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The map label for this gene is hsrA [H]

Identifier: 154244788

GI number: 154244788

Start: 936120

End: 937559

Strand: Reverse

Name: hsrA [H]

Synonym: Xaut_0838

Alternate gene names: 154244788

Gene position: 937559-936120 (Counterclockwise)

Preceding gene: 154244790

Following gene: 154244784

Centisome position: 17.66

GC content: 68.12

Gene sequence:

>1440_bases
ATGCCGCGCCACGCGCTGCCGCCGCAGGTTCTCATTCCCCTTATCGTCGCCTGTGCCCTGTTCATGGAGCAGGTGGACGC
GACGGTGATCGCCACCTCCCTGCCCGCAATCGCCGCCGACCTGAAGGAAGACCCGGTAGCGCTCAAGCTGGCGCTCACCT
CCTACCTGCTCTCCCTCGCGGTCTTCATTCCGGCCAGCGGCTGGGCGGCGGACCGCTATGGCGCGCGCACCGTGTTCCGC
TCCGCCATCGTCATCTTCACCATCGGCTCGATCCTGTGCGGGCTCTCCACCTCGCTCACCGACTTCGTACTCTACCGCAT
CGTCCAGGGCATGGGCGGAGCCATGATGGTGCCGGTGGGGCGGCTCGTCATCCTGCGCTCGGTGCCGAAGACGGAGCTGG
TGTCGGCTCTGGCGTGGCTCACCATTCCCGCCCTGCTGGGTCCGGTGTTCGGCCCGCCGCTGGGGGGCTTCATCACCACC
TATTTCGACTGGCGGCTGATCTTCTTCATCAATGTGCCCATCGGGGTGCTGGGGGTGTTCCTCGCCACACGCTTCATCGA
GAATGTTCGGGAAGAGGACGTGCCGCCGCTCGACCTGAAGGGCCTCGTTTTGTCCGGAATCGGGCTCGCCGGCCTGGTCT
TCGGCTTCGCCGTGCTGGGACAGGAGCTGGTGCCGGTGTGGGCCGCCCTCGCCGTGGCCGGCATCGGCGCCGGCGCCCTG
TGGCTCTATGTGCGCCATGCGCGGGTCACGCCCCATGCGGTGCTCGACCTGAACCTCTTGCGGCATTCCTCGTTCCGCGC
CGGCGTAGTGGGCGGCTCGCTGTTCCGGGTGGGCATCGGCGCCCTGCCCTTCCTGCTGCCGCTGCTGCTCCAGCTGTCGT
TCGGCCTGTCGCCCTTCGCCTCGGGCATGCTCACCTTCGCCGCCTCGGCGGGGGCCCTCATCATGAAATTCACCGCCGCA
CCGCTGCTGCGGCGGCTCGGCTACAAGCGCGTGCTCCTTGCCAACGCCGTGCTTTCGGCCGGCTTCATCGCGGTGAACGC
CGCCTTCACGCCGTTCACGCCCCATTGGATCATCGTCATGGTGCTGCTGGTGGGCGGCTTCCTGCGCTCGCTCCAGTTCA
CAGCGCTCAATGCGCTGAGCTATGCGGAAGTGGAGCCCCAGGAGATGAGCCGTGCCACCTCCTTCGCCAGCGTGGCGCAG
CAGGTGTCGCTGTCCTGCGGCGTAGCGCTGGCCGGCTTTGTGCTGGAGACCATGCGCGCCCACCGGGGCGAGATGGCGGT
AACCCAGAGCGACTTCGCCGTCGCCTTCCTGGTGGTGGCGGTGGTGAGCCTGGCGAGCCTCGCCTATTTCGTCGGCCTGC
CCCGGAATGCCGGTGCGGAGCTGAACGGCCGCAAGCCGGACCTCGCCGACCCGCGCAGCGAGGTCAGTCCCGATCACTGA

Upstream 100 bases:

>100_bases
TTGATCACGGCGTGTGGAGCCCCTATTCGGGACGCCGGGCTCAACGCGTCGCTCTGCCCCCGAAGACCCTGCCCCGAGGC
GCGACCCTACGGAAACGCTC

Downstream 100 bases:

>100_bases
TCGCGGGGCGCCTGCGCCTCGGCGGTCCCGGTGCCATCGGTCCCGGCATCGTCCGTCTCGGCCCGGTCCGCCTCGCCGCG
GAAGCCGGTGGCCAGCACAT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MPRHALPPQVLIPLIVACALFMEQVDATVIATSLPAIAADLKEDPVALKLALTSYLLSLAVFIPASGWAADRYGARTVFR
SAIVIFTIGSILCGLSTSLTDFVLYRIVQGMGGAMMVPVGRLVILRSVPKTELVSALAWLTIPALLGPVFGPPLGGFITT
YFDWRLIFFINVPIGVLGVFLATRFIENVREEDVPPLDLKGLVLSGIGLAGLVFGFAVLGQELVPVWAALAVAGIGAGAL
WLYVRHARVTPHAVLDLNLLRHSSFRAGVVGGSLFRVGIGALPFLLPLLLQLSFGLSPFASGMLTFAASAGALIMKFTAA
PLLRRLGYKRVLLANAVLSAGFIAVNAAFTPFTPHWIIVMVLLVGGFLRSLQFTALNALSYAEVEPQEMSRATSFASVAQ
QVSLSCGVALAGFVLETMRAHRGEMAVTQSDFAVAFLVVAVVSLASLAYFVGLPRNAGAELNGRKPDLADPRSEVSPDH

Sequences:

>Translated_479_residues
MPRHALPPQVLIPLIVACALFMEQVDATVIATSLPAIAADLKEDPVALKLALTSYLLSLAVFIPASGWAADRYGARTVFR
SAIVIFTIGSILCGLSTSLTDFVLYRIVQGMGGAMMVPVGRLVILRSVPKTELVSALAWLTIPALLGPVFGPPLGGFITT
YFDWRLIFFINVPIGVLGVFLATRFIENVREEDVPPLDLKGLVLSGIGLAGLVFGFAVLGQELVPVWAALAVAGIGAGAL
WLYVRHARVTPHAVLDLNLLRHSSFRAGVVGGSLFRVGIGALPFLLPLLLQLSFGLSPFASGMLTFAASAGALIMKFTAA
PLLRRLGYKRVLLANAVLSAGFIAVNAAFTPFTPHWIIVMVLLVGGFLRSLQFTALNALSYAEVEPQEMSRATSFASVAQ
QVSLSCGVALAGFVLETMRAHRGEMAVTQSDFAVAFLVVAVVSLASLAYFVGLPRNAGAELNGRKPDLADPRSEVSPDH
>Mature_478_residues
PRHALPPQVLIPLIVACALFMEQVDATVIATSLPAIAADLKEDPVALKLALTSYLLSLAVFIPASGWAADRYGARTVFRS
AIVIFTIGSILCGLSTSLTDFVLYRIVQGMGGAMMVPVGRLVILRSVPKTELVSALAWLTIPALLGPVFGPPLGGFITTY
FDWRLIFFINVPIGVLGVFLATRFIENVREEDVPPLDLKGLVLSGIGLAGLVFGFAVLGQELVPVWAALAVAGIGAGALW
LYVRHARVTPHAVLDLNLLRHSSFRAGVVGGSLFRVGIGALPFLLPLLLQLSFGLSPFASGMLTFAASAGALIMKFTAAP
LLRRLGYKRVLLANAVLSAGFIAVNAAFTPFTPHWIIVMVLLVGGFLRSLQFTALNALSYAEVEPQEMSRATSFASVAQQ
VSLSCGVALAGFVLETMRAHRGEMAVTQSDFAVAFLVVAVVSLASLAYFVGLPRNAGAELNGRKPDLADPRSEVSPDH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=467, Percent_Identity=38.1156316916488, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1788392, Length=434, Percent_Identity=35.9447004608295, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789042, Length=439, Percent_Identity=25.9681093394077, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788710, Length=435, Percent_Identity=25.0574712643678, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87081983, Length=320, Percent_Identity=25.9375, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790146, Length=157, Percent_Identity=28.0254777070064, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=207, Percent_Identity=27.0531400966184, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=178, Percent_Identity=26.4044943820225, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50788; Mature: 50657

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHALPPQVLIPLIVACALFMEQVDATVIATSLPAIAADLKEDPVALKLALTSYLLSLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VFIPASGWAADRYGARTVFRSAIVIFTIGSILCGLSTSLTDFVLYRIVQGMGGAMMVPVG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEHHHH
RLVILRSVPKTELVSALAWLTIPALLGPVFGPPLGGFITTYFDWRLIFFINVPIGVLGVF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEECCHHHHHHH
LATRFIENVREEDVPPLDLKGLVLSGIGLAGLVFGFAVLGQELVPVWAALAVAGIGAGAL
HHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
WLYVRHARVTPHAVLDLNLLRHSSFRAGVVGGSLFRVGIGALPFLLPLLLQLSFGLSPFA
HHHHHHCCCCCHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
SGMLTFAASAGALIMKFTAAPLLRRLGYKRVLLANAVLSAGFIAVNAAFTPFTPHWIIVM
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHH
VLLVGGFLRSLQFTALNALSYAEVEPQEMSRATSFASVAQQVSLSCGVALAGFVLETMRA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRGEMAVTQSDFAVAFLVVAVVSLASLAYFVGLPRNAGAELNGRKPDLADPRSEVSPDH
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PRHALPPQVLIPLIVACALFMEQVDATVIATSLPAIAADLKEDPVALKLALTSYLLSLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VFIPASGWAADRYGARTVFRSAIVIFTIGSILCGLSTSLTDFVLYRIVQGMGGAMMVPVG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEHHHH
RLVILRSVPKTELVSALAWLTIPALLGPVFGPPLGGFITTYFDWRLIFFINVPIGVLGVF
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEECCHHHHHHH
LATRFIENVREEDVPPLDLKGLVLSGIGLAGLVFGFAVLGQELVPVWAALAVAGIGAGAL
HHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
WLYVRHARVTPHAVLDLNLLRHSSFRAGVVGGSLFRVGIGALPFLLPLLLQLSFGLSPFA
HHHHHHCCCCCHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
SGMLTFAASAGALIMKFTAAPLLRRLGYKRVLLANAVLSAGFIAVNAAFTPFTPHWIIVM
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHHH
VLLVGGFLRSLQFTALNALSYAEVEPQEMSRATSFASVAQQVSLSCGVALAGFVLETMRA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRGEMAVTQSDFAVAFLVVAVVSLASLAYFVGLPRNAGAELNGRKPDLADPRSEVSPDH
CCCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]