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The map label for this gene is nhaA [H]

Identifier: 154245323

GI number: 154245323

Start: 1577717

End: 1578604

Strand: Direct

Name: nhaA [H]

Synonym: Xaut_1376

Alternate gene names: 154245323

Gene position: 1577717-1578604 (Clockwise)

Preceding gene: 154245322

Following gene: 154245324

Centisome position: 29.72

GC content: 69.93

Gene sequence:

>888_bases
ATGGCCGACAGCTTCCTTTCTTCCCTTTCGCGCCGCGTCAGCGGCATCCTCCCCAGAAAATGGCGCCGTGACCTGCCGGT
GGTGCCGGTGGTGCGGCTCTCCGGCGCCATCGGCATGCAGACGACGCCATTCGCGCGCAGCCTGTCGCTGGCCGGCACCG
CGCAGGCGCTGGACAAGGCCTTCGCCATGAAGTCGGCGCCGGCGGTGGCGCTGCTCATCAATTCGCCGGGCGGCTCGCCG
GTGCAGTCGCACCTGATCTTCCGGCGCATCCGCGCGCTGGCGGAGGAGAAGGAGAAGCACGTCTTCGCCTTCGTGGAGGA
TGCGGCGGCCTCCGGCGGCTACATGATCGCCTGCGCGGCGGACGAGATCTTCGCCGATCCCTGCTCCATCGTCGGCTCCA
TCGGGGTGGTGACGGCGGGCTTCGGCTTCGACAAGGCCATCGAGAAGCTGGGCGTGGAGCGGCGCGTCTATACCGCCGGC
GAACGCAAGGTGACCCTCGACCCGTTCCGTCCCACGCGGCCGGAGGACGTGGAACGGCTCGACGTGCTCTTGAAGGAACT
TCACACCGTGTTCGTGGACCTCGTGCGCTCCCGGCGCAGCGATGCGCTGCCGGCCGACGACGAGAGCCTGTTTTCCGGCG
AGTTCTGGCTGGGCACGCAGGCCGCGGGACTTGGCCTCGTGGATGGGCTGGGCGACGTGCGCTCCATCCTGAAGGCGCGG
TACGGCGAGGAGGTGCGCATGCCACTGGTGCAGTCGTCCTCCGGCCTCATCCCGCGCCGTCCGGGCGGTTTTGGCGCGGC
CTTGGCCGGCAGCCTTGCGTCTCAGGCGGCGGACGGGGCCATGGCGGCAGTGGAGGAGCGCGCCCTGTGGTCGCGGCTTG
GCCTGTGA

Upstream 100 bases:

>100_bases
TGGCCGCCCCGCTTGGCGTGCGTCACTGCTCGCGTGAGTCCCCTGCCTTGAGTGCGTCACCTGCCTTGAGTGCGTCACCT
GCGCGCCCTACATCTGGACC

Downstream 100 bases:

>100_bases
TCGACCCAAAACGCCGCGCGGCAGCCCCTCCGGGGTGCCGCGATGGCGCCGGATGAGGCAGATTTCGCACCTGCCCTTTT
CTTGCCCTTTCCCCCCTTCG

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MADSFLSSLSRRVSGILPRKWRRDLPVVPVVRLSGAIGMQTTPFARSLSLAGTAQALDKAFAMKSAPAVALLINSPGGSP
VQSHLIFRRIRALAEEKEKHVFAFVEDAAASGGYMIACAADEIFADPCSIVGSIGVVTAGFGFDKAIEKLGVERRVYTAG
ERKVTLDPFRPTRPEDVERLDVLLKELHTVFVDLVRSRRSDALPADDESLFSGEFWLGTQAAGLGLVDGLGDVRSILKAR
YGEEVRMPLVQSSSGLIPRRPGGFGAALAGSLASQAADGAMAAVEERALWSRLGL

Sequences:

>Translated_295_residues
MADSFLSSLSRRVSGILPRKWRRDLPVVPVVRLSGAIGMQTTPFARSLSLAGTAQALDKAFAMKSAPAVALLINSPGGSP
VQSHLIFRRIRALAEEKEKHVFAFVEDAAASGGYMIACAADEIFADPCSIVGSIGVVTAGFGFDKAIEKLGVERRVYTAG
ERKVTLDPFRPTRPEDVERLDVLLKELHTVFVDLVRSRRSDALPADDESLFSGEFWLGTQAAGLGLVDGLGDVRSILKAR
YGEEVRMPLVQSSSGLIPRRPGGFGAALAGSLASQAADGAMAAVEERALWSRLGL
>Mature_294_residues
ADSFLSSLSRRVSGILPRKWRRDLPVVPVVRLSGAIGMQTTPFARSLSLAGTAQALDKAFAMKSAPAVALLINSPGGSPV
QSHLIFRRIRALAEEKEKHVFAFVEDAAASGGYMIACAADEIFADPCSIVGSIGVVTAGFGFDKAIEKLGVERRVYTAGE
RKVTLDPFRPTRPEDVERLDVLLKELHTVFVDLVRSRRSDALPADDESLFSGEFWLGTQAAGLGLVDGLGDVRSILKARY
GEEVRMPLVQSSSGLIPRRPGGFGAALAGSLASQAADGAMAAVEERALWSRLGL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=196, Percent_Identity=33.6734693877551, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788064, Length=168, Percent_Identity=32.7380952380952, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 31480; Mature: 31348

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSFLSSLSRRVSGILPRKWRRDLPVVPVVRLSGAIGMQTTPFARSLSLAGTAQALDKA
CCHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
FAMKSAPAVALLINSPGGSPVQSHLIFRRIRALAEEKEKHVFAFVEDAAASGGYMIACAA
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCEEEEEEC
DEIFADPCSIVGSIGVVTAGFGFDKAIEKLGVERRVYTAGERKVTLDPFRPTRPEDVERL
HHHHHCHHHHHHHHHHHEECCCHHHHHHHHCCHHHEEECCCCEEEECCCCCCCCHHHHHH
DVLLKELHTVFVDLVRSRRSDALPADDESLFSGEFWLGTQAAGLGLVDGLGDVRSILKAR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEECCCCCCCHHHHCHHHHHHHHHHH
YGEEVRMPLVQSSSGLIPRRPGGFGAALAGSLASQAADGAMAAVEERALWSRLGL
CCCHHCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADSFLSSLSRRVSGILPRKWRRDLPVVPVVRLSGAIGMQTTPFARSLSLAGTAQALDKA
CHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
FAMKSAPAVALLINSPGGSPVQSHLIFRRIRALAEEKEKHVFAFVEDAAASGGYMIACAA
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCCEEEEEEC
DEIFADPCSIVGSIGVVTAGFGFDKAIEKLGVERRVYTAGERKVTLDPFRPTRPEDVERL
HHHHHCHHHHHHHHHHHEECCCHHHHHHHHCCHHHEEECCCCEEEECCCCCCCCHHHHHH
DVLLKELHTVFVDLVRSRRSDALPADDESLFSGEFWLGTQAAGLGLVDGLGDVRSILKAR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEECCCCCCCHHHHCHHHHHHHHHHH
YGEEVRMPLVQSSSGLIPRRPGGFGAALAGSLASQAADGAMAAVEERALWSRLGL
CCCHHCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA