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The map label for this gene is ispA [C]

Identifier: 154244163

GI number: 154244163

Start: 206967

End: 207893

Strand: Reverse

Name: ispA [C]

Synonym: Xaut_0205

Alternate gene names: 154244163

Gene position: 207893-206967 (Counterclockwise)

Preceding gene: 154244167

Following gene: 154244162

Centisome position: 3.92

GC content: 74.33

Gene sequence:

>927_bases
GTGACCTTTTCCCTCAAGGACCGGCTCGACGCCTCCGCCGCGGCCACCGAGGCCCGCCTCGCCCTCGCCCTCGCCGACGC
CGCGCTCCCCGGCGAGCGGCTACGGCCCGAGCGGCTGATGGCCGCCATGCGCCACGGCGCGCTCGGCGGCGGCAAACGGC
TGCGGCCGTTCCTGGTGATCGAAAGCGCTGCCCTGTTCGGCATCCCGGCCGATCAGGCGGTGACGGCCGCCACCGCCATC
GAGTGCATCCATTGCTATTCCCTGGTCCATGACGATCTGCCAGCCATGGACGACGACGATCTGCGCCGGGGCCGGCCCAC
CGTGCACCGGGCCTTTGACGAGGCCACCGCCATCCTCGCCGGCGACGGCCTGCTCACCCTCGCCTTCGACCTTCTGGCGG
GGGAGGATGCCCATCCCGATCCGGCCGTGCGCATCGCACTGGTGCGGGCGCTGGCCCGCGCTTCGGGCATCGGCGGCATG
GTGGGCGGGCAGATGCTGGACCTCGCCGCCGAGGGCCGCTTCTCCGGCGGCACCCCCCTCGCCCTGGCGGAAGACGCCAT
CCGCGACCTCCAGGCCATGAAGACCGGCGCGCTTTTGGCGGTCTCCGTGGAGGCCGGCGCGCTTTTGGGTGGCGCCACGG
CGGACGAGCGCGCGGCGCTCCTGGCCTATGGCCGGGCGCTGGGCGCCGCCTTCCAGATCGCCGACGACATCCTCGACGTG
GAAGGCACCGCCGAGGAGGTGGGCAAGAAGGTGGGCAAGGACGCCGCCGCCGGCAAGGCGACCCTGGTCTCCCGCCTCGG
CCTGCCCGCCGCCCGCACCCTGCTCGACCGGCTGGTGGCGGATGCGTCTGCCGCCCTCGCCCCCTTCGGCGCGCGCGGCG
CGGTGCTGGCCGAGGCCGCCCTGTTCGTGGCCAACCGGCGCAACTGA

Upstream 100 bases:

>100_bases
TCAACGGCGCGCCCGGCCCGGGCGTTCCCTCCCGCCCCGTTTGTGGCCCGCAGGCGTCGGCCCGCAGGTTCTGGCCCTTT
TGCCCCAAGGTGACCCGATC

Downstream 100 bases:

>100_bases
GTTTCCGCGATACCGCGCGCCCGTTCCGCGCGCGATCATGTGACGGGAACGCCCATGAGGCCGGTTCAACCGGGGCCGTT
CCGGCTTTATGGTCACGTCC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTFSLKDRLDASAAATEARLALALADAALPGERLRPERLMAAMRHGALGGGKRLRPFLVIESAALFGIPADQAVTAATAI
ECIHCYSLVHDDLPAMDDDDLRRGRPTVHRAFDEATAILAGDGLLTLAFDLLAGEDAHPDPAVRIALVRALARASGIGGM
VGGQMLDLAAEGRFSGGTPLALAEDAIRDLQAMKTGALLAVSVEAGALLGGATADERAALLAYGRALGAAFQIADDILDV
EGTAEEVGKKVGKDAAAGKATLVSRLGLPAARTLLDRLVADASAALAPFGARGAVLAEAALFVANRRN

Sequences:

>Translated_308_residues
MTFSLKDRLDASAAATEARLALALADAALPGERLRPERLMAAMRHGALGGGKRLRPFLVIESAALFGIPADQAVTAATAI
ECIHCYSLVHDDLPAMDDDDLRRGRPTVHRAFDEATAILAGDGLLTLAFDLLAGEDAHPDPAVRIALVRALARASGIGGM
VGGQMLDLAAEGRFSGGTPLALAEDAIRDLQAMKTGALLAVSVEAGALLGGATADERAALLAYGRALGAAFQIADDILDV
EGTAEEVGKKVGKDAAAGKATLVSRLGLPAARTLLDRLVADASAALAPFGARGAVLAEAALFVANRRN
>Mature_307_residues
TFSLKDRLDASAAATEARLALALADAALPGERLRPERLMAAMRHGALGGGKRLRPFLVIESAALFGIPADQAVTAATAIE
CIHCYSLVHDDLPAMDDDDLRRGRPTVHRAFDEATAILAGDGLLTLAFDLLAGEDAHPDPAVRIALVRALARASGIGGMV
GGQMLDLAAEGRFSGGTPLALAEDAIRDLQAMKTGALLAVSVEAGALLGGATADERAALLAYGRALGAAFQIADDILDVE
GTAEEVGKKVGKDAAAGKATLVSRLGLPAARTLLDRLVADASAALAPFGARGAVLAEAALFVANRRN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=32, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786623, Length=279, Percent_Identity=46.5949820788531, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1789578, Length=214, Percent_Identity=33.6448598130841, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=201, Percent_Identity=32.8358208955224, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651612, Length=226, Percent_Identity=30.5309734513274, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31557; Mature: 31425

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSLKDRLDASAAATEARLALALADAALPGERLRPERLMAAMRHGALGGGKRLRPFLVI
CCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
ESAALFGIPADQAVTAATAIECIHCYSLVHDDLPAMDDDDLRRGRPTVHRAFDEATAILA
ECHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHC
GDGLLTLAFDLLAGEDAHPDPAVRIALVRALARASGIGGMVGGQMLDLAAEGRFSGGTPL
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHCCCCCCCCCH
ALAEDAIRDLQAMKTGALLAVSVEAGALLGGATADERAALLAYGRALGAAFQIADDILDV
HHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
EGTAEEVGKKVGKDAAAGKATLVSRLGLPAARTLLDRLVADASAALAPFGARGAVLAEAA
CCCHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LFVANRRN
HHHHCCCC
>Mature Secondary Structure 
TFSLKDRLDASAAATEARLALALADAALPGERLRPERLMAAMRHGALGGGKRLRPFLVI
CCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEE
ESAALFGIPADQAVTAATAIECIHCYSLVHDDLPAMDDDDLRRGRPTVHRAFDEATAILA
ECHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHC
GDGLLTLAFDLLAGEDAHPDPAVRIALVRALARASGIGGMVGGQMLDLAAEGRFSGGTPL
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHCCCCCCCCCH
ALAEDAIRDLQAMKTGALLAVSVEAGALLGGATADERAALLAYGRALGAAFQIADDILDV
HHHHHHHHHHHHHHCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
EGTAEEVGKKVGKDAAAGKATLVSRLGLPAARTLLDRLVADASAALAPFGARGAVLAEAA
CCCHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LFVANRRN
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]