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The map label for this gene is phoR [H]

Identifier: 154244154

GI number: 154244154

Start: 196556

End: 198088

Strand: Direct

Name: phoR [H]

Synonym: Xaut_0196

Alternate gene names: 154244154

Gene position: 196556-198088 (Clockwise)

Preceding gene: 154244152

Following gene: 154244155

Centisome position: 3.7

GC content: 72.02

Gene sequence:

>1533_bases
ATGGCGATGGCTGGACCCGAGCGGGATATGGATCTCCAGCCCGCTGCGGCACCCCGCGGTGGGCCTGCTGGCGCCAGCGG
CGGGCGGGAGCCGGTGGCCGCTGAAGCTCAGGCGCGCGCAGCGGAGGTTGGCGCCGTCGTGGTGAAGGGACCCGAGTCGA
GCGCGCCGACGCCGGGGTCCCCCGATGCCGCTTCACTCCCGGCGGGCAGCCCGACGCAGCAAGGCGCGAAGCAAGGCCCA
CGTCGGCGGTCGCTCCTCCTCGTGGCCGCCCTGGCGCTGGTCGTCGTCGCCGGGGTGGTCCTCGGCGAGCTCGATCCGCT
GCTCGCCACGCTCATGGTGGCGTTGCTGGTGGCGCTCCTGTTCAGCCTGCCTCAGATCCCTTCTCTCCCCGCCCTTCCGG
AGGCGCCGCCCTTGCCCCCGCCGCCCGCGCCGCCAGTGCGCGGCGATGCCCAGGCGGCGGCGGTGGTGGCCGCCCTGCCG
GAGCCGGCCCTGCTGCTGTCGGCCACCGGCGAGATCATCACCGCCAACGAGCGCTTCAACCTCGCCATCGGCACGACCCG
GGTGGGTGATCCTTTGTCCTTCGTGGTGCGTGTGCCGGAGGTGCTGGACGCGGTGCGCGCCGCCGCCGAGGACGGCCTGC
CGCGGCGGGTGGAATTCGCCGAGCGCATCCCGCTCGATCGCTGGCTGGAGGCCCATGTGGTGCCGCTGCGGCTGGAGGCC
CACGCCGGCATCCGCTCCGGCGGGCGGCGGGCGGCGGATGTGCCGGATGCGGTGCTGCTCACCTTCCGCGACCTCACCCA
GCAGCGCCGGGTGGAGCAGATGCGGGCCGATTTCGTGGCCAATGCCAGCCACGAGCTGCGCACCCCGCTCGCCTCCCTGT
CCGGCTTCATCGAGACCCTGCAAGGCCCGGCGCGCAACGATGCTCCGGCGCGCGAGCGCTTCCTCGCCATCATGGCGGCT
CAGGCGCGGCGCATGTCGCGGCTCATCGACGACCTGCTCTCCCTGTCGCGGATCGAGCTCAACGCCCATGTGCGGCCGCA
GACCAAGGTCGATCTCGGCGGCATCCTCGCCCATGTGTGCGACACCCTCTCCCCCCTCGCCAGGGATCGCGGCGTGACGC
TGGATCAGGTGAAGGACGCCGTGCCGCTGGAGGTGCTGGGCGACCGGGACGAACTGATCCGCCTGTTCGAGAACCTGGTG
GAGAACGCGCTGAAATATGGCGCGCCCGGCAAAAGGATCGAGGTTCGCCTGTTCCGCGAGAACGGGACGGCGGTGGTGAG
CATCCGCGATTTCGGTCCCGGCATCCCCCCCGAGCACCTGCCGCGCCTCACCGAGCGCTTCTACCGGGTGGACGTGGCGG
CGAGCCGCGACCAGGGCGGTACGGGGCTGGGGCTCGCCATCGTCAAGCACATCGTGGCCCGCCATCGGGGCCGGCTGGGC
ATCGATAGCGTGCTGGGCGAAGGCGCAACCTTCAGCGTGCGCCTTGACGCTTTGCCGGGTCCGGAAAAAAATGGCGGGCA
GACAGCCGCTTAG

Upstream 100 bases:

>100_bases
TGAGCGGCTCCAGCATTCAGGTAAGCGGACGCCAAAGGGCGATTCGCCCGGCTGGCGCCGGAACGGCGCCCAACACAGAC
GCCCGGGAGGCGCGAAGAGG

Downstream 100 bases:

>100_bases
AGCGTCATCTCCGTGTCACGCGGTCGTCATAGAACCTTGGCTGACCGGGGCTAAGAGTCCCGAGCCCAATGTTGCCCCGG
CGTCAGGCCTGGACCGGCAG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MAMAGPERDMDLQPAAAPRGGPAGASGGREPVAAEAQARAAEVGAVVVKGPESSAPTPGSPDAASLPAGSPTQQGAKQGP
RRRSLLLVAALALVVVAGVVLGELDPLLATLMVALLVALLFSLPQIPSLPALPEAPPLPPPPAPPVRGDAQAAAVVAALP
EPALLLSATGEIITANERFNLAIGTTRVGDPLSFVVRVPEVLDAVRAAAEDGLPRRVEFAERIPLDRWLEAHVVPLRLEA
HAGIRSGGRRAADVPDAVLLTFRDLTQQRRVEQMRADFVANASHELRTPLASLSGFIETLQGPARNDAPARERFLAIMAA
QARRMSRLIDDLLSLSRIELNAHVRPQTKVDLGGILAHVCDTLSPLARDRGVTLDQVKDAVPLEVLGDRDELIRLFENLV
ENALKYGAPGKRIEVRLFRENGTAVVSIRDFGPGIPPEHLPRLTERFYRVDVAASRDQGGTGLGLAIVKHIVARHRGRLG
IDSVLGEGATFSVRLDALPGPEKNGGQTAA

Sequences:

>Translated_510_residues
MAMAGPERDMDLQPAAAPRGGPAGASGGREPVAAEAQARAAEVGAVVVKGPESSAPTPGSPDAASLPAGSPTQQGAKQGP
RRRSLLLVAALALVVVAGVVLGELDPLLATLMVALLVALLFSLPQIPSLPALPEAPPLPPPPAPPVRGDAQAAAVVAALP
EPALLLSATGEIITANERFNLAIGTTRVGDPLSFVVRVPEVLDAVRAAAEDGLPRRVEFAERIPLDRWLEAHVVPLRLEA
HAGIRSGGRRAADVPDAVLLTFRDLTQQRRVEQMRADFVANASHELRTPLASLSGFIETLQGPARNDAPARERFLAIMAA
QARRMSRLIDDLLSLSRIELNAHVRPQTKVDLGGILAHVCDTLSPLARDRGVTLDQVKDAVPLEVLGDRDELIRLFENLV
ENALKYGAPGKRIEVRLFRENGTAVVSIRDFGPGIPPEHLPRLTERFYRVDVAASRDQGGTGLGLAIVKHIVARHRGRLG
IDSVLGEGATFSVRLDALPGPEKNGGQTAA
>Mature_509_residues
AMAGPERDMDLQPAAAPRGGPAGASGGREPVAAEAQARAAEVGAVVVKGPESSAPTPGSPDAASLPAGSPTQQGAKQGPR
RRSLLLVAALALVVVAGVVLGELDPLLATLMVALLVALLFSLPQIPSLPALPEAPPLPPPPAPPVRGDAQAAAVVAALPE
PALLLSATGEIITANERFNLAIGTTRVGDPLSFVVRVPEVLDAVRAAAEDGLPRRVEFAERIPLDRWLEAHVVPLRLEAH
AGIRSGGRRAADVPDAVLLTFRDLTQQRRVEQMRADFVANASHELRTPLASLSGFIETLQGPARNDAPARERFLAIMAAQ
ARRMSRLIDDLLSLSRIELNAHVRPQTKVDLGGILAHVCDTLSPLARDRGVTLDQVKDAVPLEVLGDRDELIRLFENLVE
NALKYGAPGKRIEVRLFRENGTAVVSIRDFGPGIPPEHLPRLTERFYRVDVAASRDQGGTGLGLAIVKHIVARHRGRLGI
DSVLGEGATFSVRLDALPGPEKNGGQTAA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=263, Percent_Identity=41.06463878327, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788393, Length=208, Percent_Identity=37.5, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1786783, Length=376, Percent_Identity=29.2553191489362, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=32.7935222672065, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788713, Length=384, Percent_Identity=23.9583333333333, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=30.2521008403361, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=32.4444444444444, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=25.2032520325203, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=29.0598290598291, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788549, Length=361, Percent_Identity=26.8698060941828, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=208, Percent_Identity=33.1730769230769, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789403, Length=198, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=29.9559471365639, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=27.0742358078603, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=28.3261802575107, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=202, Percent_Identity=27.2277227722772, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=27.5193798449612, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=28.1818181818182, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53800; Mature: 53668

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMAGPERDMDLQPAAAPRGGPAGASGGREPVAAEAQARAAEVGAVVVKGPESSAPTPGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCCCCCCCC
PDAASLPAGSPTQQGAKQGPRRRSLLLVAALALVVVAGVVLGELDPLLATLMVALLVALL
CCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSLPQIPSLPALPEAPPLPPPPAPPVRGDAQAAAVVAALPEPALLLSATGEIITANERFN
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCEEECCCEEE
LAIGTTRVGDPLSFVVRVPEVLDAVRAAAEDGLPRRVEFAERIPLDRWLEAHVVPLRLEA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCEEEEEEEC
HAGIRSGGRRAADVPDAVLLTFRDLTQQRRVEQMRADFVANASHELRTPLASLSGFIETL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QGPARNDAPARERFLAIMAAQARRMSRLIDDLLSLSRIELNAHVRPQTKVDLGGILAHVC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHH
DTLSPLARDRGVTLDQVKDAVPLEVLGDRDELIRLFENLVENALKYGAPGKRIEVRLFRE
HHHHHHHHHCCCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
NGTAVVSIRDFGPGIPPEHLPRLTERFYRVDVAASRDQGGTGLGLAIVKHIVARHRGRLG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCC
IDSVLGEGATFSVRLDALPGPEKNGGQTAA
HHHHHCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AMAGPERDMDLQPAAAPRGGPAGASGGREPVAAEAQARAAEVGAVVVKGPESSAPTPGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCCCCCCCC
PDAASLPAGSPTQQGAKQGPRRRSLLLVAALALVVVAGVVLGELDPLLATLMVALLVALL
CCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSLPQIPSLPALPEAPPLPPPPAPPVRGDAQAAAVVAALPEPALLLSATGEIITANERFN
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCEEECCCEEE
LAIGTTRVGDPLSFVVRVPEVLDAVRAAAEDGLPRRVEFAERIPLDRWLEAHVVPLRLEA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCEEEEEEEC
HAGIRSGGRRAADVPDAVLLTFRDLTQQRRVEQMRADFVANASHELRTPLASLSGFIETL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QGPARNDAPARERFLAIMAAQARRMSRLIDDLLSLSRIELNAHVRPQTKVDLGGILAHVC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHH
DTLSPLARDRGVTLDQVKDAVPLEVLGDRDELIRLFENLVENALKYGAPGKRIEVRLFRE
HHHHHHHHHCCCCHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEC
NGTAVVSIRDFGPGIPPEHLPRLTERFYRVDVAASRDQGGTGLGLAIVKHIVARHRGRLG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCC
IDSVLGEGATFSVRLDALPGPEKNGGQTAA
HHHHHCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]