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The map label for this gene is hisI [H]

Identifier: 154245592

GI number: 154245592

Start: 1867628

End: 1868122

Strand: Reverse

Name: hisI [H]

Synonym: Xaut_1648

Alternate gene names: 154245592

Gene position: 1868122-1867628 (Counterclockwise)

Preceding gene: 154245593

Following gene: 154245591

Centisome position: 35.19

GC content: 67.88

Gene sequence:

>495_bases
ATGAGTTCCGAAATATCATCCCCCTTCGCCTTCCCCGCCCCCGGCAAGGGCGCGGCGCTGGAGGAGGACACCCTCCTCTC
CCCCCGCTTCGACGCCAACGGCCTCATCACCTGCGTCGCGGTGGATGCCGTGACCGGCGAGGTGCTGATGCTCGCCCACA
TGAACGCGCAGGCCCTCGCCCTCACCATCGAGACCGGAGAGGCGCATTATTTCAGCCGCTCCCGCGGCAAGCTCTGGAAG
AAGGGCGAAACCTCCGGCCACACCCAGAAGGTGCGGGAGATGCGCATCGACTGCGACCAGGACGCGGTGGTGATCAAGGT
GGAGATGGGCGGCACGGGCGCGGCCTGCCACACCGGCCGGCGGTCCTGCTTCTACCGCACCATACCGCTCGGCGCGGCGC
CCTCGGCCGAATTGAAGCTCGCCTTCACCGGTGACGCGCCGCGTTTCGATCCCGCTGCCGTCTACGGCAAGGACGGCCAC
GGTCACGATCACTGA

Upstream 100 bases:

>100_bases
GGGTCCTGACCACCGGTCCTGACCGGGCGTACTTGACGTTCAAACTTCATCGGGGCGTTCCTGCCATGCAGGGACGCCCC
TTTACTTTCGGCGAGAGACC

Downstream 100 bases:

>100_bases
AACGGTAAAATAGCGCCACGCTTCCGACACCGGAAATTAGTAACCTGCTGCCAAGCTCCGGAGCACGCGCCGATCCTGCC
ATCGAAAGAGGGCGGGCACC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSSEISSPFAFPAPGKGAALEEDTLLSPRFDANGLITCVAVDAVTGEVLMLAHMNAQALALTIETGEAHYFSRSRGKLWK
KGETSGHTQKVREMRIDCDQDAVVIKVEMGGTGAACHTGRRSCFYRTIPLGAAPSAELKLAFTGDAPRFDPAAVYGKDGH
GHDH

Sequences:

>Translated_164_residues
MSSEISSPFAFPAPGKGAALEEDTLLSPRFDANGLITCVAVDAVTGEVLMLAHMNAQALALTIETGEAHYFSRSRGKLWK
KGETSGHTQKVREMRIDCDQDAVVIKVEMGGTGAACHTGRRSCFYRTIPLGAAPSAELKLAFTGDAPRFDPAAVYGKDGH
GHDH
>Mature_163_residues
SSEISSPFAFPAPGKGAALEEDTLLSPRFDANGLITCVAVDAVTGEVLMLAHMNAQALALTIETGEAHYFSRSRGKLWKK
GETSGHTQKVREMRIDCDQDAVVIKVEMGGTGAACHTGRRSCFYRTIPLGAAPSAELKLAFTGDAPRFDPAAVYGKDGHG
HDH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=93, Percent_Identity=43.010752688172, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=106, Percent_Identity=38.6792452830189, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 17461; Mature: 17330

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEISSPFAFPAPGKGAALEEDTLLSPRFDANGLITCVAVDAVTGEVLMLAHMNAQALA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEECCCEEEE
LTIETGEAHYFSRSRGKLWKKGETSGHTQKVREMRIDCDQDAVVIKVEMGGTGAACHTGR
EEEECCCCEEEECCCCCEEECCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCEECCCC
RSCFYRTIPLGAAPSAELKLAFTGDAPRFDPAAVYGKDGHGHDH
CCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SSEISSPFAFPAPGKGAALEEDTLLSPRFDANGLITCVAVDAVTGEVLMLAHMNAQALA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEECCCEEEE
LTIETGEAHYFSRSRGKLWKKGETSGHTQKVREMRIDCDQDAVVIKVEMGGTGAACHTGR
EEEECCCCEEEECCCCCEEECCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCEECCCC
RSCFYRTIPLGAAPSAELKLAFTGDAPRFDPAAVYGKDGHGHDH
CCEEEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA