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The map label for this gene is merR1 [H]

Identifier: 154244750

GI number: 154244750

Start: 892202

End: 892630

Strand: Direct

Name: merR1 [H]

Synonym: Xaut_0800

Alternate gene names: 154244750

Gene position: 892202-892630 (Clockwise)

Preceding gene: 154244740

Following gene: 154244761

Centisome position: 16.81

GC content: 68.53

Gene sequence:

>429_bases
ATGCGCGATCACGCTGGCGTGAAGGGCCTGCAGCGGGCTGAGCTCGCCCGGCGGACGGGCAGCAATCTGGAGACTGTGCG
CTACTACGAGAAGGTCGGGCTCCTGCCCGAGCCACCGCGCACGGCGGCCGGCTACCGCAGCTACGACACGACGCACGAGC
GGCGCCTTCGCTTTGTGCTGCGGGCACGCGAGCTCGGCTTCTCACTCGACGAAATCCGCGAGCTGTTGCGCCTGGTCGAC
GAACGCGACCAGCCCTGCGCCGAGGCAAGCGCGGTCGCCGCCGCGCATCTCGACGATGTGCGGGCGAAGATCGCTGACCT
GAAGCGCATGGAGCGGGTGCTCAAGGACGTCGTCGCGCAATGCGCCGACGGCACGCGGCCGGAATGTCCGCTGATTGAGG
CGCTGTTCCGGGAGCGAACTGTCAACTGA

Upstream 100 bases:

>100_bases
CGCGATATATCCATGTCCGATCTCGCTTTCCTTGCCGAAATCCTCATTGCGCAGTACCATGCGGTCTGTAGCAACTACAG
GGTCAAGAGGGATTTTTGCG

Downstream 100 bases:

>100_bases
TCGGGTCGAGGAGCGCCTATGCGGCGCCCCTGACGTCGTTCCGGCAAGCGTTGCCCTGCTGGGCGTGCAGCCAGTCGGCG
ATCTGCTGCGCCTTGGCTGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MRDHAGVKGLQRAELARRTGSNLETVRYYEKVGLLPEPPRTAAGYRSYDTTHERRLRFVLRARELGFSLDEIRELLRLVD
ERDQPCAEASAVAAAHLDDVRAKIADLKRMERVLKDVVAQCADGTRPECPLIEALFRERTVN

Sequences:

>Translated_142_residues
MRDHAGVKGLQRAELARRTGSNLETVRYYEKVGLLPEPPRTAAGYRSYDTTHERRLRFVLRARELGFSLDEIRELLRLVD
ERDQPCAEASAVAAAHLDDVRAKIADLKRMERVLKDVVAQCADGTRPECPLIEALFRERTVN
>Mature_142_residues
MRDHAGVKGLQRAELARRTGSNLETVRYYEKVGLLPEPPRTAAGYRSYDTTHERRLRFVLRARELGFSLDEIRELLRLVD
ERDQPCAEASAVAAAHLDDVRAKIADLKRMERVLKDVVAQCADGTRPECPLIEALFRERTVN

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=126, Percent_Identity=36.5079365079365, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1786695, Length=123, Percent_Identity=29.2682926829268, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16188; Mature: 16188

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDHAGVKGLQRAELARRTGSNLETVRYYEKVGLLPEPPRTAAGYRSYDTTHERRLRFVL
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RARELGFSLDEIRELLRLVDERDQPCAEASAVAAAHLDDVRAKIADLKRMERVLKDVVAQ
HHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CADGTRPECPLIEALFRERTVN
HCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRDHAGVKGLQRAELARRTGSNLETVRYYEKVGLLPEPPRTAAGYRSYDTTHERRLRFVL
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RARELGFSLDEIRELLRLVDERDQPCAEASAVAAAHLDDVRAKIADLKRMERVLKDVVAQ
HHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CADGTRPECPLIEALFRERTVN
HCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]