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The map label for this gene is lpd3 [H]

Identifier: 154244117

GI number: 154244117

Start: 155918

End: 157321

Strand: Direct

Name: lpd3 [H]

Synonym: Xaut_0159

Alternate gene names: 154244117

Gene position: 155918-157321 (Clockwise)

Preceding gene: 154244116

Following gene: 154244119

Centisome position: 2.94

GC content: 67.17

Gene sequence:

>1404_bases
ATGTCCTACGATCTCACCATCATCGGTACCGGCCCCGGCGGCTATGTGTGTGCCATTCGCGCGGCCCAGCTCGGTCTCAA
GGTGGCCGTGGTGGAGAAGCGCGGCACCCATGGCGGCACCTGCCTCAACGTGGGCTGCATCCCGTCCAAGGCGCTGCTCT
ACGCTTCCGAGCTGTTCGAGGAAGCCGGGCACAAGTTCGGCGAGATGGGCATCGGCGTGCCGGCCCCCAAGCTCGACCTG
AAGGCGATGCTGGCCTTCAAGGACAAGGGCGTGGACGGCAACGTCAAGGGCGTCGAGTTCCTGCTCAAGAAGAACAAGGT
CGACGTCTACATGGGCGCCGGCAAGATCCTCGGCACCGGCAAGGTCGAGGTGACGCTGAATGCCGATGGCAAGGTCGAGG
TCCTGGAGACCAAGAACATCGTCATCGCCACCGGCTCGGACGTGGCACCCCTGCCGGGCGTGACCATCGACGAGCAGCGC
ATCGTCTCCTCCACCGGCGCGCTGTCGCTGCCGAAGGTGCCGGGCAAGCTGCTGGTGGTGGGTGCCGGCGTCATCGGCCT
GGAGCTGGGCTCGGTGTGGCGCCGTCTCGGGGCGCAGGTGACCGTGGTGGAGTTCCTCGACCGCATCCTGCCCGGCATGG
ACAGCGACGTGGCCAAGAGCTTCCAGCGCATCCTCGACAAGCAGGGCTTTGCCTTCAAGCTCGGCACCAAGGTCACCGGG
GTCGATACCTCGGGCAAGACCCTGAAGGTGTCGGTGGAGCCGGCGGCCGGCGGCGCGGCCGAGGTAATCGAGGCGGACGT
GGTGCTGGTGGCCATCGGCCGCATTCCCTACACCGCGGGCCTCGGCCTCGACGAGGCGGGCGTTGCCAAGGACGGCCGCG
GCCGCGTGGTCACCGACCACCACTTCGCCACCAACGTGCCGGGCATCTATGCCATCGGCGACGTGATCGTCGGCCCCATG
CTCGCCCACAAGGCCGAGGATGAAGGCGTGGCGCTGGCGGAATTGCTGGCGGGCAAGGCCGGCCACGTGAACTATGACGT
GATCCCCGGCGTCGTCTACACCTTCCCGGAAGTGGCCTCCGTCGGCAAGTCCGAGGACGACCTGAAGGCGGCGGGCGTGG
CCTACAAGGTGGGCAAGTTCCCCTTCACCGCCAACGGCCGCACCAAGGTGAACAACACCACGGACGGCTTCGTGAAGATC
ATCGCCGACGCCGCCACCGACAAGGTGCTGGGCGCCCACATCATCGGCCCCGAGGCCGGCGAGATGATCCACGAATGCGC
GGTGCTGATGGAGTTCGGCGGCTCGTCGGAAGACCTCGCCCGCACCTGCCATGCTCACCCCACCCGCTCGGAAGCGGTGA
AGGAAGCGGCGATGGCCGTGGAGAAGCGCGCCATTCACATGTGA

Upstream 100 bases:

>100_bases
AGTATAAATCACCTCGACTGGAGCCGGTCGACCGGCATCGTGCTCGATGCGGTCCGGGATCATGGACAGCGGCTTTACTT
GAGGTCTGGAGACTAAAGCG

Downstream 100 bases:

>100_bases
TGGCCGGCGCGGGGCCGGCTGGCGGCCGCCCCGCGTCTCTTCATTTTGGAACGCGGCGCCATGCCGTCCGCAGCCTCGGC
CGACATCTGTCGTCCGGGGC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSYDLTIIGTGPGGYVCAIRAAQLGLKVAVVEKRGTHGGTCLNVGCIPSKALLYASELFEEAGHKFGEMGIGVPAPKLDL
KAMLAFKDKGVDGNVKGVEFLLKKNKVDVYMGAGKILGTGKVEVTLNADGKVEVLETKNIVIATGSDVAPLPGVTIDEQR
IVSSTGALSLPKVPGKLLVVGAGVIGLELGSVWRRLGAQVTVVEFLDRILPGMDSDVAKSFQRILDKQGFAFKLGTKVTG
VDTSGKTLKVSVEPAAGGAAEVIEADVVLVAIGRIPYTAGLGLDEAGVAKDGRGRVVTDHHFATNVPGIYAIGDVIVGPM
LAHKAEDEGVALAELLAGKAGHVNYDVIPGVVYTFPEVASVGKSEDDLKAAGVAYKVGKFPFTANGRTKVNNTTDGFVKI
IADAATDKVLGAHIIGPEAGEMIHECAVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM

Sequences:

>Translated_467_residues
MSYDLTIIGTGPGGYVCAIRAAQLGLKVAVVEKRGTHGGTCLNVGCIPSKALLYASELFEEAGHKFGEMGIGVPAPKLDL
KAMLAFKDKGVDGNVKGVEFLLKKNKVDVYMGAGKILGTGKVEVTLNADGKVEVLETKNIVIATGSDVAPLPGVTIDEQR
IVSSTGALSLPKVPGKLLVVGAGVIGLELGSVWRRLGAQVTVVEFLDRILPGMDSDVAKSFQRILDKQGFAFKLGTKVTG
VDTSGKTLKVSVEPAAGGAAEVIEADVVLVAIGRIPYTAGLGLDEAGVAKDGRGRVVTDHHFATNVPGIYAIGDVIVGPM
LAHKAEDEGVALAELLAGKAGHVNYDVIPGVVYTFPEVASVGKSEDDLKAAGVAYKVGKFPFTANGRTKVNNTTDGFVKI
IADAATDKVLGAHIIGPEAGEMIHECAVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM
>Mature_466_residues
SYDLTIIGTGPGGYVCAIRAAQLGLKVAVVEKRGTHGGTCLNVGCIPSKALLYASELFEEAGHKFGEMGIGVPAPKLDLK
AMLAFKDKGVDGNVKGVEFLLKKNKVDVYMGAGKILGTGKVEVTLNADGKVEVLETKNIVIATGSDVAPLPGVTIDEQRI
VSSTGALSLPKVPGKLLVVGAGVIGLELGSVWRRLGAQVTVVEFLDRILPGMDSDVAKSFQRILDKQGFAFKLGTKVTGV
DTSGKTLKVSVEPAAGGAAEVIEADVVLVAIGRIPYTAGLGLDEAGVAKDGRGRVVTDHHFATNVPGIYAIGDVIVGPML
AHKAEDEGVALAELLAGKAGHVNYDVIPGVVYTFPEVASVGKSEDDLKAAGVAYKVGKFPFTANGRTKVNNTTDGFVKII
ADAATDKVLGAHIIGPEAGEMIHECAVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=57.9520697167756, Blast_Score=515, Evalue=1e-146,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=29.8056155507559, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI33519430, Length=467, Percent_Identity=29.9785867237687, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI33519428, Length=467, Percent_Identity=29.9785867237687, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI33519426, Length=467, Percent_Identity=29.9785867237687, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI148277071, Length=467, Percent_Identity=29.9785867237687, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI148277065, Length=467, Percent_Identity=29.9785867237687, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI22035672, Length=488, Percent_Identity=30.9426229508197, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=30.8695652173913, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI291045268, Length=454, Percent_Identity=29.9559471365639, Blast_Score=123, Evalue=5e-28,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=41.9213973799127, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87082354, Length=474, Percent_Identity=31.2236286919831, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87081717, Length=466, Percent_Identity=29.8283261802575, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=441, Percent_Identity=29.9319727891156, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=457, Percent_Identity=56.4551422319475, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=31.5126050420168, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71982272, Length=495, Percent_Identity=29.6969696969697, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=28.159645232816, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=28.159645232816, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17559934, Length=267, Percent_Identity=26.5917602996255, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=52.8541226215645, Blast_Score=468, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=33.9019189765458, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=30.1282051282051, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=57.4235807860262, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24640553, Length=491, Percent_Identity=31.3645621181263, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24640549, Length=491, Percent_Identity=31.3645621181263, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24640551, Length=491, Percent_Identity=31.3645621181263, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17737741, Length=495, Percent_Identity=29.4949494949495, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48514; Mature: 48383

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDLTIIGTGPGGYVCAIRAAQLGLKVAVVEKRGTHGGTCLNVGCIPSKALLYASELFE
CCEEEEEEECCCCCEEEEEEEHHCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
EAGHKFGEMGIGVPAPKLDLKAMLAFKDKGVDGNVKGVEFLLKKNKVDVYMGAGKILGTG
HHCHHHHCCCCCCCCCCCCHHEEEEEECCCCCCCCHHHHEEEECCCEEEEEECCEEEECC
KVEVTLNADGKVEVLETKNIVIATGSDVAPLPGVTIDEQRIVSSTGALSLPKVPGKLLVV
EEEEEECCCCCEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHCCCCEECCCCCCEEEEE
GAGVIGLELGSVWRRLGAQVTVVEFLDRILPGMDSDVAKSFQRILDKQGFAFKLGTKVTG
ECCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCEEEE
VDTSGKTLKVSVEPAAGGAAEVIEADVVLVAIGRIPYTAGLGLDEAGVAKDGRGRVVTDH
ECCCCCEEEEEECCCCCCHHHHHHCCEEEEEECCCCEECCCCCCCCCCCCCCCCCEEECC
HFATNVPGIYAIGDVIVGPMLAHKAEDEGVALAELLAGKAGHVNYDVIPGVVYTFPEVAS
CCCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEECCCHHHCCHHHHH
VGKSEDDLKAAGVAYKVGKFPFTANGRTKVNNTTDGFVKIIADAATDKVLGAHIIGPEAG
CCCCCCHHHHCCEEEEECCCEECCCCCEECCCCCCCCEEEEEHHHCCCCCEEEEECCCHH
EMIHECAVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM
HHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYDLTIIGTGPGGYVCAIRAAQLGLKVAVVEKRGTHGGTCLNVGCIPSKALLYASELFE
CEEEEEEECCCCCEEEEEEEHHCCEEEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
EAGHKFGEMGIGVPAPKLDLKAMLAFKDKGVDGNVKGVEFLLKKNKVDVYMGAGKILGTG
HHCHHHHCCCCCCCCCCCCHHEEEEEECCCCCCCCHHHHEEEECCCEEEEEECCEEEECC
KVEVTLNADGKVEVLETKNIVIATGSDVAPLPGVTIDEQRIVSSTGALSLPKVPGKLLVV
EEEEEECCCCCEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHCCCCEECCCCCCEEEEE
GAGVIGLELGSVWRRLGAQVTVVEFLDRILPGMDSDVAKSFQRILDKQGFAFKLGTKVTG
ECCHHHHHHHHHHHHHCCEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCEEEE
VDTSGKTLKVSVEPAAGGAAEVIEADVVLVAIGRIPYTAGLGLDEAGVAKDGRGRVVTDH
ECCCCCEEEEEECCCCCCHHHHHHCCEEEEEECCCCEECCCCCCCCCCCCCCCCCEEECC
HFATNVPGIYAIGDVIVGPMLAHKAEDEGVALAELLAGKAGHVNYDVIPGVVYTFPEVAS
CCCCCCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEECCCHHHCCHHHHH
VGKSEDDLKAAGVAYKVGKFPFTANGRTKVNNTTDGFVKIIADAATDKVLGAHIIGPEAG
CCCCCCHHHHCCEEEEECCCEECCCCCEECCCCCCCCEEEEEHHHCCCCCEEEEECCCHH
EMIHECAVLMEFGGSSEDLARTCHAHPTRSEAVKEAAMAVEKRAIHM
HHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]