGGACCGCTTCCTCACCGACGCCAAGGTGGCGGGGGTGGACGGCCTCA
TCGTGGTGGACCTGCCGCCGGAGGAGGACGACGAGCTCTGCCTGCCAGCCCTGAACGCCGGGCTCGACTTCATCCGCCTC
GCCACCCCCACCACCGACGACAAGCGCCTGCCGACGGTGCTCGAGCACACGGCGGGCTTCGTCTATTACGTCTCCATCAC
CGGCATCACCGGCTCGGCGACGCCGGACGCGGATCTGGTGGCCGCCGCCGTCGCCCGCATCAAGTCCCACACCGACCTGC
CGGTGGCCGTGGGCTTCGGCGTGCGGACGCCGGAACAGGCCAAGGCCATCGCCGCCGGTGCCGACGCGGTGGTGGTGGGC
TCCGCCCTGGTGGAGGTGGTGCGCCGCACCCTCGATGCCGAGGGCAACGCCACCGCCAACACCCTGCCGGGCGTGGAAGC
GCTGGTGAGCGAACTGGCCGAGGCGGTGCGCAGCATCAAGCGCTGA

Upstream 100 bases:

>100_bases
ATCAGCCTCGGTCATCGACCGAGGCTGAGTGGGTACGCTCAAGCGCCACACGGGCCAGCCCCGTGTCCCGGGGAGCTTTC
TCCCGCGCCCTCCTCTTTCC

Downstream 100 bases:

>100_bases
GGCACCTGCCCCCTTAAGCCGGGCGAGGGAGGCACCGGGGTAGACGAATGTGCGGCCCGGCTTCGTCCTGCCGCACTTTC
GCCGCGTCGCGCTTGCCATT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MHPGRPMTTRISTRFAALKEEGRPGLVTFVTAGDPDGETSLAILKALPGAGADVIELGIPFTDPMADGPAIQAAGLRALK
GGQTLAKTIEMVRVFRTEDTTTPVVLMGYFNPIYIYGVDRFLTDAKVAGVDGLIVVDLPPEEDDELCLPALNAGLDFIRL
ATPTTDDKRLPTVLEHTAGFVYYVSITGITGSATPDADLVAAAVARIKSHTDLPVAVGFGVRTPEQAKAIAAGADAVVVG
SALVEVVRRTLDAEGNATANTLPGVEALVSELAEAVRSIKR

Sequences:

>Translated_281_residues
MHPGRPMTTRISTRFAALKEEGRPGLVTFVTAGDPDGETSLAILKALPGAGADVIELGIPFTDPMADGPAIQAAGLRALK
GGQTLAKTIEMVRVFRTEDTTTPVVLMGYFNPIYIYGVDRFLTDAKVAGVDGLIVVDLPPEEDDELCLPALNAGLDFIRL
ATPTTDDKRLPTVLEHTAGFVYYVSITGITGSATPDADLVAAAVARIKSHTDLPVAVGFGVRTPEQAKAIAAGADAVVVG
SALVEVVRRTLDAEGNATANTLPGVEALVSELAEAVRSIKR
>Mature_281_residues
MHPGRPMTTRISTRFAALKEEGRPGLVTFVTAGDPDGETSLAILKALPGAGADVIELGIPFTDPMADGPAIQAAGLRALK
GGQTLAKTIEMVRVFRTEDTTTPVVLMGYFNPIYIYGVDRFLTDAKVAGVDGLIVVDLPPEEDDELCLPALNAGLDFIRL
ATPTTDDKRLPTVLEHTAGFVYYVSITGITGSATPDADLVAAAVARIKSHTDLPVAVGFGVRTPEQAKAIAAGADAVVVG
SALVEVVRRTLDAEGNATANTLPGVEALVSELAEAVRSIKR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=270, Percent_Identity=36.2962962962963, Blast_Score=159, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321412, Length=240, Percent_Identity=45.8333333333333, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29345; Mature: 29345

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPGRPMTTRISTRFAALKEEGRPGLVTFVTAGDPDGETSLAILKALPGAGADVIELGIP
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEECCC
FTDPMADGPAIQAAGLRALKGGQTLAKTIEMVRVFRTEDTTTPVVLMGYFNPIYIYGVDR
CCCCCCCCCCCHHHCHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEHHH
FLTDAKVAGVDGLIVVDLPPEEDDELCLPALNAGLDFIRLATPTTDDKRLPTVLEHTAGF
HHCCCCCCCCCCEEEEECCCCCCCCEEHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCE
VYYVSITGITGSATPDADLVAAAVARIKSHTDLPVAVGFGVRTPEQAKAIAAGADAVVVG
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHH
SALVEVVRRTLDAEGNATANTLPGVEALVSELAEAVRSIKR
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHPGRPMTTRISTRFAALKEEGRPGLVTFVTAGDPDGETSLAILKALPGAGADVIELGIP
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEECCC
FTDPMADGPAIQAAGLRALKGGQTLAKTIEMVRVFRTEDTTTPVVLMGYFNPIYIYGVDR
CCCCCCCCCCCHHHCHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEHHH
FLTDAKVAGVDGLIVVDLPPEEDDELCLPALNAGLDFIRLATPTTDDKRLPTVLEHTAGF
HHCCCCCCCCCCEEEEECCCCCCCCEEHHHHHCCCCEEEEECCCCCCCCCHHHHHHCCCE
VYYVSITGITGSATPDADLVAAAVARIKSHTDLPVAVGFGVRTPEQAKAIAAGADAVVVG
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHH
SALVEVVRRTLDAEGNATANTLPGVEALVSELAEAVRSIKR
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA