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The map label for this gene is nuoN [H]

Identifier: 154245528

GI number: 154245528

Start: 1793774

End: 1795279

Strand: Reverse

Name: nuoN [H]

Synonym: Xaut_1582

Alternate gene names: 154245528

Gene position: 1795279-1793774 (Counterclockwise)

Preceding gene: 154245529

Following gene: 154245527

Centisome position: 33.82

GC content: 71.45

Gene sequence:

>1506_bases
GTGAGCGCCCTTCTCGTCCTCGCGATCACGGCGCCGCTCCTCGGCCTCGTGCCGCTTCTCCTGCTCGGGCCGCGCACCGG
CGAGCGCGCGGCGCTGGGGATGCTCGCCGTCAATGTTGCCATCACCGCCGGCATCGCCGAGCGGGTGGCGCAGGGCGGAC
GGGCGCTGGGCTATTTCGTCGGCGGCTTTGCCCCGCCGCTGGGCGTCGGGCTGCGGGCGGACGGCTTTGCCGCCGCCATG
ATGCTGATGGCCGCCCTGGTGCTGCTCTTCACCGGCCTGTTCGCCATGACCGGGCCGGGGGACATGACGCGCAAGGTGAA
TGCGCGTGGCTCGGCGGGCATGCCGGCCACCTTCTTCATCCTGCTTTTGTCGCTCGCCTGCGCGCTCAACCTCGCCTTCC
TGGCGCAGGACCTCTTCACCCTCTATGTGGCGCTGGAACTGCTCACCTTCGCCGCCGTGCCCCTGGTGTGCCTGGAAGGC
AAGGCGGGGCAGCTTGCGGCGGCGCTCACCTACCTGCTGTTCGCCCTGTTCGGCTCGGTGCTGTACCTGCTGGGCGTGGT
GCTCATCTACGGCCTGTTCGGCACGCTGGACATCGCCCACCTCGCCGGCCTGATGGCGCACGGAGCCGGCGGGGCGACCG
CCGCCGCGGCGCTTGCCTTGATGAGCGCGGGGCTGATGGCCAAGGCCGCCCTGTTCCCGCTCCACCTCTGGCTGCCGCCG
GCCCATTCCGGCGCACCGCCGGCGGCGAGCGCGGTGCTTTCCGCCGTGGTCATCAAGGCGCCGCTGTTCCTTCTGGTGCG
GCTCTGGTCGGACCTTGCGCCCTTGCCCCTGACCCAGCTGGCCGGCCCGGTCTTCGCCCTATGCGGGGCGGCTGCCATCG
TGTTCTGCGGGGTGGTGGCGCTGGCGCAGGAGCGGCTGAAGCTGCTCATCGCTTATTCCACGGCGGCGCAGATCGGCTAC
CTGTGCCTCATGTTCCCCCTCGCGGCGTCCAGCGACGGGCCATCGAGCGCGCTGGCGTGGACCGGGGGCACGCTGCACCT
CGTCTCCCACGCCTTGTCCAAGGCCGCCATGTTCCTTGCCGCCGGGCTGATAGCCGAGACCATGGGGCATGACCGGTTGT
CCGGATTGGGGGGCGTCGGCCGGCTGGCGCCGGTGAGCGTCGCCGCCTTCGGCCTCGGCGGCCTGTCGCTCATGGGGCTG
CCGCCCTCCGGCGGGTTCGTGGCCAAGGTGATGCTGCTGACCTCGGCCCTGCAGCAGGGCTCGTGGTGGATCGCCACGGT
GGTGCTCGTTGGCGGGCTGCTGGCGGGCGGCTATGTGCTGCGGGTGGTGGTGATCGCCCTGCAATATCCCGATGCCGACC
TGCCCGAAGCGCGGGAGTGCCGCTGGCGGGCGCTGATCGCCCTCGCCCTCGCCTTCGGGGCCATGCTGGTGGGCTTCATG
CCGCTCGCTCCCCTGCCCTTCCTGGAGATCGGCCGCCCCCTGACCTGGACGGGAGTGATGCCATGA

Upstream 100 bases:

>100_bases
TTGTGGCCTTCTGCGCCACCGCCCTCGCCGCCGCCCTGCTGGTGCGGTTGTCCGCAACTCAGGCCGAGGCCGCGCACGAA
GATCAGCGGGAGAAGGACAC

Downstream 100 bases:

>100_bases
CCGGCGAGACCCTGTCCCCGCCGCTCGATCTCTCCGCCCTGGAACCGGCCATGCCGGCGCTGTCCGAGGCGCTCATGGTG
GTGGCGATCGCGCTGCCGCT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSALLVLAITAPLLGLVPLLLLGPRTGERAALGMLAVNVAITAGIAERVAQGGRALGYFVGGFAPPLGVGLRADGFAAAM
MLMAALVLLFTGLFAMTGPGDMTRKVNARGSAGMPATFFILLLSLACALNLAFLAQDLFTLYVALELLTFAAVPLVCLEG
KAGQLAAALTYLLFALFGSVLYLLGVVLIYGLFGTLDIAHLAGLMAHGAGGATAAAALALMSAGLMAKAALFPLHLWLPP
AHSGAPPAASAVLSAVVIKAPLFLLVRLWSDLAPLPLTQLAGPVFALCGAAAIVFCGVVALAQERLKLLIAYSTAAQIGY
LCLMFPLAASSDGPSSALAWTGGTLHLVSHALSKAAMFLAAGLIAETMGHDRLSGLGGVGRLAPVSVAAFGLGGLSLMGL
PPSGGFVAKVMLLTSALQQGSWWIATVVLVGGLLAGGYVLRVVVIALQYPDADLPEARECRWRALIALALAFGAMLVGFM
PLAPLPFLEIGRPLTWTGVMP

Sequences:

>Translated_501_residues
MSALLVLAITAPLLGLVPLLLLGPRTGERAALGMLAVNVAITAGIAERVAQGGRALGYFVGGFAPPLGVGLRADGFAAAM
MLMAALVLLFTGLFAMTGPGDMTRKVNARGSAGMPATFFILLLSLACALNLAFLAQDLFTLYVALELLTFAAVPLVCLEG
KAGQLAAALTYLLFALFGSVLYLLGVVLIYGLFGTLDIAHLAGLMAHGAGGATAAAALALMSAGLMAKAALFPLHLWLPP
AHSGAPPAASAVLSAVVIKAPLFLLVRLWSDLAPLPLTQLAGPVFALCGAAAIVFCGVVALAQERLKLLIAYSTAAQIGY
LCLMFPLAASSDGPSSALAWTGGTLHLVSHALSKAAMFLAAGLIAETMGHDRLSGLGGVGRLAPVSVAAFGLGGLSLMGL
PPSGGFVAKVMLLTSALQQGSWWIATVVLVGGLLAGGYVLRVVVIALQYPDADLPEARECRWRALIALALAFGAMLVGFM
PLAPLPFLEIGRPLTWTGVMP
>Mature_500_residues
SALLVLAITAPLLGLVPLLLLGPRTGERAALGMLAVNVAITAGIAERVAQGGRALGYFVGGFAPPLGVGLRADGFAAAMM
LMAALVLLFTGLFAMTGPGDMTRKVNARGSAGMPATFFILLLSLACALNLAFLAQDLFTLYVALELLTFAAVPLVCLEGK
AGQLAAALTYLLFALFGSVLYLLGVVLIYGLFGTLDIAHLAGLMAHGAGGATAAAALALMSAGLMAKAALFPLHLWLPPA
HSGAPPAASAVLSAVVIKAPLFLLVRLWSDLAPLPLTQLAGPVFALCGAAAIVFCGVVALAQERLKLLIAYSTAAQIGYL
CLMFPLAASSDGPSSALAWTGGTLHLVSHALSKAAMFLAAGLIAETMGHDRLSGLGGVGRLAPVSVAAFGLGGLSLMGLP
PSGGFVAKVMLLTSALQQGSWWIATVVLVGGLLAGGYVLRVVVIALQYPDADLPEARECRWRALIALALAFGAMLVGFMP
LAPLPFLEIGRPLTWTGVMP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=336, Percent_Identity=25, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI251831116, Length=314, Percent_Identity=28.0254777070064, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1788827, Length=358, Percent_Identity=29.608938547486, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788831, Length=374, Percent_Identity=26.7379679144385, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788614, Length=461, Percent_Identity=27.9826464208243, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693160, Length=435, Percent_Identity=28.0459770114943, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788613, Length=295, Percent_Identity=26.4406779661017, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788829, Length=182, Percent_Identity=30.2197802197802, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI2367154, Length=288, Percent_Identity=30.5555555555556, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51081; Mature: 50950

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALLVLAITAPLLGLVPLLLLGPRTGERAALGMLAVNVAITAGIAERVAQGGRALGYFV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
GGFAPPLGVGLRADGFAAAMMLMAALVLLFTGLFAMTGPGDMTRKVNARGSAGMPATFFI
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCCCCHHHHH
LLLSLACALNLAFLAQDLFTLYVALELLTFAAVPLVCLEGKAGQLAAALTYLLFALFGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
LYLLGVVLIYGLFGTLDIAHLAGLMAHGAGGATAAAALALMSAGLMAKAALFPLHLWLPP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCC
AHSGAPPAASAVLSAVVIKAPLFLLVRLWSDLAPLPLTQLAGPVFALCGAAAIVFCGVVA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAQERLKLLIAYSTAAQIGYLCLMFPLAASSDGPSSALAWTGGTLHLVSHALSKAAMFLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHH
AGLIAETMGHDRLSGLGGVGRLAPVSVAAFGLGGLSLMGLPPSGGFVAKVMLLTSALQQG
HHHHHHHHCCHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCC
SWWIATVVLVGGLLAGGYVLRVVVIALQYPDADLPEARECRWRALIALALAFGAMLVGFM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
PLAPLPFLEIGRPLTWTGVMP
CCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SALLVLAITAPLLGLVPLLLLGPRTGERAALGMLAVNVAITAGIAERVAQGGRALGYFV
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH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CCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA