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The map label for this gene is gyaR [H]

Identifier: 154244461

GI number: 154244461

Start: 559028

End: 559996

Strand: Direct

Name: gyaR [H]

Synonym: Xaut_0504

Alternate gene names: 154244461

Gene position: 559028-559996 (Clockwise)

Preceding gene: 154244453

Following gene: 154244462

Centisome position: 10.53

GC content: 70.28

Gene sequence:

>969_bases
ATGACCGATCAAGCAACCGATCAAGCCCGCCCGGCCGTCCTTCTGACCGGACCAGTGATGGAGGAGGTGGTGGAGCGCCA
GCTCGCCTCCCGCTTCGATCTTCTGCCCCTGGATGCCCTGTCCGACGCCACCGCCGCCGCGGTGCGCGCCATCGCCACAC
GCGGCAAGGAGCGGGTGGACGAGGCACTGATGGCGCGCCTGCCCGCTCTGAAGATCGTCGCCAATTTCGGCGTCGGCTAC
GACACGGTGGATGCCGCCGCCGCCGCCCGGCGCGGCGTGATCGTCACCAATACGCCGGACGTGCTGAACGAGGAGGTGGC
CGATCTCACCCTCGGCCTGCTGCTCGCCACCGTGCGGCAGATCCCCCAGGCCGACCGCTTCGTGCGCGACGGCAAGTGGC
TGAAGGGCGCCTATCCTCTGGGGCCGACGCTGCGCGAGCGGACGGTAGGCATCGTCGGCATGGGCCGCATCGGCAAGGCC
ATCGCCCGGCGGCTGGAGGCCTTCGCGGTGCCGGTCGCCTACCACAGCCGGCGCCAGCAGCCGGACGTGGACCTGCCCTA
TTTCGCAAGCCTGCTCGACCTCGCGCGGGCGGTGAGCGTGCTGGTGGTCATCGTCCCCGGCGGGGCGGCTACCCGCCATC
TGGTGAATGCCGACGTGCTCGCCGCTCTGGGGCCGGACGGCATCCTCATCAACGTCGCCCGCGGCACCGTGGTGGACGAG
GCGGCGCTGCTCAAGGCGCTGCAATCGCGCACCATTCTCGCCGCCGGGCTCGATGTGTTCGAGAAGGAGCCCCATGTGCC
GGAGGCCTTCCTCGGCCTCGACAATGTAGTGCTGCTGCCCCACGTGGGCTCGTCGACGCACCATACCCGCGCGGCCATGG
GCCAACTGGTGGTGGACAACATCGTCGCCTTCCTGGACGGCAAGGGTCCGCTGACCCCGGTGGCGGAGACCCCCTGGCCG
AAGGCCTGA

Upstream 100 bases:

>100_bases
CAGGGGGCGATCCCAGCTGCGCCGGGATACCAAACTACCGTTTGCTTGCCCTCGGCTTTGGTCCTGGGCCAGATTTGACC
GTCGGAACCGAAAGCCCGCC

Downstream 100 bases:

>100_bases
GGCGCGCTCGCTGACCCCTCGCGGCGACGCTCCCCCTAGCGTAAGGCCACACCATCGGCCAGCCGGGAGCGGCGCGCCGA
ACCGCGCTCGCGCGCGCCGG

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTDQATDQARPAVLLTGPVMEEVVERQLASRFDLLPLDALSDATAAAVRAIATRGKERVDEALMARLPALKIVANFGVGY
DTVDAAAAARRGVIVTNTPDVLNEEVADLTLGLLLATVRQIPQADRFVRDGKWLKGAYPLGPTLRERTVGIVGMGRIGKA
IARRLEAFAVPVAYHSRRQQPDVDLPYFASLLDLARAVSVLVVIVPGGAATRHLVNADVLAALGPDGILINVARGTVVDE
AALLKALQSRTILAAGLDVFEKEPHVPEAFLGLDNVVLLPHVGSSTHHTRAAMGQLVVDNIVAFLDGKGPLTPVAETPWP
KA

Sequences:

>Translated_322_residues
MTDQATDQARPAVLLTGPVMEEVVERQLASRFDLLPLDALSDATAAAVRAIATRGKERVDEALMARLPALKIVANFGVGY
DTVDAAAAARRGVIVTNTPDVLNEEVADLTLGLLLATVRQIPQADRFVRDGKWLKGAYPLGPTLRERTVGIVGMGRIGKA
IARRLEAFAVPVAYHSRRQQPDVDLPYFASLLDLARAVSVLVVIVPGGAATRHLVNADVLAALGPDGILINVARGTVVDE
AALLKALQSRTILAAGLDVFEKEPHVPEAFLGLDNVVLLPHVGSSTHHTRAAMGQLVVDNIVAFLDGKGPLTPVAETPWP
KA
>Mature_321_residues
TDQATDQARPAVLLTGPVMEEVVERQLASRFDLLPLDALSDATAAAVRAIATRGKERVDEALMARLPALKIVANFGVGYD
TVDAAAAARRGVIVTNTPDVLNEEVADLTLGLLLATVRQIPQADRFVRDGKWLKGAYPLGPTLRERTVGIVGMGRIGKAI
ARRLEAFAVPVAYHSRRQQPDVDLPYFASLLDLARAVSVLVVIVPGGAATRHLVNADVLAALGPDGILINVARGTVVDEA
ALLKALQSRTILAAGLDVFEKEPHVPEAFLGLDNVVLLPHVGSSTHHTRAAMGQLVVDNIVAFLDGKGPLTPVAETPWPK
A

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=39.4308943089431, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=33.1034482758621, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI61743967, Length=211, Percent_Identity=30.3317535545024, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4557497, Length=211, Percent_Identity=30.3317535545024, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=27.027027027027, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=27.027027027027, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=27.027027027027, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI87082289, Length=312, Percent_Identity=36.5384615384615, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1789279, Length=273, Percent_Identity=30.03663003663, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787645, Length=203, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081824, Length=270, Percent_Identity=29.2592592592593, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788660, Length=258, Percent_Identity=31.3953488372093, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=250, Percent_Identity=32.4, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=24.2647058823529, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=273, Percent_Identity=33.6996336996337, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=282, Percent_Identity=28.3687943262411, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=269, Percent_Identity=27.5092936802974, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=279, Percent_Identity=26.8817204301075, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=32.8859060402685, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=221, Percent_Identity=24.8868778280543, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=37.9310344827586, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=37.9310344827586, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=37.9310344827586, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=37.9310344827586, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=37.9310344827586, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=40.1544401544402, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574286, Length=262, Percent_Identity=35.8778625954198, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=33.4661354581673, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19921140, Length=285, Percent_Identity=28.7719298245614, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646446, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646448, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646452, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646450, Length=230, Percent_Identity=32.1739130434783, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=230, Percent_Identity=32.1739130434783, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34169; Mature: 34038

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQATDQARPAVLLTGPVMEEVVERQLASRFDLLPLDALSDATAAAVRAIATRGKERVD
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
EALMARLPALKIVANFGVGYDTVDAAAAARRGVIVTNTPDVLNEEVADLTLGLLLATVRQ
HHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
IPQADRFVRDGKWLKGAYPLGPTLRERTVGIVGMGRIGKAIARRLEAFAVPVAYHSRRQQ
CCHHHHHHHCCCEECCCCCCCCCHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
PDVDLPYFASLLDLARAVSVLVVIVPGGAATRHLVNADVLAALGPDGILINVARGTVVDE
CCCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
AALLKALQSRTILAAGLDVFEKEPHVPEAFLGLDNVVLLPHVGSSTHHTRAAMGQLVVDN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH
IVAFLDGKGPLTPVAETPWPKA
HHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDQATDQARPAVLLTGPVMEEVVERQLASRFDLLPLDALSDATAAAVRAIATRGKERVD
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
EALMARLPALKIVANFGVGYDTVDAAAAARRGVIVTNTPDVLNEEVADLTLGLLLATVRQ
HHHHHHCCHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHH
IPQADRFVRDGKWLKGAYPLGPTLRERTVGIVGMGRIGKAIARRLEAFAVPVAYHSRRQQ
CCHHHHHHHCCCEECCCCCCCCCHHHHHCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCC
PDVDLPYFASLLDLARAVSVLVVIVPGGAATRHLVNADVLAALGPDGILINVARGTVVDE
CCCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHH
AALLKALQSRTILAAGLDVFEKEPHVPEAFLGLDNVVLLPHVGSSTHHTRAAMGQLVVDN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH
IVAFLDGKGPLTPVAETPWPKA
HHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA