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The map label for this gene is hisD

Identifier: 154245179

GI number: 154245179

Start: 1416793

End: 1418085

Strand: Direct

Name: hisD

Synonym: Xaut_1231

Alternate gene names: 154245179

Gene position: 1416793-1418085 (Clockwise)

Preceding gene: 154245178

Following gene: 154245180

Centisome position: 26.69

GC content: 70.07

Gene sequence:

>1293_bases
ATGCCGATCCGCCTCATCACAGAACAACCCGATTTTCCCGAGCGTTTCACCACCTTCCTCGGCTCCAAGCGCGAGGCCTC
GGTGGACGTGCAGGAACAGGTGGCCACCATCATCGCCGACGTGCGCGCGCGGGGCGATGATGCTCTCATCGATCTGTCGC
GCACCTTCGACCGGGTGGACCTTGCGAAGCTCGGCCTGCGCGTGACCGACGCGGAGCTGGACGCGGCCCTCGCCTCCATC
CCGCCGGAAACCCGCGAAGCCCTCGCCTTCGCCAAGGCGCGCATCGAATCCCATCATGCCCGCCAGAAGCCGGCCGACGA
CAGCTATCGCGACGCCGCCGGCGTCGTGCTGGGCCATCGCTGGACCAGCGTGGACGCGGTGGGCCTGTACGTGCCCGGCG
GTACCGCGGCCTATCCCTCGTCCGTGCTCATGAATGCGGTGCCGGCGCAGGTCGCGGGCGTGCCGCGCATCGTCATGGTG
GTTCCGGCCCCCGATGGCGAGATCGCGCCTTTGGTGCTTGCGGCGGCGCGCCTTGCCGGCGTGCACGAGGTCTATCGCGT
TGGAGGCGCCCAGGCGGTGGCGGCACTGGCCTATGGCACGCAGACCATCCAGCCGGTGGACAAGATCGTCGGCCCCGGCA
ACGCCTATGTGGCGGCCGCCAAGCGGCAGGTGTTCGGCAAGGTGGGCATCGACATGGTGGCCGGCCCCTCCGAGGTGCTG
ATCCTCGCCGACGGGAACGCCAGCGCCGACTGGATCGCCGCCGACCTCCTCGCCCAGGCCGAGCACGACACCGCCGCCCA
GTCCATCCTCATCACCGATTCGCACGAGCTGGCGGACCAGGTGGAGAAGGCGGTGGAGGGCATGCTGGCGACCCTGCCGC
GCGTGGCCATCGCCTCCGCCTCGTGGCGCGACCATGGTGCCATCATCCTGGTGCCAGACCTCGCCTCCGCCATTCCGCTG
GTGGACCGCATCGCGCCGGAGCACCTGGAGATCCACGCCGCCAACGCGGACGCGCTTGCGGCCAAGGTACGGCATGCGGG
GGCGATCTTCGTGGGCGCCTTCACGCCGGAGGCCATCGGCGATTACGTCGGCGGCACCAACCACGTGCTCCCCACCGCCC
GCTCGGCGCGCTTCTCCTCGGGCCTGTCCGTGCTCGATTTCATGAAGCGCACCTCCATCCTGAAGCTCGACGCCGGCGCG
CTGGAACAGCTCGGGCCGGCGGCCGTGCGCCTTGCGGCGGTGGAGCGGCTCGATGCCCACGGGCGGTCTGTCTCCATCCG
CACCAACAGATGA

Upstream 100 bases:

>100_bases
AGGGTTCCGCTGCTTGAGCGGAGCCACGGAAGCGCCGGCGCGGCGCGGCACGGTGACCGCGGGGCTTCCCTCGCGGGCGA
AGCTGCTCTAGCAAGGCGTC

Downstream 100 bases:

>100_bases
TCGGAAGGACGAGGCGATGAGCGACAAGCCGGATGCGCGCCCCTCAGCCCGCCTCAGCGCGGTGACGCTCGACGACGCCT
CCATCGGCCATTCCAGCGCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MPIRLITEQPDFPERFTTFLGSKREASVDVQEQVATIIADVRARGDDALIDLSRTFDRVDLAKLGLRVTDAELDAALASI
PPETREALAFAKARIESHHARQKPADDSYRDAAGVVLGHRWTSVDAVGLYVPGGTAAYPSSVLMNAVPAQVAGVPRIVMV
VPAPDGEIAPLVLAAARLAGVHEVYRVGGAQAVAALAYGTQTIQPVDKIVGPGNAYVAAAKRQVFGKVGIDMVAGPSEVL
ILADGNASADWIAADLLAQAEHDTAAQSILITDSHELADQVEKAVEGMLATLPRVAIASASWRDHGAIILVPDLASAIPL
VDRIAPEHLEIHAANADALAAKVRHAGAIFVGAFTPEAIGDYVGGTNHVLPTARSARFSSGLSVLDFMKRTSILKLDAGA
LEQLGPAAVRLAAVERLDAHGRSVSIRTNR

Sequences:

>Translated_430_residues
MPIRLITEQPDFPERFTTFLGSKREASVDVQEQVATIIADVRARGDDALIDLSRTFDRVDLAKLGLRVTDAELDAALASI
PPETREALAFAKARIESHHARQKPADDSYRDAAGVVLGHRWTSVDAVGLYVPGGTAAYPSSVLMNAVPAQVAGVPRIVMV
VPAPDGEIAPLVLAAARLAGVHEVYRVGGAQAVAALAYGTQTIQPVDKIVGPGNAYVAAAKRQVFGKVGIDMVAGPSEVL
ILADGNASADWIAADLLAQAEHDTAAQSILITDSHELADQVEKAVEGMLATLPRVAIASASWRDHGAIILVPDLASAIPL
VDRIAPEHLEIHAANADALAAKVRHAGAIFVGAFTPEAIGDYVGGTNHVLPTARSARFSSGLSVLDFMKRTSILKLDAGA
LEQLGPAAVRLAAVERLDAHGRSVSIRTNR
>Mature_429_residues
PIRLITEQPDFPERFTTFLGSKREASVDVQEQVATIIADVRARGDDALIDLSRTFDRVDLAKLGLRVTDAELDAALASIP
PETREALAFAKARIESHHARQKPADDSYRDAAGVVLGHRWTSVDAVGLYVPGGTAAYPSSVLMNAVPAQVAGVPRIVMVV
PAPDGEIAPLVLAAARLAGVHEVYRVGGAQAVAALAYGTQTIQPVDKIVGPGNAYVAAAKRQVFGKVGIDMVAGPSEVLI
LADGNASADWIAADLLAQAEHDTAAQSILITDSHELADQVEKAVEGMLATLPRVAIASASWRDHGAIILVPDLASAIPLV
DRIAPEHLEIHAANADALAAKVRHAGAIFVGAFTPEAIGDYVGGTNHVLPTARSARFSSGLSVLDFMKRTSILKLDAGAL
EQLGPAAVRLAAVERLDAHGRSVSIRTNR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=407, Percent_Identity=42.2604422604423, Blast_Score=298, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=39.2771084337349, Blast_Score=268, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45152; Mature: 45021

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRLITEQPDFPERFTTFLGSKREASVDVQEQVATIIADVRARGDDALIDLSRTFDRVD
CCEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
LAKLGLRVTDAELDAALASIPPETREALAFAKARIESHHARQKPADDSYRDAAGVVLGHR
HHHHCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCEEEECC
WTSVDAVGLYVPGGTAAYPSSVLMNAVPAQVAGVPRIVMVVPAPDGEIAPLVLAAARLAG
CCCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
VHEVYRVGGAQAVAALAYGTQTIQPVDKIVGPGNAYVAAAKRQVFGKVGIDMVAGPSEVL
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEECCCCEEE
ILADGNASADWIAADLLAQAEHDTAAQSILITDSHELADQVEKAVEGMLATLPRVAIASA
EEECCCCCCHHHHHHHHHHCCCCHHHCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCC
SWRDHGAIILVPDLASAIPLVDRIAPEHLEIHAANADALAAKVRHAGAIFVGAFTPEAIG
CCCCCCCEEEECCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEEECCCHHHHH
DYVGGTNHVLPTARSARFSSGLSVLDFMKRTSILKLDAGALEQLGPAAVRLAAVERLDAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCEEEECCHHHHHCCHHHHHHHHHHHHHCC
GRSVSIRTNR
CCEEEEEECC
>Mature Secondary Structure 
PIRLITEQPDFPERFTTFLGSKREASVDVQEQVATIIADVRARGDDALIDLSRTFDRVD
CEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHH
LAKLGLRVTDAELDAALASIPPETREALAFAKARIESHHARQKPADDSYRDAAGVVLGHR
HHHHCCEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCEEEECC
WTSVDAVGLYVPGGTAAYPSSVLMNAVPAQVAGVPRIVMVVPAPDGEIAPLVLAAARLAG
CCCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
VHEVYRVGGAQAVAALAYGTQTIQPVDKIVGPGNAYVAAAKRQVFGKVGIDMVAGPSEVL
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEHHHHHHHHHHCCCEEECCCCEEE
ILADGNASADWIAADLLAQAEHDTAAQSILITDSHELADQVEKAVEGMLATLPRVAIASA
EEECCCCCCHHHHHHHHHHCCCCHHHCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCC
SWRDHGAIILVPDLASAIPLVDRIAPEHLEIHAANADALAAKVRHAGAIFVGAFTPEAIG
CCCCCCCEEEECCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCEEEEECCCHHHHH
DYVGGTNHVLPTARSARFSSGLSVLDFMKRTSILKLDAGALEQLGPAAVRLAAVERLDAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCEEEECCHHHHHCCHHHHHHHHHHHHHCC
GRSVSIRTNR
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA