Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 154245373

GI number: 154245373

Start: 1633743

End: 1636196

Strand: Reverse

Name: uvrD [H]

Synonym: Xaut_1426

Alternate gene names: 154245373

Gene position: 1636196-1633743 (Counterclockwise)

Preceding gene: 154245374

Following gene: 154245372

Centisome position: 30.82

GC content: 68.7

Gene sequence:

>2454_bases
TTGACCGATCCGCGCCGGCGCCCGGCTGAGCCGGCGCCCGAGCGTCCCGCCCCCCGTGCGGGCGGCATCGCCGCGCGGGC
CACCGCCATCTCCGCCGCTCCGCCCGCCCCGGATTATCTCAACGGCCTCAATCCCGAGCAGCGCGAAGCCGTCGAGACCC
TGGACGGCCCCCTTCTGGTCCTCGCCGGAGCCGGCACCGGCAAGACGCGGGTGCTGACCGCCCGCGTCGCCCACATCCTC
TCCCAGGGCCGCGCCTACCCCTCCCAGATCCTGGTGGTGACCTTCACCAATAAGGCCGCGCGGGAGATGAAGGACCGCAT
CCACGCCATGGTGGGCGACCAGATCGAGGGCATGCCCTGGCTCGGCACCTTCCACTCCATCGGCGTGCGCATCCTGCGGC
GCCACCACGAACTGGTGGGGCTGAAATCCGGCTTCACCATCCTCGACACCGACGACCAGATCCGCCTGCTCAAGCAATTG
CTCGCCGCCGAGAACATCGACGAGAAGCGCTGGCCGGCCCGGCTCCTGGCCTCCACCATCGACAGCTGGAAGAACCGCGG
CCTGTCGCCGAAAGACGTGCCGCCCGGCGAGGGCGCGGTCTTCGCCAATGGCCGGGGCGGCACCCTCTACGCCGCCTATC
AGGCGCGGCTGAAGGCGCTGAACGCGGTGGATTTCGGCGACCTGCTGCTGGAGGGCATCCGCCTGTTCCGCGAGAATCCC
GACGTGCTCGCGGAATATCACAAGCGCTTCAAGTACCTGCTGGTGGACGAGTATCAAGATACCAACGTCGCCCAGTATCT
GTGGCTGCGCCTGCTCGCCCAGGGCTCCAAGAATGTGTGCTGCGTGGGCGACGACGACCAGTCCATCTATGGCTGGCGCG
GCGCCGAGGTGGATAACATCCTCAGGTTCGAGAGCGACTTTCCCGGCGCCAAGGTGATCCGGCTGGAGCGCAACTACCGC
TCCACCGGCCACATCCTCGCCTCCGCCGCCCACCTCATCGCCCACAACGAGGGCCGGCTCGGCAAGACCCTGTTCTCCGA
GGGCGAGGACGGCGAGCAGGTCACCGTCACCGGAGCGTGGGATTCGGGCGAGGAAGCCCGCGCCGTCGGCGAGGAGATCG
AGGCGCTGCAACGCGCCGGGCATAAATTGTCCGAGATCGCCATCCTCGTGCGCGCCTCGTTCCAGATGCGCGAGTTCGAG
GATCGTTTCGTGACGCTGGGCCTGCCGTACCGCGTCATCGGCGGCCCGCGCTTTTACGAGCGGGCGGAAATCCGCGACGC
GCTGGCCTATCTGCGCTGCGTGAATTCGTCCGCCGACGACCTCGCCTTCGAGCGCATCGTCAACGTTCCCAAGCGCGGCA
TCGGCGACGCCACGGTCAAGCAGATCCATGATGTGGCCCGCGCCGTCGGCCTGCCGCTTCAGGAGGCCACCCGAGTCCTG
ACCGAGAGCGAGGAGCTGAAGCCCAAGGTGCGTGCCACCCTGCGCGGCGTCGTGGAGGCGTTCGGACGCTGGCGCGAGCA
GGCGCGCGTGCTGTCCCACACCGAGCTGGCCGAGATCGTGCTGGACGAGAGCGGCTACACGGAGATGTGGCAGAAGGACC
GCTCGGCGGAAGCCGCCGGGCGGCTGGAGAACCTGAAGGAGCTGGTGCGCTCCATGGAGCCGTTCGAGAACCTCTCCGGC
TTCCTCGAGCACATCTCCCTCGTCATGGACACCGACAACGGCGCCGGCGAGGACGCGGTGCAGATCATGACCCTGCATTC
CGCCAAGGGGCTGGAATTCGACACCGTCTTCCTGCCCGGCTGGGAGGAGGGCCTGTTTCCCCACCAGCGCGCGCTGGACG
AGCAGGGCAAGGCGGGGCTCGAGGAAGAGCGCCGCCTCGCCTATGTGGGCATCACCCGGGCCCGGGCCTCGGCGCGGATC
TTCGTCGCCTCCAATCGGCGCATCCACGGCATGTGGAACTCCACCGTCCCCTCCCGCTTCCTCGACGAGTTGCCCGATGC
CCATGTGCGGGTGGAGGAAAGCCGCGGCGGCGCGGGCTGGGGCGGGTCGAGCTATGGCGGCGGCAGCTATGGGCAGAGCC
GCTTCGACCGGGCCGAGCCGTTTTCCGCCTCATCCTATTCCACCCCCGGCTGGCAGCGGGCGCAGGCCAACCGTGGCCGC
ACCGACCAGGGCGGCTTCGCAGGCGCTTCTTCGGGTTCTTCCCGCAGCGGCTTCTCCGAACGGGGCGGGCGTTATGATGC
GGGCGGCTCCGCCCGGCGCGGTCCCATGGTGATCGAGGGCACGCTGGTGGCCACCTCCGCCGGCCCGGCATCGGCCTTCC
ACACCGGCGAGCGGGTGTTCCACATCAAGTTCGGCTATGGCGAGGTGACCGGCATCGACGGCAACAAGCTGACGGTGCAG
TTCGACAAGGCCGGCGAGAAGCGGGTGCTGGAAACGTTCGTCGATAAGGTGTGA

Upstream 100 bases:

>100_bases
GGAGCCGGTTCCGGCGGCCCGCTCTCGCAATCGCCGTCATTGAGTGCCATTTTGTTCTCAAGAGAGAATCAGGCCTTGCG
AGAGTTTGCCCGTGACCCAG

Downstream 100 bases:

>100_bases
GCACGCCATGACCGGCGGCGGTGGCCTCAGCGCCGCCCGCCTGGCTCGCGCCAAGCGCGCGGGTGCCGGCCCGACTGGCA
GCCCAACCGCCGGGCCAACT

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 817; Mature: 816

Protein sequence:

>817_residues
MTDPRRRPAEPAPERPAPRAGGIAARATAISAAPPAPDYLNGLNPEQREAVETLDGPLLVLAGAGTGKTRVLTARVAHIL
SQGRAYPSQILVVTFTNKAAREMKDRIHAMVGDQIEGMPWLGTFHSIGVRILRRHHELVGLKSGFTILDTDDQIRLLKQL
LAAENIDEKRWPARLLASTIDSWKNRGLSPKDVPPGEGAVFANGRGGTLYAAYQARLKALNAVDFGDLLLEGIRLFRENP
DVLAEYHKRFKYLLVDEYQDTNVAQYLWLRLLAQGSKNVCCVGDDDQSIYGWRGAEVDNILRFESDFPGAKVIRLERNYR
STGHILASAAHLIAHNEGRLGKTLFSEGEDGEQVTVTGAWDSGEEARAVGEEIEALQRAGHKLSEIAILVRASFQMREFE
DRFVTLGLPYRVIGGPRFYERAEIRDALAYLRCVNSSADDLAFERIVNVPKRGIGDATVKQIHDVARAVGLPLQEATRVL
TESEELKPKVRATLRGVVEAFGRWREQARVLSHTELAEIVLDESGYTEMWQKDRSAEAAGRLENLKELVRSMEPFENLSG
FLEHISLVMDTDNGAGEDAVQIMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGKAGLEEERRLAYVGITRARASARI
FVASNRRIHGMWNSTVPSRFLDELPDAHVRVEESRGGAGWGGSSYGGGSYGQSRFDRAEPFSASSYSTPGWQRAQANRGR
TDQGGFAGASSGSSRSGFSERGGRYDAGGSARRGPMVIEGTLVATSAGPASAFHTGERVFHIKFGYGEVTGIDGNKLTVQ
FDKAGEKRVLETFVDKV

Sequences:

>Translated_817_residues
MTDPRRRPAEPAPERPAPRAGGIAARATAISAAPPAPDYLNGLNPEQREAVETLDGPLLVLAGAGTGKTRVLTARVAHIL
SQGRAYPSQILVVTFTNKAAREMKDRIHAMVGDQIEGMPWLGTFHSIGVRILRRHHELVGLKSGFTILDTDDQIRLLKQL
LAAENIDEKRWPARLLASTIDSWKNRGLSPKDVPPGEGAVFANGRGGTLYAAYQARLKALNAVDFGDLLLEGIRLFRENP
DVLAEYHKRFKYLLVDEYQDTNVAQYLWLRLLAQGSKNVCCVGDDDQSIYGWRGAEVDNILRFESDFPGAKVIRLERNYR
STGHILASAAHLIAHNEGRLGKTLFSEGEDGEQVTVTGAWDSGEEARAVGEEIEALQRAGHKLSEIAILVRASFQMREFE
DRFVTLGLPYRVIGGPRFYERAEIRDALAYLRCVNSSADDLAFERIVNVPKRGIGDATVKQIHDVARAVGLPLQEATRVL
TESEELKPKVRATLRGVVEAFGRWREQARVLSHTELAEIVLDESGYTEMWQKDRSAEAAGRLENLKELVRSMEPFENLSG
FLEHISLVMDTDNGAGEDAVQIMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGKAGLEEERRLAYVGITRARASARI
FVASNRRIHGMWNSTVPSRFLDELPDAHVRVEESRGGAGWGGSSYGGGSYGQSRFDRAEPFSASSYSTPGWQRAQANRGR
TDQGGFAGASSGSSRSGFSERGGRYDAGGSARRGPMVIEGTLVATSAGPASAFHTGERVFHIKFGYGEVTGIDGNKLTVQ
FDKAGEKRVLETFVDKV
>Mature_816_residues
TDPRRRPAEPAPERPAPRAGGIAARATAISAAPPAPDYLNGLNPEQREAVETLDGPLLVLAGAGTGKTRVLTARVAHILS
QGRAYPSQILVVTFTNKAAREMKDRIHAMVGDQIEGMPWLGTFHSIGVRILRRHHELVGLKSGFTILDTDDQIRLLKQLL
AAENIDEKRWPARLLASTIDSWKNRGLSPKDVPPGEGAVFANGRGGTLYAAYQARLKALNAVDFGDLLLEGIRLFRENPD
VLAEYHKRFKYLLVDEYQDTNVAQYLWLRLLAQGSKNVCCVGDDDQSIYGWRGAEVDNILRFESDFPGAKVIRLERNYRS
TGHILASAAHLIAHNEGRLGKTLFSEGEDGEQVTVTGAWDSGEEARAVGEEIEALQRAGHKLSEIAILVRASFQMREFED
RFVTLGLPYRVIGGPRFYERAEIRDALAYLRCVNSSADDLAFERIVNVPKRGIGDATVKQIHDVARAVGLPLQEATRVLT
ESEELKPKVRATLRGVVEAFGRWREQARVLSHTELAEIVLDESGYTEMWQKDRSAEAAGRLENLKELVRSMEPFENLSGF
LEHISLVMDTDNGAGEDAVQIMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEQGKAGLEEERRLAYVGITRARASARIF
VASNRRIHGMWNSTVPSRFLDELPDAHVRVEESRGGAGWGGSSYGGGSYGQSRFDRAEPFSASSYSTPGWQRAQANRGRT
DQGGFAGASSGSSRSGFSERGGRYDAGGSARRGPMVIEGTLVATSAGPASAFHTGERVFHIKFGYGEVTGIDGNKLTVQF
DKAGEKRVLETFVDKV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=645, Percent_Identity=45.5813953488372, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI48994965, Length=659, Percent_Identity=39.6054628224583, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1787196, Length=353, Percent_Identity=30.5949008498584, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=754, Percent_Identity=27.3209549071618, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 89819; Mature: 89688

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPRRRPAEPAPERPAPRAGGIAARATAISAAPPAPDYLNGLNPEQREAVETLDGPLLV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCHHHCCCCHHHHHHHHHCCCCEEE
LAGAGTGKTRVLTARVAHILSQGRAYPSQILVVTFTNKAAREMKDRIHAMVGDQIEGMPW
EEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
LGTFHSIGVRILRRHHELVGLKSGFTILDTDDQIRLLKQLLAAENIDEKRWPARLLASTI
CHHHHHHHHHHHHHHHHHHEECCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DSWKNRGLSPKDVPPGEGAVFANGRGGTLYAAYQARLKALNAVDFGDLLLEGIRLFRENP
HHHHHCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCH
DVLAEYHKRFKYLLVDEYQDTNVAQYLWLRLLAQGSKNVCCVGDDDQSIYGWRGAEVDNI
HHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHH
LRFESDFPGAKVIRLERNYRSTGHILASAAHLIAHNEGRLGKTLFSEGEDGEQVTVTGAW
HHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEECC
DSGEEARAVGEEIEALQRAGHKLSEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYE
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHHHH
RAEIRDALAYLRCVNSSADDLAFERIVNVPKRGIGDATVKQIHDVARAVGLPLQEATRVL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
TESEELKPKVRATLRGVVEAFGRWREQARVLSHTELAEIVLDESGYTEMWQKDRSAEAAG
HCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHH
RLENLKELVRSMEPFENLSGFLEHISLVMDTDNGAGEDAVQIMTLHSAKGLEFDTVFLPG
HHHHHHHHHHHHCHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCC
WEEGLFPHQRALDEQGKAGLEEERRLAYVGITRARASARIFVASNRRIHGMWNSTVPSRF
CCCCCCCHHHHHHHHCCCCCCHHHEEEEEEEEECCCCEEEEEECCCEEEECCCCCCHHHH
LDELPDAHVRVEESRGGAGWGGSSYGGGSYGQSRFDRAEPFSASSYSTPGWQRAQANRGR
HHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCCC
TDQGGFAGASSGSSRSGFSERGGRYDAGGSARRGPMVIEGTLVATSAGPASAFHTGERVF
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHCCCCEEE
HIKFGYGEVTGIDGNKLTVQFDKAGEKRVLETFVDKV
EEEECCCEEECCCCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDPRRRPAEPAPERPAPRAGGIAARATAISAAPPAPDYLNGLNPEQREAVETLDGPLLV
CCCCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCHHHCCCCHHHHHHHHHCCCCEEE
LAGAGTGKTRVLTARVAHILSQGRAYPSQILVVTFTNKAAREMKDRIHAMVGDQIEGMPW
EEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
LGTFHSIGVRILRRHHELVGLKSGFTILDTDDQIRLLKQLLAAENIDEKRWPARLLASTI
CHHHHHHHHHHHHHHHHHHEECCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DSWKNRGLSPKDVPPGEGAVFANGRGGTLYAAYQARLKALNAVDFGDLLLEGIRLFRENP
HHHHHCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCH
DVLAEYHKRFKYLLVDEYQDTNVAQYLWLRLLAQGSKNVCCVGDDDQSIYGWRGAEVDNI
HHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHH
LRFESDFPGAKVIRLERNYRSTGHILASAAHLIAHNEGRLGKTLFSEGEDGEQVTVTGAW
HHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEECC
DSGEEARAVGEEIEALQRAGHKLSEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYE
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHHHH
RAEIRDALAYLRCVNSSADDLAFERIVNVPKRGIGDATVKQIHDVARAVGLPLQEATRVL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
TESEELKPKVRATLRGVVEAFGRWREQARVLSHTELAEIVLDESGYTEMWQKDRSAEAAG
HCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHH
RLENLKELVRSMEPFENLSGFLEHISLVMDTDNGAGEDAVQIMTLHSAKGLEFDTVFLPG
HHHHHHHHHHHHCHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEEECCCCCCEEEEECCC
WEEGLFPHQRALDEQGKAGLEEERRLAYVGITRARASARIFVASNRRIHGMWNSTVPSRF
CCCCCCCHHHHHHHHCCCCCCHHHEEEEEEEEECCCCEEEEEECCCEEEECCCCCCHHHH
LDELPDAHVRVEESRGGAGWGGSSYGGGSYGQSRFDRAEPFSASSYSTPGWQRAQANRGR
HHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCCC
TDQGGFAGASSGSSRSGFSERGGRYDAGGSARRGPMVIEGTLVATSAGPASAFHTGERVF
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHCCCCEEE
HIKFGYGEVTGIDGNKLTVQFDKAGEKRVLETFVDKV
EEEECCCEEECCCCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA