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The map label for this gene is adh [H]

Identifier: 154245282

GI number: 154245282

Start: 1530433

End: 1531467

Strand: Reverse

Name: adh [H]

Synonym: Xaut_1334

Alternate gene names: 154245282

Gene position: 1531467-1530433 (Counterclockwise)

Preceding gene: 154245284

Following gene: 154245272

Centisome position: 28.85

GC content: 64.54

Gene sequence:

>1035_bases
ATGAAGGGTCTGGTCTATCGTGGCCCCGGCAAGAAGGCGCTGGAGGAAGTGCCGCATCCGCGGATCGAACAGCCTACCGA
CGCCGTGGTGAAGATCCTGCGGACGACCATATGCGGCAGCGACCTGCACATCCTGAAGGGCGACGTGCCCACCGTGAAGC
CCGGCACCGTGCTTGGCCACGAGGGCGTCGGCGTCATCGAGGAGGTTGGCCAGGCGGTCTCGGCCTTCAGGAAAGGGGAC
CATGTCCTCATCTCCTGCATCTCATCCTGCGGGCGCTGTGAGTACTGCAAGCGCGGCATGTATTCCCACTGCTCCGTCGC
CGGCTGGATGCTCGGCCACACCATCCACGGGACGCAGGCCGAATATGTCCGCATTCCCTTTGCGGACACCTCCCTGCATC
GCATCCCAGACGGCATGGACGAGGAAGCCCTCGTCATGCTCAGCGATATCCTGCCCACCGGCTTCGAGTGCGGCGTGCTG
AACGGCAAGGTGCAGCCCGGCAGCACTGTTGCCATCGTAGGGGCTGGGCCCGTGGGCCTGGCGGCGCTCCTTACCGCGCA
ATTCTACTCCCCCGCCGAGATCATCATGATCGATCTCGACGACAACCGCCTGGAAGTCGCCCTGACCTTCGGCGCCACGA
AGACGGTGAACAGCGGCCGCGAGAATGCGGTCGAGCGGGTCATGGCCCTGACTGGCGGCATCGGCGTGGACACCGCGATT
GAGGCGGTCGGCATTCCCGCCACCTTCGTGCTGTGCCAGGACATCGTGGCCCCCGGCGGCACCATCGCCAATGTGGGGGT
TCACGGCACCAAGGCCGACCTCCACCTTGAACGCTTGTGGGCTCACAACATCACCCTCACCACGCGGCTGGTGGACACCG
TGACGACGCCGATGCTGCTGAAGACGGTGCAGTCGAAGAAGCTCGATCCGCAAAGGCTGATCACCCATCGCTTCGCCCTC
GCCGACATCCTCGAAGCCTACGAGACCTTCGAGAAGGCCGCGCAGACCCGAGCCCTGAAAGTGATCATCGGATAG

Upstream 100 bases:

>100_bases
GCCTTCAGCCATGGCATCTGTTTTGCCGAGGAGGCGGCGCGGAAAGCGGCCGTTGTCCCGCGTGCCGCCAATTCAACGAC
ACTGGAAAGGGAGATCCCTC

Downstream 100 bases:

>100_bases
CGCAAGCCTTCAGCGAGAGCGCTTCAGGCGAAGCGGATTGCTGTTCGCATCAAGAAGATACGTGAAACGACACCCGCGTG
GGTTCCGTGAGCCGATGCGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKGLVYRGPGKKALEEVPHPRIEQPTDAVVKILRTTICGSDLHILKGDVPTVKPGTVLGHEGVGVIEEVGQAVSAFRKGD
HVLISCISSCGRCEYCKRGMYSHCSVAGWMLGHTIHGTQAEYVRIPFADTSLHRIPDGMDEEALVMLSDILPTGFECGVL
NGKVQPGSTVAIVGAGPVGLAALLTAQFYSPAEIIMIDLDDNRLEVALTFGATKTVNSGRENAVERVMALTGGIGVDTAI
EAVGIPATFVLCQDIVAPGGTIANVGVHGTKADLHLERLWAHNITLTTRLVDTVTTPMLLKTVQSKKLDPQRLITHRFAL
ADILEAYETFEKAAQTRALKVIIG

Sequences:

>Translated_344_residues
MKGLVYRGPGKKALEEVPHPRIEQPTDAVVKILRTTICGSDLHILKGDVPTVKPGTVLGHEGVGVIEEVGQAVSAFRKGD
HVLISCISSCGRCEYCKRGMYSHCSVAGWMLGHTIHGTQAEYVRIPFADTSLHRIPDGMDEEALVMLSDILPTGFECGVL
NGKVQPGSTVAIVGAGPVGLAALLTAQFYSPAEIIMIDLDDNRLEVALTFGATKTVNSGRENAVERVMALTGGIGVDTAI
EAVGIPATFVLCQDIVAPGGTIANVGVHGTKADLHLERLWAHNITLTTRLVDTVTTPMLLKTVQSKKLDPQRLITHRFAL
ADILEAYETFEKAAQTRALKVIIG
>Mature_344_residues
MKGLVYRGPGKKALEEVPHPRIEQPTDAVVKILRTTICGSDLHILKGDVPTVKPGTVLGHEGVGVIEEVGQAVSAFRKGD
HVLISCISSCGRCEYCKRGMYSHCSVAGWMLGHTIHGTQAEYVRIPFADTSLHRIPDGMDEEALVMLSDILPTGFECGVL
NGKVQPGSTVAIVGAGPVGLAALLTAQFYSPAEIIMIDLDDNRLEVALTFGATKTVNSGRENAVERVMALTGGIGVDTAI
EAVGIPATFVLCQDIVAPGGTIANVGVHGTKADLHLERLWAHNITLTTRLVDTVTTPMLLKTVQSKKLDPQRLITHRFAL
ADILEAYETFEKAAQTRALKVIIG

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=26.4788732394366, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=26.4788732394366, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4501929, Length=342, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI34577061, Length=340, Percent_Identity=26.4705882352941, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4501933, Length=342, Percent_Identity=24.8538011695906, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71565154, Length=339, Percent_Identity=25.6637168141593, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156523966, Length=353, Percent_Identity=26.0623229461756, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71565152, Length=360, Percent_Identity=24.4444444444444, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4501939, Length=342, Percent_Identity=26.6081871345029, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786825, Length=386, Percent_Identity=29.0155440414508, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1788073, Length=320, Percent_Identity=28.4375, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=26.6106442577031, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790045, Length=330, Percent_Identity=26.969696969697, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=26.5895953757225, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082125, Length=343, Percent_Identity=30.0291545189504, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87081918, Length=269, Percent_Identity=33.8289962825279, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI226510992, Length=318, Percent_Identity=27.0440251572327, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788407, Length=356, Percent_Identity=26.685393258427, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=342, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790718, Length=303, Percent_Identity=24.4224422442244, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=345, Percent_Identity=29.8550724637681, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71997431, Length=344, Percent_Identity=29.3604651162791, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562876, Length=326, Percent_Identity=28.2208588957055, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17565904, Length=352, Percent_Identity=29.5454545454545, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=29.4460641399417, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=173, Percent_Identity=31.7919075144509, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=344, Percent_Identity=29.0697674418605, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=344, Percent_Identity=29.0697674418605, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323099, Length=342, Percent_Identity=27.1929824561404, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=333, Percent_Identity=27.3273273273273, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=305, Percent_Identity=27.2131147540984, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=366, Percent_Identity=24.3169398907104, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=279, Percent_Identity=28.3154121863799, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=273, Percent_Identity=27.1062271062271, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=277, Percent_Identity=28.5198555956679, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=273, Percent_Identity=27.1062271062271, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737895, Length=342, Percent_Identity=30.1169590643275, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17137530, Length=337, Percent_Identity=29.9703264094956, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17737897, Length=339, Percent_Identity=30.9734513274336, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45550770, Length=321, Percent_Identity=24.9221183800623, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45551930, Length=321, Percent_Identity=24.9221183800623, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221457811, Length=321, Percent_Identity=24.9221183800623, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36746; Mature: 36746

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLVYRGPGKKALEEVPHPRIEQPTDAVVKILRTTICGSDLHILKGDVPTVKPGTVLGH
CCCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECC
EGVGVIEEVGQAVSAFRKGDHVLISCISSCGRCEYCKRGMYSHCSVAGWMLGHTIHGTQA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHCEECCCCC
EYVRIPFADTSLHRIPDGMDEEALVMLSDILPTGFECGVLNGKVQPGSTVAIVGAGPVGL
CEEEEECCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHH
AALLTAQFYSPAEIIMIDLDDNRLEVALTFGATKTVNSGRENAVERVMALTGGIGVDTAI
HHHHHHHCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
EAVGIPATFVLCQDIVAPGGTIANVGVHGTKADLHLERLWAHNITLTTRLVDTVTTPMLL
HHCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHH
KTVQSKKLDPQRLITHRFALADILEAYETFEKAAQTRALKVIIG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC
>Mature Secondary Structure
MKGLVYRGPGKKALEEVPHPRIEQPTDAVVKILRTTICGSDLHILKGDVPTVKPGTVLGH
CCCCEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECC
EGVGVIEEVGQAVSAFRKGDHVLISCISSCGRCEYCKRGMYSHCSVAGWMLGHTIHGTQA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHCEECCCCC
EYVRIPFADTSLHRIPDGMDEEALVMLSDILPTGFECGVLNGKVQPGSTVAIVGAGPVGL
CEEEEECCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHH
AALLTAQFYSPAEIIMIDLDDNRLEVALTFGATKTVNSGRENAVERVMALTGGIGVDTAI
HHHHHHHCCCCCEEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
EAVGIPATFVLCQDIVAPGGTIANVGVHGTKADLHLERLWAHNITLTTRLVDTVTTPMLL
HHCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHH
KTVQSKKLDPQRLITHRFALADILEAYETFEKAAQTRALKVIIG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]