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The map label for this gene is pepB [H]

Identifier: 154244238

GI number: 154244238

Start: 283682

End: 285049

Strand: Reverse

Name: pepB [H]

Synonym: Xaut_0281

Alternate gene names: 154244238

Gene position: 285049-283682 (Counterclockwise)

Preceding gene: 154244239

Following gene: 154244237

Centisome position: 5.37

GC content: 73.32

Gene sequence:

>1368_bases
ATGCTCGATTGTATTGCGCCCGCCTCTTCCATGAGCCTTCCCGTCTGGTGCGTCACCAAGGAGACCTTCGCGTCTGCCTC
CGTGCCGGAGACGGCTCGCCGCTTCGCCGAGGCCGCCGGCTTTGGCGGTGAGGGTGGCAAGCTGCTCCTGGTGCCCGCGC
CCGAGGGAGGCCTCGCCGGCGCCCTGTTCGGCGTCGCGGCCGGGGCCCGGGCGGATGCCTTCGCCGCCGGCGCCCTGCCC
GGCCTGTTGCCAGCCGGCGCGTGGCGGCTGGAGGGCGAGGTGGCGAGCCCGCGCCTCGCCGCGCTGGCGTTCGCGCTGGG
CACCTACCGCTTCACCCGCTACAAGGCCGCCCCCGCCCGCGACGTGCGGCTCGTGCTGCCCGAAGGGGTGGATGCCGACG
CTTTGGTGCGCACCGTCGAGGCCGTGACTCTCACCCGCGACCTCGTGAACACCCCCGCCAACGACCTCGGCCCGCCGGAG
CTGGAAGACGCCGCCCGCGCGCTCGCCGCCCGCCATGGCGCCGCCTTCCGCTCCGTCACCGGCGAGCGGCTGCTGGTGGA
GAACTTCCCCATGATCCATGCGGTGGGCCGCGCCGCCGACCGCGCCCCGCGCCTCATCGAGATCCGCGCCGGCGATCCCG
CCCACCCCAAGGTGACGCTGGTGGGCAAGGGCGTGGCCTTCGACACCGGCGGCCTCGATCTCAAGCCCTCCTCGGCCATG
CTGCTGATGAAGAAGGACATGGGCGGCGCGGCGAACGCGCTGGGCCTTGCCCATCTCCTGCTCTCGCGCGGGGCCAAGGT
GAACCTGCGGGTGCTGATTCCCGCCGTGGAGAATTCGGTCTCCGCGGCCGCCTTCCGGCCGGGCGACATCCTCAAGAGCC
GCAAGGGCCTCTCCGTGGAAATCGGCAACACGGACGCGGAGGGCCGCCTCGTGCTCGCCGACGCCCTCGCCCTCTCCGAC
GAGGAGGCGCCCGAACTGGTGATCGATTTCGCCACCCTCACCGGCGCGGCACGGGTGGCGCTGGGGCCGCAGCTTCCCGC
GGCCTTCACCCAGGACGAGGACCTCGCCGCTGACCTGGCCCGTCACGCCATGGTGGAGGCCGACCCCCTGTGGCGCCTGC
CGCTGTGGGCGCCCTACCAGGGCATGCTCGAGTCCAAGATCGCCGACACCAACAACGTGTCCTCCGGCGGCCTCGCCGGA
GCCATCACCGCCGCCCTGTTCCTGGAGAAGTTCGTGGGCGCGGCCCGCGCCTGGCTGCACCTCGACCTGTTCGCCTGGAA
TTCCGGCGCCCGCCCCGGACGCCCCGAGGGCGGCGAGGCCCAGACCATCCGCGCCCTCGATGCGCTGCTGGCCGAGCGCT
ACGGCTAG

Upstream 100 bases:

>100_bases
TTGCCATATTGCCGGATCGCGCTCTACCCATTGGCCTACAGGTCCTTTCGCGCGCCGCGCCGCCGCGTCCACGGCCCCGG
CGGCGCGCAGGAGTTCATTC

Downstream 100 bases:

>100_bases
CGCGCTTTCCGTGCGCATGGGCTCACGGAAAACGCGCTAGATTCTCTGGTTGACGCGTTTTCTTCACGCGAACCGGTGCC
CACTTCGCTCGAAAACGCTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDCIAPASSMSLPVWCVTKETFASASVPETARRFAEAAGFGGEGGKLLLVPAPEGGLAGALFGVAAGARADAFAAGALP
GLLPAGAWRLEGEVASPRLAALAFALGTYRFTRYKAAPARDVRLVLPEGVDADALVRTVEAVTLTRDLVNTPANDLGPPE
LEDAARALAARHGAAFRSVTGERLLVENFPMIHAVGRAADRAPRLIEIRAGDPAHPKVTLVGKGVAFDTGGLDLKPSSAM
LLMKKDMGGAANALGLAHLLLSRGAKVNLRVLIPAVENSVSAAAFRPGDILKSRKGLSVEIGNTDAEGRLVLADALALSD
EEAPELVIDFATLTGAARVALGPQLPAAFTQDEDLAADLARHAMVEADPLWRLPLWAPYQGMLESKIADTNNVSSGGLAG
AITAALFLEKFVGAARAWLHLDLFAWNSGARPGRPEGGEAQTIRALDALLAERYG

Sequences:

>Translated_455_residues
MLDCIAPASSMSLPVWCVTKETFASASVPETARRFAEAAGFGGEGGKLLLVPAPEGGLAGALFGVAAGARADAFAAGALP
GLLPAGAWRLEGEVASPRLAALAFALGTYRFTRYKAAPARDVRLVLPEGVDADALVRTVEAVTLTRDLVNTPANDLGPPE
LEDAARALAARHGAAFRSVTGERLLVENFPMIHAVGRAADRAPRLIEIRAGDPAHPKVTLVGKGVAFDTGGLDLKPSSAM
LLMKKDMGGAANALGLAHLLLSRGAKVNLRVLIPAVENSVSAAAFRPGDILKSRKGLSVEIGNTDAEGRLVLADALALSD
EEAPELVIDFATLTGAARVALGPQLPAAFTQDEDLAADLARHAMVEADPLWRLPLWAPYQGMLESKIADTNNVSSGGLAG
AITAALFLEKFVGAARAWLHLDLFAWNSGARPGRPEGGEAQTIRALDALLAERYG
>Mature_455_residues
MLDCIAPASSMSLPVWCVTKETFASASVPETARRFAEAAGFGGEGGKLLLVPAPEGGLAGALFGVAAGARADAFAAGALP
GLLPAGAWRLEGEVASPRLAALAFALGTYRFTRYKAAPARDVRLVLPEGVDADALVRTVEAVTLTRDLVNTPANDLGPPE
LEDAARALAARHGAAFRSVTGERLLVENFPMIHAVGRAADRAPRLIEIRAGDPAHPKVTLVGKGVAFDTGGLDLKPSSAM
LLMKKDMGGAANALGLAHLLLSRGAKVNLRVLIPAVENSVSAAAFRPGDILKSRKGLSVEIGNTDAEGRLVLADALALSD
EEAPELVIDFATLTGAARVALGPQLPAAFTQDEDLAADLARHAMVEADPLWRLPLWAPYQGMLESKIADTNNVSSGGLAG
AITAALFLEKFVGAARAWLHLDLFAWNSGARPGRPEGGEAQTIRALDALLAERYG

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=335, Percent_Identity=34.3283582089552, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI47155554, Length=300, Percent_Identity=32.6666666666667, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI87082123, Length=343, Percent_Identity=38.4839650145773, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790710, Length=295, Percent_Identity=39.3220338983051, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=303, Percent_Identity=38.2838283828383, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=215, Percent_Identity=31.6279069767442, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24661038, Length=285, Percent_Identity=32.9824561403509, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21355725, Length=285, Percent_Identity=32.6315789473684, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI221379063, Length=303, Percent_Identity=35.3135313531353, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI221379062, Length=303, Percent_Identity=35.3135313531353, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21357381, Length=303, Percent_Identity=35.3135313531353, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24662227, Length=331, Percent_Identity=26.2839879154079, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129969, Length=305, Percent_Identity=27.2131147540984, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21355645, Length=323, Percent_Identity=24.7678018575851, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24662223, Length=323, Percent_Identity=24.7678018575851, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129963, Length=337, Percent_Identity=26.4094955489614, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922386, Length=348, Percent_Identity=25.5747126436782, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161077148, Length=338, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI20130057, Length=338, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646701, Length=334, Percent_Identity=29.0419161676647, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=334, Percent_Identity=29.0419161676647, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=334, Percent_Identity=29.0419161676647, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 47255; Mature: 47255

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDCIAPASSMSLPVWCVTKETFASASVPETARRFAEAAGFGGEGGKLLLVPAPEGGLAG
CCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHH
ALFGVAAGARADAFAAGALPGLLPAGAWRLEGEVASPRLAALAFALGTYRFTRYKAAPAR
HHHHHHCCCCCCHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCC
DVRLVLPEGVDADALVRTVEAVTLTRDLVNTPANDLGPPELEDAARALAARHGAAFRSVT
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCC
GERLLVENFPMIHAVGRAADRAPRLIEIRAGDPAHPKVTLVGKGVAFDTGGLDLKPSSAM
CCEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCEEECCCCCCCCCCCEE
LLMKKDMGGAANALGLAHLLLSRGAKVNLRVLIPAVENSVSAAAFRPGDILKSRKGLSVE
EEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCEEECCHHHHHCCCCCEEE
IGNTDAEGRLVLADALALSDEEAPELVIDFATLTGAARVALGPQLPAAFTQDEDLAADLA
ECCCCCCCEEEEEEEHHCCCCCCCEEEEEEHHHCCCCEEEECCCCCCCCCCCHHHHHHHH
RHAMVEADPLWRLPLWAPYQGMLESKIADTNNVSSGGLAGAITAALFLEKFVGAARAWLH
HHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
LDLFAWNSGARPGRPEGGEAQTIRALDALLAERYG
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDCIAPASSMSLPVWCVTKETFASASVPETARRFAEAAGFGGEGGKLLLVPAPEGGLAG
CCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHH
ALFGVAAGARADAFAAGALPGLLPAGAWRLEGEVASPRLAALAFALGTYRFTRYKAAPAR
HHHHHHCCCCCCHHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHEEEEECCCCC
DVRLVLPEGVDADALVRTVEAVTLTRDLVNTPANDLGPPELEDAARALAARHGAAFRSVT
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCC
GERLLVENFPMIHAVGRAADRAPRLIEIRAGDPAHPKVTLVGKGVAFDTGGLDLKPSSAM
CCEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCEEECCCCCCCCCCCEE
LLMKKDMGGAANALGLAHLLLSRGAKVNLRVLIPAVENSVSAAAFRPGDILKSRKGLSVE
EEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCEEECCHHHHHCCCCCEEE
IGNTDAEGRLVLADALALSDEEAPELVIDFATLTGAARVALGPQLPAAFTQDEDLAADLA
ECCCCCCCEEEEEEEHHCCCCCCCEEEEEEHHHCCCCEEEECCCCCCCCCCCHHHHHHHH
RHAMVEADPLWRLPLWAPYQGMLESKIADTNNVSSGGLAGAITAALFLEKFVGAARAWLH
HHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
LDLFAWNSGARPGRPEGGEAQTIRALDALLAERYG
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA