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The map label for this gene is hemC [H]

Identifier: 154245106

GI number: 154245106

Start: 1331495

End: 1332448

Strand: Direct

Name: hemC [H]

Synonym: Xaut_1158

Alternate gene names: 154245106

Gene position: 1331495-1332448 (Clockwise)

Preceding gene: 154245100

Following gene: 154245107

Centisome position: 25.08

GC content: 72.12

Gene sequence:

>954_bases
ATGAGTGAGAATACGAAATCCGTTTACCATCCCGTCCACCCCCGTTTGCGCATCGGCACCCGTGGCAGCCCGCTGGCCCT
GTGGCAGGCCCATGCGGTGCAGGCCGCGCTCGCTGTTGCGCTGGGGGTCGAGAAGGAGGCCATCGCCGTCGAGGTCATCA
AGACCTCCGGCGACCAGATCCAGGACCGGGCGCTGTCCGAGGCGGGGGGCAAGGGCCTCTTCACCAAGGAGATCGAGGAG
GCGCTGCTGGACGGCCGCGTCGACCTCGCCGTCCATTCCGCCAAGGACGTGGCGACGGTGCTGCCCGATGGCCTGCATCT
GGCCGGCTATCTGCCGCGCGCCGACGTGCGCGATGCCCTGATTCTCAAGTCCGGCGCCGCGCTGGCCGACCTGCCGGCGG
GCGCGAAGGTGGGCACCGCCTCGCTGCGGCGGGAGGCGCAGTTGCGCCGCATCCGTCCGGATCTGAAGGTGGAGCTGCTG
CGCGGCAACGTCCACACCCGCCTCGCCAAGGTGAAGGACGGGGATTTCGACGCCACATTGCTGGCGCTTGCCGGCCTCAC
CCGCCTCGGCATGGCGCAGGCGGCAAGCTGCGTGCTGGCGACCGATGATTTCCTGCCCGCCGTGGGGCAGGGGGCGGTGG
CGATCGAGTGCCGCATCGCCGATCCCGATACCAATGCCGCCATCGCCGCTATCGCCTGCCGCGACACCGGCATCGCGCTG
GAGGCGGAGCGGGCGTTCCTGGCGGCGCTGGACGGCTCGTGCCGCACCCCCATCGCCGGCCTCGCCACGGTGGAGGGGGA
GAGCGTGCGCCTGCGCGGCCTCGTCCTGTCGCCGGACGGCAGCGATGCCGCCGAGATCGCCGAACTGGCGCCCATCGCCG
ACGCGGCCCGGCTCGGCGCGGAATGTGGGGCGCGCCTGCGCACCAGCGCACCGGCGCGGGCGCTGGGGCTTTAG

Upstream 100 bases:

>100_bases
ACCCTCCCAGATCCGTTCTTGTACGGTATTCCAATATGGAGCCGCTGCGCCCGAACGCCGCTCTATCCCATTTCGATTCC
GTCGCGCATTGTACGCCGCC

Downstream 100 bases:

>100_bases
GGCGGAGGGCACGGGAGAATGATGGTGCTCGCAGGTGAAGCGGGTTGATTGGGCCGGGACCGGCGCAGAACCCTCTCCCG
CCGAGGAGGGGAGAGGGGGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSENTKSVYHPVHPRLRIGTRGSPLALWQAHAVQAALAVALGVEKEAIAVEVIKTSGDQIQDRALSEAGGKGLFTKEIEE
ALLDGRVDLAVHSAKDVATVLPDGLHLAGYLPRADVRDALILKSGAALADLPAGAKVGTASLRREAQLRRIRPDLKVELL
RGNVHTRLAKVKDGDFDATLLALAGLTRLGMAQAASCVLATDDFLPAVGQGAVAIECRIADPDTNAAIAAIACRDTGIAL
EAERAFLAALDGSCRTPIAGLATVEGESVRLRGLVLSPDGSDAAEIAELAPIADAARLGAECGARLRTSAPARALGL

Sequences:

>Translated_317_residues
MSENTKSVYHPVHPRLRIGTRGSPLALWQAHAVQAALAVALGVEKEAIAVEVIKTSGDQIQDRALSEAGGKGLFTKEIEE
ALLDGRVDLAVHSAKDVATVLPDGLHLAGYLPRADVRDALILKSGAALADLPAGAKVGTASLRREAQLRRIRPDLKVELL
RGNVHTRLAKVKDGDFDATLLALAGLTRLGMAQAASCVLATDDFLPAVGQGAVAIECRIADPDTNAAIAAIACRDTGIAL
EAERAFLAALDGSCRTPIAGLATVEGESVRLRGLVLSPDGSDAAEIAELAPIADAARLGAECGARLRTSAPARALGL
>Mature_316_residues
SENTKSVYHPVHPRLRIGTRGSPLALWQAHAVQAALAVALGVEKEAIAVEVIKTSGDQIQDRALSEAGGKGLFTKEIEEA
LLDGRVDLAVHSAKDVATVLPDGLHLAGYLPRADVRDALILKSGAALADLPAGAKVGTASLRREAQLRRIRPDLKVELLR
GNVHTRLAKVKDGDFDATLLALAGLTRLGMAQAASCVLATDDFLPAVGQGAVAIECRIADPDTNAAIAAIACRDTGIALE
AERAFLAALDGSCRTPIAGLATVEGESVRLRGLVLSPDGSDAAEIAELAPIADAARLGAECGARLRTSAPARALGL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=275, Percent_Identity=41.0909090909091, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI20149500, Length=275, Percent_Identity=41.0909090909091, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI48994974, Length=268, Percent_Identity=48.134328358209, Blast_Score=225, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319996, Length=284, Percent_Identity=38.0281690140845, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20130425, Length=280, Percent_Identity=41.0714285714286, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32806; Mature: 32675

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENTKSVYHPVHPRLRIGTRGSPLALWQAHAVQAALAVALGVEKEAIAVEVIKTSGDQI
CCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCHH
QDRALSEAGGKGLFTKEIEEALLDGRVDLAVHSAKDVATVLPDGLHLAGYLPRADVRDAL
HHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCEEEECCCCCCCCCEE
ILKSGAALADLPAGAKVGTASLRREAQLRRIRPDLKVELLRGNVHTRLAKVKDGDFDATL
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHEEECCCCCCCHHH
LALAGLTRLGMAQAASCVLATDDFLPAVGQGAVAIECRIADPDTNAAIAAIACRDTGIAL
HHHHHHHHHHHHHHCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCEE
EAERAFLAALDGSCRTPIAGLATVEGESVRLRGLVLSPDGSDAAEIAELAPIADAARLGA
EHHHHEEEECCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ECGARLRTSAPARALGL
HHCCHHCCCCCHHHCCC
>Mature Secondary Structure 
SENTKSVYHPVHPRLRIGTRGSPLALWQAHAVQAALAVALGVEKEAIAVEVIKTSGDQI
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCHH
QDRALSEAGGKGLFTKEIEEALLDGRVDLAVHSAKDVATVLPDGLHLAGYLPRADVRDAL
HHHHHHHCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCEEEECCCCCCCCCEE
ILKSGAALADLPAGAKVGTASLRREAQLRRIRPDLKVELLRGNVHTRLAKVKDGDFDATL
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHEEECCCCCCCHHH
LALAGLTRLGMAQAASCVLATDDFLPAVGQGAVAIECRIADPDTNAAIAAIACRDTGIAL
HHHHHHHHHHHHHHCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCEE
EAERAFLAALDGSCRTPIAGLATVEGESVRLRGLVLSPDGSDAAEIAELAPIADAARLGA
EHHHHEEEECCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ECGARLRTSAPARALGL
HHCCHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA