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The map label for this gene is tmd [H]

Identifier: 154244867

GI number: 154244867

Start: 1031611

End: 1033815

Strand: Direct

Name: tmd [H]

Synonym: Xaut_0917

Alternate gene names: 154244867

Gene position: 1031611-1033815 (Clockwise)

Preceding gene: 154244866

Following gene: 154244868

Centisome position: 19.43

GC content: 66.89

Gene sequence:

>2205_bases
ATGACGCACGAAACGCTGGGTGTCAGCAAATACGATATTCTGTTCGAGCCGATCAAGATCGGCCCGAAAACCCTTCGGAA
CCGCTTCTACCAGGTGCCCCATTGCATCGGCGCCGGTTCCGACAAGCCCGGCTTCCAGGCCGCGCACCGCTCGCTCAAGG
CCGAAGGCGGCTGGGCGGCGCTCAACACCGAATACTGTTCCATCCATCCCGAATCCGACGACACCCATCGCGTGTCCGCC
CGCATCTGGGACGAGGGCGACGTGCGCAACCTCGCCGCCATGACCTCGGAAATCCATAAATACGGTGCGCTCGCGGGCGT
TGAGCTGTGGTACGGCGGCGCCCACGCCCCCTGCATGGAGACGCGCCAGACCGCGCGCGGGCCGAGCCAGTACGCGTCCG
AGTTCGAATCCCTCACCTATTGCCACGAGATGGACCACGACGACATCCGTCGCGTGCAGGGCTTCTATGTGGAGGCGGCG
CGCCGCGCCCGCGATGCCGGCTTCGACATCATCTACTGCTACGGCGCGCATTCCTATCTGCCGCTGCAGTTCCTCTCCAA
ATACTACAACAAGCGCACCGACAAATACGGCGGCAGCTTCGAGAACCGCGCCCGGTTCTGGATCGAGACGCTGGAGCAGA
TGAAGGCGGCGGTGGGCTCCGAATGCGCCATCGCCACCCGCTTCGCCGTCGATACGCTGATCGGCGAGGAAGGCATCGAG
GTGGAGCGCGACGGGCTCAAGTTCGTCGAGCTGGCCGACGATCTCGTGGACCTGTGGGACGTGAACGTGGGCGACATCGC
CGAATGGGGCGAGGATGCCGGCCCCTCGCGCTTCTACCGCCAGGGCCACCAGCTCTCCTGGCAGAAGTTCGTGAAGCAGG
CGTCCAAGAAGGTCGTGCTCGGCGTCGGCCGCTTCACCGATCCGGAGAAGATGGTGGAGGTCATCCGCAACGGCGAGCTC
GACGTGATCGGCGCCGCCCGGCCCTCCATCGCCGATCCCTTCCTGCCGGAGAAGATCCGCGACGGGCGGCTCGACGACAT
CCGCACTTGCATCGGCTGCAACGTGTGCATCTCCCGCTGGGAGATCGGCGGCCCGCCCATGATCTGCACCCAGAACGCCA
CCGCCGGCGAGGAATTCCGCCGCGGCTGGCATCCCGAGCGCTTCCCCAAGAAGGGCTCCGACGATGCCATTCTGGTGGTG
GGCGCCGGCCCTTCCGGCTCGGAATGCGCCCGCGTGCTCATGGAGCGCGGCTATGTGGTGCATCTGGTGGACAGCGCTGA
GAAAGTCGGCGGCTATGTGAACGAGGTGGCGAGCCTGCCCGGCCTCGGCGAGTGGAGCTACCACCGCGATTATCGCGAGG
TGCAGCTCGCCAAGCTGGTGAAGCGCAATCGCGACAGCCAGATCGCCCTCGGCGGCAAGAAGCTGACGGTGGAGGACGTG
CTCTCCTACGGCGCCGACAAGGTGGTGATCGCCACCGGCGCCCACTGGGTGGCGGACGGCACCAACTGCCTCACCCACGC
GCCCATTCCGGGCTTGGAGACGCCGCGGGCCAACGTGCTGACCCCGGAAGACGTGATCCGCGGCGACAAGCCCATCGGCA
AGCGCGTCGTCATCCTCAACGCCGATCCCTATTACATGGCGCCGAGCCTCGCCCAGAAGCTGGCCGAGGCAGGGCATGAG
GTGACGGTGGCGTCCGGCGTGGAGCTGGGCCGCTACATGCACTTCACCCTCGAAGCGCCGAACATGCACCGCATGCTGCA
CGAGCTGCACATCAACGTGCTGTCCAACACCTGGGCGAGCCGCGTGGAAGACGGGCGGATCGAGCTCTACAACCTCTGGG
GCGACGGCCATAAGCGGCTCTATACTGGCCCCGGCAAGTCACCGCGCACCGCCAACACCACCCATGCCTGGCACGACTAC
GACACCCTCGTCCTCGTCACCGCCCGCCGCTCCGACGACGCCCTCTACCGGGCGCTGAAGGCGCGCTCCGGCGAGTGGGA
CGCCCGTGGCATAAAGGGCGTGTATGTGATCGGCGACGCCTGGGCGCCCAAGCTCATCGCCGACGCCACCTTCGACGGGC
AGCGCCTCGCCCGCGAGATCGAGGAGGCGAACCCGCAGGAGCCGAAGCCCTACCGCCGGGAGGCCGCCGTCTACGGCACG
CCCTACCAGCCGGGCGGCTCCTACGAGATCCGCTACCAGGGCTAG

Upstream 100 bases:

>100_bases
GAGTGCGCACCCGTGCGCGCTGAGCCTGCCGCTTGTCCTTATCGGCAAATAAATCCGGTCGTCGCACACCTGCCTTCCGG
ATTTTTCACGGGGAGTCGAG

Downstream 100 bases:

>100_bases
TTCCCCTCGCCCTGGGAGAAGCGGGCGGGGCGCGTCAGGGCACGCGCCCCGCATGCCCGGCTGCGGCCGGGCCCCAATGC
CGCCGGTGGAACGGCGCGGC

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: NA

Alternate protein names: TMADh [H]

Number of amino acids: Translated: 734; Mature: 733

Protein sequence:

>734_residues
MTHETLGVSKYDILFEPIKIGPKTLRNRFYQVPHCIGAGSDKPGFQAAHRSLKAEGGWAALNTEYCSIHPESDDTHRVSA
RIWDEGDVRNLAAMTSEIHKYGALAGVELWYGGAHAPCMETRQTARGPSQYASEFESLTYCHEMDHDDIRRVQGFYVEAA
RRARDAGFDIIYCYGAHSYLPLQFLSKYYNKRTDKYGGSFENRARFWIETLEQMKAAVGSECAIATRFAVDTLIGEEGIE
VERDGLKFVELADDLVDLWDVNVGDIAEWGEDAGPSRFYRQGHQLSWQKFVKQASKKVVLGVGRFTDPEKMVEVIRNGEL
DVIGAARPSIADPFLPEKIRDGRLDDIRTCIGCNVCISRWEIGGPPMICTQNATAGEEFRRGWHPERFPKKGSDDAILVV
GAGPSGSECARVLMERGYVVHLVDSAEKVGGYVNEVASLPGLGEWSYHRDYREVQLAKLVKRNRDSQIALGGKKLTVEDV
LSYGADKVVIATGAHWVADGTNCLTHAPIPGLETPRANVLTPEDVIRGDKPIGKRVVILNADPYYMAPSLAQKLAEAGHE
VTVASGVELGRYMHFTLEAPNMHRMLHELHINVLSNTWASRVEDGRIELYNLWGDGHKRLYTGPGKSPRTANTTHAWHDY
DTLVLVTARRSDDALYRALKARSGEWDARGIKGVYVIGDAWAPKLIADATFDGQRLAREIEEANPQEPKPYRREAAVYGT
PYQPGGSYEIRYQG

Sequences:

>Translated_734_residues
MTHETLGVSKYDILFEPIKIGPKTLRNRFYQVPHCIGAGSDKPGFQAAHRSLKAEGGWAALNTEYCSIHPESDDTHRVSA
RIWDEGDVRNLAAMTSEIHKYGALAGVELWYGGAHAPCMETRQTARGPSQYASEFESLTYCHEMDHDDIRRVQGFYVEAA
RRARDAGFDIIYCYGAHSYLPLQFLSKYYNKRTDKYGGSFENRARFWIETLEQMKAAVGSECAIATRFAVDTLIGEEGIE
VERDGLKFVELADDLVDLWDVNVGDIAEWGEDAGPSRFYRQGHQLSWQKFVKQASKKVVLGVGRFTDPEKMVEVIRNGEL
DVIGAARPSIADPFLPEKIRDGRLDDIRTCIGCNVCISRWEIGGPPMICTQNATAGEEFRRGWHPERFPKKGSDDAILVV
GAGPSGSECARVLMERGYVVHLVDSAEKVGGYVNEVASLPGLGEWSYHRDYREVQLAKLVKRNRDSQIALGGKKLTVEDV
LSYGADKVVIATGAHWVADGTNCLTHAPIPGLETPRANVLTPEDVIRGDKPIGKRVVILNADPYYMAPSLAQKLAEAGHE
VTVASGVELGRYMHFTLEAPNMHRMLHELHINVLSNTWASRVEDGRIELYNLWGDGHKRLYTGPGKSPRTANTTHAWHDY
DTLVLVTARRSDDALYRALKARSGEWDARGIKGVYVIGDAWAPKLIADATFDGQRLAREIEEANPQEPKPYRREAAVYGT
PYQPGGSYEIRYQG
>Mature_733_residues
THETLGVSKYDILFEPIKIGPKTLRNRFYQVPHCIGAGSDKPGFQAAHRSLKAEGGWAALNTEYCSIHPESDDTHRVSAR
IWDEGDVRNLAAMTSEIHKYGALAGVELWYGGAHAPCMETRQTARGPSQYASEFESLTYCHEMDHDDIRRVQGFYVEAAR
RARDAGFDIIYCYGAHSYLPLQFLSKYYNKRTDKYGGSFENRARFWIETLEQMKAAVGSECAIATRFAVDTLIGEEGIEV
ERDGLKFVELADDLVDLWDVNVGDIAEWGEDAGPSRFYRQGHQLSWQKFVKQASKKVVLGVGRFTDPEKMVEVIRNGELD
VIGAARPSIADPFLPEKIRDGRLDDIRTCIGCNVCISRWEIGGPPMICTQNATAGEEFRRGWHPERFPKKGSDDAILVVG
AGPSGSECARVLMERGYVVHLVDSAEKVGGYVNEVASLPGLGEWSYHRDYREVQLAKLVKRNRDSQIALGGKKLTVEDVL
SYGADKVVIATGAHWVADGTNCLTHAPIPGLETPRANVLTPEDVIRGDKPIGKRVVILNADPYYMAPSLAQKLAEAGHEV
TVASGVELGRYMHFTLEAPNMHRMLHELHINVLSNTWASRVEDGRIELYNLWGDGHKRLYTGPGKSPRTANTTHAWHDYD
TLVLVTARRSDDALYRALKARSGEWDARGIKGVYVIGDAWAPKLIADATFDGQRLAREIEEANPQEPKPYRREAAVYGTP
YQPGGSYEIRYQG

Specific function: Catalyzes The NADP-Dependent Reduction Of 2,4-Dienoyl- CoA To Yield Trans-2- Enoyl-CoA. [C]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=541, Percent_Identity=26.2476894639556, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI1787939, Length=218, Percent_Identity=26.1467889908257, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17559802, Length=275, Percent_Identity=29.4545454545455, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI72001454, Length=286, Percent_Identity=29.3706293706294, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559804, Length=282, Percent_Identity=28.3687943262411, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17564188, Length=294, Percent_Identity=28.2312925170068, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17565138, Length=250, Percent_Identity=28, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540738, Length=290, Percent_Identity=30, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321973, Length=225, Percent_Identity=29.7777777777778, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325086, Length=226, Percent_Identity=29.646017699115, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.5.8.2 [H]

Molecular weight: Translated: 81835; Mature: 81704

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHETLGVSKYDILFEPIKIGPKTLRNRFYQVPHCIGAGSDKPGFQAAHRSLKAEGGWAA
CCCCCCCCCEEHEEECCHHCCHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHCCCCCEEE
LNTEYCSIHPESDDTHRVSARIWDEGDVRNLAAMTSEIHKYGALAGVELWYGGAHAPCME
ECCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
TRQTARGPSQYASEFESLTYCHEMDHDDIRRVQGFYVEAARRARDAGFDIIYCYGAHSYL
HHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PLQFLSKYYNKRTDKYGGSFENRARFWIETLEQMKAAVGSECAIATRFAVDTLIGEEGIE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCE
VERDGLKFVELADDLVDLWDVNVGDIAEWGEDAGPSRFYRQGHQLSWQKFVKQASKKVVL
ECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHCCCEEEE
GVGRFTDPEKMVEVIRNGELDVIGAARPSIADPFLPEKIRDGRLDDIRTCIGCNVCISRW
EECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHCCHHHHHHE
EIGGPPMICTQNATAGEEFRRGWHPERFPKKGSDDAILVVGAGPSGSECARVLMERGYVV
ECCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEE
HLVDSAEKVGGYVNEVASLPGLGEWSYHRDYREVQLAKLVKRNRDSQIALGGKKLTVEDV
EEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEHHHH
LSYGADKVVIATGAHWVADGTNCLTHAPIPGLETPRANVLTPEDVIRGDKPIGKRVVILN
HHCCCCEEEEEECCEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEC
ADPYYMAPSLAQKLAEAGHEVTVASGVELGRYMHFTLEAPNMHRMLHELHINVLSNTWAS
CCCCEECHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
RVEDGRIELYNLWGDGHKRLYTGPGKSPRTANTTHAWHDYDTLVLVTARRSDDALYRALK
HCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHH
ARSGEWDARGIKGVYVIGDAWAPKLIADATFDGQRLAREIEEANPQEPKPYRREAAVYGT
HCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHCEEEECC
PYQPGGSYEIRYQG
CCCCCCCEEEEECC
>Mature Secondary Structure 
THETLGVSKYDILFEPIKIGPKTLRNRFYQVPHCIGAGSDKPGFQAAHRSLKAEGGWAA
CCCCCCCCEEHEEECCHHCCHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHCCCCCEEE
LNTEYCSIHPESDDTHRVSARIWDEGDVRNLAAMTSEIHKYGALAGVELWYGGAHAPCME
ECCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
TRQTARGPSQYASEFESLTYCHEMDHDDIRRVQGFYVEAARRARDAGFDIIYCYGAHSYL
HHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
PLQFLSKYYNKRTDKYGGSFENRARFWIETLEQMKAAVGSECAIATRFAVDTLIGEEGIE
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCE
VERDGLKFVELADDLVDLWDVNVGDIAEWGEDAGPSRFYRQGHQLSWQKFVKQASKKVVL
ECCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHCCCEEEE
GVGRFTDPEKMVEVIRNGELDVIGAARPSIADPFLPEKIRDGRLDDIRTCIGCNVCISRW
EECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHCCHHHHHHE
EIGGPPMICTQNATAGEEFRRGWHPERFPKKGSDDAILVVGAGPSGSECARVLMERGYVV
ECCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEE
HLVDSAEKVGGYVNEVASLPGLGEWSYHRDYREVQLAKLVKRNRDSQIALGGKKLTVEDV
EEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEHHHH
LSYGADKVVIATGAHWVADGTNCLTHAPIPGLETPRANVLTPEDVIRGDKPIGKRVVILN
HHCCCCEEEEEECCEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEC
ADPYYMAPSLAQKLAEAGHEVTVASGVELGRYMHFTLEAPNMHRMLHELHINVLSNTWAS
CCCCEECHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
RVEDGRIELYNLWGDGHKRLYTGPGKSPRTANTTHAWHDYDTLVLVTARRSDDALYRALK
HCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHH
ARSGEWDARGIKGVYVIGDAWAPKLIADATFDGQRLAREIEEANPQEPKPYRREAAVYGT
HCCCCCCCCCCCEEEEEECCCCCHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHCEEEECC
PYQPGGSYEIRYQG
CCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1505666; 620783; 1551870; 12567183 [H]